产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
RPA2单克隆抗体(9H8)
目录 :
MA1-26418
规格 :
500微升
价格 :
美国516.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
9H8
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, EMSA, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 43
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 5d
Moquin D, Genois M, Zhang J, Ouyang J, Yadav T, Buisson R, et al. Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination. Genes Dev. 2019;33:75-89 pubmed 出版商
  • 免疫细胞化学; 人类
Mortusewicz O, Evers B, Helleday T. PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites. Oncogene. 2016;35:761-70 pubmed 出版商
  • 免疫细胞化学; 人类; 1:300; 图 1
Averbeck N, Ringel O, Herrlitz M, Jakob B, Durante M, Taucher Scholz G. DNA end resection is needed for the repair of complex lesions in G1-phase human cells. Cell Cycle. 2014;13:2509-16 pubmed 出版商
  • 免疫细胞化学; 人类; 1:2000
Quinet A, Vessoni A, Rocha C, Gottifredi V, Biard D, Sarasin A, et al. Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome. DNA Repair (Amst). 2014;14:27-38 pubmed 出版商
  • 免疫细胞化学; 人类
Lam T, Thomas L, White C, Li G, Pone E, Xu Z, et al. Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination. PLoS ONE. 2013;8:e80414 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Ouyang K, Yagle M, Matunis M, Ellis N. BLM SUMOylation regulates ssDNA accumulation at stalled replication forks. Front Genet. 2013;4:167 pubmed 出版商
  • 免疫细胞化学; 小鼠
Schaetzlein S, Chahwan R, Avdievich E, Roa S, Wei K, Eoff R, et al. Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes. Proc Natl Acad Sci U S A. 2013;110:E2470-9 pubmed 出版商
  • 免疫细胞化学; 人类; 1:300
Muller I, Merk B, Voss K, Averbeck N, Jakob B, Durante M, et al. Species conserved DNA damage response at the inactive human X chromosome. Mutat Res. 2013;756:30-6 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500
BURRELL R, McClelland S, Endesfelder D, Groth P, Weller M, Shaikh N, et al. Replication stress links structural and numerical cancer chromosomal instability. Nature. 2013;494:492-496 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Soria G, Almouzni G. Differential contribution of HP1 proteins to DNA end resection and homology-directed repair. Cell Cycle. 2013;12:422-9 pubmed 出版商
  • 流式细胞仪; 人类
Beck H, Nähse Kumpf V, Larsen M, O Hanlon K, Patzke S, Holmberg C, et al. Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption. Mol Cell Biol. 2012;32:4226-36 pubmed
  • 免疫细胞化学; 人类
Sharma S, Hicks J, Chute C, Brennan J, Ahn J, Glover T, et al. REV1 and polymerase ? facilitate homologous recombination repair. Nucleic Acids Res. 2012;40:682-91 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Sun J, Oma Y, Harata M, Kono K, Shima H, Kinomura A, et al. ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot. PLoS ONE. 2010;5:e13554 pubmed 出版商
  • 免疫细胞化学; 人类
Kratz K, Schöpf B, Kaden S, Sendoel A, Eberhard R, Lademann C, et al. Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents. Cell. 2010;142:77-88 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Lee D, Pan Y, Kanner S, Sung P, Borowiec J, Chowdhury D. A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination. Nat Struct Mol Biol. 2010;17:365-72 pubmed 出版商
  • 免疫印迹; 人类
Zuco V, Benedetti V, Zunino F. ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968. Cancer Lett. 2010;292:186-96 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Fugger K, Mistrik M, Danielsen J, Dinant C, Falck J, Bartek J, et al. Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities. J Cell Biol. 2009;186:655-63 pubmed 出版商
  • 免疫印迹; 人类
Zuco V, Benedetti V, De Cesare M, Zunino F. Sensitization of ovarian carcinoma cells to the atypical retinoid ST1926 by the histone deacetylase inhibitor, RC307: enhanced DNA damage response. Int J Cancer. 2010;126:1246-55 pubmed 出版商
  • 免疫印迹; 人类; 1:4000
Stephan H, Concannon C, Kremmer E, Carty M, Nasheuer H. Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis. Nucleic Acids Res. 2009;37:6028-41 pubmed 出版商
  • 免疫细胞化学; 人类
Watrin E, Peters J. The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells. EMBO J. 2009;28:2625-35 pubmed 出版商
  • EMSA; 人类
Lange S, Reddy M, Vasquez K. Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks. DNA Repair (Amst). 2009;8:865-72 pubmed 出版商
  • 免疫印迹; 人类
Giommarelli C, Corti A, Supino R, Favini E, Paolicchi A, Pompella A, et al. Gamma-glutamyltransferase-dependent resistance to arsenic trioxide in melanoma cells and cellular sensitization by ascorbic acid. Free Radic Biol Med. 2009;46:1516-26 pubmed 出版商
  • 免疫组化; 人类; 1:200
Planchard D, Domont J, Taranchon E, Monnet I, Tredaniel J, Caliandro R, et al. The NER proteins are differentially expressed in ever smokers and in never smokers with lung adenocarcinoma. Ann Oncol. 2009;20:1257-63 pubmed 出版商
  • 免疫组化; 人类; 1:200
Barrientos K, Kendellen M, Freibaum B, Armbruster B, Etheridge K, Counter C. Distinct functions of POT1 at telomeres. Mol Cell Biol. 2008;28:5251-64 pubmed 出版商
  • EMSA; 人类
  • 免疫印迹; 人类
Pisano C, Zuco V, De Cesare M, Benedetti V, Vesci L, Foderà R, et al. Intracellular accumulation and DNA damage persistence as determinants of human squamous cell carcinoma hypersensitivity to the novel camptothecin ST1968. Eur J Cancer. 2008;44:1332-40 pubmed 出版商
  • 免疫印迹; 人类
Giommarelli C, Corti A, Supino R, Favini E, Paolicchi A, Pompella A, et al. Cellular response to oxidative stress and ascorbic acid in melanoma cells overexpressing gamma-glutamyltransferase. Eur J Cancer. 2008;44:750-9 pubmed 出版商
  • 免疫印迹; 人类; 1:4000
Braet C, Stephan H, Dobbie I, Togashi D, Ryder A, Földes Papp Z, et al. Mobility and distribution of replication protein A in living cells using fluorescence correlation spectroscopy. Exp Mol Pathol. 2007;82:156-62 pubmed
  • 免疫沉淀; 人类
  • 酶联免疫吸附测定; 人类; 2 ug/ml
  • 免疫印迹; 人类; 1:500
Yamasaki Y, Narain S, Hernandez L, Barker T, Ikeda K, Segal M, et al. Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases. Arthritis Res Ther. 2006;8:R111 pubmed
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Rossi R, Lidonnici M, Soza S, Biamonti G, Montecucco A. The dispersal of replication proteins after Etoposide treatment requires the cooperation of Nbs1 with the ataxia telangiectasia Rad3-related/Chk1 pathway. Cancer Res. 2006;66:1675-83 pubmed
  • 免疫印迹; 人类
Zuco V, Zanchi C, Lanzi C, Beretta G, Supino R, Pisano C, et al. Development of resistance to the atypical retinoid, ST1926, in the lung carcinoma cell line H460 is associated with reduced formation of DNA strand breaks and a defective DNA damage response. Neoplasia. 2005;7:667-77 pubmed
Hossain M, Lin Y, Driscoll G, Li J, McMahon A, Matos J, et al. APE2 Is a General Regulator of the ATR-Chk1 DNA Damage Response Pathway to Maintain Genome Integrity in Pancreatic Cancer Cells. Front Cell Dev Biol. 2021;9:738502 pubmed 出版商
Ju M, Shin K, Lee J, Khim K, A Lee E, Ra J, et al. NSMF promotes the replication stress-induced DNA damage response for genome maintenance. Nucleic Acids Res. 2021;49:5605-5622 pubmed 出版商
Jegadesan N, Branzei D. DDX11 loss causes replication stress and pharmacologically exploitable DNA repair defects. Proc Natl Acad Sci U S A. 2021;118: pubmed 出版商
Genois M, Gagné J, Yasuhara T, Jackson J, Saxena S, Langelier M, et al. CARM1 regulates replication fork speed and stress response by stimulating PARP1. Mol Cell. 2021;81:784-800.e8 pubmed 出版商
Lin Y, Raj J, Li J, Ha A, Hossain M, Richardson C, et al. APE1 senses DNA single-strand breaks for repair and signaling. Nucleic Acids Res. 2020;48:1925-1940 pubmed 出版商
Moiseeva T, Hood B, Schamus S, O Connor M, Conrads T, Bakkenist C. ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1. Nat Commun. 2017;8:1392 pubmed 出版商
Taglialatela A, Alvarez S, Leuzzi G, Sannino V, Ranjha L, Huang J, et al. Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers. Mol Cell. 2017;68:414-430.e8 pubmed 出版商
Dubois J, Yates M, Gaudreau Lapierre A, Clement G, Cappadocia L, Gaudreau L, et al. A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination. Nucleic Acids Res. 2017;45:8859-8872 pubmed 出版商
Nguyen H, Yadav T, Giri S, Saez B, Graubert T, Zou L. Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1. Mol Cell. 2017;65:832-847.e4 pubmed 出版商
Hu R, Wang E, Peng G, Dai H, Lin S. Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage. Cell Cycle. 2013;12:2033-41 pubmed 出版商
Ricke R, Bielinsky A. Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha. Mol Cell. 2004;16:173-85 pubmed
Zuco V, Zanchi C, Cassinelli G, Lanzi C, Supino R, Pisano C, et al. Induction of apoptosis and stress response in ovarian carcinoma cell lines treated with ST1926, an atypical retinoid. Cell Death Differ. 2004;11:280-9 pubmed
Sukhodolets K, Hickman A, Agarwal S, Sukhodolets M, Obungu V, Novotny E, et al. The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene. Mol Cell Biol. 2003;23:493-509 pubmed
产品信息
产品类型 :
抗体
产品名称 :
RPA2单克隆抗体(9H8)
目录# :
MA1-26418
规格 :
500微升
价格 :
美国516.00
克隆性 :
单克隆
纯度 :
IgG分馏成分
宿主 :
小鼠
反应物种 :
Human, Non-human primate
应用 :
Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:500
物种 :
Human, Non-human primate
克隆 :
9H8
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage.
免疫原 :
全长人类蛋白
格式 :
液体
应用w/稀释 :
Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:500
别名 :
30-kDa protein; AA409079; AI325195; AU020965; HSSB; hypothetical protein; I79_004200; p32; p32-subunit of replication protein A; p34; REPA2; Replication factor A protein 2; replication protein A 32 kDa subunit; Replication protein A 32kDa subunit; Replication protein A 34 kDa subunit; Replication protein A 34kDa subunit; replication protein A2; replication protein A2, 32kDa; replication protein A4; RFA; RF-A protein 2; Rf-A2; RP21C; RP4-547C9.3; RP-A p32; RP-A p34; RPA2; RPA32; RPA34; RPA4; RpLP1; RpP2
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国