产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
雌激素受体α单克隆抗体(33)
目录 :
MA1-310
规格 :
100微克
价格 :
美国450.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
33
反应物种 :
人类, 小鼠, 大鼠, 牛, pigs , 家羊
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, EMSA, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 45
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| Kalthoff S, Winkler A, Freiberg N, Manns M, Strassburg C. Gender matters: estrogen receptor alpha (ER?) and histone deacetylase (HDAC) 1 and 2 control the gender-specific transcriptional regulation of human uridine diphosphate glucuronosyltransferases genes (UGT1A). J Hepatol. 2013;59:797-804 pubmed 出版商
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| Zhao Q, Tan Z, Guo J, Chen Y. Estrous cycle-dependent expression of estrogen receptor alpha in periodontal tissue. Chronobiol Int. 2007;24:425-33 pubmed
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| Köhler H, Kloas W, Schirling M, Lutz I, Reye A, Langen J, et al. Sex steroid receptor evolution and signalling in aquatic invertebrates. Ecotoxicology. 2007;16:131-43 pubmed
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| Capellino S, Riepl B, Rauch L, Angele P, Cutolo M, Straub R. Quantitative determination of steroid hormone receptor positive cells in the synovium of patients with rheumatoid arthritis and osteoarthritis: is there a link to inflammation?. Ann Rheum Dis. 2007;66:53-8 pubmed
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| Lamote I, Meyer E, De Ketelaere A, Duchateau L, Burvenich C. Expression of the estrogen receptor in blood neutrophils of dairy cows during the periparturient period. Theriogenology. 2006;65:1082-98 pubmed
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Dhawan L, Liu B, Blaxall B, Taubman M. A novel role for the glucocorticoid receptor in the regulation of monocyte chemoattractant protein-1 mRNA stability. J Biol Chem. 2007;282:10146-52 pubmed
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Tilton S, Foran C, Benson W. Effects of cadmium on the reproductive axis of Japanese medaka (Oryzias latipes). Comp Biochem Physiol C Toxicol Pharmacol. 2003;136:265-76 pubmed
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Gopalkrishnan K, Katkam R, Sachdeva G, Kholkute S, Padwal V, Puri C. Effects of an antiprogestin onapristone on the endometrium of bonnet monkeys: morphometric and ultrastructural studies. Biol Reprod. 2003;68:1959-67 pubmed
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Wiren K, Chapman Evans A, Zhang X. Osteoblast differentiation influences androgen and estrogen receptor-alpha and -beta expression. J Endocrinol. 2002;175:683-94 pubmed
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Kobayashi K, Mandai M, Suzuma I, Kobayashi H, Okinami S. Expression of estrogen receptor in the choroidal neovascular membranes in highly myopic eyes. Retina. 2002;22:418-22 pubmed
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Foran C, Peterson B, Benson W. Transgenerational and developmental exposure of Japanese medaka (Oryzias latipes) to ethinylestradiol results in endocrine and reproductive differences in the response to ethinylestradiol as adults. Toxicol Sci. 2002;68:389-402 pubmed
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van der Eerden B, Gevers E, Lowik C, Karperien M, Wit J. Expression of estrogen receptor alpha and beta in the epiphyseal plate of the rat. Bone. 2002;30:478-85 pubmed
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Song R, McPherson R, Adam L, Bao Y, Shupnik M, Kumar R, et al. Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activation. Mol Endocrinol. 2002;16:116-27 pubmed
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Cao S, Hudnall S, Kohen F, Lu L. Measurement of estrogen receptors in intact cells by flow cytometry. Cytometry. 2000;41:109-14 pubmed
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Mendez M, Chavez B, Echeverria O, Vilchis F, Vázquez Nin G, Pedernera E. Evidence for estrogen receptor expression in germ cell and somatic cell subpopulations in the ovary of the newly hatched chicken. Cell Tissue Res. 1999;298:145-52 pubmed
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Suzuma I, Mandai M, Takagi H, Suzuma K, Otani A, Oh H, et al. 17 Beta-estradiol increases VEGF receptor-2 and promotes DNA synthesis in retinal microvascular endothelial cells. Invest Ophthalmol Vis Sci. 1999;40:2122-9 pubmed
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Falkner K, Xiao G, Pinaire J, Pendleton M, Lindahl R, Prough R. The negative regulation of the rat aldehyde dehydrogenase 3 gene by glucocorticoids: involvement of a single imperfect palindromic glucocorticoid responsive element. Mol Pharmacol. 1999;55:649-57 pubmed
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Kobayashi K, Kobayashi H, Ueda M, Honda Y. Estrogen receptor expression in bovine and rat retinas. Invest Ophthalmol Vis Sci. 1998;39:2105-10 pubmed
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Yang N, Venugopalan M, Hardikar S, Glasebrook A. Identification of an estrogen response element activated by metabolites of 17beta-estradiol and raloxifene. Science. 1996;273:1222-5 pubmed
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Shevde N, Pike J. Estrogen modulates the recruitment of myelopoietic cell progenitors in rat through a stromal cell-independent mechanism involving apoptosis. Blood. 1996;87:2683-92 pubmed
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Ikegami A, Inoue S, Hosoi T, Mizuno Y, Nakamura T, Ouchi Y, et al. Immunohistochemical detection and northern blot analysis of estrogen receptor in osteoblastic cells. J Bone Miner Res. 1993;8:1103-9 pubmed
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Sierralta W, Bonig I, Thole H. Immunogold labelling of estradiol receptor in MCF7 cells. Cell Tissue Res. 1995;279:445-52 pubmed
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Orimo A, Inoue S, Ikegami A, Hosoi T, Akishita M, Ouchi Y, et al. Vascular smooth muscle cells as target for estrogen. Biochem Biophys Res Commun. 1993;195:730-6 pubmed
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Traish A, Ettinger R, Kim N, Marshak Rothstein A, Wotiz H. Development and characterization of monoclonal antibodies to a specific domain of human estrogen receptor. Steroids. 1990;55:196-208 pubmed
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Watanabe M, Tanaka H, Kamada M, Okano J, Takahashi H, Uchida K, et al. Establishment of the human BSMZ breast cancer cell line, which overexpresses the erbB-2 and c-myc genes. Cancer Res. 1992;52:5178-82 pubmed
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图像
图像 1 :
产品信息
产品类型 :
抗体
产品名称 :
雌激素受体α单克隆抗体(33)
目录# :
MA1-310
规格 :
100微克
价格 :
美国450.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
Bovine, Human, Mouse, Non-human primate, Rat
应用 :
Immunocytochemistry: 10 µg/mL, Immunohistochemistry: 1:20 - 1:100, Western Blot: 4 µg/mL
物种 :
Bovine, Human, Mouse, Non-human primate, Rat
克隆 :
33
抗体亚型 :
IgG1
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
免疫原 :
Synthetic peptide corresponding to the residues E(247) V G M M K G G I R K D R R G(261) of the ER alpha DNA binding domain.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 10 µg/mL, Immunohistochemistry: 1:20 - 1:100, Western Blot: 4 µg/mL
别名 :
DKFZp686N23123; ER; Er alpha; ER36; ERa; ERalpha; ER-alpha; ERalpha protein; ESR; esr 1; Esr1; esr-1; ESRA; Estr; Estra; Estradiol receptor; estrogen nuclear receptor alpha; Estrogen receptor; estrogen receptor 1; estrogen receptor 1 (alpha); estrogen receptor alpha; estrogen receptor alpha c-terminus splice variant 1-2; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; estrogen receptor alpha splice variant, CTERP-1; estrogen receptor alpha splice variant, ERalphaDup5; estrogen receptor alpha splice variant, ERalphai45a; estrogen receptor alpha splice variant, ERalphai45bL; estrogen receptor alpha splice variant, ERalphai45bS; estrogen receptor alpha splice variant, ERalphai45c; estrogen receptor alpha splice variant, ERalphai56; estrogen receptor alpha splice variant, ERalphai67; estrogen receptor alpha variant delta 4; estrogen receptor protein; estrogen receptor, alpha; ESTRR; hER-alpha36; I79_001166; Nr3a1; nuclear receptor; nuclear receptor subfamily 3 group A member 1; RNESTROR; RP1-130E4.1; unnamed protein product
更多信息或购买 :
公司信息
赛默飞世尔