产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD8单克隆抗体(SP16)
目录 :
MA1-39566
规格 :
1毫升
价格 :
美国696.00
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
SP16
反应物种 :
人类, 大鼠
应用 :
免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 42
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类; 图 4a
Biasci D, Smoragiewicz M, Connell C, Wang Z, Gao Y, Thaventhiran J, et al. CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response. Proc Natl Acad Sci U S A. 2020;117:28960-28970 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 1e
Noh B, Kwak J, Eom D. Immune classification for the PD-L1 expression and tumour-infiltrating lymphocytes in colorectal adenocarcinoma. BMC Cancer. 2020;20:58 pubmed 出版商
  • 免疫组化; 人类; 图 4d
Smillie C, Biton M, Ordovas Montanes J, Sullivan K, Burgin G, Graham D, et al. Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis. Cell. 2019;178:714-730.e22 pubmed 出版商
  • 免疫组化; 人类; 图 3a
Garcia Hernandez M, Uribe Uribe N, Espinosa González R, Kast W, Khader S, Rangel Moreno J. A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression. Front Immunol. 2017;8:563 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Kim W, Jung H, Nam S, Kim T, Heo D, Kim C, et al. Expression of programmed cell death ligand 1 (PD-L1) in advanced stage EBV-associated extranodal NK/T cell lymphoma is associated with better prognosis. Virchows Arch. 2016;469:581-590 pubmed
  • 免疫组化-冰冻切片; 人类; 1:100; 表 s2
Leong Y, Chen Y, Ong H, Wu D, Man K, Deléage C, et al. CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles. Nat Immunol. 2016;17:1187-96 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
Kim K, Wen X, Yang H, Kim W, Kang G. Prognostic Implication of M2 Macrophages Are Determined by the Proportional Balance of Tumor Associated Macrophages and Tumor Infiltrating Lymphocytes in Microsatellite-Unstable Gastric Carcinoma. PLoS ONE. 2015;10:e0144192 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 1
Liu T, Weng S, Wang M, Huang W. Nontuberculous mycobacterial infection with concurrent IgG4-related lymphadenopathy. APMIS. 2016;124:216-20 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:150; 图 1
Liu K, Yang K, Wu B, Chen H, Chen X, Chen X, et al. Tumor-Infiltrating Immune Cells Are Associated With Prognosis of Gastric Cancer. Medicine (Baltimore). 2015;94:e1631 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Jeon Y, Kim J, Sung J, Han J, Ko Y. Epstein-Barr virus-positive nodal T/NK-cell lymphoma: an analysis of 15 cases with distinct clinicopathological features. Hum Pathol. 2015;46:981-90 pubmed 出版商
  • 免疫组化; 人类
Kim M, Koh J, Kim S, Go H, Jeon Y, Chung D. Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma: Comparison with tumor-infiltrating T cells and the status of oncogenic drivers. Lung Cancer. 2015;88:24-33 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Novinger L, Ashikaga T, Krag D. Identification of tumor-binding scFv derived from clonally related B cells in tumor and lymph node of a patient with breast cancer. Cancer Immunol Immunother. 2015;64:29-39 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
Yuan Z, Luo R, Peng R, Wang S, Xue C. High infiltration of tumor-associated macrophages in triple-negative breast cancer is associated with a higher risk of distant metastasis. Onco Targets Ther. 2014;7:1475-80 pubmed 出版商
  • 免疫组化; 人类; 1:50
Fan Y, Hu S, Liu J, Xiao F, Li X, Yu W, et al. Low intraprostatic DHT promotes the infiltration of CD8+ T cells in BPH tissues via modulation of CCL5 secretion. Mediators Inflamm. 2014;2014:397815 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Rizzo S, Basso C, Troost D, Aronica E, Frigo A, Driessen A, et al. T-cell-mediated inflammatory activity in the stellate ganglia of patients with ion-channel disease and severe ventricular arrhythmias. Circ Arrhythm Electrophysiol. 2014;7:224-9 pubmed 出版商
  • 免疫组化; 人类; 1:50
Sereti I, Estes J, Thompson W, Morcock D, Fischl M, Croughs T, et al. Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration. PLoS Pathog. 2014;10:e1003890 pubmed 出版商
  • 免疫组化; 人类; 1:250
Pohl M, Kawakami N, Kitic M, Bauer J, Martins R, Fischer M, et al. T cell-activation in neuromyelitis optica lesions plays a role in their formation. Acta Neuropathol Commun. 2013;1:85 pubmed 出版商
  • 免疫细胞化学; 人类
Kühnemuth B, Mühlberg L, Schipper M, Griesmann H, Neesse A, Milosevic N, et al. CUX1 modulates polarization of tumor-associated macrophages by antagonizing NF-?B signaling. Oncogene. 2015;34:177-87 pubmed 出版商
  • 免疫组化; 人类; 1:100
Kim K, Lee K, Cho H, Kim Y, Yang H, Kim W, et al. Prognostic implications of tumor-infiltrating FoxP3+ regulatory T cells and CD8+ cytotoxic T cells in microsatellite-unstable gastric cancers. Hum Pathol. 2014;45:285-93 pubmed 出版商
  • 免疫组化; 人类; 1:25
Abramov D, Oschlies I, Zimmermann M, Konovalov D, Damm Welk C, Wössmann W, et al. Expression of CD8 is associated with non-common type morphology and outcome in pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Haematologica. 2013;98:1547-53 pubmed 出版商
  • 免疫组化; 人类
Kim S, Jeong H, Woo O, Seo J, Kim A, Lee E, et al. Tumor-infiltrating lymphocytes, tumor characteristics, and recurrence in patients with early breast cancer. Am J Clin Oncol. 2013;36:224-31 pubmed 出版商
  • 免疫组化; 人类; 1:100; 图 3
Zeng M, Southern P, Reilly C, Beilman G, Chipman J, Schacker T, et al. Lymphoid tissue damage in HIV-1 infection depletes naïve T cells and limits T cell reconstitution after antiretroviral therapy. PLoS Pathog. 2012;8:e1002437 pubmed 出版商
  • 免疫组化; 人类; 1:100
West N, Milne K, Truong P, MacPherson N, Nelson B, Watson P. Tumor-infiltrating lymphocytes predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer. Breast Cancer Res. 2011;13:R126 pubmed 出版商
  • 免疫组化; 人类; 1:100
Chang I, Chen H, Ma M, Huang W. Anaplastic large cell lymphoma with paraneoplastic leukocytosis: a clinicopathological analysis of five cases. APMIS. 2011;119:794-801 pubmed 出版商
  • 免疫组化; 人类; 1:50
Caramori G, Lasagna L, Casalini A, Adcock I, Casolari P, Contoli M, et al. Immune response to Mycobacterium tuberculosis infection in the parietal pleura of patients with tuberculous pleurisy. PLoS ONE. 2011;6:e22637 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 表 2
West N, Panet Raymond V, Truong P, Alexander C, Babinszky S, Milne K, et al. Intratumoral Immune Responses Can Distinguish New Primary and True Recurrence Types of Ipsilateral Breast Tumor Recurrences (IBTR). Breast Cancer (Auckl). 2011;5:105-15 pubmed 出版商
  • 免疫组化; 人类
Piet B, de Bree G, Smids Dierdorp B, van der Loos C, Remmerswaal E, von der Thüsen J, et al. CD8? T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung. J Clin Invest. 2011;121:2254-63 pubmed 出版商
  • 免疫组化; 人类
de Boer O, Teeling P, Jansen M, Ploegmakers H, van der Loos C, Kummer J, et al. Spatial differences in the presence of FOXP3+ and GranzymeB+ T cells between the intra- and extravascular compartments in renal allograft vasculopathy. PLoS ONE. 2011;6:e18656 pubmed 出版商
  • 免疫组化; 人类; 1:50
Riezu Boj J, Larrea E, Aldabe R, Guembe L, Casares N, Galeano E, et al. Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection. J Hepatol. 2011;54:422-31 pubmed 出版商
  • 免疫组化; 人类
Sonar S, Hsu Y, Conrad M, Majeau G, Kilic A, Garber E, et al. Antagonism of TIM-1 blocks the development of disease in a humanized mouse model of allergic asthma. J Clin Invest. 2010;120:2767-81 pubmed 出版商
  • 免疫组化; 人类; 1:200
Gualco G, Wludarski S, Hayashi Silva L, Medeiros Filho P, Veras G, Bacchi C. Primary central nervous system peripheral T-cell lymphoma in a child. Fetal Pediatr Pathol. 2010;29:224-30 pubmed 出版商
  • 免疫组化; 人类; 1:100
Prabhu S, Gupta P, Durgapal H, Rath S, Gupta S, Acharya S, et al. Study of cellular immune response against Hepatitis E virus (HEV). J Viral Hepat. 2011;18:587-94 pubmed 出版商
  • 免疫组化; 人类
Imanguli M, Swaim W, League S, Gress R, Pavletic S, Hakim F. Increased T-bet+ cytotoxic effectors and type I interferon-mediated processes in chronic graft-versus-host disease of the oral mucosa. Blood. 2009;113:3620-30 pubmed 出版商
  • 免疫组化; 人类; 1:100; 图 1
Milne K, Barnes R, Girardin A, Mawer M, Nesslinger N, Ng A, et al. Tumor-infiltrating T cells correlate with NY-ESO-1-specific autoantibodies in ovarian cancer. PLoS ONE. 2008;3:e3409 pubmed 出版商
  • 免疫组化; 人类
van Es L, De Heer E, Vleming L, van der Wal A, Mallat M, Bajema I, et al. GMP-17-positive T-lymphocytes in renal tubules predict progression in early stages of IgA nephropathy. Kidney Int. 2008;73:1426-33 pubmed 出版商
  • 免疫组化; 人类
Keller T, van der Meer J, Teeling P, van der Sluijs K, Idu M, Rimmelzwaan G, et al. Selective expansion of influenza A virus-specific T cells in symptomatic human carotid artery atherosclerotic plaques. Stroke. 2008;39:174-9 pubmed
  • 免疫组化; 大鼠
Avunduk A, Avunduk M, Baltaci A, Mogulkoc R. Effect of melatonin and zinc on the immune response in experimental Toxoplasma retinochoroiditis. Ophthalmologica. 2007;221:421-5 pubmed
  • 免疫组化; 人类
Abel M, Sene D, Pol S, Bourliere M, Poynard T, Charlotte F, et al. Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection. Hepatology. 2006;44:1607-16 pubmed
Ac xfa rcio R, Pozzi S, Carreira B, Pojo M, G xf3 mez Cebri xe1 n N, Casimiro S, et al. Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment. J Immunother Cancer. 2022;10: pubmed 出版商
Ludwig B, Ludwig S, Steffen A, Knauf Y, Zimerman B, Heinke S, et al. Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes. Proc Natl Acad Sci U S A. 2017;114:11745-11750 pubmed 出版商
Koh J, Kim S, Kim M, Go H, Jeon Y, Chung D. Prognostic implications of intratumoral CD103+ tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma. Oncotarget. 2017;8:13762-13769 pubmed 出版商
Sun H, Xu J, Huang M, Huang Q, Sun R, Xiao W, et al. CD200R, a co-inhibitory receptor on immune cells, predicts the prognosis of human hepatocellular carcinoma. Immunol Lett. 2016;178:105-13 pubmed 出版商
图像
图像 1 :
赛默飞世尔 MA1-39566 图像 1
产品信息
产品类型 :
抗体
产品名称 :
CD8单克隆抗体(SP16)
目录# :
MA1-39566
规格 :
1毫升
价格 :
美国696.00
克隆性 :
单克隆
宿主 :
兔
反应物种 :
人类
应用 :
Flow Cytometry: 1:1,000, Immunohistochemistry (Paraffin): 1:100
物种 :
人类
克隆 :
SP16
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-beta1.
免疫原 :
Synthetic peptide corresponding to the C-terminus of alpha chain of the human CD8 molecule
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1:1,000, Immunohistochemistry (Paraffin): 1:100
别名 :
BB154331; CD8; CD8 alpha; CD8 alpha chain; CD8 alpha chain precursor; CD8 antigen; CD8 antigen 32 kDa chain; CD8 antigen 37 kDa chain; CD8 antigen alpha polypeptide; CD8 antigen alpha protein; CD8 antigen alpha protein precursor; CD8 antigen alpha-chain; CD8 antigen beta polypeptide; CD8 antigen beta polypeptide precursor; CD8 antigen beta-chain; CD8 antigen, alpha chain; CD8 antigen, alpha polypeptide; CD8 antigen, alpha polypeptide (p32); CD8 antigen, alpha-chain; CD8 antigen, beta chain; CD8 antigen, beta chain 1; CD8 antigen, beta polypeptide; CD8 antigen, beta polypeptide 1 (p37); CD8 antigen, beta-chain; CD8 beta; CD8 beta chain; CD8 beta-2; CD8a; CD8A antigen alpha; CD8a molecule; CD8A; T-cell surface glycoprotein; CD8alpha; CD8B; CD8b antigen; CD8b molecule; CD8b molecule pseudogene; Cd8b1; CD8beta; CD8BP; fCD8; LEU2; Leu-2; Leu2 T-lymphocyte antigen; leu-2a; Ly-2; LY3; Ly-3; Ly-35; Ly-B; Ly-C; Lymphocyte antigen 3; Lyt2; Lyt-2; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); Lyt3; Lyt-3; MAL; membrane glycoprotein; membrane protein; OKT8 T-cell antigen; OX-8 membrane antigen; p32; P37; RHACD8-4; T cell co-receptor; T lymphocyte surface glycoprotein beta chain; T8 T-cell antigen; T-cell antigen Leu2; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-2; T-cell surface glycoprotein Lyt-3; T-cell surface molecule; T-lymphocyte differentiation antigen T8/Leu-2; type I transmembrane glycoprotein
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国