产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Toll样受体2单克隆抗体(Toll样受体2.45)
目录 :
MA1-40318
规格 :
100µg
价格 :
美国402
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
Toll样受体2.45
反应物种 :
人类
应用 :
免疫细胞化学, 免疫沉淀, 流式细胞仪
更多信息或购买 :
产品信息
产品类型 :
抗体
产品名称 :
Toll样受体2单克隆抗体(Toll样受体2.45)
目录# :
MA1-40318
规格 :
100µg
价格 :
美国402
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: 1:50, Immunofluorescence: 1:50, Immunoprecipitation: 1:50
物种 :
人类
克隆 :
Toll样受体2.45
抗体亚型 :
IgG1
储存 :
4° C
描述 :
TLR2 is a member of the Toll-like receptor (TLR) family which play a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. TLR2 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Ten human homologs of TLRs (TLR1-10) have been described. TLR2 is expressed in human cells such as tonsils, microglia, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes express the highest level of TLR2 followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.
免疫原 :
人类FLAG标签标签Toll样受体2
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1:50, Immunofluorescence: 1:50, Immunoprecipitation: 1:50
别名 :
CD282; Ly105; TIL4; Tlr2; TLR-2; toll like receptor 2; Toll/interleukin-1 receptor-like protein 4; Toll-like receptor 2; toll-like receptor 2 variant 1; toll-like receptor 2 variant 2
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国