产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
AHR单克隆抗体(RPT1)
目录 :
MA1-514
规格 :
100微升
价格 :
美国500.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
RPT1
反应物种 :
人类, 小鼠, 大鼠, pigs
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化基因敲除验证
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 47
出版应用/物种/样本/稀释参考文献
  • 免疫组化基因敲除验证; 小鼠; 图 1f
Rico Leo E, Moreno Marín N, González Rico F, Barrasa E, Ortega Ferrusola C, Martín Muñoz P, et al. piRNA-associated proteins and retrotransposons are differentially expressed in murine testis and ovary of aryl hydrocarbon receptor deficient mice. Open Biol. 2016;6: pubmed 出版商
  • 免疫印迹; 人类; 图 s5
Ogando J, Tardáguila M, Díaz Alderete A, Usategui A, Miranda Ramos V, Martínez Herrera D, et al. Notch-regulated miR-223 targets the aryl hydrocarbon receptor pathway and increases cytokine production in macrophages from rheumatoid arthritis patients. Sci Rep. 2016;6:20223 pubmed 出版商
  • 免疫印迹; 人类
Forrester A, Elias M, Woodward E, Graham M, Williams F, Reynolds N. Induction of a chloracne phenotype in an epidermal equivalent model by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on aryl hydrocarbon receptor activation and is not reproduced by aryl hydrocarbon receptor knock down. J Dermatol Sci. 2014;73:10-22 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Zhao S, Ohara S, Kanno Y, Midorikawa Y, Nakayama M, Makimura M, et al. HER2 overexpression-mediated inflammatory signaling enhances mammosphere formation through up-regulation of aryl hydrocarbon receptor transcription. Cancer Lett. 2013;330:41-8 pubmed 出版商
  • 免疫印迹; 人类
Tanos R, Murray I, Smith P, Patterson A, Perdew G. Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver. Toxicol Sci. 2012;129:372-9 pubmed 出版商
  • 免疫印迹; 小鼠
Tanos R, Patel R, Murray I, Smith P, Patterson A, Perdew G. Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner. Hepatology. 2012;55:1994-2004 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Zhao S, Kanno Y, Nakayama M, Makimura M, Ohara S, Inouye Y. Activation of the aryl hydrocarbon receptor represses mammosphere formation in MCF-7 cells. Cancer Lett. 2012;317:192-8 pubmed 出版商
  • 免疫印迹; 人类; 1:250
O Shaughnessy P, Monteiro A, Bhattacharya S, Fowler P. Maternal smoking and fetal sex significantly affect metabolic enzyme expression in the human fetal liver. J Clin Endocrinol Metab. 2011;96:2851-60 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Roman A, González Rico F, Moltó E, Hernando H, Neto A, Vicente Garcia C, et al. Dioxin receptor and SLUG transcription factors regulate the insulator activity of B1 SINE retrotransposons via an RNA polymerase switch. Genome Res. 2011;21:422-32 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1,000
Mukai R, Shirai Y, Saito N, Fukuda I, Nishiumi S, Yoshida K, et al. Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction. Arch Biochem Biophys. 2010;501:134-41 pubmed 出版商
  • 免疫印迹; 小鼠
Flaveny C, Murray I, Perdew G. Differential gene regulation by the human and mouse aryl hydrocarbon receptor. Toxicol Sci. 2010;114:217-25 pubmed 出版商
  • 免疫印迹; 人类
Murray I, Morales J, Flaveny C, Dinatale B, Chiaro C, Gowdahalli K, et al. Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity. Mol Pharmacol. 2010;77:247-54 pubmed 出版商
  • 免疫印迹; 人类
Murray I, Flaveny C, Dinatale B, Chairo C, Schroeder J, Kusnadi A, et al. Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone. J Pharmacol Exp Ther. 2010;332:135-44 pubmed 出版商
  • 酶联免疫吸附测定; 小鼠
Mukai R, Satsu H, Shimizu M, Ashida H. Inhibition of P-glycoprotein enhances the suppressive effect of kaempferol on transformation of the aryl hydrocarbon receptor. Biosci Biotechnol Biochem. 2009;73:1635-9 pubmed
  • 酶联免疫吸附测定; 大鼠
  • 免疫印迹; 大鼠; 1:1500
Mukai R, Fukuda I, Nishiumi S, Natsume M, Osakabe N, Yoshida K, et al. Cacao polyphenol extract suppresses transformation of an aryl hydrocarbon receptor in C57BL/6 mice. J Agric Food Chem. 2008;56:10399-405 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Roman A, Benitez D, Carvajal Gonzalez J, Fernandez Salguero P. Genome-wide B1 retrotransposon binds the transcription factors dioxin receptor and Slug and regulates gene expression in vivo. Proc Natl Acad Sci U S A. 2008;105:1632-7 pubmed 出版商
  • 免疫印迹; 人类; 1:1,000
Du L, Neis M, Ladd P, Keeney D. Differentiation-specific factors modulate epidermal CYP1-4 gene expression in human skin in response to retinoic acid and classic aryl hydrocarbon receptor ligands. J Pharmacol Exp Ther. 2006;319:1162-71 pubmed
  • 免疫印迹; pigs ; 1:250
Hombach Klonisch S, Pocar P, Kauffold J, Klonisch T. Dioxin exerts anti-estrogenic actions in a novel dioxin-responsive telomerase-immortalized epithelial cell line of the porcine oviduct (TERT-OPEC). Toxicol Sci. 2006;90:519-28 pubmed
  • 免疫印迹; pigs ; 1:250
Pocar P, Klonisch T, Brandsch C, Eder K, Frohlich C, Hoang Vu C, et al. AhR-agonist-induced transcriptional changes of genes involved in thyroid function in primary porcine thyrocytes. Toxicol Sci. 2006;89:408-14 pubmed
Kim Y, Ko B, Kim D, Tak J, Han C, Cho J, et al. Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D. Nat Commun. 2022;13:6080 pubmed 出版商
Das S, Song Z, Han H, Ge X, Désert R, Athavale D, et al. Intestinal Osteopontin Protects From Alcohol-induced Liver Injury by Preserving the Gut Microbiome and the Intestinal Barrier Function. Cell Mol Gastroenterol Hepatol. 2022;14:813-839 pubmed 出版商
Ren R, Fang Y, Sherchan P, Lu Q, Lenahan C, Zhang J, et al. Kynurenine/Aryl Hydrocarbon Receptor Modulates Mitochondria-Mediated Oxidative Stress and Neuronal Apoptosis in Experimental Intracerebral Hemorrhage. Antioxid Redox Signal. 2022;37:1111-1129 pubmed 出版商
Rubini E, Minacori M, Paglia G, Macone A, Chichiarelli S, Altieri F, et al. Tomato and Olive Bioactive Compounds: A Natural Shield against the Cellular Effects Induced by β-Hexachlorocyclohexane-Activated Signaling Pathways. Molecules. 2021;26: pubmed 出版商
van de Veerdonk F, Renga G, Pariano M, Bellet M, Servillo G, Fallarino F, et al. Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy. J Clin Invest. 2021;: pubmed 出版商
Mandarano M, Andolfi M, Colella R, Monacelli M, Polistena A, Moretti S, et al. Impact of Epithelial-Mesenchymal Immunophenotype on Local Aggressiveness in Papillary Thyroid Carcinoma Invading the Airway. J Clin Med. 2021;10: pubmed 出版商
Rubini E, Paglia G, Cannella D, Macone A, Di Sotto A, Gullì M, et al. β-Hexachlorocyclohexane: A Small Molecule with a Big Impact on Human Cellular Biochemistry. Biomedicines. 2020;8: pubmed 出版商
Granger C, Brown A, Aladren S, Narda M. Night Cream Containing Melatonin, Carnosine and Helichrysum italicum Extract Helps Reduce Skin Reactivity and Signs of Photodamage: Ex Vivo and Clinical Studies. Dermatol Ther (Heidelb). 2020;10:1315-1329 pubmed 出版商
Giovannoni F, Bosch I, Polonio C, Torti M, Wheeler M, Li Z, et al. AHR is a Zika virus host factor and a candidate target for antiviral therapy. Nat Neurosci. 2020;23:939-951 pubmed 出版商
Ramos García N, Orozco Ibarra M, Estudillo E, Elizondo G, Gómez Apo E, Chávez Macías L, et al. Aryl Hydrocarbon Receptor in Post-Mortem Hippocampus and in Serum from Young, Elder, and Alzheimer's Patients. Int J Mol Sci. 2020;21: pubmed 出版商
González Barbosa E, García Aguilar R, Vega L, Cabañas Cortés M, Gonzalez F, Segovia J, et al. Parkin is transcriptionally regulated by the aryl hydrocarbon receptor: Impact on α-synuclein protein levels. Biochem Pharmacol. 2019;168:429-437 pubmed 出版商
Marinelli L, Martin Gallausiaux C, Bourhis J, Béguet Crespel F, Blottiere H, Lapaque N. Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells. Sci Rep. 2019;9:643 pubmed 出版商
Moreno Marín N, Merino J, Alvarez Barrientos A, Patel D, Takahashi S, González Sancho J, et al. Aryl Hydrocarbon Receptor Promotes Liver Polyploidization and Inhibits PI3K, ERK, and Wnt/?-Catenin Signaling. iScience. 2018;4:44-63 pubmed 出版商
Narasimhan S, Stanford Zulick E, Novikov O, Parks A, Schlezinger J, Wang Z, et al. Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor. Int J Mol Sci. 2018;19: pubmed 出版商
Ash P, Stanford E, Al Abdulatif A, Ramirez Cardenas A, Ballance H, Boudeau S, et al. Dioxins and related environmental contaminants increase TDP-43 levels. Mol Neurodegener. 2017;12:35 pubmed 出版商
Cheng J, Li W, Kang B, Zhou Y, Song J, Dan S, et al. Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. Nat Commun. 2015;6:7209 pubmed 出版商
Sadegh M, Ekman M, Krawczyk K, Svensson D, Göransson O, Dahan D, et al. Detrusor induction of miR-132/212 following bladder outlet obstruction: association with MeCP2 repression and cell viability. PLoS ONE. 2015;10:e0116784 pubmed 出版商
Hao N, Whitelaw M, Shearwin K, Dodd I, Chapman Smith A. Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR. Nucleic Acids Res. 2011;39:3695-709 pubmed 出版商
Flaveny C, Reen R, Kusnadi A, Perdew G. The mouse and human Ah receptor differ in recognition of LXXLL motifs. Arch Biochem Biophys. 2008;471:215-23 pubmed 出版商
Morales J, Krzeminski J, Amin S, Perdew G. Characterization of the antiallergic drugs 3-[2-(2-phenylethyl) benzoimidazole-4-yl]-3-hydroxypropanoic acid and ethyl 3-hydroxy-3-[2-(2-phenylethyl)benzoimidazol-4-yl]propanoate as full aryl hydrocarbon receptor agonists. Chem Res Toxicol. 2008;21:472-82 pubmed 出版商
Murray I, Perdew G. Omeprazole stimulates the induction of human insulin-like growth factor binding protein-1 through aryl hydrocarbon receptor activation. J Pharmacol Exp Ther. 2008;324:1102-10 pubmed
Ray S, Swanson H. Dioxin-induced immortalization of normal human keratinocytes and silencing of p53 and p16INK4a. J Biol Chem. 2004;279:27187-93 pubmed
Fukuda I, Nishiumi S, Yabushita Y, Mukai R, Kodoi R, Hashizume K, et al. A new southwestern chemistry-based ELISA for detection of aryl hydrocarbon receptor transformation: application to the screening of its receptor agonists and antagonists. J Immunol Methods. 2004;287:187-201 pubmed
Thomsen J, Kietz S, Strom A, Gustafsson J. HES-1, a novel target gene for the aryl hydrocarbon receptor. Mol Pharmacol. 2004;65:165-71 pubmed
Dull A, Carlson D, Petrulis J, Perdew G. Characterization of the phosphorylation status of the hepatitis B virus X-associated protein 2. Arch Biochem Biophys. 2002;406:209-21 pubmed
Meyer B, Perdew G. Characterization of the AhR-hsp90-XAP2 core complex and the role of the immunophilin-related protein XAP2 in AhR stabilization. Biochemistry. 1999;38:8907-17 pubmed
Vaziri C, Schneider A, Sherr D, Faller D. Expression of the aryl hydrocarbon receptor is regulated by serum and mitogenic growth factors in murine 3T3 fibroblasts. J Biol Chem. 1996;271:25921-7 pubmed
Chen H, Perdew G. Subunit composition of the heteromeric cytosolic aryl hydrocarbon receptor complex. J Biol Chem. 1994;269:27554-8 pubmed
产品信息
产品类型 :
抗体
产品名称 :
AHR单克隆抗体(RPT1)
目录# :
MA1-514
规格 :
100微升
价格 :
美国500.00
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:10 - 1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1:500-1:2,000
物种 :
人类, 小鼠, 大鼠
克隆 :
RPT1
抗体亚型 :
IgG1
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
AHR (Ah Receptor) belongs to a family of proteins comprised of its dimerization partner ARNT (HIF-1 Beta) and the Drosophila proteins PER and SIM. AHR contains an N-terminal sequence of approximately 200 amino acids termed the PAS domain. AHR, found in a variety of tissues, binds to a specific DNA enhancer sequence and initiates transcription of the mRNA for the cytochrome P-450 (CYPIA1) gene. The gene for AHR encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. AHR has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450, and its ligands included a variety of aromatic hydrocarbons. AHR is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AHR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for AHR. Studies indicate that in non-ligand activated cells, AHR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AhR is believed to transform to a nuclear, DNA binding form, and this transformation process appears to involve dissociation of HSP90 from AhR followed by formation of a heterodimer with AhR nuclear translocator protein (Arnt). Diseases associated with AHR include eosinophilic fasciitis and seborrheic dermatitis.
免疫原 :
Synthetic peptide corresponding to residues R(12) K R R K P(17) V(22) K P I P A E G I K(31) of human AhR.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:10 - 1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1:500-1:2,000
别名 :
Ah; Ah receptor; Ahh; Ahr; Ahre; AH-receptor; aromatic hydrocarbon receptor; aryl hydrocarbon receptor; aryl-hydrocarbon receptor; bHLHe76; Class E basic helix-loop-helix protein 76; dioxin receptor; In
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国