产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD3z单克隆抗体(H146-968)
目录 :
MA1-70049
规格 :
250微克
价格 :
美国436.00
克隆性 :
单克隆
宿主 :
仓鼠
共轭标签 :
未共轭
克隆名称 :
H146-968
反应物种 :
小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 流式细胞仪
更多信息或购买 :
文章摘录数: 2
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产品信息
产品类型 :
抗体
产品名称 :
CD3z单克隆抗体(H146-968)
目录# :
MA1-70049
规格 :
250微克
价格 :
美国436.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
亚美尼亚仓鼠
反应物种 :
小鼠
应用 :
ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Western Blot: Assay-dependent
物种 :
小鼠
克隆 :
H146-968
抗体亚型 :
IgG2
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
CD3z complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules, and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Diseases associated with CD3z include Immunodeficiency 25 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta.
免疫原 :
KLH conjugated mouse zeta-chain (CD3) sequence 151-164.
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Western Blot: Assay-dependent
别名 :
4930549J05Rik; A430104F18Rik; antigen CD3Z, zeta polypeptide; AW552088; Cd247; CD247 antigen; CD247 antigen, zeta subunit; Cd247 molecule; Cd3; CD3 antigen, zeta polypeptide; CD3 zeta; CD3 zeta chain; CD3e antigen; CD3-epsilon; Cd3-eta; CD3H; CD3Q; Cd3z; CD3Z antigen, zeta polypeptide (TiT3 complex); Cd3zeta; Cd3-zeta; CD3zeta chain; CD3-zeta/eta; FLJ18683; IMD25; T3E; T3z; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell receptor T3 eta chain; T-cell receptor T3 zeta chain; T-cell receptor zeta chain; T-cell surface glycoprotein CD3 zeta chain; TCR zeta chain; TCRE; Tcrk; TCRZ; TCRzeta
更多信息或购买 :
公司信息
赛默飞世尔