产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
VDR单克隆抗体(9A7)
目录 :
MA1-710
规格 :
100微克
价格 :
美国430.00
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
9A7
反应物种 :
仓鼠, 人类, 小鼠, 大鼠, 犬, 鸡
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, EMSA, 染色质免疫沉淀 , 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 113
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 人类; 图 1a
Al Azhri J, Zhang Y, Bshara W, Zirpoli G, McCann S, Khoury T, et al. Tumor Expression of Vitamin D Receptor and Breast Cancer Histopathological Characteristics and Prognosis. Clin Cancer Res. 2017;23:97-103 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Verone Boyle A, Shoemaker S, Attwood K, Morrison C, Makowski A, Battaglia S, et al. Diet-derived 25-hydroxyvitamin D3 activates vitamin D receptor target gene expression and suppresses EGFR mutant non-small cell lung cancer growth in vitro and in vivo. Oncotarget. 2016;7:995-1013 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:250; 图 2d
Mazzilli S, Hershberger P, Reid M, Bogner P, Atwood K, Trump D, et al. Vitamin D Repletion Reduces the Progression of Premalignant Squamous Lesions in the NTCU Lung Squamous Cell Carcinoma Mouse Model. Cancer Prev Res (Phila). 2015;8:895-904 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6.a,b
Iwahori S, Hakki M, Chou S, Kalejta R. Molecular Determinants for the Inactivation of the Retinoblastoma Tumor Suppressor by the Viral Cyclin-dependent Kinase UL97. J Biol Chem. 2015;290:19666-80 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 3
  • 免疫印迹; 小鼠
Bothwell K, Shaurova T, Merzianu M, Suresh A, Kuriakose M, Johnson C, et al. Impact of Short-term 1,25-Dihydroxyvitamin D3 on the Chemopreventive Efficacy of Erlotinib against Oral Cancer. Cancer Prev Res (Phila). 2015;8:765-76 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
  • 免疫印迹; 小鼠; 1:500
Bach F, Rutten K, Hendriks K, Riemers F, Cornelissen P, de Bruin A, et al. The paracrine feedback loop between vitamin D? (1,25(OH)?D?) and PTHrP in prehypertrophic chondrocytes. J Cell Physiol. 2014;229:1999-2014 pubmed 出版商
  • 免疫印迹; 人类; 1:200
Wahler J, So J, Kim Y, Liu F, Maehr H, Uskokovic M, et al. Inhibition of the transition of ductal carcinoma in situ to invasive ductal carcinoma by a Gemini vitamin D analog. Cancer Prev Res (Phila). 2014;7:617-26 pubmed 出版商
  • 免疫组化; 仓鼠; 1:150
Ford J, Carnes K, Hess R. Ductuli efferentes of the male Golden Syrian hamster reproductive tract. Andrology. 2014;2:510-20 pubmed 出版商
  • 免疫组化; 人类
Yuan F, Valiyaparambil J, Woods M, Tran H, Pant R, Adams J, et al. Vitamin D signaling regulates oral keratinocyte proliferation in vitro and in vivo. Int J Oncol. 2014;44:1625-33 pubmed 出版商
  • 免疫细胞化学; 人类
Campos L, Brentani H, Roela R, Katayama M, Lima L, Rolim C, et al. Differences in transcriptional effects of 1?,25 dihydroxyvitamin D3 on fibroblasts associated to breast carcinomas and from paired normal breast tissues. J Steroid Biochem Mol Biol. 2013;133:12-24 pubmed 出版商
  • 免疫印迹; 人类
Jiang Y, Fleet J. Phorbol esters enhance 1?,25-dihydroxyvitamin D3-regulated 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) gene expression through ERK-mediated phosphorylation of specific protein 3 (Sp3) in Caco-2 cells. Mol Cell Endocrinol. 2012;361:31-9 pubmed 出版商
  • 免疫组化; 人类; 1:500
Suetani R, Ho K, Jindal S, Manavis J, Neilsen P, Pishas K, et al. A comparison of vitamin D activity in paired non-malignant and malignant human breast tissues. Mol Cell Endocrinol. 2012;362:202-10 pubmed 出版商
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Wang Y, Zhu J, DeLuca H. Where is the vitamin D receptor?. Arch Biochem Biophys. 2012;523:123-33 pubmed 出版商
  • 免疫组化; 人类
Parker Autry C, Burgio K, Richter H. Vitamin D status: a review with implications for the pelvic floor. Int Urogynecol J. 2012;23:1517-26 pubmed 出版商
  • 免疫印迹; 人类
Zhang Q, Kanterewicz B, Buch S, Petkovich M, Parise R, Beumer J, et al. CYP24 inhibition preserves 1?,25-dihydroxyvitamin D(3) anti-proliferative signaling in lung cancer cells. Mol Cell Endocrinol. 2012;355:153-61 pubmed 出版商
  • 免疫组化; 鸡; 1:100
  • 免疫印迹; 鸡; 1:1000
Wojtusik J, Johnson P. Vitamin D regulates anti-Mullerian hormone expression in granulosa cells of the hen. Biol Reprod. 2012;86:91 pubmed 出版商
  • 免疫细胞化学; 人类
Ching S, Kashinkunti S, Niehaus M, Zinser G. Mammary adipocytes bioactivate 25-hydroxyvitamin D? and signal via vitamin D? receptor, modulating mammary epithelial cell growth. J Cell Biochem. 2011;112:3393-405 pubmed 出版商
  • 免疫组化; 小鼠; 1:60
  • 免疫印迹; 小鼠
Welsh J, Zinser L, Mianecki Morton L, Martin J, Waltz S, James H, et al. Age-related changes in the epithelial and stromal compartments of the mammary gland in normocalcemic mice lacking the vitamin D3 receptor. PLoS ONE. 2011;6:e16479 pubmed 出版商
  • 免疫印迹; 人类
Alimirah F, Peng X, Murillo G, Mehta R. Functional significance of vitamin D receptor FokI polymorphism in human breast cancer cells. PLoS ONE. 2011;6:e16024 pubmed 出版商
  • 免疫组化; 人类
Wang Y, DeLuca H. Is the vitamin d receptor found in muscle?. Endocrinology. 2011;152:354-63 pubmed 出版商
  • 免疫细胞化学; 人类
Hertting O, Holm A, Lüthje P, Brauner H, Dyrdak R, Jonasson A, et al. Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. PLoS ONE. 2010;5:e15580 pubmed 出版商
  • 免疫组化; 人类
Srinivasan M, Parwani A, Hershberger P, Lenzner D, Weissfeld J. Nuclear vitamin D receptor expression is associated with improved survival in non-small cell lung cancer. J Steroid Biochem Mol Biol. 2011;123:30-6 pubmed 出版商
  • 免疫组化; 犬
Malone E, Rassnick K, Wakshlag J, Russell D, Al Sarraf R, Ruslander D, et al. Calcitriol (1,25-dihydroxycholecalciferol) enhances mast cell tumour chemotherapy and receptor tyrosine kinase inhibitor activity in vitro and has single-agent activity against spontaneously occurring canine mast cell tumours. Vet Comp Oncol. 2010;8:209-20 pubmed 出版商
  • 免疫印迹; 人类
Peleg S, Nguyen C. The importance of nuclear import in protection of the vitamin D receptor from polyubiquitination and proteasome-mediated degradation. J Cell Biochem. 2010;110:926-34 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Zhang Z, Kovalenko P, Cui M, Desmet M, Clinton S, Fleet J. Constitutive activation of the mitogen-activated protein kinase pathway impairs vitamin D signaling in human prostate epithelial cells. J Cell Physiol. 2010;224:433-42 pubmed 出版商
  • 免疫组化; 人类
Russell D, Rassnick K, Erb H, Vaughan M, McDonough S. An immunohistochemical study of vitamin D receptor expression in canine cutaneous mast cell tumours. J Comp Pathol. 2010;143:223-6 pubmed 出版商
  • 免疫沉淀; 大鼠; 1:200
Zhao G, Simpson R. Interaction between vitamin D receptor with caveolin-3 and regulation by 1,25-dihydroxyvitamin D3 in adult rat cardiomyocytes. J Steroid Biochem Mol Biol. 2010;121:159-63 pubmed 出版商
  • 免疫印迹; 小鼠
Lee H, So J, DeCastro A, Smolarek A, Paul S, Maehr H, et al. Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling. J Steroid Biochem Mol Biol. 2010;121:408-12 pubmed 出版商
  • 免疫印迹; 人类; 1:4,000
Washington M, Weigel N. 1{alpha},25-Dihydroxyvitamin D3 inhibits growth of VCaP prostate cancer cells despite inducing the growth-promoting TMPRSS2:ERG gene fusion. Endocrinology. 2010;151:1409-17 pubmed 出版商
  • 免疫印迹; 人类
Silvagno F, De Vivo E, Attanasio A, Gallo V, Mazzucco G, Pescarmona G. Mitochondrial localization of vitamin D receptor in human platelets and differentiated megakaryocytes. PLoS ONE. 2010;5:e8670 pubmed 出版商
  • 免疫沉淀; 大鼠
Zhao G, Simpson R. Membrane localization, Caveolin-3 association and rapid actions of vitamin D receptor in cardiac myocytes. Steroids. 2010;75:555-9 pubmed 出版商
  • 免疫印迹; 人类
Chow E, Sun H, Khan A, Groothuis G, Pang K. Effects of 1alpha,25-dihydroxyvitamin D3 on transporters and enzymes of the rat intestine and kidney in vivo. Biopharm Drug Dispos. 2010;31:91-108 pubmed 出版商
  • EMSA; 人类
Dwivedi P, Gao X, Tan J, Evdokiou A, Ferrante A, Morris H, et al. A role for the phosphatidylinositol 3-kinase--protein kinase C zeta--Sp1 pathway in the 1,25-dihydroxyvitamin D3 induction of the 25-hydroxyvitamin D3 24-hydroxylase gene in human kidney cells. Cell Signal. 2010;22:543-52 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1500
Gonzalez Pardo V, Martin D, Gutkind J, Verstuyf A, Bouillon R, de Boland A, et al. 1 Alpha,25-dihydroxyvitamin D3 and its TX527 analog inhibit the growth of endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein-coupled receptor in vitro and in vivo. Endocrinology. 2010;151:23-31 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2000
Chow E, Maeng H, Liu S, Khan A, Groothuis G, Pang K. 1alpha,25-Dihydroxyvitamin D(3) triggered vitamin D receptor and farnesoid X receptor-like effects in rat intestine and liver in vivo. Biopharm Drug Dispos. 2009;30:457-75 pubmed 出版商
  • 免疫印迹; 鸡
Ellis B, Gattoni Celli S, Mancia A, Kindy M. The vitamin D3 transcriptomic response in skin cells derived from the Atlantic bottlenose dolphin. Dev Comp Immunol. 2009;33:901-12 pubmed 出版商
  • 免疫组化; 人类; 1:400
Pospechova K, Rozehnal V, Stejskalova L, Vrzal R, Pospisilova N, Jamborova G, et al. Expression and activity of vitamin D receptor in the human placenta and in choriocarcinoma BeWo and JEG-3 cell lines. Mol Cell Endocrinol. 2009;299:178-87 pubmed 出版商
  • 免疫印迹; 人类
Kemmis C, Welsh J. Mammary epithelial cell transformation is associated with deregulation of the vitamin D pathway. J Cell Biochem. 2008;105:980-8 pubmed 出版商
  • 免疫细胞化学; 人类; 10 ug/ml
Du W, Cui Z, Tsui Z, Chen Q, Willingham M. In situ immunocytochemical detection of altered membrane composition induced by cell-cell contact in cultured mammalian cells. Microsc Res Tech. 2008;71:749-59 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Gonzalez Pardo V, Boland R, de Boland A. Vitamin D receptor levels and binding are reduced in aged rat intestinal subcellular fractions. Biogerontology. 2008;9:109-18 pubmed
  • 免疫印迹; 人类
Rapuri P, Gallagher J, Nawaz Z. Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells. J Steroid Biochem Mol Biol. 2007;103:368-71 pubmed
  • 免疫印迹; 人类; 1:200
Bosse Y, Maghni K, Hudson T. 1alpha,25-dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes. Physiol Genomics. 2007;29:161-8 pubmed
  • 免疫细胞化学; 小鼠
Baroni E, Biffi M, Benigni F, Monno A, Carlucci D, Carmeliet G, et al. VDR-dependent regulation of mast cell maturation mediated by 1,25-dihydroxyvitamin D3. J Leukoc Biol. 2007;81:250-62 pubmed
  • 免疫组化; 人类; 1:100
Yang A, Hsu C, Chen J, Tseng L, Won G, Lee C. Normocalcemic primary hyperparathyroidism in patients with recurrent kidney stones: pathological analysis of parathyroid glands. Virchows Arch. 2006;449:62-8 pubmed
  • 免疫组化; 小鼠
Benigni F, Baroni E, Zecevic M, Zvara P, Streng T, Hedlund P, et al. Oral treatment with a vitamin D3 analogue (BXL628) has anti-inflammatory effects in rodent model of interstitial cystitis. BJU Int. 2006;97:617-24 pubmed
  • EMSA; 人类
Sepulveda V, Weigel N, Falzon M. Prostate cancer cell type-specific involvement of the VDR and RXR in regulation of the human PTHrP gene via a negative VDRE. Steroids. 2006;71:102-15 pubmed
  • 免疫细胞化学; 人类; 1:100
Diaw L, Roth M, Schwinn D, d Alelio M, Green L, Tangrea J. Characteristics of a human prostate stromal cell line related to its use in a stromal-epithelial coculture model for the study of cancer chemoprevention. In Vitro Cell Dev Biol Anim. 2005;41:142-8 pubmed
  • 免疫组化; 鸡
Milliken E, Zhang X, Flask C, Duerk J, MacDonald P, Keri R. EB1089, a vitamin D receptor agonist, reduces proliferation and decreases tumor growth rate in a mouse model of hormone-induced mammary cancer. Cancer Lett. 2005;229:205-15 pubmed
  • EMSA; 人类
McGaffin K, Chrysogelos S. Identification and characterization of a response element in the EGFR promoter that mediates transcriptional repression by 1,25-dihydroxyvitamin D3 in breast cancer cells. J Mol Endocrinol. 2005;35:117-33 pubmed
  • 免疫印迹; 小鼠
Nakagawa K, Kawaura A, Kato S, Takeda E, Okano T. 1 alpha,25-Dihydroxyvitamin D(3) is a preventive factor in the metastasis of lung cancer. Carcinogenesis. 2005;26:429-40 pubmed
Slominski A, Bro x17c yna A, Kim T, Elsayed M, Janjetovic Z, Qayyum S, et al. CYP11A1‑derived vitamin D hydroxyderivatives as candidates for therapy of basal and squamous cell carcinomas. Int J Oncol. 2022;61: pubmed 出版商
Holah N. The Clinical Value of VDR and CTLA 4 in Evaluating the Prognosis of Invasive Duct Carcinoma of Egyptian Patients and their Benefit as a Target Therapy. Asian Pac J Cancer Prev. 2021;22:1183-1194 pubmed 出版商
Hui Q, Zhao X, Lu P, Liu S, Nyachoti M, O K, et al. Molecular distribution and localization of extracellular calcium-sensing receptor (CaSR) and vitamin D receptor (VDR) at three different laying stages in laying hens (Gallus gallus domesticus). Poult Sci. 2021;100:101060 pubmed 出版商
Grzesiak M, Burzawa G, Kurowska P, Blaszczyk K, Szlaga A, Blasiak A, et al. Altered vitamin D3 metabolism in the ovary and periovarian adipose tissue of rats with letrozole-induced PCOS. Histochem Cell Biol. 2021;155:101-116 pubmed 出版商
Slominski A, Brozyna A, Zmijewski M, Janjetovic Z, Kim T, Slominski R, et al. The Role of Classical and Novel Forms of Vitamin D in the Pathogenesis and Progression of Nonmelanoma Skin Cancers. Adv Exp Med Biol. 2020;1268:257-283 pubmed 出版商
Verma A, Vincent Chong V, Dejong H, Hershberger P, Seshadri M. Impact of dietary vitamin D on initiation and progression of oral cancer. J Steroid Biochem Mol Biol. 2020;199:105603 pubmed 出版商
Gooding S, Olechnowicz S, Morris E, Armitage A, Arezes J, Frost J, et al. Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease. Nat Commun. 2019;10:4533 pubmed 出版商
Zhu X, Wu S, Guo H. Active Vitamin D and Vitamin D Receptor Help Prevent High Glucose Induced Oxidative Stress of Renal Tubular Cells via AKT/UCP2 Signaling Pathway. Biomed Res Int. 2019;2019:9013904 pubmed 出版商
Vincent Chong V, Dejong H, Attwood K, Hershberger P, Seshadri M. Preclinical Prevention Trial of Calcitriol: Impact of Stage of Intervention and Duration of Treatment on Oral Carcinogenesis. Neoplasia. 2019;21:376-388 pubmed 出版商
Lin Y, Sun H, Chiu W, Su H, Chien Y, Chong L, et al. Calcitriol Inhibits HCV Infection via Blockade of Activation of PPAR and Interference with Endoplasmic Reticulum-Associated Degradation. Viruses. 2018;10: pubmed 出版商
Battaglia S, Karasik E, Gillard B, Williams J, Winchester T, Moser M, et al. LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer. Clin Epigenetics. 2017;9:82 pubmed 出版商
Janmaat V, van de Winkel A, Peppelenbosch M, Spaander M, Uitterlinden A, Pourfarzad F, et al. Vitamin D Receptor Polymorphisms Are Associated with Reduced Esophageal Vitamin D Receptor Expression and Reduced Esophageal Adenocarcinoma Risk. Mol Med. 2015;21:346-54 pubmed 出版商
Blumberg J, Tzameli I, Astapova I, Lam F, Flier J, Hollenberg A. Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. J Biol Chem. 2006;281:11205-13 pubmed
Miyauchi Y, Michigami T, Sakaguchi N, Sekimoto T, Yoneda Y, Pike J, et al. Importin 4 is responsible for ligand-independent nuclear translocation of vitamin D receptor. J Biol Chem. 2005;280:40901-8 pubmed
Mallya S, Gallagher J, Wild Y, Kifor O, Costa Guda J, Saucier K, et al. Abnormal parathyroid cell proliferation precedes biochemical abnormalities in a mouse model of primary hyperparathyroidism. Mol Endocrinol. 2005;19:2603-9 pubmed
Beer T, Myrthue A, Garzotto M, O Hara M, Chin R, Lowe B, et al. Randomized study of high-dose pulse calcitriol or placebo prior to radical prostatectomy. Cancer Epidemiol Biomarkers Prev. 2004;13:2225-32 pubmed
Capiati D, Rossi A, Picotto G, Benassati S, Boland R. Inhibition of serum-stimulated mitogen activated protein kinase by 1alpha,25(OH)2-vitamin D3 in MCF-7 breast cancer cells. J Cell Biochem. 2004;93:384-97 pubmed
Zinser G, Welsh J. Vitamin D receptor status alters mammary gland morphology and tumorigenesis in MMTV-neu mice. Carcinogenesis. 2004;25:2361-72 pubmed
Narayanan R, Sepulveda V, Falzon M, Weigel N. The functional consequences of cross-talk between the vitamin D receptor and ERK signaling pathways are cell-specific. J Biol Chem. 2004;279:47298-310 pubmed
Zinser G, Welsh J. Accelerated mammary gland development during pregnancy and delayed postlactational involution in vitamin D3 receptor null mice. Mol Endocrinol. 2004;18:2208-23 pubmed
Christensen G, Jepsen J, Fog C, Christensen I, Lykkesfeldt A. Sequential versus combined treatment of human breast cancer cells with antiestrogens and the vitamin D analogue EB1089 and evaluation of predictive markers for vitamin D treatment. Breast Cancer Res Treat. 2004;85:53-63 pubmed
Krishan A, Arya P, Ganjei Azar P, Shirley S, Escoffery C, Nadji M. Androgen and vitamin D receptor expression in archival human breast tumors. Cytometry B Clin Cytom. 2004;58:53-60 pubmed
Ismail A, Nguyen C, Ahene A, Fleet J, Uskokovic M, Peleg S. Effect of cellular environment on the selective activation of the vitamin D receptor by 1alpha,25-dihydroxyvitamin D3 and its analog 1alpha-fluoro-16-ene-20-epi-23-ene-26,27-bishomo-25-hydroxyvitamin D3 (Ro-26-9228). Mol Endocrinol. 2004;18:874-87 pubmed
Barbosa E, Nonogaki S, Katayama M, Folgueira M, Alves V, Brentani M. Vitamin D3 modulation of plasminogen activator inhibitor type-1 in human breast carcinomas under organ culture. Virchows Arch. 2004;444:175-82 pubmed
Zhang C, Dowd D, Staal A, Gu C, Lian J, Van Wijnen A, et al. Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing. J Biol Chem. 2003;278:35325-36 pubmed
Flanagan L, Packman K, Juba B, O Neill S, Tenniswood M, Welsh J. Efficacy of Vitamin D compounds to modulate estrogen receptor negative breast cancer growth and invasion. J Steroid Biochem Mol Biol. 2003;84:181-92 pubmed
Fleet J, Eksir F, Hance K, Wood R. Vitamin D-inducible calcium transport and gene expression in three Caco-2 cell lines. Am J Physiol Gastrointest Liver Physiol. 2002;283:G618-25 pubmed
Erben R, Soegiarto D, Weber K, Zeitz U, Lieberherr M, Gniadecki R, et al. Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D. Mol Endocrinol. 2002;16:1524-37 pubmed
Barletta F, Freedman L, Christakos S. Enhancement of VDR-mediated transcription by phosphorylation: correlation with increased interaction between the VDR and DRIP205, a subunit of the VDR-interacting protein coactivator complex. Mol Endocrinol. 2002;16:301-14 pubmed
Sunn K, Cock T, Crofts L, Eisman J, Gardiner E. Novel N-terminal variant of human VDR. Mol Endocrinol. 2001;15:1599-609 pubmed
David J, Rincon M, Neff L, Horne W, Baron R. Carbonic anhydrase II is an AP-1 target gene in osteoclasts. J Cell Physiol. 2001;188:89-97 pubmed
Issa L, Leong G, Barry J, Sutherland R, Eisman J. Glucocorticoid receptor-interacting protein-1 and receptor-associated coactivator-3 differentially interact with the vitamin D receptor (VDR) and regulate VDR-retinoid X receptor transcriptional cross-talk. Endocrinology. 2001;142:1606-15 pubmed
Shang Y, Hu X, DiRenzo J, Lazar M, Brown M. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell. 2000;103:843-52 pubmed
Liu Y, Nguyen C, Peleg S. Regulation of ligand-induced heterodimerization and coactivator interaction by the activation function-2 domain of the vitamin D receptor. Mol Endocrinol. 2000;14:1776-87 pubmed
Nemere I, Campbell K. Immunochemical studies on the putative plasmalemmal receptor for 1, 25-dihydroxyvitamin D(3). III. Vitamin D status. Steroids. 2000;65:451-7 pubmed
Nemere I, Ray R, McManus W. Immunochemical studies on the putative plasmalemmal receptor for 1, 25(OH)(2)D(3). I. Chick intestine. Am J Physiol Endocrinol Metab. 2000;278:E1104-14 pubmed
Dwivedi P, Omdahl J, Kola I, Hume D, May B. Regulation of rat cytochrome P450C24 (CYP24) gene expression. Evidence for functional cooperation of Ras-activated Ets transcription factors with the vitamin D receptor in 1,25-dihydroxyvitamin D(3)-mediated induction. J Biol Chem. 2000;275:47-55 pubmed
Michigami T, Suga A, Yamazaki M, Shimizu C, Cai G, Okada S, et al. Identification of amino acid sequence in the hinge region of human vitamin D receptor that transfers a cytosolic protein to the nucleus. J Biol Chem. 1999;274:33531-8 pubmed
Li X, Boudjelal M, Xiao J, Peng Z, Asuru A, Kang S, et al. 1,25-Dihydroxyvitamin D3 increases nuclear vitamin D3 receptors by blocking ubiquitin/proteasome-mediated degradation in human skin. Mol Endocrinol. 1999;13:1686-94 pubmed
Manfredini R, Trevisan F, Grande A, Tagliafico E, Montanari M, Lemoli R, et al. Induction of a functional vitamin D receptor in all-trans-retinoic acid-induced monocytic differentiation of M2-type leukemic blast cells. Cancer Res. 1999;59:3803-11 pubmed
Amizuka N, Kwan M, Goltzman D, Ozawa H, White J. Vitamin D3 differentially regulates parathyroid hormone/parathyroid hormone-related peptide receptor expression in bone and cartilage. J Clin Invest. 1999;103:373-81 pubmed
Morgan J, Sliney D, Morgan D, Maizel A. Differential regulation of gene transcription in subpopulations of human B lymphocytes by vitamin D3. Endocrinology. 1999;140:381-91 pubmed
Nakajima S, Yamagata M, Sakai N, Ozono K. Characterization of the activation function-2 domain of the human 1,25-dihydroxyvitamin D3 receptor. Mol Cell Endocrinol. 1998;139:15-24 pubmed
Thompson P, Jurutka P, Haussler C, Whitfield G, Haussler M. Heterodimeric DNA binding by the vitamin D receptor and retinoid X receptors is enhanced by 1,25-dihydroxyvitamin D3 and inhibited by 9-cis-retinoic acid. Evidence for allosteric receptor interactions. J Biol Chem. 1998;273:8483-91 pubmed
Barsony J, Renyi I, McKoy W. Subcellular distribution of normal and mutant vitamin D receptors in living cells. Studies with a novel fluorescent ligand. J Biol Chem. 1997;272:5774-82 pubmed
Mackey S, Heymont J, Kronenberg H, Demay M. Vitamin D receptor binding to the negative human parathyroid hormone vitamin D response element does not require the retinoid x receptor. Mol Endocrinol. 1996;10:298-305 pubmed
Liu S, Koszewski N, Lupez M, Malluche H, Olivera A, Russell J. Characterization of a response element in the 5'-flanking region of the avian (chicken) PTH gene that mediates negative regulation of gene transcription by 1,25-dihydroxyvitamin D3 and binds the vitamin D3 receptor. Mol Endocrinol. 1996;10:206-15 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
VDR单克隆抗体(9A7)
目录# :
MA1-710
规格 :
100微克
价格 :
美国430.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
大鼠
反应物种 :
Chicken, Human, Many, Mouse, Rat
应用 :
ChIP Assay: Assay-dependent, Gel Shift: Assay-dependent, Immunocytochemistry: 1:10-1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1 µg/mL
物种 :
Chicken, Human, Many, Mouse, Rat
克隆 :
9A7
抗体亚型 :
IgG2b
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors. Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. Studies have found VDR in the intestine, bone, kidney, epidermis, and cells of the endocrine immune system. Repression of T-cell proliferation and interleukin-2 (IL-2) gene expression, for example, occurs when VDR binds within the IL-2 enhancer. Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)2D3 has been shown to interfere with assembly of nuclear factor of activated T-cells (NFATp)/Fos/Jun/DNA complex and subsequent IL-2 gene transcription. The corresponding gene for the vitamin D receptor is NR1I1.
免疫原 :
Partially purified chicken intestinal cytoplasmic 1,25-(OH)2D3 receptor protein.
格式 :
液体
应用w/稀释 :
ChIP Assay: Assay-dependent, Gel Shift: Assay-dependent, Immunocytochemistry: 1:10-1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1 µg/mL
别名 :
1,25-dihydroxyvitamin D3 receptor; HGNC:12679; I79_025795; Nr1i1; Nuclear receptor subfamily 1 group I member 1; PPP1R163; protein phosphatase 1, regulatory subunit 163; vdr; vdr.S; vdr-A; vitamin D (1,25- dihydroxyvitamin D3) receptor; vitamin D (1,25- dihydroxyvitamin D3) receptor S homeolog; vitamin D (1,25-dihydroxyvitamin D3) receptor; vitamin D nuclear receptor variant 1; vitamin D receptor; vitamin D receptor protein; vitamin D receptor S homeolog; Vitamin D3 receptor; XELAEV_18015993mg; xVDR
更多信息或购买 :
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公司信息
赛默飞世尔
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1084193588
公司总部: 美国