产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
PI3K p85甲单克隆抗体(U5)
目录 :
MA1-74183
规格 :
200微克
价格 :
美国496.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
U5
反应物种 :
人类, 小鼠, 大鼠, 牛
应用 :
免疫印迹, 免疫组化, 免疫沉淀, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 17
| 参考文献 |
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Perrot Applanat M, Gualillo O, Buteau H, Edery M, Kelly P. Internalization of prolactin receptor and prolactin in transfected cells does not involve nuclear translocation. J Cell Sci. 1997;110 ( Pt 9):1123-32 pubmed
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Ormandy C, Camus A, Barra J, Damotte D, Lucas B, Buteau H, et al. Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev. 1997;11:167-78 pubmed
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Gagnerault M, Touraine P, Savino W, Kelly P, Dardenne M. Expression of prolactin receptors in murine lymphoid cells in normal and autoimmune situations. J Immunol. 1993;150:5673-81 pubmed
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Rui H, Lebrun J, Kirken R, Kelly P, Farrar W. JAK2 activation and cell proliferation induced by antibody-mediated prolactin receptor dimerization. Endocrinology. 1994;135:1299-306 pubmed
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Royster M, Driscoll P, Kelly P, Freemark M. The prolactin receptor in the fetal rat: cellular localization of messenger ribonucleic acid, immunoreactive protein, and ligand-binding activity and induction of expression in late gestation. Endocrinology. 1995;136:3892-900 pubmed
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Waters M, Daniel N, Bignon C, Djiane J. The rabbit mammary gland prolactin receptor is tyrosine-phosphorylated in response to prolactin in vivo and in vitro. J Biol Chem. 1995;270:5136-43 pubmed
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Okamura H, Raguet S, Bell A, Gagnon J, Kelly P. Purification and protein sequence analysis of rat liver prolactin receptor. J Biol Chem. 1989;264:5904-11 pubmed
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Okamura H, Zachwieja J, Raguet S, Kelly P. Characterization and applications of monoclonal antibodies to the prolactin receptor. Endocrinology. 1989;124:2499-508 pubmed
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Elberg G, Kelly P, Djiane J, Binder L, Gertler A. Mitogenic and binding properties of monoclonal antibodies to the prolactin receptor in Nb2 rat lymphoma cells. Selective enhancement by anti-mouse IgG. J Biol Chem. 1990;265:14770-6 pubmed
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Dardenne M, Kelly P, Bach J, Savino W. Identification and functional activity of prolactin receptors in thymic epithelial cells. Proc Natl Acad Sci U S A. 1991;88:9700-4 pubmed
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Rozakis Adcock M, Kelly P. Mutational analysis of the ligand-binding domain of the prolactin receptor. J Biol Chem. 1991;266:16472-7 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
PI3K p85甲单克隆抗体(U5)
目录# :
MA1-74183
规格 :
200微克
价格 :
美国496.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
Bovine, Human, Mouse, Non-human primate, Rat
应用 :
Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:100-1:1,000
物种 :
Bovine, Human, Mouse, Non-human primate, Rat
克隆 :
U5
抗体亚型 :
IgG1
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
Phosphatidylinositol 3-kinase (PIK3) is a signaling protein that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. Signaling is initiated when upstream tyrosine kinase receptors or G protein coupled receptors are bound by their ligands. It binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. During insulin stimulation, it also binds to IRS-1. Mutations in the gene can result in Agammaglobulinemia 7, SHORT syndrome, or Immunodeficiency 36.
免疫原 :
Recombinant bovine p85 alpha subunit of PI-3 kinase, expressed in Baculovirus.
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:100-1:1,000
别名 :
AGM7; GRB1; IMD36; p50alpha; p55alpha; p55-GAMMA; p55PIK; p85; p85alpha; p85-ALPHA; phosphatidylinositol 3-kinase; phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase regulatory subunit gamma; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase-associated p-85 alpha; Phosphoinositide 3-kinase p85 (other splicing variants: p55 and p50); Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphoinositide-3-kinase regulatory subunit; phosphoinositide-3-kinase regulatory subunit 1; phosphoinositide-3-kinase regulatory subunit alpha; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha); phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); PI3K; PI3K regulatory subunit alpha; PI3K regulatory subunit gamma; PI3KA; PI3-kinase p85 subunit alpha; PI3-kinase p85-subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3-kinase subunit p85-alpha; Pik3r1; polypeptide 1 p85 alpha; ptdIns-3-kinase p85-alpha; ptdIns-3-kinase regulatory subunit alpha; PtdIns-3-kinase regulatory subunit p85-al; ptdIns-3-kinase regulatory subunit p85-alpha; RP4-533D7.2
更多信息或购买 :
公司信息
赛默飞世尔