产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
RARA单克隆抗体(Ralpha10)
目录 :
MA1-810A
规格 :
50微克
价格 :
美国430.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
Ralpha10
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学
更多信息或购买 :
文章摘录数: 3
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产品信息
产品类型 :
抗体
产品名称 :
RARA单克隆抗体(Ralpha10)
目录# :
MA1-810A
规格 :
50微克
价格 :
美国430.00
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 1:10-1:200, Western Blot: 1:100-1:1,000
物种 :
人类, 小鼠, 大鼠
克隆 :
Ralpha10
抗体亚型 :
IgG1
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
RARA is a receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.
免疫原 :
Synthetic peptide corresponding to residues C(444) S P S L S P S S H R S S P A T Q S P(462) of mouse RAR alpha.
格式 :
冻干
应用w/稀释 :
Immunocytochemistry: 1:10-1:200, Western Blot: 1:100-1:1,000
别名 :
Nr1b1; nuclear receptor subfamily 1 group B member 1; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; RAR; RAR Alpha; RAR alpha 1; RARA; RAR-alpha; RARalpha1; retinoic acid; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; retinoic acid receptor; retinoic acid receptor alpha; retinoic acid receptor, alpha; retinoic acid receptor, alpha polypeptide; RRA
更多信息或购买 :
公司信息
赛默飞世尔