产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
c Myc单克隆抗体(9E10), HRP
目录 :
MA1-81357
规格 :
100微克
价格 :
美国460.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
HRP
克隆名称 :
9E10
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 34
参考文献
Gu Z, Chen X, Yang W, Qi Y, Yu H, Wang X, et al. The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-κB activation and the innate immune response. Cell Mol Immunol. 2021;18:1981-1994 pubmed 出版商
Pesch T, Bonati L, Kelton W, Parola C, Ehling R, Csepregi L, et al. Molecular Design, Optimization, and Genomic Integration of Chimeric B Cell Receptors in Murine B Cells. Front Immunol. 2019;10:2630 pubmed 出版商
Redditt T, Chung E, Karimi H, Rodibaugh N, Zhang Y, Trinidad J, et al. AvrRpm1 Functions as an ADP-Ribosyl Transferase to Modify NOI Domain-Containing Proteins, Including Arabidopsis and Soybean RPM1-Interacting Protein4. Plant Cell. 2019;31:2664-2681 pubmed 出版商
Geng C, Kaochar S, Li M, Rajapakshe K, Fiskus W, Dong J, et al. SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein. Oncogene. 2017;36:4767-4777 pubmed 出版商
Lee J, Reiter W, Dohnal I, Gregori C, Beese Sims S, Kuchler K, et al. MAPK Hog1 closes the S. cerevisiae glycerol channel Fps1 by phosphorylating and displacing its positive regulators. Genes Dev. 2013;27:2590-601 pubmed 出版商
Giessrigl B, Schmidt W, Kalipciyan M, Jeitler M, Bilban M, Gollinger M, et al. Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013;109:2751-62 pubmed 出版商
Waga C, Asano H, Sanagi T, Suzuki E, Nakamura Y, Tsuchiya A, et al. Identification of two novel Shank3 transcripts in the developing mouse neocortex. J Neurochem. 2014;128:280-93 pubmed 出版商
Grzenda A, Leonard P, Seo S, Mathison A, Urrutia G, Calvo E, et al. Functional impact of Aurora A-mediated phosphorylation of HP1? at serine 83 during cell cycle progression. Epigenetics Chromatin. 2013;6:21 pubmed 出版商
Gleyzer N, Scarpulla R. Activation of a PGC-1-related coactivator (PRC)-dependent inflammatory stress program linked to apoptosis and premature senescence. J Biol Chem. 2013;288:8004-15 pubmed 出版商
Moghe S, Jiang F, Miura Y, Cerny R, Tsai M, Furukawa M. The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A. Biol Open. 2012;1:82-91 pubmed 出版商
Cai L, Phong B, Fisher A, Wang Z. Regulation of fertility, survival, and cuticle collagen function by the Caenorhabditis elegans eaf-1 and ell-1 genes. J Biol Chem. 2011;286:35915-21 pubmed 出版商
Silva Fernandes I, Alves M, Lima V, de Lima M, Barros M, Ferreira M, et al. Differential expression of MYC in H. pylori-related intestinal and diffuse gastric tumors. Virchows Arch. 2011;458:725-31 pubmed 出版商
Cho Y, Shusta E. Antibody library screens using detergent-solubilized mammalian cell lysates as antigen sources. Protein Eng Des Sel. 2010;23:567-77 pubmed 出版商
Hart D, Santra M, Raha T, Green M. Selective interaction between Trf3 and Taf3 required for early development and hematopoiesis. Dev Dyn. 2009;238:2540-9 pubmed 出版商
Hagan G, Lin Y, Magnuson M, Avruch J, Czech M. A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes. Mol Cell Biol. 2008;28:4215-26 pubmed 出版商
Lima M, Ferreira M, Barros M, Pardini M, Ferrasi A, Mota R, et al. Relationship between EBV infection and expression of cellular proteins c-Myc, Bcl-2, and Bax in gastric carcinomas. Diagn Mol Pathol. 2008;17:82-9 pubmed 出版商
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Andrews P, He Y, Xiong Y. Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function. Oncogene. 2006;25:4534-48 pubmed
Zacharek S, Xiong Y, Shumway S. Negative regulation of TSC1-TSC2 by mammalian D-type cyclins. Cancer Res. 2005;65:11354-60 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
c Myc单克隆抗体(9E10), HRP
目录# :
MA1-81357
规格 :
100微克
价格 :
美国460.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA: 1:100-1:500, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Western Blot: 1:100-1:500
物种 :
人类
克隆 :
9E10
抗体亚型 :
IgG1
储存 :
4° C, 不冻结
描述 :
The c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in tumor development, which distributes blood throughout the cells. The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation, and the deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins. c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to the immunoglobulin loci on chromosome 14 (heavy chain); 2 (delta light chain); or 22 (light chain) is described in Burkitts lymphoma and other B-cell lymphoproliferative conditions. An aberrant expression of the c-myc gene occurs in tumors of different origins such as colorectal, gastric, gallbladder, hepatic, mammary, ovarian, endometrial, head and neck, pulmonary, prostatic, thyroidal, oral, ocular, nasopharyngeal, endocrine, as well as hematopoietic neoplasms.
免疫原 :
Synthetic peptide sequence AEEQKLISEEDLL corresponding to the C-terminal region of human c-myc
格式 :
液体
应用w/稀释 :
ELISA: 1:100-1:500, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Western Blot: 1:100-1:500
别名 :
AU016757; Avian myelocytomatosis viral (v-myc) oncogene homolog; avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; class E basic helix-loop-helix protein 39; cmyc; c-Myc; c-myc epitope tag; c-myc proto-oncogene; mMyc; MRTL; Myc; Myc protein; Myc proto-oncogene protein; MYC proto-oncogene, bHLH transcription factor; Myc2; MYCC; myc-related translation/localization regulatory factor; myelocytomatosis oncogene; myelocytomatosis viral oncogene homolog; Niard; Nird; Proto-oncogene c-Myc; RNCMYC; Transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene-like protein
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国