产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
ErbB3单克隆抗体(RTJ2)
目录 :
MA1-860
规格 :
200微克
价格 :
425美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
RTJ2
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 3
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
| Offterdinger M, Schneider S, Grunt T. Heregulin and retinoids synergistically induce branching morphogenesis of breast cancer cells cultivated in 3D collagen gels. J Cell Physiol. 2003;195:260-75 pubmed
|
Gilmour L, MacLeod K, McCaig A, Sewell J, Gullick W, Smyth J, et al. Neuregulin expression, function, and signaling in human ovarian cancer cells. Clin Cancer Res. 2002;8:3933-42 pubmed
| |
Offterdinger M, Schöfer C, Weipoltshammer K, Grunt T. c-erbB-3: a nuclear protein in mammary epithelial cells. J Cell Biol. 2002;157:929-39 pubmed
|
产品信息
产品类型 :
抗体
产品名称 :
ErbB3单克隆抗体(RTJ2)
目录# :
MA1-860
规格 :
200微克
价格 :
425美元
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类, 小鼠
应用 :
ELISA: Assay dependent, Flow Cytometry: 0.5-2 µg / 10^6 cells, Immunocytochemistry: 5 µg/mL, Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL, Immunoprecipitation: Assay dependent, Western Blot: Assay Dependent
物种 :
人类, 小鼠
克隆 :
RTJ2
抗体亚型 :
IgG1
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family. ErbB3 is over-expressed in a variety of tumors in the prostate, bladder, breast, stomach, pancreas, and colon. Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents. The ErbB3 gene is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6. 2kb mRNA which is translated into a 160/180 kDa glycoprotein. The ErbB3 gene encodes a transmembrane receptor tyrosine kinase due to alternative splicing and forms heterodimers with other EGF receptor family members that have kinase activity. Heterodimerization leads to the activation of pathways that lead to cell proliferation or differentiation. Alternate transcriptional splice variants encoding different isoforms of ErbB3 have been characterized. One ErbB3 isoform lacks the intermembrane region, is secreted outside the cell, and acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
免疫原 :
Synthetic Peptide: E(1004) L E P E L D L D L D L E(1016)
格式 :
液体
应用w/稀释 :
ELISA: Assay dependent, Flow Cytometry: 0.5-2 µg / 10^6 cells, Immunocytochemistry: 5 µg/mL, Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL, Immunoprecipitation: Assay dependent, Western Blot: Assay Dependent
别名 :
avian erythroblastosis oncogene B 3; avian erythroblastosis oncogene B 3 receptor; C76256; c-erbB3; c-erbB-3; C-errB-3; erb-b2 receptor tyrosine kinase 3; ERBB3; ErbB-3; Erbb3r; erbB3-S; Glial growth factor receptor; HER3; human epidermal growth factor receptor 3; LCCS2; MDA BF 1; MDA-BF-1; MGC88033; nuc-ErbB3; p180 ErbB3; p180-ErbB3; p45 sErbB3; p45-sErbB3; p85 sErbB3; p85-sErbB3; Proto-oncogene-like protein c-ErbB-3; receptor tyrosine kinase; receptor tyrosine-protein kinase erbB-3; Tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
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公司信息
赛默飞世尔