产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
alpha突触核蛋白单克隆抗体(4B12)
目录 :
MA1-90346
规格 :
100微升
价格 :
475美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
4B12
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片, dot blot
更多信息或购买 :
文章摘录数: 2
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类; 1:1000
  • 免疫组化; 人类; 1:600
  • 免疫印迹; 人类; 1:10000
Myöhänen T, Hannula M, Van Elzen R, Gerard M, Van der Veken P, Garcia Horsman J, et al. A prolyl oligopeptidase inhibitor, KYP-2047, reduces ?-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease. Br J Pharmacol. 2012;166:1097-113 pubmed 出版商
Sahin C, Lorenzen N, Lemminger L, Christiansen G, Møller I, Vesterager L, et al. Antibodies against the C-terminus of ?-synuclein modulate its fibrillation. Biophys Chem. 2017;220:34-41 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
alpha突触核蛋白单克隆抗体(4B12)
目录# :
MA1-90346
规格 :
100微升
价格 :
475美元
克隆性 :
单克隆
纯度 :
硫酸铵沉淀
宿主 :
小鼠
反应物种 :
人类
应用 :
Dot blot: 1:100-1:10,000, ELISA: Assay dependent, Immunohistochemistry (Frozen): 1:100-1:1000, Immunohistochemistry (Paraffin): 1:100-1:1000, Immunohistochemistry: Assay Dependent, Western Blot: 1:100-1:10,000
物种 :
人类
克隆 :
4B12
抗体亚型 :
IgG1
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
Alpha-Synuclein belongs to the Synuclein family, which includes beta and gamma Synuclein, and is predominantly expressed in neurons, and concentrated at synaptic terminals. Synucleins may be involved in the regulation of dopamine release and transport and the modulation of synaptic vesicle function. Alpha-Synuclein is a small, presynaptic protein that is the major nonamyloid component of the pathological inclusions characteristic of a wide range of neurodegenerative disorders, collectively known as synucleinopathies. Alpha-Synuclein is involved in the formation of SNARE complexes, and most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders. Mutation of the alpha-synuclein gene is associated with familial forms of PD. Alpha-Synuclein is known to reduce the fibrillization of the microtubule-associated protein, tau, to bind various targets such as 14-3-3, protein kinase C, synphilin-1, Elk and Tat-binding protein 1. The alpha and beta synucleins are found primarily in brain tissue where they are seen mainly in neuronal cytosol and presynaptic terminals. The antibody specific for alpha-synuclein does not cross react with beta-synuclein and will be useful for the confirmation of Parkinson's disease and Lewy body dementia and other studies for the localization and detection of alpha-synuclein. Four alternatively spliced transcripts that encode two different isoforms of the alpha-synuclein protein have been identified.
免疫原 :
Recombinant human alpha synuclein produced in E. coli.
格式 :
液体
应用w/稀释 :
Dot blot: 1:100-1:10,000, ELISA: Assay dependent, Immunohistochemistry (Frozen): 1:100-1:1000, Immunohistochemistry (Paraffin): 1:100-1:1000, Immunohistochemistry: Assay Dependent, Western Blot: 1:100-1:10,000
别名 :
Alpha synuclein; alphaSYN; Alpha-synuclein; MGC110988; MGC110988 antibody; NACP; NACP antibody; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; OTTHUMP00000218549; OTTHUMP00000218551; OTTHUMP00000218552; OTTHUMP00000218553; OTTHUMP00000218554; PARK 1; PARK 1 antibody; PARK 4; PARK 4 antibody; PARK1; PARK1 antibody; PARK4; PARK4 antibody; PD 1 antibody; PD1; PD1 antibody; Snca; SNCA antibody; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor); SYUA
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国