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抗体

CD55单克隆抗体(BRIC-216)

MA1-91161

200微克

美国499.00

单克隆

小鼠

未共轭

BRIC-216

免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪

CD55单克隆抗体(BRIC-216)

MA1-91161

200微克

美国499.00

单克隆

蛋白质G

小鼠

人类

Flow Cytometry: 10 µL for 10^6 cells in 100 µL, Functional assay: Assay-dependent, Immunocytochemistry: 1:100, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

人类

BRIC-216

IgG1

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

CD55 (decay-accelerating factor, DAF) is a GPI-anchored membrane glycoprotein that protects autologous cells from classical and alternative pathway of complement cascade. Bidirectional interactions between CD55 and CD97 are involved in T cell regulation and CD55 can regulate complement when bound to CD97. In tumors, CD55 promotes neoangiogenesis, tumorigenesis, invasiveness and evasion of apoptosis. CD55 is a 70 kDa glycoprotein (in erythrocytes) anchored in the membrane by glycosylphosphatidylinositol tail. In other cells, the apparent molecular weight is somewhat larger for CD55 and has a substantial content of O-glycans. CD55 binds to activated C4b or C3b complement fragments on the cell surface, preventing the assembly and accelerating the decay of both classical and alternative pathways. CD55 carries the Cromer related blood group antigens. Two alternatively spliced transcripts encoding CD55 have been identified, and the predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. CD55 has been studied to have a role in prostate cancer growth and survival.

人类成纤维细胞细胞株

液体

Flow Cytometry: 10 µL for 10^6 cells in 100 µL, Functional assay: Assay-dependent, Immunocytochemistry: 1:100, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

CD55; CD55 antigen; CD55 molecule (Cromer blood group); CD55 molecule, decay accelerating factor for complement; CD55 molecule, decay accelerating factor for complement (Cromer blood group); Cd55a; Complement decay-accelerating factor; complement decay-accelerating factor, GPI-anchored; complement-glycosylphosphatidylinositol; CR; CROM; Cromer blood group; Daf; Daf1; DAF-GPI; decay accelarating factor 1; decay accelerating factor 1; decay accelerating factor GPI-form; decay-accelarating factor; glycosylphophatidylinositol-anchored form; GPI anchor addition signal; GPI-DAF; RP11-357P18.1; TC