产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD11a单克隆抗体(TS1/22)
目录 :
MA11A10
规格 :
200微克
价格 :
美国395.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
TS1/22
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 流式细胞仪, 抑制或激活实验
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 42
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 s2b
Liu H, Dai X, Cao X, Yan H, Ji X, Zhang H, et al. PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin β2 expression. EMBO Rep. 2018;19: pubmed 出版商
  • 抑制或激活实验; 人类; 图 5c
Yeap W, Wong K, Shimasaki N, Teo E, Quek J, Yong H, et al. CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes. Sci Rep. 2016;6:34310 pubmed 出版商
  • 抑制或激活实验; 人类; 10 ug/ml; 图 3b
Kawamoto E, Okamoto T, Takagi Y, Honda G, Suzuki K, Imai H, et al. LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin. Biochem Biophys Res Commun. 2016;473:1005-1012 pubmed 出版商
  • 流式细胞仪; 人类; 图 2
Tuli A, Thiery J, James A, Michelet X, Sharma M, Garg S, et al. Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. Mol Biol Cell. 2013;24:3721-35 pubmed 出版商
  • 抑制或激活实验; 人类
Podgrabinska S, Kamalu O, Mayer L, Shimaoka M, Snoeck H, Randolph G, et al. Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism. J Immunol. 2009;183:1767-79 pubmed 出版商
  • 流式细胞仪; 人类
Kanno H, Watabe D, Shimizu N, Sawai T. Adhesion of Epstein-Barr virus-positive natural killer cell lines to cultured endothelial cells stimulated with inflammatory cytokines. Clin Exp Immunol. 2008;151:519-27 pubmed 出版商
  • 抑制或激活实验; 人类; 50 ug/ml
Kofler S, Schlichting C, Jankl S, Nickel T, Weis M. Dual mode of HMG-CoA reductase inhibition on dendritic cell invasion. Atherosclerosis. 2008;197:105-10 pubmed
  • 抑制或激活实验; 人类
Watabe D, Kanno H, Yoshida A, Kurose A, Akasaka T, Sawai T. Adhesion of peripheral blood mononuclear cells and CD4+ T cells from patients with psoriasis to cultured endothelial cells via the interaction between lymphocyte function-associated antigen type 1 and intercellular adhesion molecule 1. Br J Dermatol. 2007;157:259-65 pubmed
  • 抑制或激活实验; 人类
Simonson W, Franco S, Huttenlocher A. Talin1 regulates TCR-mediated LFA-1 function. J Immunol. 2006;177:7707-14 pubmed
  • 酶联免疫吸附测定; 人类
Combs J, Kim S, Tan S, Ligon L, Holzbaur E, Kuhn J, et al. Recruitment of dynein to the Jurkat immunological synapse. Proc Natl Acad Sci U S A. 2006;103:14883-8 pubmed
  • 抑制或激活实验; 人类
Sonnet C, Lafuste P, Arnold L, Brigitte M, Poron F, Authier F, et al. Human macrophages rescue myoblasts and myotubes from apoptosis through a set of adhesion molecular systems. J Cell Sci. 2006;119:2497-507 pubmed
  • 抑制或激活实验; 人类; 20 ug/ml
Konstandin M, Sester U, Klemke M, Weschenfelder T, Wabnitz G, Samstag Y. A novel flow-cytometry-based assay for quantification of affinity and avidity changes of integrins. J Immunol Methods. 2006;310:67-77 pubmed
  • 抑制或激活实验; 人类; 50 ug/ml
Schlichting C, Schareck W, Weis M. Dendritic cell adhesion is enhanced on endothelial cells preexposed to calcineurin inhibitors. J Cardiovasc Pharmacol. 2005;46:250-4 pubmed
  • 流式细胞仪; 人类
Agea E, Russano A, Bistoni O, Mannucci R, Nicoletti I, Corazzi L, et al. Human CD1-restricted T cell recognition of lipids from pollens. J Exp Med. 2005;202:295-308 pubmed
  • 流式细胞仪; 人类
Peterson M, Jin R, Hyduk S, Duchesneau P, Cybulsky M, Waddell T. Monocyte adhesion to xenogeneic endothelium during laminar flow is dependent on alpha-Gal-mediated monocyte activation. J Immunol. 2005;174:8072-81 pubmed
Jung O, Beauvais D, Adams K, Rapraeger A. VLA-4 phosphorylation during tumor and immune cell migration relies on its coupling to VEGFR2 and CXCR4 by syndecan-1. J Cell Sci. 2019;132: pubmed 出版商
Kronstad L, Seiler C, Vergara R, Holmes S, Blish C. Differential Induction of IFN-? and Modulation of CD112 and CD54 Expression Govern the Magnitude of NK Cell IFN-? Response to Influenza A Viruses. J Immunol. 2018;201:2117-2131 pubmed 出版商
Guo H, Cranert S, Lu Y, Zhong M, Zhang S, Chen J, et al. Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1. J Exp Med. 2016;213:2187-207 pubmed 出版商
Iikura M, Ebisawa M, Yamaguchi M, Tachimoto H, Ohta K, Yamamoto K, et al. Transendothelial migration of human basophils. J Immunol. 2004;173:5189-95 pubmed
Zen K, Utech M, Liu Y, Soto I, Nusrat A, Parkos C. Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils. J Biol Chem. 2004;279:44924-30 pubmed
Dagia N, Harii N, Meli A, Sun X, Lewis C, Kohn L, et al. Phenyl methimazole inhibits TNF-alpha-induced VCAM-1 expression in an IFN regulatory factor-1-dependent manner and reduces monocytic cell adhesion to endothelial cells. J Immunol. 2004;173:2041-9 pubmed
Ehlers R, Ustinov V, Chen Z, Zhang X, Rao R, Luscinskas F, et al. Targeting platelet-leukocyte interactions: identification of the integrin Mac-1 binding site for the platelet counter receptor glycoprotein Ibalpha. J Exp Med. 2003;198:1077-88 pubmed
Riteau B, Barber D, Long E. Vav1 phosphorylation is induced by beta2 integrin engagement on natural killer cells upstream of actin cytoskeleton and lipid raft reorganization. J Exp Med. 2003;198:469-74 pubmed
Horvath Arcidiacono J, Tsuyuki S, Mostowski H, Bloom E. Human natural killer cell activity against porcine targets: modulation by control of the oxidation-reduction environment and role of adhesion molecule interactions. Cell Immunol. 2003;222:35-44 pubmed
Weis M, Schlichting C, Engleman E, Cooke J. Endothelial determinants of dendritic cell adhesion and migration: new implications for vascular diseases. Arterioscler Thromb Vasc Biol. 2002;22:1817-23 pubmed
Tibaldi E, Salgia R, Reinherz E. CD2 molecules redistribute to the uropod during T cell scanning: implications for cellular activation and immune surveillance. Proc Natl Acad Sci U S A. 2002;99:7582-7 pubmed
Morgan M, Labno C, van Seventer G, Denny M, Straus D, Burkhardt J. Superantigen-induced T cell:B cell conjugation is mediated by LFA-1 and requires signaling through Lck, but not ZAP-70. J Immunol. 2001;167:5708-18 pubmed
Wang P, Malkovsky M. Different roles of the CD2 and LFA-1 T-cell co-receptors for regulating cytotoxic, proliferative, and cytokine responses of human V gamma 9/V delta 2 T cells. Mol Med. 2000;6:196-207 pubmed
Crutchfield K, Shinde Patil V, Campbell C, Parkos C, Allport J, Goetz D. CD11b/CD18-coated microspheres attach to E-selectin under flow. J Leukoc Biol. 2000;67:196-205 pubmed
Babina M, Mammeri K, Henz B. ICAM-3 (CD50) is expressed by human mast cells: induction of homotypic mast cell aggregation via ICAM-3. Cell Adhes Commun. 1999;7:195-209 pubmed
Chan J, Hyduk S, Cybulsky M. Alpha 4 beta 1 integrin/VCAM-1 interaction activates alpha L beta 2 integrin-mediated adhesion to ICAM-1 in human T cells. J Immunol. 2000;164:746-53 pubmed
Edwards C, Fisher K, Presta L, Bodary S. Mapping the intercellular adhesion molecule-1 and -2 binding site on the inserted domain of leukocyte function-associated antigen-1. J Biol Chem. 1998;273:28937-44 pubmed
Petruzzelli L, Maduzia L, Springer T. Differential requirements for LFA-1 binding to ICAM-1 and LFA-1-mediated cell aggregation. J Immunol. 1998;160:4208-16 pubmed
Wang W, Goldman L, Schleider D, Appenheimer M, Subjeck J, Repasky E, et al. Fever-range hyperthermia enhances L-selectin-dependent adhesion of lymphocytes to vascular endothelium. J Immunol. 1998;160:961-9 pubmed
Poccia F, Boullier S, Lecoeur H, Cochet M, Poquet Y, Colizzi V, et al. Peripheral V gamma 9/V delta 2 T cell deletion and anergy to nonpeptidic mycobacterial antigens in asymptomatic HIV-1-infected persons. J Immunol. 1996;157:449-61 pubmed
Stark J, Godding V, Sedgwick J, Busse W. Respiratory syncytial virus infection enhances neutrophil and eosinophil adhesion to cultured respiratory epithelial cells. Roles of CD18 and intercellular adhesion molecule-1. J Immunol. 1996;156:4774-82 pubmed
Mobley J, Ennis E, Shimizu Y. Isolation and characterization of cell lines with genetically distinct mutations downstream of protein kinase C that result in defective activation-dependent regulation of T cell integrin function. J Immunol. 1996;156:948-56 pubmed
Xie J, Li R, Kotovuori P, Vermot Desroches C, Wijdenes J, Arnaout M, et al. Intercellular adhesion molecule-2 (CD102) binds to the leukocyte integrin CD11b/CD18 through the A domain. J Immunol. 1995;155:3619-28 pubmed
Sanchez Madrid F, Nagy J, Robbins E, Simon P, Springer T. A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule. J Exp Med. 1983;158:1785-1803 pubmed
Kishimoto T, Hollander N, Roberts T, Anderson D, Springer T. Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency. Cell. 1987;50:193-202 pubmed
Kishimoto T, O CONNOR K, Lee A, Roberts T, Springer T. Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family. Cell. 1987;48:681-90 pubmed
Hale L, Martin M, McCollum D, Nunley J, Springer T, Singer K, et al. Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment. Arthritis Rheum. 1989;32:22-30 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CD11a单克隆抗体(TS1/22)
目录# :
MA11A10
规格 :
200微克
价格 :
美国395.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类, 小鼠
应用 :
Flow Cytometry: 0.5 µg/test
物种 :
人类, 小鼠
克隆 :
TS1/22
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
CD11a (LFA-1 alpha, ITGAL) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. CD11a plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. CD11a is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of CD11a to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. CD11a is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of CD11a function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti- CD11a antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation, binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity. Two transcript variants encoding different isoforms of CD11a have been found. Diseases associated with CD11a dysfunction include benign cephalic histiocytosis and leukocyte adhesion deficiency.
免疫原 :
Human 180 kD alpha chain of the CD11alpha complex.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.5 µg/test
别名 :
(p180); alpha L integrin; antigen CD11A (p180); antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide; antigen CD11A p180; CD11 antigen-like family member A; CD11a; integrin alpha L; integrin alphaL; integrin alpha-L; integrin alpha-L precursor; integrin gene promoter; integrin subunit alpha L; integrin surface receptor; integrin, alpha L; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide); ITGAL; Leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; LFA-1; LFA-1 alpha; LFA1A; LFA-1A; Ly-15; Ly-21; lymphocyte antigen 15; lymphocyte function associated antigen 1, alpha polypeptide; lymphocyte function-associated antigen 1; lymphocyte function-associated antigen 1, alpha polypeptide; lymphocyte function-associated antigen-1
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国