产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD18单克隆抗体(TS1/18)
目录 :
MA1810
规格 :
200微克
价格 :
美国346.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
TS1/18
反应物种 :
人类, 小鼠
应用 :
酶联免疫吸附测定, 免疫细胞化学, 流式细胞仪, 抑制或激活实验
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 37
出版应用/物种/样本/稀释参考文献
  • 酶联免疫吸附测定; 人类
Furugen R, Hayashida H, Saito T. Porphyromonas gingivalis and Escherichia coli lipopolysaccharide causes resistin release from neutrophils. Oral Dis. 2013;19:479-83 pubmed 出版商
  • 抑制或激活实验; 人类; 5 ug/ml
Sugimoto A, Suzuki M, Otani T, Okochi A, Takeuchi M, Yamasaki F, et al. HOZOTs, novel human regulatory T-cell lines, exhibit helper or suppressor activities depending on dendritic cell or anti-CD3 stimulation. Exp Hematol. 2009;37:1454-63 pubmed 出版商
  • 抑制或激活实验; 人类
Boehmler A, Drost A, Jaggy L, Seitz G, Wiesner T, Denzlinger C, et al. The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells. J Immunol. 2009;182:6789-98 pubmed 出版商
  • 流式细胞仪; 人类
Kieba I, Fong K, Tang H, Hoffman K, Speicher D, Klickstein L, et al. Aggregatibacter actinomycetemcomitans leukotoxin requires beta-sheets 1 and 2 of the human CD11a beta-propeller for cytotoxicity. Cell Microbiol. 2007;9:2689-99 pubmed
  • 抑制或激活实验; 人类; 10 ug/ml
Baratin M, Roetynck S, Pouvelle B, Lemmers C, Viebig N, Johansson S, et al. Dissection of the role of PfEMP1 and ICAM-1 in the sensing of Plasmodium-falciparum-infected erythrocytes by natural killer cells. PLoS ONE. 2007;2:e228 pubmed
  • 抑制或激活实验; 人类; 10 ug/ml
Simonson W, Franco S, Huttenlocher A. Talin1 regulates TCR-mediated LFA-1 function. J Immunol. 2006;177:7707-14 pubmed
  • 抑制或激活实验; 人类; 10 ug/ml
Lo S, Hung C, Lin D, Peng H, Huang T. Involvement of platelet glycoprotein Ib in platelet microparticle mediated neutrophil activation. J Biomed Sci. 2006;13:787-96 pubmed
  • 抑制或激活实验; 小鼠
Wang X, Cheng Y, Ba X. Engagement of PSGL-1 enhances beta(2)-integrin-involved adhesion of neutrophils to recombinant ICAM-1. Acta Pharmacol Sin. 2006;27:617-22 pubmed
  • 流式细胞仪; 人类
Agea E, Russano A, Bistoni O, Mannucci R, Nicoletti I, Corazzi L, et al. Human CD1-restricted T cell recognition of lipids from pollens. J Exp Med. 2005;202:295-308 pubmed
  • 流式细胞仪; 人类
Peterson M, Jin R, Hyduk S, Duchesneau P, Cybulsky M, Waddell T. Monocyte adhesion to xenogeneic endothelium during laminar flow is dependent on alpha-Gal-mediated monocyte activation. J Immunol. 2005;174:8072-81 pubmed
  • 流式细胞仪; 人类
Zou X, Shinde Patil V, Dagia N, Smith L, Wargo M, Interliggi K, et al. PSGL-1 derived from human neutrophils is a high-efficiency ligand for endothelium-expressed E-selectin under flow. Am J Physiol Cell Physiol. 2005;289:C415-24 pubmed
  • 抑制或激活实验; 人类
Martinez M, Joffraud M, Giraud S, Baïsse B, Bernimoulin M, Schapira M, et al. Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII. J Biol Chem. 2005;280:5378-90 pubmed
Carisey A, Mace E, Saeed M, Davis D, Orange J. Nanoscale Dynamism of Actin Enables Secretory Function in Cytolytic Cells. Curr Biol. 2018;28:489-502.e9 pubmed 出版商
Xu T, Liu W, Luo J, Li C, Ba X, Ampah K, et al. Lipid Raft is required for PSGL-1 ligation induced HL-60 cell adhesion on ICAM-1. PLoS ONE. 2013;8:e81807 pubmed 出版商
Jannat R, Robbins G, Ricart B, Dembo M, Hammer D. Neutrophil adhesion and chemotaxis depend on substrate mechanics. J Phys Condens Matter. 2010;22:194117 pubmed 出版商
Zwartz G, Chigaev A, Dwyer D, Foutz T, Edwards B, Sklar L. Real-time analysis of very late antigen-4 affinity modulation by shear. J Biol Chem. 2004;279:38277-86 pubmed
Sklar L, Tsuji H, Edwards B, Larson R, Schuyler M. Eosinophil traffic in the circulation following allergen challenge. Allergy. 2004;59:596-605 pubmed
Zwartz G, Chigaev A, Foutz T, Larson R, Posner R, Sklar L. Relationship between molecular and cellular dissociation rates for VLA-4/VCAM-1 interaction in the absence of shear stress. Biophys J. 2004;86:1243-52 pubmed
Mohle R, Boehmler A, Denzlinger C, Kanz L. Nonpeptide mediators in the hematopoietic microenvironment. Ann N Y Acad Sci. 2003;996:61-6 pubmed
Horvath Arcidiacono J, Tsuyuki S, Mostowski H, Bloom E. Human natural killer cell activity against porcine targets: modulation by control of the oxidation-reduction environment and role of adhesion molecule interactions. Cell Immunol. 2003;222:35-44 pubmed
Takeda Y, Tachibana I, Miyado K, Kobayashi M, Miyazaki T, Funakoshi T, et al. Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes. J Cell Biol. 2003;161:945-56 pubmed
Bernimoulin M, Zeng X, Abbal C, Giraud S, Martinez M, Michielin O, et al. Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51. J Biol Chem. 2003;278:37-47 pubmed
Tibaldi E, Salgia R, Reinherz E. CD2 molecules redistribute to the uropod during T cell scanning: implications for cellular activation and immune surveillance. Proc Natl Acad Sci U S A. 2002;99:7582-7 pubmed
Welzenbach K, Hommel U, Weitz Schmidt G. Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition. J Biol Chem. 2002;277:10590-8 pubmed
Wu Q, Wang J, Condron C, Bouchier Hayes D, Redmond H. Human neutrophils facilitate tumor cell transendothelial migration. Am J Physiol Cell Physiol. 2001;280:C814-22 pubmed
Moreno A, Villar M, Camara C, Luque R, Cespon C, Gonzalez Porque P, et al. Interleukin-6 dimers produced by endothelial cells inhibit apoptosis of B-chronic lymphocytic leukemia cells. Blood. 2001;97:242-9 pubmed
Crutchfield K, Shinde Patil V, Campbell C, Parkos C, Allport J, Goetz D. CD11b/CD18-coated microspheres attach to E-selectin under flow. J Leukoc Biol. 2000;67:196-205 pubmed
Babina M, Mammeri K, Henz B. ICAM-3 (CD50) is expressed by human mast cells: induction of homotypic mast cell aggregation via ICAM-3. Cell Adhes Commun. 1999;7:195-209 pubmed
Harler M, Wakshull E, Filardo E, Albina J, Reichner J. Promotion of neutrophil chemotaxis through differential regulation of beta 1 and beta 2 integrins. J Immunol. 1999;162:6792-9 pubmed
Barnett C, Moore E, Mierau G, Partrick D, Biffl W, Elzi D, et al. ICAM-1-CD18 interaction mediates neutrophil cytotoxicity through protease release. Am J Physiol. 1998;274:C1634-44 pubmed 出版商
Wang G, Collinge M, Blasi F, Pardi R, Bender J. Posttranscriptional regulation of urokinase plasminogen activator receptor messenger RNA levels by leukocyte integrin engagement. Proc Natl Acad Sci U S A. 1998;95:6296-301 pubmed
Smith J, Cortes N, Evans G, Read R, Finn A. Induction of beta2 integrin-dependent neutrophil adhesion to human alveolar epithelial cells by type 1 Streptococcus pneumoniae and derived soluble factors. J Infect Dis. 1998;177:977-85 pubmed
Manshouri T, Yang Y, Lin H, Stass S, Glassman A, Keating M, et al. Downregulation of RAR alpha in mice by antisense transgene leads to a compensatory increase in RAR beta and RAR gamma and development of lymphoma. Blood. 1997;89:2507-15 pubmed
Mohle R, Moore M, Nachman R, Rafii S. Transendothelial migration of CD34+ and mature hematopoietic cells: an in vitro study using a human bone marrow endothelial cell line. Blood. 1997;89:72-80 pubmed
Poccia F, Boullier S, Lecoeur H, Cochet M, Poquet Y, Colizzi V, et al. Peripheral V gamma 9/V delta 2 T cell deletion and anergy to nonpeptidic mycobacterial antigens in asymptomatic HIV-1-infected persons. J Immunol. 1996;157:449-61 pubmed
Stark J, Godding V, Sedgwick J, Busse W. Respiratory syncytial virus infection enhances neutrophil and eosinophil adhesion to cultured respiratory epithelial cells. Roles of CD18 and intercellular adhesion molecule-1. J Immunol. 1996;156:4774-82 pubmed
Hill S, Milla P, Ciampolillo A, Napolitano G, Bottazzo G, Mirakian R. LFA-1 and ICAM-1 molecule expression in jejunal mucosa from children with autoimmune enteropathy. Autoimmunity. 1992;13:233-41 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CD18单克隆抗体(TS1/18)
目录# :
MA1810
规格 :
200微克
价格 :
美国346.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: 0.5 µg/test, Immunocytochemistry: 1:10-1:100, Inhibition Assays: Assay-dependent
物种 :
人类
克隆 :
TS1/18
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leucocytes. CD18 can combine with integrin molecules CD11a-c to form heterodimers at the cell surface, and these heterodimers are known to participate in the process of cell adhesion as well as cell-surface mediated signaling. CD18 forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits, and these integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1, severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis. Defects in the CD18 gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the CD18 protein have been identified.
免疫原 :
人类乙2整合素
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.5 µg/test, Immunocytochemistry: 1:10-1:100, Inhibition Assays: Assay-dependent
别名 :
2E6; AI528527; antigen CD18; B-2 integrin; CD18; CD18 leukocyte adhesion molecule; CD18 subunit; cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor); cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; complement component 3 receptor 3 and 4 subunit; complement receptor C3 beta-subunit; complement receptor C3 subunit beta; integrin beta 2; integrin beta chain, beta 2; integrin beta-2; integrin subunit beta 2; integrin, beta 2; integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit); integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2); integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); ITGB2; LAD; LCAMB; Leu-CAM receptor; leukocyte cell adhesion molecule CD18; leukocyte surface protein; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; Lfa1; LFA-1; lymphocyte function associated antigen 1; MAC-1; Mac-1 beta; macrophage antigen 1 (mac-1) beta subunit); macrophage antigen-1 beta; MF17; MFI7
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国