产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
HSP60单克隆抗体(4B9/89)
目录 :
MA3-012
规格 :
100微克
价格 :
美国425.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
4B9/89
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 抑制或激活实验
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文章摘录数: 16
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
| |
| |
| Ahuja N, Schwer B, Carobbio S, Waltregny D, North B, Castronovo V, et al. Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem. 2007;282:33583-92 pubmed
|
| Osterloh A, Kalinke U, Weiss S, Fleischer B, Breloer M. Synergistic and differential modulation of immune responses by Hsp60 and lipopolysaccharide. J Biol Chem. 2007;282:4669-80 pubmed
|
Schwer B, North B, Frye R, Ott M, Verdin E. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol. 2002;158:647-57 pubmed
| |
Bassan M, Zamostiano R, Giladi E, Davidson A, Wollman Y, Pitman J, et al. The identification of secreted heat shock 60 -like protein from rat glial cells and a human neuroblastoma cell line. Neurosci Lett. 1998;250:37-40 pubmed
| |
Lau S, Patnaik N, Sayen M, Mestril R. Simultaneous overexpression of two stress proteins in rat cardiomyocytes and myogenic cells confers protection against ischemia-induced injury. Circulation. 1997;96:2287-94 pubmed
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Morris S, Cumming D, Latchman D, Yellon D. Specific induction of the 70-kD heat stress proteins by the tyrosine kinase inhibitor herbimycin-A protects rat neonatal cardiomyocytes. A new pharmacological route to stress protein expression?. J Clin Invest. 1996;97:706-12 pubmed
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Soltys B, Gupta R. Immunoelectron microscopic localization of the 60-kDa heat shock chaperonin protein (Hsp60) in mammalian cells. Exp Cell Res. 1996;222:16-27 pubmed
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Jindal S, Dudani A, Singh B, Harley C, Gupta R. Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen. Mol Cell Biol. 1989;9:2279-83 pubmed
| |
Langer T, Pfeifer G, Martin J, Baumeister W, Hartl F. Chaperonin-mediated protein folding: GroES binds to one end of the GroEL cylinder, which accommodates the protein substrate within its central cavity. EMBO J. 1992;11:4757-65 pubmed
|
图像
图像 1 :
Immunofluorescent analysis of Heat Shock Protein 60 using Anti-Heat Shock Protein 60 Monoclonal Antibody (4B9/89) (Product# MA3-012) shows staining in Hela Cells. Heat Shock Protein 60 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing Heat Shock Protein 60 (Product# MA3-012) at a dilution of 1:100 over night at 4 ?C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product# 35503, Goat Anti-Mouse). Images were taken at 60X magnification.
产品信息
产品类型 :
抗体
产品名称 :
HSP60单克隆抗体(4B9/89)
目录# :
MA3-012
规格 :
100微克
价格 :
美国425.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
Human, Mouse, Non-human primate, Rat
应用 :
ELISA: Assay-dependent, Flow Cytometry: 1-20 µg/mL, Immunocytochemistry: 1:50-1:60, Immunohistochemistry: 1:200, Immunoprecipitation: 2 µg, Western Blot: 1:100-1:1,000
物种 :
Human, Mouse, Non-human primate, Rat
克隆 :
4B9/89
抗体亚型 :
IgG2a
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.
免疫原 :
Human placental HSP60.
格式 :
冻干
应用w/稀释 :
ELISA: Assay-dependent, Flow Cytometry: 1-20 µg/mL, Immunocytochemistry: 1:50-1:60, Immunohistochemistry: 1:200, Immunoprecipitation: 2 µg, Western Blot: 1:100-1:1,000
别名 :
60 kDa chaperonin; 60 kDa heat shock protein; 60 kDa heat shock protein, mitochondrial; 60kDa; Chaperonin 60; CPN60; GROEL; heat shock 60kD protein 1 (chaperonin); heat shock 60kDa protein 1; heat shock 60kDa protein 1 (chaperonin); Heat shock protein; heat shock protein 1 (chaperonin); heat shock protein 60; heat shock protein 60 (liver); heat shock protein 65; heat shock protein family D (Hsp60) member 1; heat shock protein, 60 kDa; HLD4; HSP; Hsp60; HSP-60; Hsp60s1; HSP65; HSP-65; Hspd1; Hspd1-30p; HuCHA60; hypothetical protein; I79_011398; mitochondrial matrix protein P1; P1 protein; P60 lymphocyte protein; RCJMB04_7g5; short heat shock protein 60 Hsp60s1; SPG13; Unknown (protein for IMAGE:7943409)
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公司信息
赛默飞世尔