产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
PDI单克隆抗体(RL77)
目录 :
MA3-018
规格 :
100微升
价格 :
美国425.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
RL77
反应物种 :
中国人仓鼠, African green monkey, 人类, 小鼠, 大鼠, , pigs , 非洲爪蛙, 猕猴
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 抑制或激活实验
更多信息或购买 :
文章摘录数: 40
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 2d
Braganza A, Li J, Zeng X, Yates N, Dey N, Andrews J, et al. UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase. J Biol Chem. 2017;292:2470-2484 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100; 图 s3b
Matsunaga K, Taoka M, Isobe T, Izumi T. Rab2a and Rab27a cooperatively regulate the transition from granule maturation to exocytosis through the dual effector Noc2. J Cell Sci. 2017;130:541-550 pubmed 出版商
  • 免疫印迹; 人类; 图 s4
Van Damme P, Kalvik T, Starheim K, Jonckheere V, Myklebust L, Menschaert G, et al. A Role for Human N-alpha Acetyltransferase 30 (Naa30) in Maintaining Mitochondrial Integrity. Mol Cell Proteomics. 2016;15:3361-3372 pubmed
  • 免疫细胞化学; African green monkey; 1:200; 图 4
Stoica R, De Vos K, Paillusson S, Mueller S, Sancho R, Lau K, et al. ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43. Nat Commun. 2014;5:3996 pubmed 出版商
  • 免疫沉淀; 小鼠; 35 ug/500 ug
Kenche H, Baty C, Vedagiri K, Shapiro S, Blumental Perry A. Cigarette smoking affects oxidative protein folding in endoplasmic reticulum by modifying protein disulfide isomerase. FASEB J. 2013;27:965-77 pubmed 出版商
  • 抑制或激活实验; 猕猴
Calderon M, Guerrero C, Acosta O, Lopez S, Arias C. Inhibiting rotavirus infection by membrane-impermeant thiol/disulfide exchange blockers and antibodies against protein disulfide isomerase. Intervirology. 2012;55:451-64 pubmed 出版商
  • 免疫印迹; 人类
De Vos K, Mórotz G, Stoica R, Tudor E, Lau K, Ackerley S, et al. VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis. Hum Mol Genet. 2012;21:1299-311 pubmed 出版商
  • 免疫细胞化学; 人类
Mahoney D, Lefebvre C, Allan K, Brun J, Sanaei C, Baird S, et al. Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death. Cancer Cell. 2011;20:443-56 pubmed 出版商
  • 免疫细胞化学; 大鼠
Hao Y, Hao C, Perkinton M, Chan W, Chan H, Miller C, et al. GULP1 is a novel APP-interacting protein that alters APP processing. Biochem J. 2011;436:631-9 pubmed 出版商
  • 免疫沉淀; 人类; 10 ug/ml
  • 免疫印迹; 人类; 1 ug/ml
Swiatkowska M, Padula G, Michalec L, Stasiak M, Skurzynski S, Cierniewski C. Ero1alpha is expressed on blood platelets in association with protein-disulfide isomerase and contributes to redox-controlled remodeling of alphaIIbbeta3. J Biol Chem. 2010;285:29874-83 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
Bernasconi R, Pertel T, Luban J, Molinari M. A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal. J Biol Chem. 2008;283:16446-54 pubmed 出版商
  • 流式细胞仪; 人类
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Swiatkowska M, Szymanski J, Padula G, Cierniewski C. Interaction and functional association of protein disulfide isomerase with alphaVbeta3 integrin on endothelial cells. FEBS J. 2008;275:1813-23 pubmed 出版商
  • 免疫细胞化学; 人类
Garver W, Jelinek D, Francis G, Murphy B. The Niemann-Pick C1 gene is downregulated by feedback inhibition of the SREBP pathway in human fibroblasts. J Lipid Res. 2008;49:1090-102 pubmed 出版商
  • 免疫印迹; 人类
Labriola L, Ferreira G, Montor W, Demasi M, Pimenta D, Lojudice F, et al. Prolactin-induced changes in protein expression in human pancreatic islets. Mol Cell Endocrinol. 2007;264:16-27 pubmed
  • 流式细胞仪; 人类; 10 ug/ml
  • 免疫细胞化学; 人类; 1:100
Ou W, Silver J. Role of protein disulfide isomerase and other thiol-reactive proteins in HIV-1 envelope protein-mediated fusion. Virology. 2006;350:406-17 pubmed
  • 免疫细胞化学; 人类; 1:200
O Donnell V, LaRocco M, Duque H, Baxt B. Analysis of foot-and-mouth disease virus internalization events in cultured cells. J Virol. 2005;79:8506-18 pubmed
  • 免疫印迹; 大鼠
Stillemark Billton P, Beck C, Boren J, Olofsson S. Relation of the size and intracellular sorting of apoB to the formation of VLDL 1 and VLDL 2. J Lipid Res. 2005;46:104-14 pubmed
Lopes da Silva M, McCormack J, Burden J, Harrison Lavoie K, Ferraro F, Cutler D. A GBF1-Dependent Mechanism for Environmentally Responsive Regulation of ER-Golgi Transport. Dev Cell. 2019;49:786-801.e6 pubmed 出版商
Talebi A, Dehairs J, Rambow F, Rogiers A, Nittner D, Derua R, et al. Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy. Nat Commun. 2018;9:2500 pubmed 出版商
Sun J, Jiang J, Lu K, Chen Q, Tao D, Chen Z. Therapeutic potential of ADAM17 modulation in gastric cancer through regulation of the EGFR and TNF-? signalling pathways. Mol Cell Biochem. 2017;426:17-26 pubmed 出版商
Kenche H, Ye Z, Vedagiri K, Richards D, Gao X, Tew K, et al. Adverse Outcomes Associated with Cigarette Smoke Radicals Related to Damage to Protein-disulfide Isomerase. J Biol Chem. 2016;291:4763-78 pubmed 出版商
Gladue D, O Donnell V, Baker Branstetter R, Holinka L, Pacheco J, Fernandez Sainz I, et al. Foot-and-mouth disease virus nonstructural protein 2C interacts with Beclin1, modulating virus replication. J Virol. 2012;86:12080-90 pubmed 出版商
Wang Y, Yao Y, Tang X, Wang Z. Mouse RIC-3, an endoplasmic reticulum chaperone, promotes assembly of the alpha7 acetylcholine receptor through a cytoplasmic coiled-coil domain. J Neurosci. 2009;29:12625-35 pubmed 出版商
Petrucelli A, Rak M, Grainger L, Goodrum F. Characterization of a novel Golgi apparatus-localized latency determinant encoded by human cytomegalovirus. J Virol. 2009;83:5615-29 pubmed 出版商
Schultz Norton J, McDonald W, Yates J, Nardulli A. Protein disulfide isomerase serves as a molecular chaperone to maintain estrogen receptor alpha structure and function. Mol Endocrinol. 2006;20:1982-95 pubmed
Minogue P, Liu X, Ebihara L, Beyer E, Berthoud V. An aberrant sequence in a connexin46 mutant underlies congenital cataracts. J Biol Chem. 2005;280:40788-95 pubmed
Wierenga C, Ibata K, Turrigiano G. Postsynaptic expression of homeostatic plasticity at neocortical synapses. J Neurosci. 2005;25:2895-905 pubmed
Tao Y, Johnson N, Segaloff D. Constitutive and agonist-dependent self-association of the cell surface human lutropin receptor. J Biol Chem. 2004;279:5904-14 pubmed
Knoblach B, Keller B, Groenendyk J, Aldred S, Zheng J, Lemire B, et al. ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins. Mol Cell Proteomics. 2003;2:1104-19 pubmed
Shames I, Fraser A, Colby J, Orfali W, Snipes G. Phenotypic differences between peripheral myelin protein-22 (PMP22) and myelin protein zero (P0) mutations associated with Charcot-Marie-Tooth-related diseases. J Neuropathol Exp Neurol. 2003;62:751-64 pubmed
Clark R, Li S, Pearson D, Leidal K, Clark J, Denning G, et al. Regulation of calreticulin expression during induction of differentiation in human myeloid cells. Evidence for remodeling of the endoplasmic reticulum. J Biol Chem. 2002;277:32369-78 pubmed
Sargsyan E, Baryshev M, Szekely L, Sharipo A, Mkrtchian S. Identification of ERp29, an endoplasmic reticulum lumenal protein, as a new member of the thyroglobulin folding complex. J Biol Chem. 2002;277:17009-15 pubmed
Li P, Nakanishi A, Clark S, Kasamatsu H. Formation of transitory intrachain and interchain disulfide bonds accompanies the folding and oligomerization of simian virus 40 Vp1 in the cytoplasm. Proc Natl Acad Sci U S A. 2002;99:1353-8 pubmed
Torres V, Cai Y, Chen X, Wu G, Geng L, Cleghorn K, et al. Vascular expression of polycystin-2. J Am Soc Nephrol. 2001;12:1-9 pubmed
Colby J, Nicholson R, Dickson K, Orfali W, Naef R, Suter U, et al. PMP22 carrying the trembler or trembler-J mutation is intracellularly retained in myelinating Schwann cells. Neurobiol Dis. 2000;7:561-73 pubmed
Berryman M, Bretscher A. Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. Mol Biol Cell. 2000;11:1509-21 pubmed
Bennett T, Edwards B, Sklar L, Rogelj S. Sulfhydryl regulation of L-selectin shedding: phenylarsine oxide promotes activation-independent L-selectin shedding from leukocytes. J Immunol. 2000;164:4120-9 pubmed
Basu S, Srivastava P. Calreticulin, a peptide-binding chaperone of the endoplasmic reticulum, elicits tumor- and peptide-specific immunity. J Exp Med. 1999;189:797-802 pubmed
Kuznetsov G, Chen L, Nigam S. Several endoplasmic reticulum stress proteins, including ERp72, interact with thyroglobulin during its maturation. J Biol Chem. 1994;269:22990-5 pubmed
Kaetzel C, Rao C, Lamm M. Protein disulphide-isomerase from human placenta and rat liver. Purification and immunological characterization with monoclonal antibodies. Biochem J. 1987;241:39-47 pubmed
图像
图像 1 :
赛默飞世尔 MA3-018 图像 1
Immunofluorescent analysis of PDI using anti-PDI monoclonal antibody (Product# MA3-018) shows staining in HMVEC Cells.
产品信息
产品类型 :
抗体
产品名称 :
PDI单克隆抗体(RL77)
目录# :
MA3-018
规格 :
100微升
价格 :
美国425.00
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
狗, 仓鼠, 人类, 小鼠, 猪, 大鼠, 非洲爪蛙
应用 :
Flow Cytometry: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunohistochemistry: 1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1:200-1:2,000
物种 :
狗, 仓鼠, 人类, 小鼠, 猪, 大鼠, 非洲爪蛙
克隆 :
RL77
抗体亚型 :
IgG2b
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, the protein seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. It may therefore cause structural modifications of exofacial proteins. Inside the cell, PDI seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, it functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity). PDI may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. It also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
免疫原 :
纯化大鼠PDI蛋白
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunohistochemistry: 1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1:200-1:2,000
别名 :
1810041F13Rik; AI661267; CaO19.12595; cellular thyroid hormone binding protein; cellular thyroid hormone-binding protein; CLCRP1; collagen prolyl 4-hydroxylase beta; DSI; Endoplasmic reticulum resident protein 59; Eps1p; ER protein 59; ERBA2L; ERp59; GIT; glutathione-insulin transhydrogenase; I79_002399; LOW QUALITY PROTEIN: protein disulfide-isomerase A2; MFP1; P4HB; p4hb.L; P4Hbeta; p55; p58; Pancreas-specific protein disulfide isomerase; pancreatic protein disulfide isomerase; PDA2; PDI; PDI (E.C.5.3.4.1); PDI1; PDI1P; Pdia1; pdia2; pdia2.L; PDIP; Pdipl; PDIR; PHDB; PO4DB; PO4HB; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide; PROHB; prolyl 4-hydroxylase beta polypeptide; Prolyl 4-hydroxylase subunit beta; prolyl 4-hydroxylase subunit beta L homeolog; prolyl 4-hydroxylase subunit beta L homeolog; prolyl 4-hydroxylase, beta polypeptide L homeolog; prolyl 4-hydroxylase, beta polypeptide; prolyl 4-hydroxylase, beta subunit; protein disulfide isomerase; protein disulfide isomerase (pancreas) like; Protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide); protein disulfide isomerase A2; protein disulfide isomerase associated 2; protein disulfide isomerase family A member 2; protein disulfide isomerase family A member 2 L homeolog; protein disulfide isomerase family A, member 1; protein disulfide isomerase family A, member 2; protein disulfide isomerase PDI1; protein disulfide isomerase, pancreatic; protein disulfide isomerase/oxidoreductase; protein disulfide isomerase-associated 1; protein disulfide isomerase-associated 2; protein disulfide-isomerase; Protein disulfide-isomerase A2; protocollagen hydroxylase; Rho GDP dissociation inhibitor gamma; testicular secretory protein Li 32; Thbp; Thioredoxin-related glycoprotein 1; thyroid hormone-binding protein p55; TRG1; XELAEV_18043753mg; XELAEV_18045582mg; XPDIp; YCL043C; YCL313; YCL43C
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国