产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
NPM1单克隆抗体(FC-61991), Alexa Fluor系列荧光染料647
目录 :
MA3-25200-A647
规格 :
50µl
价格 :
美国305
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
AF647
克隆名称 :
FC-61991
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫细胞化学
更多信息或购买 :
产品信息
产品类型 :
抗体
产品名称 :
NPM1单克隆抗体(FC-61991), Alexa Fluor系列荧光染料647
目录# :
MA3-25200-A647
规格 :
50µl
价格 :
美国305
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 1-10 µg/mL, Immunofluorescence: 1-10 µg/mL
物种 :
人类, 小鼠, 大鼠
克隆 :
FC-61991
抗体亚型 :
IgG1
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
NPM1 (Nucleophosmin 1, B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in ribosome assembly/transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and regulation of p53. NPM1 continuously shuttles between the nucleus, cytoplasm, nucleolus and chaperoning core histones from the nucleus to the cytoplasm. NPM1 has been shown to bind nucleic acid, prevent protein aggregation via its chaperon activities, protect enzymes during thermal denaturation, and facilitate renaturation of chemically denatured proteins. In its cellular structure role, there is evidence suggesting NPM1 is associated with the centrosome, and is the substrate of CDK2/cyclin E during duplication of centrosomes (cellular division). Due to the NPM1 gene interaction with several tumor-associated chromosome translocations, NPM1 is thought to be a portion of several fusion proteins: NPM-ALK, NPM-RAR, and NPM-MLF1. While it is not thought to be part of the transforming potential of these fusion proteins, NPM1 is believed to act as the interface for oligomerization and oncogenic conversion of these tumor promoting fusion proteins. Further, NPM1 is also known to sequester the tumor suppressor RF in the nucleolus, protecting it from degradation until it is necessary. Dysfunction of the NPM1 protein is associated with diseases such as acute myeloid leukemia and lymphomatoid papulosis.
免疫原 :
NPM/B23 purified from rat hepatoma
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1-10 µg/mL, Immunofluorescence: 1-10 µg/mL
别名 :
Npm, B23, NO38, NPM, B23NP
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国