产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
p23单克隆抗体(JJ3)
目录 :
MA3-414
规格 :
100微升
价格 :
美国399.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
JJ3
反应物种 :
豚鼠, 人类, 小鼠, 大鼠, 鸡, domestic rabbit
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 核糖核酸免疫沉淀
更多信息或购买 :
文章摘录数: 40
| 出版应用/物种/样本/稀释 | 参考文献 |
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| Caligiuri I, Toffoli G, Giordano A, Rizzolio F. pRb controls estrogen receptor alpha protein stability and activity. Oncotarget. 2013;4:875-83 pubmed
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| Oda T, Hayano T, Miyaso H, Takahashi N, Yamashita T. Hsp90 regulates the Fanconi anemia DNA damage response pathway. Blood. 2007;109:5016-26 pubmed
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| Oxelmark E, Roth J, Brooks P, Braunstein S, Schneider R, Garabedian M. The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion. Mol Cell Biol. 2006;26:5205-13 pubmed
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| Maida M, Hurley S, Daeschner J, Moore A, O Banion M. Cytosolic prostaglandin E2 synthase (cPGES) expression is decreased in discrete cortical regions in psychiatric disease. Brain Res. 2006;1103:164-72 pubmed
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| Waza M, Adachi H, Katsuno M, Minamiyama M, Sang C, Tanaka F, et al. 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration. Nat Med. 2005;11:1088-95 pubmed
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Bhangoo M, Tzankov S, Fan A, Dejgaard K, Thomas D, Young J. Multiple 40-kDa heat-shock protein chaperones function in Tom70-dependent mitochondrial import. Mol Biol Cell. 2007;18:3414-28 pubmed
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Pollenz R, Dougherty E. Redefining the role of the endogenous XAP2 and C-terminal hsp70-interacting protein on the endogenous Ah receptors expressed in mouse and rat cell lines. J Biol Chem. 2005;280:33346-56 pubmed
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Meadows J, Pitzer B, Brockman D, Myatt L. Expression and localization of adipophilin and perilipin in human fetal membranes: association with lipid bodies and enzymes involved in prostaglandin synthesis. J Clin Endocrinol Metab. 2005;90:2344-50 pubmed
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Gold B, Zhong Y. FK506 requires stimulation of the extracellular signal-regulated kinase 1/2 and the steroid receptor chaperone protein p23 for neurite elongation. Neurosignals. 2004;13:122-9 pubmed
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Stavreva D, Müller W, Hager G, Smith C, McNally J. Rapid glucocorticoid receptor exchange at a promoter is coupled to transcription and regulated by chaperones and proteasomes. Mol Cell Biol. 2004;24:2682-97 pubmed
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Botos J, Xian W, Smith D, Smith C. Progesterone receptor deficient in chromatin binding has an altered cellular state. J Biol Chem. 2004;279:15231-9 pubmed
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Subbaramaiah K, Yoshimatsu K, Scherl E, Das K, Glazier K, Golijanin D, et al. Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1. J Biol Chem. 2004;279:12647-58 pubmed
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Tahbaz N, Carmichael J, Hobman T. GERp95 belongs to a family of signal-transducing proteins and requires Hsp90 activity for stability and Golgi localization. J Biol Chem. 2001;276:43294-9 pubmed
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Felts S, Owen B, Nguyen P, Trepel J, Donner D, Toft D. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. J Biol Chem. 2000;275:3305-12 pubmed
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Gilmore R, Coffey M, Lee P. Active participation of Hsp90 in the biogenesis of the trimeric reovirus cell attachment protein sigma1. J Biol Chem. 1998;273:15227-33 pubmed
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Hu J, Toft D, Seeger C. Hepadnavirus assembly and reverse transcription require a multi-component chaperone complex which is incorporated into nucleocapsids. EMBO J. 1997;16:59-68 pubmed
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Johnson J, Beito T, Krco C, Toft D. Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes. Mol Cell Biol. 1994;14:1956-63 pubmed
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Johnson J, Toft D. A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23. J Biol Chem. 1994;269:24989-93 pubmed
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图像
图像 1 :
Immunofluorescent analysis of p23 using Anti-p23 Monoclonal Antibody (JJ5) (Product# MA3-414) shows staining in C6 Cells. p23 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing p23 (Product# MA3-414) at a dilution of 1:500 over night at 4 ?C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product# 35503, Goat Anti-Mouse). Images were taken at 60X magnification.
产品信息
产品类型 :
抗体
产品名称 :
p23单克隆抗体(JJ3)
目录# :
MA3-414
规格 :
100微升
价格 :
美国399.00
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
鸡, 豚鼠, 人类, 小鼠, 兔, 大鼠
应用 :
Flow Cytometry: 1/100, Immunocytochemistry: 1:200-1:2,000, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: Assay-dependent, RNA Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000
物种 :
鸡, 豚鼠, 人类, 小鼠, 兔, 大鼠
克隆 :
JJ3
抗体亚型 :
IgG1
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion. Steroid receptor complex proteins include heat shock proteins (HSP70 and HSP90), immunosuppressant binding proteins called immunophilins (the FK506 binding proteins, FKBP52 & FKBP54 and the cyclosporin binding protein, CyP-40) and at least three other proteins termed p23, p60 and p48. p23 along with HSP70, HSP90 and p60, combine with progesterone receptor (PR) as members of a transient intermediate complex. Cloned human p23 encodes a protein of 160 amino acids that is highly conserved between species and shows no homology to previously identified proteins. p23 is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites. In vitro studies have suggested that p23 binds to HSP90 and is necessary for the binding of HSP90 and CyP-40 to PR. While neither its exact function nor mechanism of action have been identified, p23 appears to be an important factor in PR function.
免疫原 :
重组人类p23蛋白
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1/100, Immunocytochemistry: 1:200-1:2,000, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: Assay-dependent, RNA Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000
别名 :
5730442A20Rik; Co chaperone p23; cPGES; cytosolic prostaglandin E synthase; cytosolic prostaglandin E2 synthase; Hsp90 co chaperone; Hsp90 co-chaperone; LOC100351480; P23; p23 cochaperone; progesterone receptor; progesterone receptor complex p23; Prostaglandin E synthase 3; prostaglandin E synthase 3 (cytosolic); prostaglandin-E synthase 3; Ptges; PTGES3; ptges3 {ECO:0000250; RGD1561913; sid 3177; Sid3177; Tebp; telomerase binding protein, p23; telomerase-binding protein p23; unactive progesterone receptor, 23 kD; UniProtKB:Q15185}
更多信息或购买 :
公司信息
赛默飞世尔