产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD31单克隆抗体(HEC7)
目录 :
MA3100
规格 :
200微克
价格 :
美国375.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
HEC7
反应物种 :
人类, 小鼠, 牛
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 抑制或激活实验
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 28
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 s1-2
Bersini S, Schulte R, Huang L, Tsai H, Hetzer M. Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. elife. 2020;9: pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 4i
Wang X, Liu R, Zhu W, Chu H, Yu H, Wei P, et al. UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis. Nature. 2019;571:127-131 pubmed 出版商
  • 免疫组化; 小鼠; 图 2f
Lovric S, Gonçalves S, Gee H, Oskouian B, Srinivas H, Choi W, et al. Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. J Clin Invest. 2017;127:912-928 pubmed 出版商
  • 免疫细胞化学; 人类
Totonchy J, Osborn J, Botto S, Clepper L, Moses A. Aberrant proliferation in CXCR7+ endothelial cells via degradation of the retinoblastoma protein. PLoS ONE. 2013;8:e69828 pubmed 出版商
  • 流式细胞仪; 人类
Alexaki V, Notas G, Pelekanou V, Kampa M, Valkanou M, Theodoropoulos P, et al. Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development. J Immunol. 2009;183:5948-56 pubmed 出版商
  • 抑制或激活实验; 人类; 20 ug/ml
Williams M, Sakurai Y, Zughaier S, Eskin S, McIntire L. Transmigration across activated endothelium induces transcriptional changes, inhibits apoptosis, and decreases antimicrobial protein expression in human monocytes. J Leukoc Biol. 2009;86:1331-43 pubmed 出版商
  • 抑制或激活实验; 人类; 20 ug/ml
Schlichting C, Schareck W, Weis M. Dendritic cell adhesion is enhanced on endothelial cells preexposed to calcineurin inhibitors. J Cardiovasc Pharmacol. 2005;46:250-4 pubmed
  • 免疫组化; 人类
Garmy Susini B, Jin H, Zhu Y, Sung R, Hwang R, Varner J. Integrin alpha4beta1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation. J Clin Invest. 2005;115:1542-51 pubmed
  • 免疫组化; 人类
Burman A, Haworth O, Hardie D, Amft E, Siewert C, Jackson D, et al. A chemokine-dependent stromal induction mechanism for aberrant lymphocyte accumulation and compromised lymphatic return in rheumatoid arthritis. J Immunol. 2005;174:1693-700 pubmed
  • 流式细胞仪; 人类
  • 免疫沉淀; 人类
  • 免疫细胞化学; 人类
Albelda S, Muller W, Buck C, Newman P. Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule. J Cell Biol. 1991;114:1059-68 pubmed
Morgenroth A, Tinkir E, Vogg A, Sankaranarayanan R, Baazaoui F, Mottaghy F. Targeting of prostate-specific membrane antigen for radio-ligand therapy of triple-negative breast cancer. Breast Cancer Res. 2019;21:116 pubmed 出版商
Karki S, Farb M, Sharma V, Jash S, Zizza E, Hess D, et al. Fat-Specific Protein 27 Regulation of Vascular Function in Human Obesity. J Am Heart Assoc. 2019;8:e011431 pubmed 出版商
Luo W, Min J, Huang W, Wang X, Peng Y, Han S, et al. Vitexin reduces epilepsy after hypoxic ischemia in the neonatal brain via inhibition of NKCC1. J Neuroinflammation. 2018;15:186 pubmed 出版商
Li F, Huang J, Ji D, Meng Q, Wang C, Chen S, et al. Azithromycin effectively inhibits tumor angiogenesis by suppressing vascular endothelial growth factor receptor 2-mediated signaling pathways in lung cancer. Oncol Lett. 2017;14:89-96 pubmed 出版商
Totonchy J, Clepper L, Phillips K, McCarty O, Moses A. CXCR7 expression disrupts endothelial cell homeostasis and causes ligand-dependent invasion. Cell Adh Migr. 2014;8:165-76 pubmed
Link A, Hardie D, Favre S, Britschgi M, Adams D, Sixt M, et al. Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans. Am J Pathol. 2011;178:1662-75 pubmed 出版商
Keller P, Lin A, Arendt L, Klebba I, Jones A, Rudnick J, et al. Mapping the cellular and molecular heterogeneity of normal and malignant breast tissues and cultured cell lines. Breast Cancer Res. 2010;12:R87 pubmed 出版商
Mamdouh Z, Kreitzer G, Muller W. Leukocyte transmigration requires kinesin-mediated microtubule-dependent membrane trafficking from the lateral border recycling compartment. J Exp Med. 2008;205:951-66 pubmed 出版商
Stucki A, Rivier A, Gikic M, Monai N, Schapira M, Spertini O. Endothelial cell activation by myeloblasts: molecular mechanisms of leukostasis and leukemic cell dissemination. Blood. 2001;97:2121-9 pubmed
Chandrasekaran L, He C, Al Barazi H, Krutzsch H, Iruela Arispe M, Roberts D. Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1. Mol Biol Cell. 2000;11:2885-900 pubmed
Kim S, Bell K, Mousa S, Varner J. Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin. Am J Pathol. 2000;156:1345-62 pubmed
Yang S, Graham J, Kahn J, Schwartz E, Gerritsen M. Functional roles for PECAM-1 (CD31) and VE-cadherin (CD144) in tube assembly and lumen formation in three-dimensional collagen gels. Am J Pathol. 1999;155:887-95 pubmed
Groger M, Matsumura T, Kohrgruber N, Maurer D, Wolff K, Petzelbauer P. A standardized, a computer-assisted in vitro assay for the assessment of neutrophil transmigration across endothelial monolayers. J Immunol Methods. 1999;222:101-9 pubmed
Sauer A, Hartung T, Aigner J, Wendel A. Endotoxin-inducible granulocyte-mediated hepatocytotoxicity requires adhesion and serine protease release. J Leukoc Biol. 1996;60:633-43 pubmed
Luscinskas F, Ding H, Tan P, Cumming D, Tedder T, Gerritsen M. L- and P-selectins, but not CD49d (VLA-4) integrins, mediate monocyte initial attachment to TNF-alpha-activated vascular endothelium under flow in vitro. J Immunol. 1996;157:326-35 pubmed
Muller W, Weigl S, Deng X, Phillips D. PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med. 1993;178:449-60 pubmed
Muller W, Ratti C, McDonnell S, Cohn Z. A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions. J Exp Med. 1989;170:399-414 pubmed
Newman P, Berndt M, Gorski J, White G, Lyman S, Paddock C, et al. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science. 1990;247:1219-22 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CD31单克隆抗体(HEC7)
目录# :
MA3100
规格 :
200微克
价格 :
美国375.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
牛, 人类
应用 :
Flow Cytometry: 3-5 µg/1x10^6 cells, Immunocytochemistry: 1:50-1:500, Western Blot: 1:1,000
物种 :
牛, 人类
克隆 :
HEC7
抗体亚型 :
IgG2a
储存 :
-20°C
描述 :
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
免疫原 :
人类PECAM-1
格式 :
液体
应用w/稀释 :
Flow Cytometry: 3-5 µg/1x10^6 cells, Immunocytochemistry: 1:50-1:500, Western Blot: 1:1,000
别名 :
C85791; CD31; CD31 antigen; CD31, PECAM-1; CD31/EndoCAM; endoCAM; GPIIA'; I79_008304; PECA1; Pecam; PECAM1; Pecam-1; platelet and endothelial cell adhesion molecule 1; platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1; platelet/endothelial cell adhesion molecule (CD31 antigen); platelet/endothelial cell adhesion molecule 1; type I transmembrane endothelial adhesion molecule
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国