产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD31单克隆抗体(2H8)
目录 :
MA3105
规格 :
500微克
价格 :
美国399.00
克隆性 :
单克隆
宿主 :
仓鼠
共轭标签 :
未共轭
克隆名称 :
2H8
反应物种 :
人类, 小鼠
应用 :
酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 中和反应, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 抑制或激活实验
更多信息或购买 :
文章摘录数: 39
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 2e
  • 免疫组化; 小鼠; 图 s1j
Pasciuto E, Burton O, Roca C, Lagou V, Rajan W, Theys T, et al. Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition. Cell. 2020;182:625-640.e24 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 6a
Coulombe P, Paliouras G, Clayton A, Hussainkhel A, Fuller M, Jovanovic V, et al. Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling. Cell Rep. 2019;27:1769-1780.e4 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 6h
Stremmel C, Schuchert R, Wagner F, Thaler R, Weinberger T, Pick R, et al. Yolk sac macrophage progenitors traffic to the embryo during defined stages of development. Nat Commun. 2018;9:75 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 s1e
Vasilopoulou E, Kolatsi Joannou M, Lindenmeyer M, White K, Robson M, Cohen C, et al. Loss of endogenous thymosin β4 accelerates glomerular disease. Kidney Int. 2016;90:1056-1070 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 2a
Kim M, Allen B, Korhonen E, Nitschké M, Yang H, Baluk P, et al. Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation. J Clin Invest. 2016;126:3511-25 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:500
Moen I, Gebre M, Alonso Camino V, Chen D, Epstein D, McDonald D. Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors. Clin Exp Metastasis. 2015;32:799-817 pubmed 出版商
  • 免疫组化; 小鼠; 1:100; 图 6
Yotsumoto F, You W, Cejudo Martin P, Kucharova K, Sakimura K, Stallcup W. NG2 proteoglycan-dependent recruitment of tumor macrophages promotes pericyte-endothelial cell interactions required for brain tumor vascularization. Oncoimmunology. 2015;4:e1001204 pubmed
  • 免疫组化-冰冻切片; 小鼠; 图 1f
Huang J, Woolf A, Kolatsi Joannou M, Baluk P, Sandford R, Peters D, et al. Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases. J Am Soc Nephrol. 2016;27:69-77 pubmed 出版商
  • 免疫组化; 小鼠
Baluk P, Phillips K, Yao L, Adams A, Nitschké M, McDonald D. Neutrophil dependence of vascular remodeling after Mycoplasma infection of mouse airways. Am J Pathol. 2014;184:1877-89 pubmed 出版商
  • 免疫组化; 小鼠
Majima T, Takeuchi K, Sano K, Hirashima M, Zankov D, Tanaka Okamoto M, et al. An Adaptor Molecule Afadin Regulates Lymphangiogenesis by Modulating RhoA Activity in the Developing Mouse Embryo. PLoS ONE. 2013;8:e68134 pubmed 出版商
  • 抑制或激活实验; 小鼠
Sun Z, Li X, Massena S, Kutschera S, Padhan N, Gualandi L, et al. VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd. J Exp Med. 2012;209:1363-77 pubmed 出版商
  • 免疫组化; 小鼠
Turnquist H, Zhao Z, Rosborough B, Liu Q, Castellaneta A, Isse K, et al. IL-33 expands suppressive CD11b+ Gr-1(int) and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival. J Immunol. 2011;187:4598-610 pubmed 出版商
  • 免疫组化; 小鼠; 1:500
Falcon B, Pietras K, Chou J, Chen D, Sennino B, Hanahan D, et al. Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-B. Am J Pathol. 2011;178:2920-30 pubmed 出版商
  • 免疫细胞化学; 小鼠
Nakanishi K, Takeda Y, Tetsumoto S, Iwasaki T, Tsujino K, Kuhara H, et al. Involvement of endothelial apoptosis underlying chronic obstructive pulmonary disease-like phenotype in adiponectin-null mice: implications for therapy. Am J Respir Crit Care Med. 2011;183:1164-75 pubmed 出版商
  • 免疫组化; 人类; 1:500
Coxon A, Bready J, Min H, Kaufman S, Leal J, Yu D, et al. Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody. Mol Cancer Ther. 2010;9:2641-51 pubmed 出版商
  • 免疫组化; 小鼠; 1:500
Ni A, Lashnits E, Yao L, Baluk P, McDonald D. Rapid remodeling of airway vascular architecture at birth. Dev Dyn. 2010;239:2354-66 pubmed 出版商
  • 免疫组化; 人类; 1:500
Hashizume H, Falcon B, Kuroda T, Baluk P, Coxon A, Yu D, et al. Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth. Cancer Res. 2010;70:2213-23 pubmed 出版商
  • 免疫组化; 小鼠
Yao L, Baluk P, Feng J, McDonald D. Steroid-resistant lymphatic remodeling in chronically inflamed mouse airways. Am J Pathol. 2010;176:1525-41 pubmed 出版商
  • 免疫组化; 小鼠
Baluk P, Yao L, Feng J, Romano T, Jung S, Schreiter J, et al. TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice. J Clin Invest. 2009;119:2954-64 pubmed 出版商
  • 免疫组化; 小鼠; 1:1,000
Kanemura H, Satoh T, Bilasy S, Ueda S, Hirashima M, Kataoka T. Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1. Biochem Biophys Res Commun. 2009;387:754-9 pubmed 出版商
  • 免疫组化; 小鼠; 1:500
Okazaki T, Ni A, Ayeni O, Baluk P, Yao L, Vossmeyer D, et al. alpha5beta1 Integrin blockade inhibits lymphangiogenesis in airway inflammation. Am J Pathol. 2009;174:2378-87 pubmed 出版商
  • 免疫组化; 小鼠; 1:500
Okazaki T, Ni A, Baluk P, Ayeni O, Kearley J, Coyle A, et al. Capillary defects and exaggerated inflammatory response in the airways of EphA2-deficient mice. Am J Pathol. 2009;174:2388-99 pubmed 出版商
  • 酶联免疫吸附测定; 人类
Hirashima M, Sano K, Morisada T, Murakami K, Rossant J, Suda T. Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos. Dev Biol. 2008;316:149-59 pubmed 出版商
  • 免疫组化; 人类
Filer A, Parsonage G, Smith E, Osborne C, Thomas A, Curnow S, et al. Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils. Arthritis Rheum. 2006;54:2096-108 pubmed
Testini C, Smith R, Jin Y, Martinsson P, Sun Y, Hedlund M, et al. Myc-dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor-2. EMBO Rep. 2019;20:e47845 pubmed 出版商
Mastromoro G, Calcagni G, Versacci P, Putotto C, Chinali M, Lambiase C, et al. Left pulmonary artery in 22q11.2 deletion syndrome. Echocardiographic evaluation in patients without cardiac defects and role of Tbx1 in mice. PLoS ONE. 2019;14:e0211170 pubmed 出版商
Oladipupo S, Kabir A, Smith C, Choi K, Ornitz D. Impaired tumor growth and angiogenesis in mice heterozygous for Vegfr2 (Flk1). Sci Rep. 2018;8:14724 pubmed 出版商
Singhal M, Liu X, Inverso D, Jiang K, Dai J, He H, et al. Endothelial cell fitness dictates the source of regenerating liver vasculature. J Exp Med. 2018;215:2497-2508 pubmed 出版商
Høye A, Tolstrup S, Horton E, Nicolau M, Frost H, Woo J, et al. Tumor endothelial marker 8 promotes cancer progression and metastasis. Oncotarget. 2018;9:30173-30188 pubmed 出版商
Lugano R, Vemuri K, Yu D, Bergqvist M, Smits A, Essand M, et al. CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. J Clin Invest. 2018;128:3280-3297 pubmed 出版商
Kabir A, Lee T, Pan H, Berry J, Krchma K, Wu J, et al. Requisite endothelial reactivation and effective siRNA nanoparticle targeting of Etv2/Er71 in tumor angiogenesis. JCI Insight. 2018;3: pubmed 出版商
Seaman S, Zhu Z, Saha S, Zhang X, Yang M, Hilton M, et al. Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature. Cancer Cell. 2017;31:501-515.e8 pubmed 出版商
Géraud C, Koch P, Zierow J, Klapproth K, Busch K, Olsavszky V, et al. GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. J Clin Invest. 2017;127:1099-1114 pubmed 出版商
Surolia R, Li F, Wang Z, Li H, Liu G, Zhou Y, et al. 3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs. JCI Insight. 2017;2:e91377 pubmed 出版商
Baluk P, Adams A, Phillips K, Feng J, Hong Y, Brown M, et al. Preferential lymphatic growth in bronchus-associated lymphoid tissue in sustained lung inflammation. Am J Pathol. 2014;184:1577-92 pubmed 出版商
Baluk P, Hogmalm A, Bry M, Alitalo K, Bry K, McDonald D. Transgenic overexpression of interleukin-1? induces persistent lymphangiogenesis but not angiogenesis in mouse airways. Am J Pathol. 2013;182:1434-47 pubmed 出版商
Fuxe J, Tabruyn S, Colton K, Zaid H, Adams A, Baluk P, et al. Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation. Am J Pathol. 2011;178:2897-909 pubmed 出版商
Chosay J, Fisher M, Farhood A, Ready K, Dunn C, Jaeschke H. Role of PECAM-1 (CD31) in neutrophil transmigration in murine models of liver and peritoneal inflammation. Am J Physiol. 1998;274:G776-82 pubmed 出版商
Bogen S, Baldwin H, Watkins S, Albelda S, Abbas A. Association of murine CD31 with transmigrating lymphocytes following antigenic stimulation. Am J Pathol. 1992;141:843-54 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CD31单克隆抗体(2H8)
目录# :
MA3105
规格 :
500微克
价格 :
美国399.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
亚美尼亚仓鼠
反应物种 :
人类, 小鼠
应用 :
Flow Cytometry: Assay-dependent, Neutralization: Assay-dependent
物种 :
人类, 小鼠
克隆 :
2H8
抗体亚型 :
IgG
储存 :
-20°C
描述 :
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
免疫原 :
小鼠PECAM-1(CD31)
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-dependent, Neutralization: Assay-dependent
别名 :
C85791; CD31; CD31 antigen; CD31, PECAM-1; CD31/EndoCAM; endoCAM; GPIIA'; I79_008304; PECA1; Pecam; PECAM1; Pecam-1; platelet and endothelial cell adhesion molecule 1; platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1; platelet/endothelial cell adhesion molecule (CD31 antigen); platelet/endothelial cell adhesion molecule 1; type I transmembrane endothelial adhesion molecule
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国