产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸化CREB(Ser133)单克隆抗体(F.959.4)
目录 :
MA5-11192
规格 :
100微升
价格 :
美国430
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
F.959.4
反应物种 :
人类, 小鼠, 大鼠, 斑马鱼
应用 :
免疫印迹, 免疫组化, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 7
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 2a
Nakayama A, Albarrán Juárez J, Liang G, Roquid K, Iring A, Tonack S, et al. Disturbed flow-induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis. JCI Insight. 2020;5: pubmed 出版商
  • 免疫印迹; 大鼠; 图 5b
Bazzari F, Abdallah D, El Abhar H. Chenodeoxycholic Acid Ameliorates AlCl3-Induced Alzheimer's Disease Neurotoxicity and Cognitive Deterioration via Enhanced Insulin Signaling in Rats. Molecules. 2019;24: pubmed 出版商
  • 免疫组化-冰冻切片; 大鼠; 1:50; 图 6f
  • 免疫印迹; 大鼠; 1:500; 图 6a
Zhou Y, Chen S, Liu D, Manyande A, Zhang W, Yang S, et al. The Role of Spinal GABAB Receptors in Cancer-Induced Bone Pain in Rats. J Pain. 2017;18:933-946 pubmed 出版商
Ko H, Ahn S, Chang Y, Hwang I, Yun T, Sung D, et al. Human UCB-MSCs treatment upon intraventricular hemorrhage contributes to attenuate hippocampal neuron loss and circuit damage through BDNF-CREB signaling. Stem Cell Res Ther. 2018;9:326 pubmed 出版商
Chen S, Sun J, Zhou Y, Cao F, Braun C, Luo F, et al. Sinomenine attenuates cancer-induced bone pain via suppressing microglial JAK2/STAT3 and neuronal CAMKII/CREB cascades in rat models. Mol Pain. 2018;14:1744806918793232 pubmed 出版商
Isensee J, Kaufholz M, Knape M, Hasenauer J, Hammerich H, Gonczarowska Jorge H, et al. PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination. J Cell Biol. 2018;217:2167-2184 pubmed 出版商
Liu E, Xie A, Zhou Q, Li M, Zhang S, Li S, et al. GSK-3β deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory. Sci Rep. 2017;7:5781 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
磷酸化CREB(Ser133)单克隆抗体(F.959.4)
目录# :
MA5-11192
规格 :
100微升
定价 :
美国430
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠, 斑马鱼
应用 :
ChIP assay: 1:50, Flow Cytometry: 1:800, Immunohistochemistry (Frozen): 1:800, Immunohistochemistry (Paraffin): 1:800, Western Blot: 1:1,000
物种 :
人类, 小鼠, 大鼠, 斑马鱼
克隆 :
F.959.4
抗体亚型 :
IgG
储存 :
-20°C
描述 :
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory. In humans, the gene is located on the q arm of chromosome 2. Diseases associated with CREB dysfunction include Alzheimer’s Disease, histiocytoma and soft tissue melanoma.
免疫原 :
Synthetic phosphopeptide corresponding to residues surrounding pSer133 of human CREB
格式 :
液体
应用w/稀释 :
ChIP assay: 1:50, Flow Cytometry: 1:800, Immunohistochemistry (Frozen): 1:800, Immunohistochemistry (Paraffin): 1:800, Western Blot: 1:1,000
别名 :
2310001E10Rik; 3526402H21Rik; active transcription factor CREB; AV083133; cAMP response element binding protein 1; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB1; Creb-1; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP-responsive element-binding protein 1; htCREB; MGC9284; OTTHUMP00000206661; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein; Y protein
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国