出版应用/物种/样本/稀释 | 参考文献 |
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- 免疫组化-石蜡切片; 小鼠; 1:1000; 图 4c
| Perkail S, Andricovich J, Kai Y, Tzatsos A. BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice. Nat Commun. 2020;11:3018 pubmed 出版商
|
| Quilichini E, Fabre M, Dirami T, Stedman A, De Vas M, Ozguc O, et al. Pancreatic ductal deletion of Hnf1b disrupts exocrine homeostasis, leads to pancreatitis and facilitates tumorigenesis. Cell Mol Gastroenterol Hepatol. 2019;: pubmed 出版商
|
| Zhang H, Ji J, Liu Q, Xu S. MUC1 downregulation promotes TNF-α-induced necroptosis in human bronchial epithelial cells via regulation of the RIPK1/RIPK3 pathway. J Cell Physiol. 2019;: pubmed 出版商
|
| Sharon N, Chawla R, Mueller J, Vanderhooft J, Whitehorn L, Rosenthal B, et al. A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets. Cell. 2019;176:790-804.e13 pubmed 出版商
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- 免疫组化; 人类; 图 1c
- 免疫组化基因敲除验证; 小鼠; 图 2d
- 免疫印迹基因敲除验证; 小鼠; 图 2b
| Gibier J, Hemon B, Fanchon M, Gaudelot K, Pottier N, Ringot B, et al. Dual role of MUC1 mucin in kidney ischemia-reperfusion injury: Nephroprotector in early phase, but pro-fibrotic in late phase. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1336-1349 pubmed 出版商
|
| Ahmad R, Alam M, Hasegawa M, Uchida Y, Al Obaid O, Kharbanda S, et al. Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer. Mol Cancer. 2017;16:33 pubmed 出版商
|
| Yang Y, Fang J, Li D, Wang L, Ji N, Zhang J. Recurrent intracranial neurenteric cyst with malignant transformation: A case report and literature review. Oncol Lett. 2016;11:3395-3402 pubmed
|
- 染色质免疫沉淀
; 人类; 图 3b
- 免疫组化; 人类; 1:200; 图 6b
- 免疫印迹; 人类; 图 1b
| Engel B, Bowser J, Broaddus R, Carson D. MUC1 stimulates EGFR expression and function in endometrial cancer. Oncotarget. 2016;7:32796-809 pubmed 出版商
|
- 免疫组化-石蜡切片; 小鼠; 1:200; 图 7
| Ferreira M, McKenna L, Zhang J, Reichert M, Bakir B, Buza E, et al. Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of Hhex in Mice. Cell Mol Gastroenterol Hepatol. 2015;1:550-569 pubmed 出版商
|
| Tréhoux S, Lahdaoui F, Delpu Y, Renaud F, Leteurtre E, Torrisani J, et al. Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells. Biochim Biophys Acta. 2015;1853:2392-403 pubmed 出版商
|
| Poncy A, Antoniou A, Cordi S, Pierreux C, Jacquemin P, Lemaigre F. Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts. Dev Biol. 2015;404:136-48 pubmed 出版商
|
- 免疫细胞化学; 人类; 图 3
- 免疫印迹; 人类; 图 3
| Li Q, Liu G, Yuan H, Wang J, Guo Y, Chen T, et al. Mucin1 shifts Smad3 signaling from the tumor-suppressive pSmad3C/p21(WAF1) pathway to the oncogenic pSmad3L/c-Myc pathway by activating JNK in human hepatocellular carcinoma cells. Oncotarget. 2015;6:4253-65 pubmed
|
| von Figura G, Fukuda A, Roy N, Liku M, Morris Iv J, Kim G, et al. The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. Nat Cell Biol. 2014;16:255-67 pubmed 出版商
|
- 免疫组化; 人类; 1:500
- 免疫印迹; 人类; 1:3000
| Bouillez A, Gnemmi V, Gaudelot K, Hemon B, Ringot B, Pottier N, et al. MUC1-C nuclear localization drives invasiveness of renal cancer cells through a sheddase/gamma secretase dependent pathway. Oncotarget. 2014;5:754-63 pubmed
|
| Huang S, Islam M, O NEILL J, Hu Z, Yang Y, Chen Y, et al. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol. 2014;32:84-91 pubmed 出版商
|
| Xu X, Padilla M, Li B, Wells A, Kato K, Tellez C, et al. MUC1 in macrophage: contributions to cigarette smoke-induced lung cancer. Cancer Res. 2014;74:460-70 pubmed 出版商
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| Liu S, Yin L, Stroopinsky D, Rajabi H, Puissant A, Stegmaier K, et al. MUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells. Blood. 2014;123:734-42 pubmed 出版商
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- 染色质免疫沉淀
; 人类
- 免疫细胞化学; 人类
- 免疫印迹; 人类
| Alam M, Ahmad R, Rajabi H, Kharbanda A, Kufe D. MUC1-C oncoprotein activates ERK?C/EBP? signaling and induction of aldehyde dehydrogenase 1A1 in breast cancer cells. J Biol Chem. 2013;288:30892-903 pubmed 出版商
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| Puri S, García Núñez A, Hebrok M, Cano D. Elimination of von Hippel-Lindau function perturbs pancreas endocrine homeostasis in mice. PLoS ONE. 2013;8:e72213 pubmed 出版商
|
| Wang F, Li Q, Ni W, Fang F, Sun X, Xie F, et al. Expression of human full-length MUC1 inhibits the proliferation and migration of a B16 mouse melanoma cell line. Oncol Rep. 2013;30:260-8 pubmed 出版商
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| Rajabi H, Alam M, Takahashi H, Kharbanda A, Guha M, Ahmad R, et al. MUC1-C oncoprotein activates the ZEB1/miR-200c regulatory loop and epithelial-mesenchymal transition. Oncogene. 2014;33:1680-9 pubmed 出版商
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| Kharbanda A, Rajabi H, Jin C, Raina D, Kufe D. Oncogenic MUC1-C promotes tamoxifen resistance in human breast cancer. Mol Cancer Res. 2013;11:714-23 pubmed 出版商
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| Jeliazkova P, Jörs S, Lee M, Zimber Strobl U, Ferrer J, Schmid R, et al. Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1. Hepatology. 2013;57:2469-79 pubmed 出版商
|
| Matsubara D, Kishaba Y, Ishikawa S, Sakatani T, Oguni S, Tamura T, et al. Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features. Cancer Sci. 2013;104:266-73 pubmed 出版商
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| Ghosh S, Pantazopoulos P, Medarova Z, Moore A. Expression of underglycosylated MUC1 antigen in cancerous and adjacent normal breast tissues. Clin Breast Cancer. 2013;13:109-18 pubmed 出版商
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- 染色质免疫沉淀
; 人类; 33 ug/ml
- 免疫印迹; 人类; 1:1000
| Kitamoto S, Yokoyama S, Higashi M, Yamada N, Takao S, Yonezawa S. MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors. Oncogene. 2013;32:4614-21 pubmed 出版商
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| Carrasco M, Delgado I, Soria B, Martin F, Rojas A. GATA4 and GATA6 control mouse pancreas organogenesis. J Clin Invest. 2012;122:3504-15 pubmed 出版商
|
| Budiu R, Elishaev E, Brozick J, Lee M, Edwards R, Kalinski P, et al. Immunobiology of human mucin 1 in a preclinical ovarian tumor model. Oncogene. 2013;32:3664-75 pubmed 出版商
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- 免疫组化; 猕猴; 0.4 ug/ml; 图 2
- 免疫细胞化学; 人类; 0.67 ug/ml; 图 7
- 免疫印迹; 人类; 0.04 ug/ml
- 免疫印迹; African green monkey; 0.04 ug/ml
| Kumar P, Kumar P, Lindberg L, Thirkill T, Ji J, Martsching L, et al. The MUC1 extracellular domain subunit is found in nuclear speckles and associates with spliceosomes. PLoS ONE. 2012;7:e42712 pubmed 出版商
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| Gao H, Chakraborty G, Lee Lim A, Mo Q, Decker M, Vonica A, et al. The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell. 2012;150:764-79 pubmed 出版商
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| Jin C, Rajabi H, Pitroda S, Li A, Kharbanda A, Weichselbaum R, et al. Cooperative interaction between the MUC1-C oncoprotein and the Rab31 GTPase in estrogen receptor-positive breast cancer cells. PLoS ONE. 2012;7:e39432 pubmed 出版商
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| Jin C, Rajabi H, Rodrigo C, Porco J, Kufe D. Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein. Oncogene. 2013;32:2179-88 pubmed 出版商
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- 染色质免疫沉淀
; 人类
- 免疫印迹; 人类; 1:1000
| Rajabi H, Ahmad R, Jin C, Kosugi M, Alam M, Joshi M, et al. MUC1-C oncoprotein induces TCF7L2 transcription factor activation and promotes cyclin D1 expression in human breast cancer cells. J Biol Chem. 2012;287:10703-13 pubmed 出版商
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| Prevot P, Simion A, Grimont A, Colletti M, Khalaileh A, Van den Steen G, et al. Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia. Gut. 2012;61:1723-32 pubmed 出版商
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| Yonezawa S, Kitajima S, Higashi M, Osako M, Horinouchi M, Yokoyama S, et al. A novel anti-MUC1 antibody against the MUC1 cytoplasmic tail domain: use in sensitive identification of poorly differentiated cells in adenocarcinoma of the stomach. Gastric Cancer. 2012;15:370-81 pubmed 出版商
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| Kosugi M, Ahmad R, Alam M, Uchida Y, Kufe D. MUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cells. PLoS ONE. 2011;6:e28234 pubmed 出版商
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| Houston M, Augenlicht L, Heerdt B. Intrinsic mitochondrial membrane potential and associated tumor phenotype are independent of MUC1 over-expression. PLoS ONE. 2011;6:e25207 pubmed 出版商
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| Yin L, Wu Z, Avigan D, Rosenblatt J, Stone R, Kharbanda S, et al. MUC1-C oncoprotein suppresses reactive oxygen species-induced terminal differentiation of acute myelogenous leukemia cells. Blood. 2011;117:4863-70 pubmed 出版商
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- 染色质免疫沉淀
; 人类
- 免疫沉淀; 人类
- 免疫印迹; 人类
| Ahmad R, Rajabi H, Kosugi M, Joshi M, Alam M, Vasir B, et al. MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop. Sci Signal. 2011;4:ra9 pubmed 出版商
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| Lilly A, Khanim F, Hayden R, Luong Q, Drayson M, Bunce C. Nm23-h1 indirectly promotes the survival of acute myeloid leukemia blast cells by binding to more mature components of the leukemic clone. Cancer Res. 2011;71:1177-86 pubmed 出版商
|
| Shimajiri Y, Kosaka Y, Scheel D, Lynn F, Kishimoto N, Wang J, et al. A mouse model for monitoring islet cell genesis and developing therapies for diabetes. Dis Model Mech. 2011;4:268-76 pubmed 出版商
|
- 免疫组化-冰冻切片; 小鼠; 1:500; 图 1
| Kopinke D, Murtaugh L. Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas. BMC Dev Biol. 2010;10:38 pubmed 出版商
|
| Khodarev N, Ahmad R, Rajabi H, Pitroda S, Kufe T, McClary C, et al. Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer. Oncogene. 2010;29:920-9 pubmed 出版商
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- 染色质免疫沉淀
; 人类
- 免疫细胞化学; 人类
- 免疫印迹; 人类
| Ahmad R, Raina D, Joshi M, Kawano T, Ren J, Kharbanda S, et al. MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor. Cancer Res. 2009;69:7013-21 pubmed 出版商
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| Aubert S, Fauquette V, Hemon B, Lepoivre R, Briez N, Bernard D, et al. MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression. Cancer Res. 2009;69:5707-15 pubmed 出版商
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| Mikami Y, Hisatsune A, Tashiro T, Isohama Y, Katsuki H. Hypoxia enhances MUC1 expression in a lung adenocarcinoma cell line. Biochem Biophys Res Commun. 2009;379:1060-5 pubmed 出版商
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| Mahanta S, Fessler S, Park J, Bamdad C. A minimal fragment of MUC1 mediates growth of cancer cells. PLoS ONE. 2008;3:e2054 pubmed 出版商
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| Ahmad R, Raina D, Trivedi V, Ren J, Rajabi H, Kharbanda S, et al. MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signalling. Nat Cell Biol. 2007;9:1419-27 pubmed
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| Wang Y, Gao J, Li Z, Jin Z, Gong Y, Man X. Diagnostic value of mucins (MUC1, MUC2 and MUC5AC) expression profile in endoscopic ultrasound-guided fine-needle aspiration specimens of the pancreas. Int J Cancer. 2007;121:2716-22 pubmed
|
| Liu C, Chen Z, Chen Z, Zhang T, Lu Y. Multiple tumor types may originate from bone marrow-derived cells. Neoplasia. 2006;8:716-24 pubmed
|
| Han J, Cao S, Jin H, Liu Y, Wang M, Song J, et al. Localization of putative stem cells and four cell populations with different differentiation degree in mouse mammary anlagen. Histochem Cell Biol. 2006;126:35-43 pubmed
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| Vasir B, Avigan D, Wu Z, Crawford K, Turnquist S, Ren J, et al. Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanism. J Immunol. 2005;174:2376-86 pubmed
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| Yamashita N, Fushimi A, Morimoto Y, Bhattacharya A, Hagiwara M, Yamamoto M, et al. Targeting MUC1-C Suppresses Chronic Activation of Cytosolic Nucleotide Receptors and STING in Triple-Negative Breast Cancer. Cancers (Basel). 2022;14: pubmed 出版商
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| Johansson E, Liang S, Moccia C, Carlsson T, Andersson D, Fagman H, et al. Asynchrony of Apical Polarization, Luminogenesis, and Functional Differentiation in the Developing Thyroid Gland. Front Endocrinol (Lausanne). 2021;12:760541 pubmed 出版商
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| Luan Z, Morimoto Y, Fushimi A, Yamashita N, Suo W, Bhattacharya A, et al. MUC1-C Dictates Neuroendocrine Lineage Specification in Pancreatic Ductal Adenocarcinomas. Carcinogenesis. 2021;: pubmed 出版商
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| Flasse L, Yennek S, Cortijo C, Barandiaran I, Kraus M, Grapin Botton A. Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity. Cell Rep. 2020;31:107677 pubmed 出版商
|
| Seymour P, Collin C, Egeskov Madsen A, Jørgensen M, Shimojo H, Imayoshi I, et al. Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors. Dev Cell. 2020;52:731-747.e8 pubmed 出版商
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| Jobbagy S, Vitturi D, Salvatore S, Pires M, Rowart P, Emlet D, et al. Nrf2 activation protects against lithium-induced nephrogenic diabetes insipidus. JCI Insight. 2020;5: pubmed 出版商
|
| Lee B, Ahn C, Jeon B, Jung E, Yoo Y, Jeung E. Regulatory effect of dexamethasone on tracheal calcium processing proteins and mucosal secretion. J Physiol Pharmacol. 2019;70: pubmed 出版商
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| Lee K, Kim H, Lee J, Oh C, Song H, Kim H, et al. Essential Role of Protein Arginine Methyltransferase 1 in Pancreas Development by Regulating Protein Stability of Neurogenin 3. Diabetes Metab J. 2019;43:649-658 pubmed 出版商
|
| Domenici G, Aurrekoetxea Rodríguez I, Simões B, Rábano M, Lee S, Millán J, et al. A Sox2-Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells. Oncogene. 2019;38:3151-3169 pubmed 出版商
|
| Wang X, Yamada S, LaRiviere W, Ye H, Bakeberg J, Irazabal M, et al. Generation and phenotypic characterization of Pde1a mutant mice. PLoS ONE. 2017;12:e0181087 pubmed 出版商
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| Woessner D, Lim C. Disrupting BCR-ABL in combination with secondary leukemia-specific pathways in CML cells leads to enhanced apoptosis and decreased proliferation. Mol Pharm. 2013;10:270-7 pubmed 出版商
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| Landsman L, Nijagal A, Whitchurch T, Vanderlaan R, Zimmer W, MacKenzie T, et al. Pancreatic mesenchyme regulates epithelial organogenesis throughout development. PLoS Biol. 2011;9:e1001143 pubmed 出版商
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| Yin L, Huang L, Kufe D. MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress. J Biol Chem. 2004;279:45721-7 pubmed
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