产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
p53单克隆抗体(多克隆抗体1801)
目录 :
MA5-11296
规格 :
500微升
价格 :
美国472
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
多克隆抗体1801
反应物种 :
African green monkey, 人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀
, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 27
| 出版应用/物种/样本/稀释 | 参考文献 |
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| Fan C, Lin X, Wang E. Clinicopathological significance of cathepsin D expression in non-small cell lung cancer is conditional on apoptosis-associated protein phenotype: an immunohistochemistry study. Tumour Biol. 2012;33:1045-52 pubmed
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| Graziano S, Gu L, Wang X, Tatum A, Vollmer R, Strauss G, et al. Prognostic significance of mucin and p53 expression in stage IB non-small cell lung cancer: a laboratory companion study to CALGB 9633. J Thorac Oncol. 2010;5:810-7 pubmed
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| Zhu Q, Wani G, Yao J, Patnaik S, Wang Q, El Mahdy M, et al. The ubiquitin-proteasome system regulates p53-mediated transcription at p21waf1 promoter. Oncogene. 2007;26:4199-208 pubmed
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| Mangia A, Chiriatti A, Ranieri G, Abbate I, Coviello M, Simone G, et al. H pylori status and angiogenesis factors in human gastric carcinoma. World J Gastroenterol. 2006;12:5465-72 pubmed
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| Kanezaki R, Toki T, Xu G, Narayanan R, Ito E. Cloning and characterization of the novel chimeric gene p53/FXR2 in the acute megakaryoblastic leukemia cell line CMK11-5. Tohoku J Exp Med. 2006;209:169-80 pubmed
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| Heminger K, Jain V, Kadakia M, Dwarakanath B, Berberich S. Altered gene expression induced by ionizing radiation and glycolytic inhibitor 2-deoxy-glucose in a human glioma cell line: implications for radio sensitization. Cancer Biol Ther. 2006;5:815-23 pubmed
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| van Beusechem V, van den Doel P, Gerritsen W. Conditionally replicative adenovirus expressing degradation-resistant p53 for enhanced oncolysis of human cancer cells overexpressing murine double minute 2. Mol Cancer Ther. 2005;4:1013-8 pubmed
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| Elso C, Lu X, Culiat C, Rutledge J, Cacheiro N, Generoso W, et al. Heightened susceptibility to chronic gastritis, hyperplasia and metaplasia in Kcnq1 mutant mice. Hum Mol Genet. 2004;13:2813-21 pubmed
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| Barshack I, Goldberg I, Chowers Y, Weiss B, Horowitz A, Kopolovic J. Immunohistochemical analysis of candidate gene product expression in the duodenal epithelium of children with coeliac sprue. J Clin Pathol. 2001;54:684-8 pubmed
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| Evdokiou A, Atkins G, Bouralexis S, Hay S, Raggatt L, Cowled P, et al. Expression of alternatively-spliced MDM2 transcripts in giant cell tumours of bone. Int J Oncol. 2001;19:625-32 pubmed
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Wunderlich M, Ghosh M, Weghorst K, Berberich S. MdmX represses E2F1 transactivation. Cell Cycle. 2004;3:472-8 pubmed
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Chandra J, Hackbarth J, Le S, Loegering D, Bone N, Bruzek L, et al. Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells. Blood. 2003;102:4512-9 pubmed
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Ricotti L, Tesei A, De Paola F, Ulivi P, Frassineti G, Milandri C, et al. In vitro schedule-dependent interaction between docetaxel and gemcitabine in human gastric cancer cell lines. Clin Cancer Res. 2003;9:900-5 pubmed
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Blajeski A, Phan V, Kottke T, Kaufmann S. G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells. J Clin Invest. 2002;110:91-9 pubmed
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Gajra A, Tatum A, Newman N, Gamble G, Lichtenstein S, Rooney M, et al. The predictive value of neuroendocrine markers and p53 for response to chemotherapy and survival in patients with advanced non-small cell lung cancer. Lung Cancer. 2002;36:159-65 pubmed
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Nielsen L, Gurnani M, Shi B, Terracina G, Johnson R, Carroll J, et al. Derivation and initial characterization of a mouse mammary tumor cell line carrying the polyomavirus middle T antigen: utility in the development of novel cancer therapeutics. Cancer Res. 2000;60:7066-74 pubmed
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Shinobu N, Maeda T, Aso T, Ito T, Kondo T, Koike K, et al. Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53. J Biol Chem. 1999;274:17003-10 pubmed
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Boyer S, Wazer D, Band V. E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res. 1996;56:4620-4 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
p53单克隆抗体(多克隆抗体1801)
目录# :
MA5-11296
规格 :
500微升
定价 :
美国472
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类
应用 :
ChIP assay: 5 µg, Immunoprecipitation: 2 µg/mL, Western Blot: 0.5-2 µg/mL
物种 :
人类
克隆 :
多克隆抗体1801
抗体亚型 :
IgG1
储存 :
4° C
描述 :
The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization. p53 has been characterized to play a role in blocking the proliferative action of damaged cells and act as an anticancer agent. Phosphorylation of Ser392 in p53 has been shown to associate with the formation of human tumors. In addition, p53 has also been linked to the effects of aging and oxidative stress and an increase in p53 has been linked to deficits in LTP (Long Term Potentiation) in learning and memory. p53 is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families such as Li-Fraumeni syndrome.
免疫原 :
重组人类p53蛋白
格式 :
液体
应用w/稀释 :
ChIP assay: 5 µg, Immunoprecipitation: 2 µg/mL, Western Blot: 0.5-2 µg/mL
别名 :
Antigen NY-CO-13; bbl; BCC7; bfy; bhy; cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; p53; p53 cellular tumor antigen; p53 protein; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; Trp53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3
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公司信息
赛默飞世尔