产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Rb Monoclonal Antibody (1F8 (Rb1))
目录 :
MA5-11387
规格 :
500微升
价格 :
美国474
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
1F8(视网膜成神经细胞瘤相关蛋白)
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 24
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 小鼠; 1:50; 图 8a
Fomicheva M, Macara I. Genome-wide CRISPR screen identifies noncanonical NF-κB signaling as a regulator of density-dependent proliferation. elife. 2020;9: pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
Wang T, Goodman M, McGough R, Weiss K, Rao U. Immunohistochemical analysis of expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B is helpful in distinction between myxofibrosarcoma and myxoid liposarcoma. Int J Surg Pathol. 2014;22:589-99 pubmed 出版商
  • 免疫组化; 人类; 1:200
Sahi H, Savola S, Sihto H, Koljonen V, Bohling T, Knuutila S. RB1 gene in Merkel cell carcinoma: hypermethylation in all tumors and concurrent heterozygous deletions in the polyomavirus-negative subgroup. APMIS. 2014;122:1157-66 pubmed 出版商
  • 免疫组化; 人类
Yanagawa N, Wang A, Kohler D, Santos G, Sykes J, Xu J, et al. Human papilloma virus genome is rare in North American non-small cell lung carcinoma patients. Lung Cancer. 2013;79:215-20 pubmed 出版商
  • 免疫组化; 人类; 1:50
Franchi A, Baroni G, Sardi I, Giunti L, Capanna R, Campanacci D. Dedifferentiated peripheral chondrosarcoma: a clinicopathologic, immunohistochemical, and molecular analysis of four cases. Virchows Arch. 2012;460:335-42 pubmed 出版商
  • 免疫组化; 人类
Canzonieri V, Barzan L, Franchin G, Vaccher E, Talamini R, Sulfaro S, et al. Alteration of G1/S transition regulators influences recurrences in head and neck squamous carcinomas. J Cell Physiol. 2012;227:233-8 pubmed 出版商
  • 免疫印迹; 人类; 1:200
Lee S, Liu S, Mitchell R, Slagle Webb B, Hong Y, Sheehan J, et al. HFE polymorphisms influence the response to chemotherapeutic agents via induction of p16INK4A. Int J Cancer. 2011;129:2104-14 pubmed 出版商
  • 免疫组化; 人类; 1:50
Panelos J, Beltrami G, Scoccianti G, Capanna R, Paglierani M, Pepi M, et al. Prognostic significance of the alterations of the G1-S checkpoint in localized leiomyosarcoma of the peripheral soft tissue. Ann Surg Oncol. 2011;18:566-71 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200
  • 免疫组化; 人类
  • 免疫印迹; 人类; 1:200
Derenzini M, Donati G, Mazzini G, Montanaro L, Vici M, Ceccarelli C, et al. Loss of retinoblastoma tumor suppressor protein makes human breast cancer cells more sensitive to antimetabolite exposure. Clin Cancer Res. 2008;14:2199-209 pubmed 出版商
  • 免疫组化; 人类; 1:200
Jung C, Jung J, Lee K, Kang C, Kim M, Ko Y, et al. Centrosome abnormalities in non-small cell lung cancer: correlations with DNA aneuploidy and expression of cell cycle regulatory proteins. Pathol Res Pract. 2007;203:839-47 pubmed
  • 免疫细胞化学; 人类; 1:200
  • 免疫印迹; 人类; 1:200
Montanaro L, Mazzini G, Barbieri S, Vici M, Nardi Pantoli A, Govoni M, et al. Different effects of ribosome biogenesis inhibition on cell proliferation in retinoblastoma protein- and p53-deficient and proficient human osteosarcoma cell lines. Cell Prolif. 2007;40:532-49 pubmed
  • 免疫印迹; 小鼠
Kim J, Hong S, Lee B, Hong J, Kwak J, Cho S, et al. The inhibition of T-cells proliferation by mouse mesenchymal stem cells through the induction of p16INK4A-cyclin D1/cdk4 and p21waf1, p27kip1-cyclin E/cdk2 pathways. Cell Immunol. 2007;245:16-23 pubmed
  • 免疫印迹; 人类
Choi J, Murillo G, Su B, Pezzuto J, Kinghorn A, Mehta R. Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells. FEBS J. 2006;273:5714-23 pubmed
  • 免疫组化; 人类
Nam E, Kim J, Kim S, Kim Y, Kim J, Yoon B, et al. The expressions of the Rb pathway in cervical intraepithelial neoplasia; predictive and prognostic significance. Gynecol Oncol. 2007;104:207-11 pubmed
  • 免疫组化; 人类; 1:25
Yurakh A, Ramos D, Calabuig Fariñas S, Lopez Guerrero J, Rubio J, Solsona E, et al. Molecular and immunohistochemical analysis of the prognostic value of cell-cycle regulators in urothelial neoplasms of the bladder. Eur Urol. 2006;50:506-15; discussion 515 pubmed
  • 免疫印迹; 大鼠
Kuo H, Kuo W, Lee Y, Lin W, Chou F, Tseng T. Inhibitory effect of caffeic acid phenethyl ester on the growth of C6 glioma cells in vitro and in vivo. Cancer Lett. 2006;234:199-208 pubmed
Wadosky K, Berthiaume J, Tang W, Zungu M, Portman M, Gerdes A, et al. MuRF1 mono-ubiquitinates TRα to inhibit T3-induced cardiac hypertrophy in vivo. J Mol Endocrinol. 2016;56:273-90 pubmed 出版商
Trere D, Ceccarelli C, Montanaro L, Tosti E, Derenzini M. Nucleolar size and activity are related to pRb and p53 status in human breast cancer. J Histochem Cytochem. 2004;52:1601-7 pubmed
Derenzini M, Ceccarelli C, Santini D, Taffurelli M, Trere D. The prognostic value of the AgNOR parameter in human breast cancer depends on the pRb and p53 status. J Clin Pathol. 2004;57:755-61 pubmed
Tzai T, Tsai Y, Chow N. The prevalence and clinicopathologic correlate of p16INK4a, retinoblastoma and p53 immunoreactivity in locally advanced urinary bladder cancer. Urol Oncol. 2004;22:112-8 pubmed
Jayasurya R, Francis G, Kannan S, Lekshminarayanan K, Nalinakumari K, Abraham T, et al. p53, p16 and cyclin D1: molecular determinants of radiotherapy treatment response in oral carcinoma. Int J Cancer. 2004;109:710-6 pubmed
Jung C, Motwani M, Schwartz G. Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit. Clin Cancer Res. 2001;7:2527-36 pubmed
Esteller M, Cordon Cardo C, Corn P, Meltzer S, Pohar K, Watkins D, et al. p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2. Cancer Res. 2001;61:2816-21 pubmed
Huschtscha L, Noble J, Neumann A, Moy E, Barry P, Melki J, et al. Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells. Cancer Res. 1998;58:3508-12 pubmed
产品信息
产品类型 :
抗体
产品名称 :
Rb Monoclonal Antibody (1F8 (Rb1))
目录# :
MA5-11387
规格 :
500微升
定价 :
美国474
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类, 小鼠
应用 :
Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:10-1:200, Immunohistochemistry (Paraffin): 1-2 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
物种 :
人类, 小鼠
克隆 :
1F8(视网膜成神经细胞瘤相关蛋白)
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
免疫原 :
Recombinant human Rb protein
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:10-1:200, Immunohistochemistry (Paraffin): 1-2 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
别名 :
Cleaved Rb; delta RB-p70; DRb-p70; exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; OSRC; p104; p104 chicken Rb; P105RB; p105-Rb; Phospho-Retinoblastoma; pp105; pp110; PPP1R130; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; rb; RB transcriptional corepressor 1; RB1; Rb-1; Rb-p70; Retin; Retinoblastoma; retinoblastoma 1; retinoblastoma 1 (including osteosarcoma); retinoblastoma 1 protein; retinoblastoma gene; retinoblastoma isoform A; retinoblastoma protein; retinoblastoma suspectibility protein; retinoblastoma tumor suppressor; retinoblastoma-associated protein
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国