产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD45RO单克隆抗体(UCHL1)
目录 :
MA5-11532
规格 :
500微升
价格 :
美国301
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
UCHL1
反应物种 :
人类, 小鼠, 大鼠, 黑猩猩
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 51
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 人类; 图 4g
Liu X, Kong W, Peterson C, McGrail D, Hoang A, Zhang X, et al. PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma. Nat Commun. 2020;11:2135 pubmed 出版商
  • 流式细胞仪; 人类; 图 e4d
Lynn R, Weber E, Sotillo E, Gennert D, Xu P, Good Z, et al. c-Jun overexpression in CAR T cells induces exhaustion resistance. Nature. 2019;576:293-300 pubmed 出版商
  • 流式细胞仪; 人类; 图 1b
Pizzolla A, Nguyen T, Sant S, Jaffar J, Loudovaris T, Mannering S, et al. Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles. J Clin Invest. 2018;128:721-733 pubmed 出版商
  • 流式细胞仪; 人类; 图 1a
Schulten V, Tripple V, Seumois G, Qian Y, Scheuermann R, Fu Z, et al. Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells. J Allergy Clin Immunol. 2018;141:775-777.e6 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 7a
Hasby Saad M, Hasby E. Trichinella Spiralis Impact on Mesenchymal Stem Cells: Immunohistochemical Study by Image Analyzer in Murine Model. Exp Mol Pathol. 2017;102:396-407 pubmed 出版商
  • 流式细胞仪; 人类; 图 3b
Szabo P, Goswami A, Mazzuca D, Kim K, O Gorman D, Hess D, et al. Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology. J Immunol. 2017;198:2805-2818 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 表 2
Perea F, Bernal M, Sánchez Palencia A, Carretero J, Torres C, Bayarri C, et al. The absence of HLA class I expression in non-small cell lung cancer correlates with the tumor tissue structure and the pattern of T cell infiltration. Int J Cancer. 2017;140:888-899 pubmed 出版商
  • 流式细胞仪; 人类; 图 s3b
Komdeur F, Wouters M, Workel H, Tijans A, Terwindt A, Brunekreeft K, et al. CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy. Oncotarget. 2016;7:75130-75144 pubmed 出版商
  • 免疫组化; 人类
Däster S, Eppenberger Castori S, Hirt C, Zlobec I, Delko T, Nebiker C, et al. High frequency of CD8 positive lymphocyte infiltration correlates with lack of lymph node involvement in early rectal cancer. Dis Markers. 2014;2014:792183 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
Yang Y, Li Y, Liu Y, Yang M, Liu K. CD30+ extranodal natural killer/T-cell lymphoma mimicking phlegmonous myositis: A case report. Oncol Lett. 2014;7:1419-1421 pubmed
  • 免疫组化; 人类
Mungan S, Karaguzel E, Turan C, Reis A. A giant primary sclerosing lipogranuloma of the scrotum. Turk Patoloji Derg. 2014;30:78-80 pubmed 出版商
  • 流式细胞仪; 人类
Ammirati E, Cianflone D, Vecchio V, Banfi M, Vermi A, De Metrio M, et al. Effector Memory T cells Are Associated With Atherosclerosis in Humans and Animal Models. J Am Heart Assoc. 2012;1:27-41 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 表 4
Yang H, Xu C, Tang Y, Wan C, Liu W, Wang L. The significance of multiplex PCR/heteroduplex analysis-based TCR-? gene rearrangement combined with laser-capture microdissection in the diagnosis of early mycosis fungoides. J Cutan Pathol. 2012;39:337-46 pubmed 出版商
  • 流式细胞仪; 人类; 图 1
Imataki O, Ansén S, Tanaka M, Butler M, Berezovskaya A, Milstein M, et al. IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cells. J Immunol. 2012;188:1609-19 pubmed 出版商
  • 流式细胞仪; 人类; 1:100; 表 3
Su X, Huang J, Jiang Y, Tang Y, Li G, Liu W. Serous effusion cytology of extranodal natural killer/T-cell lymphoma. Cytopathology. 2012;23:96-102 pubmed 出版商
  • 免疫组化; 小鼠
Honma Y, Kawano M, Kohsaka S, Ogawa M. Axonal projections of mechanoreceptive dorsal root ganglion neurons depend on Ret. Development. 2010;137:2319-28 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Belousova I, Vanecek T, Samtsov A, Michal M, Kazakov D. A patient with clinicopathologic features of small plaque parapsoriasis presenting later with plaque-stage mycosis fungoides: report of a case and comparative retrospective study of 27 cases of "nonprogressive" small plaque parapsoriasis. J Am Acad Dermatol. 2008;59:474-82 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Kazakov D, Belousova I, Kacerovska D, Sima R, Vanecek T, Vazmitel M, et al. Hyperplasia of hair follicles and other adnexal structures in cutaneous lymphoproliferative disorders: a study of 53 cases, including so-called pseudolymphomatous folliculitis and overt lymphomas. Am J Surg Pathol. 2008;32:1468-78 pubmed 出版商
  • 流式细胞仪; 人类; 图 2
Yates J, Whittington A, Mitchell P, Lechler R, Lightstone L, Lombardi G. Natural regulatory T cells: number and function are normal in the majority of patients with lupus nephritis. Clin Exp Immunol. 2008;153:44-55 pubmed 出版商
  • 免疫细胞化学; 人类; 1:2500
Carolan B, Heguy A, Harvey B, Leopold P, Ferris B, Crystal R. Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers. Cancer Res. 2006;66:10729-40 pubmed
  • 免疫组化; 人类; 1:1000
Boudova L, Kazakov D, Jindra P, Sima R, Vanecek T, Kuntscher V, et al. Primary cutaneous histiocyte and neutrophil-rich CD30+ and CD56+ anaplastic large-cell lymphoma with prominent angioinvasion and nerve involvement in the forehead and scalp of an immunocompetent woman. J Cutan Pathol. 2006;33:584-9 pubmed
  • 流式细胞仪; 人类
Hoves S, Krause S, Schutz C, Halbritter D, Scholmerich J, Herfarth H, et al. Monocyte-derived human macrophages mediate anergy in allogeneic T cells and induce regulatory T cells. J Immunol. 2006;177:2691-8 pubmed
  • 免疫组化; 人类; 1:1000
Boudova L, Kazakov D, Sima R, Vanecek T, Torlakovic E, Lamovec J, et al. Cutaneous lymphoid hyperplasia and other lymphoid infiltrates of the breast nipple: a retrospective clinicopathologic study of fifty-six patients. Am J Dermatopathol. 2005;27:375-86 pubmed
  • 免疫组化; 人类
Zhang Y, Yuan F, Jia G, Zhang J, Hu L, Huang L, et al. CIK cells from patients with HCC possess strong cytotoxicity to multidrug-resistant cell line Bel-7402/R. World J Gastroenterol. 2005;11:3339-45 pubmed
  • 流式细胞仪; 人类; 图 1
Thompson S, Luyrink L, Graham T, Tsoras M, Ryan M, Passo M, et al. Chemokine receptor CCR4 on CD4+ T cells in juvenile rheumatoid arthritis synovial fluid defines a subset of cells with increased IL-4:IFN-gamma mRNA ratios. J Immunol. 2001;166:6899-906 pubmed
  • 流式细胞仪; 人类
Lee B, Sharron M, Montaner L, Weissman D, Doms R. Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages. Proc Natl Acad Sci U S A. 1999;96:5215-20 pubmed
  • 流式细胞仪; 人类; 图 4
Kim C, Pelus L, White J, Applebaum E, Johanson K, Broxmeyer H. CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells. J Immunol. 1998;160:2418-24 pubmed
  • 免疫组化-冰冻切片; 人类; 图 1
  • 流式细胞仪; 人类
  • 免疫沉淀; 人类; 图 2
Smith S, Brown M, Rowe D, Callard R, Beverley P. Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1. Immunology. 1986;58:63-70 pubmed
Nakano M, Riku Y, Nishioka K, Hasegawa M, Washimi Y, Arahata Y, et al. Unclassified four-repeat tauopathy associated with familial parkinsonism and progressive respiratory failure. Acta Neuropathol Commun. 2020;8:148 pubmed 出版商
Kepchia D, Huang L, Dargusch R, Rissman R, Shokhirev M, Fischer W, et al. Diverse proteins aggregate in mild cognitive impairment and Alzheimer's disease brain. Alzheimers Res Ther. 2020;12:75 pubmed 出版商
Ng A, Tan Y, Lu Z, Ng E, Ng S, Chia N, et al. Plasma ubiquitin C-terminal hydrolase L1 levels reflect disease stage and motor severity in Parkinson's disease. Aging (Albany NY). 2020;12:1488-1495 pubmed 出版商
Zarak Crnkovic M, Kania G, Jazwa Kusior A, Czepiel M, Wijnen W, Czyz J, et al. Heart non-specific effector CD4+ T cells protect from postinflammatory fibrosis and cardiac dysfunction in experimental autoimmune myocarditis. Basic Res Cardiol. 2019;115:6 pubmed 出版商
Singh M, Kasna S, Roy S, Aldosary S, Saeedan A, Ansari M, et al. Repurposing mechanistic insight of PDE-5 inhibitor in cancer chemoprevention through mitochondrial-oxidative stress intervention and blockade of DuCLOX signalling. BMC Cancer. 2019;19:996 pubmed 出版商
Johnson D, McDonnell W, Gonzalez Ericsson P, Al Rohil R, Mobley B, Salem J, et al. A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis. Nat Med. 2019;25:1243-1250 pubmed 出版商
Mielke L, Liao Y, Clemens E, Firth M, Duckworth B, Huang Q, et al. TCF-1 limits the formation of Tc17 cells via repression of the MAF-RORγt axis. J Exp Med. 2019;: pubmed 出版商
Do C, Ford B, Lee D, Tan C, Escobar P, Wagner B. Gadolinium-based contrast agents: Stimulators of myeloid-induced renal fibrosis and major metabolic disruptors. Toxicol Appl Pharmacol. 2019;375:32-45 pubmed 出版商
Do C, Drel V, Tan C, Lee D, Wagner B. 'Nephrogenic' systemic fibrosis is mediated by myeloid C-C chemokine receptor 2. J Invest Dermatol. 2019;: pubmed 出版商
Logtenberg M, Jansen J, Raaben M, Toebes M, Franke K, Brandsma A, et al. Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy. Nat Med. 2019;25:612-619 pubmed 出版商
Fu H, Zhang W, Yuan Q, Niu M, Zhou F, Qiu Q, et al. PAK1 Promotes the Proliferation and Inhibits Apoptosis of Human Spermatogonial Stem Cells via PDK1/KDR/ZNF367 and ERK1/2 and AKT Pathways. Mol Ther Nucleic Acids. 2018;12:769-786 pubmed 出版商
Augustin H, McGourty K, Allen M, Adcott J, Wong C, Boucrot E, et al. Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster. Neurobiol Aging. 2018;66:149-157 pubmed 出版商
Müller N, Landwehr K, Langeveld K, Stenzel J, Pouwels W, van der Hoorn M, et al. Generation of alloreactivity-reduced donor lymphocyte products retaining memory function by fully automatic depletion of CD45RA-positive cells. Cytotherapy. 2018;20:532-542 pubmed 出版商
Laksono B, Grosserichter Wagener C, de Vries R, Langeveld S, Brem M, van Dongen J, et al. In Vitro Measles Virus Infection of Human Lymphocyte Subsets Demonstrates High Susceptibility and Permissiveness of both Naive and Memory B Cells. J Virol. 2018;92: pubmed 出版商
Lamere S, Thompson R, Meng X, Komori H, Mark A, Salomon D. H3K27 Methylation Dynamics during CD4 T Cell Activation: Regulation of JAK/STAT and IL12RB2 Expression by JMJD3. J Immunol. 2017;199:3158-3175 pubmed 出版商
Gao H, Hartnett S, Li Y. Ubiquitin C-Terminal Hydrolase L1 regulates myoblast proliferation and differentiation. Biochem Biophys Res Commun. 2017;492:96-102 pubmed 出版商
Hegazy A, West N, Stubbington M, Wendt E, Suijker K, Datsi A, et al. Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation. Gastroenterology. 2017;153:1320-1337.e16 pubmed 出版商
Costa N, Marques O, Godinho S, Carvalho C, Leal B, Figueiredo A, et al. Two separate effects contribute to regulatory T cell defect in systemic lupus erythematosus patients and their unaffected relatives. Clin Exp Immunol. 2017;189:318-330 pubmed 出版商
Chen H, Händel N, Ngeow J, Muller J, Huhn M, Yang H, et al. Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells. J Allergy Clin Immunol. 2017;139:607-620.e15 pubmed 出版商
Liu X, Hoang A, Zhou L, Kalra S, Yetil A, Sun M, et al. Resistance to Antiangiogenic Therapy Is Associated with an Immunosuppressive Tumor Microenvironment in Metastatic Renal Cell Carcinoma. Cancer Immunol Res. 2015;3:1017-29 pubmed 出版商
Schmitt N, Liu Y, Bentebibel S, Munagala I, Bourdery L, Venuprasad K, et al. The cytokine TGF-? co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells. Nat Immunol. 2014;15:856-65 pubmed 出版商
Aki H, Tuzuner N, Ongoren S, Baslar Z, Soysal T, Ferhanoglu B, et al. T-cell-rich B-cell lymphoma: a clinicopathologic study of 21 cases and comparison with 43 cases of diffuse large B-cell lymphoma. Leuk Res. 2004;28:229-36 pubmed
Kim C, Rott L, Clark Lewis I, Campbell D, Wu L, Butcher E. Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. J Exp Med. 2001;193:1373-81 pubmed
图像
图像 1 :
赛默飞世尔 MA5-11532 图像 1
Formalin-fixed, paraffin-embedded human lymph node stained with CD45RO antibody using peroxidase-conjugate and DAB chromogen. Note cell membrane staining of T lymphocytes.
产品信息
产品类型 :
抗体
产品名称 :
CD45RO单克隆抗体(UCHL1)
目录# :
MA5-11532
规格 :
500微升
定价 :
美国301
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
Human, Mouse, Non-human primate, Rat
应用 :
Flow Cytometry: 0.5-1 µg/test, Immunohistochemistry (Paraffin): 1:200-1:400, Western Blot: 1:1-1:100
物种 :
Human, Mouse, Non-human primate, Rat
克隆 :
UCHL1
抗体亚型 :
IgG2a, kappa
储存 :
4° C
描述 :
CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
免疫原 :
白细胞介素2人类T淋巴细胞
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.5-1 µg/test, Immunohistochemistry (Paraffin): 1:200-1:400, Western Blot: 1:1-1:100
别名 :
B220; Cd45; CD45 antigen; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; loc; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国