产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
NOTCH1单克隆抗体(A6)
目录 :
MA5-11961
规格 :
500微升
价格 :
美国431
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
A6
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 流式细胞仪, 抑制或激活实验
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 19
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 人类; 1:500; 图 1
Mathan J, Ismail S, McGhee J, McGhee C, Sherwin T. Sphere-forming cells from peripheral cornea demonstrate the ability to repopulate the ocular surface. Stem Cell Res Ther. 2016;7:81 pubmed 出版商
  • 免疫组化; 人类
Krausch M, Kroepil F, Lehwald N, Lachenmayer A, Schott M, Anlauf M, et al. Notch 1 tumor expression is lacking in highly proliferative pancreatic neuroendocrine tumors. Endocrine. 2013;44:182-6 pubmed 出版商
  • 抑制或激活实验; 人类; 10 ug/ml
Del Papa B, Sportoletti P, Cecchini D, Rosati E, Balucani C, Baldoni S, et al. Notch1 modulates mesenchymal stem cells mediated regulatory T-cell induction. Eur J Immunol. 2013;43:182-7 pubmed 出版商
  • 流式细胞仪; 小鼠
Perumalsamy L, Marcel N, Kulkarni S, Radtke F, Sarin A. Distinct spatial and molecular features of notch pathway assembly in regulatory T cells. Sci Signal. 2012;5:ra53 pubmed 出版商
  • 抑制或激活实验; 人类; 20 ug/ml
Pei J, Tang Z, Zang G, Yu Y. Blockage of Notch1 signaling modulates the T-helper (Th)1/Th2 cell balance in chronic hepatitis B patients. Hepatol Res. 2010;40:799-805 pubmed 出版商
  • 流式细胞仪; 人类; 1:100
Puget S, Grill J, Valent A, Bieche I, Dantas Barbosa C, Kauffmann A, et al. Candidate genes on chromosome 9q33-34 involved in the progression of childhood ependymomas. J Clin Oncol. 2009;27:1884-92 pubmed 出版商
  • 免疫组化; 人类; 10-20 ug/ml
Kose O, Lalli A, Kutulola A, Odell E, Waseem A. Changes in the expression of stem cell markers in oral lichen planus and hyperkeratotic lesions. J Oral Sci. 2007;49:133-9 pubmed
  • 免疫细胞化学; 人类
  • 酶联免疫吸附测定; 人类
Luty W, Rodeberg D, Parness J, Vyas Y. Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates. J Immunol. 2007;179:819-29 pubmed
  • 免疫组化; 人类; 1:100
Su Y, Buchler P, Gazdhar A, Giese N, Reber H, Hines O, et al. Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway. J Gastrointest Surg. 2006;10:1230-41; discussion 1242 pubmed
  • 免疫印迹; 小鼠; 2 ug/ml
Bheeshmachar G, Purushotaman D, Sade H, Gunasekharan V, Rangarajan A, Sarin A. Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells. J Immunol. 2006;177:5041-50 pubmed
  • 免疫组化; 人类
Blaukovitsch M, Halbwedl I, Kothmaier H, Gogg Kammerer M, Popper H. Sarcomatoid carcinomas of the lung--are these histogenetically heterogeneous tumors?. Virchows Arch. 2006;449:455-61 pubmed
  • 免疫组化; 人类; 1:100
Buchler P, Gazdhar A, Schubert M, Giese N, Reber H, Hines O, et al. The Notch signaling pathway is related to neurovascular progression of pancreatic cancer. Ann Surg. 2005;242:791-800, discussion 800-1 pubmed
  • 免疫组化; 人类; 1:250
Morsczeck C, Gotz W, Schierholz J, Zeilhofer F, Kuhn U, Mohl C, et al. Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol. 2005;24:155-65 pubmed
  • 免疫组化; 人类; 1:200
  • 免疫印迹; 人类; 1:100
Purow B, Haque R, Noel M, Su Q, Burdick M, Lee J, et al. Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res. 2005;65:2353-63 pubmed
  • 抑制或激活实验; 小鼠
Sakamoto K, Chao W, Katsube K, Yamaguchi A. Distinct roles of EGF repeats for the Notch signaling system. Exp Cell Res. 2005;302:281-91 pubmed
Zhang P, Ishikawa M, Doyle A, Nakamura T, He B, Yamada Y. Pannexin 3 regulates skin development via Epiprofin. Sci Rep. 2021;11:1779 pubmed 出版商
Kim J, Han D, Byun S, Kwon M, Cho J, Pleasure S, et al. Ttyh1 regulates embryonic neural stem cell properties by enhancing the Notch signaling pathway. EMBO Rep. 2018;19: pubmed 出版商
Asano N, Watanabe T, Kitani A, Fuss I, Strober W. Notch1 signaling and regulatory T cell function. J Immunol. 2008;180:2796-804 pubmed
Cui X, Hu Q, Tekaya M, Shimoda Y, Ang B, Nie D, et al. NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes. J Biol Chem. 2004;279:25858-65 pubmed
产品信息
产品类型 :
抗体
产品名称 :
NOTCH1单克隆抗体(A6)
目录# :
MA5-11961
规格 :
500微升
定价 :
美国431
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类, 小鼠
应用 :
Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:20-1:200, Western Blot: 1:100-1:1,000
物种 :
人类, 小鼠
克隆 :
A6
抗体亚型 :
IgG2b
储存 :
4° C
描述 :
The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1, Notch2, Notch3 and Notch4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of Notch1. Mature Notch proteins are heterodimeric receptors derived from the cleavage of Notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).
免疫原 :
Recombinant protein encoding the ligand binding region of human Notch-1
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:20-1:200, Western Blot: 1:100-1:1,000
别名 :
9930111A19Rik; AOS5; AOVD1; Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila); hN1; lin-12; major type A protein; Mis6; Motch; Motch A; mT14; N1; neurogenic locus notch homolog protein 1; NEXT; NICD; NOTCH; notch 1; Notch 1 extracellular truncation; Notch 1 intracellular domain; Notch gene homolog 1; Notch homolog 1, translocation-associated; notch receptor 1; Notch1; p300; RP23-306D20.12; RP23-306D20.12-001; Tan1; Translocation-associated notch protein TAN-1; transmembrane receptor Notch1
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国