产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
XPF单克隆抗体(219)
目录 :
MA5-12054
规格 :
500微升
价格 :
美国437
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
219
反应物种 :
仓鼠, 人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 17
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:500; 图 8
Fu H, Martin M, Regairaz M, Huang L, You Y, Lin C, et al. The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage. Nat Commun. 2015;6:6746 pubmed 出版商
  • 免疫组化; 人类; 1:3000; 图 s3
Egloff A, Lee J, Langer C, Quon H, Vaezi A, Grandis J, et al. Phase II study of cetuximab in combination with cisplatin and radiation in unresectable, locally advanced head and neck squamous cell carcinoma: Eastern cooperative oncology group trial E3303. Clin Cancer Res. 2014;20:5041-51 pubmed 出版商
  • 免疫细胞化学; 人类
Godon C, Mourgues S, Nonnekens J, Mourcet A, Coin F, Vermeulen W, et al. Generation of DNA single-strand displacement by compromised nucleotide excision repair. EMBO J. 2012;31:3550-63 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
DeLoia J, Bhagwat N, Darcy K, Strange M, Tian C, Nuttall K, et al. Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum. Gynecol Oncol. 2012;126:448-54 pubmed 出版商
  • 免疫印迹; 仓鼠
Fisher L, Bessho M, Wakasugi M, Matsunaga T, Bessho T. Role of interaction of XPF with RPA in nucleotide excision repair. J Mol Biol. 2011;413:337-46 pubmed 出版商
  • 免疫细胞化学; 人类; 1:300
Rageul J, Frémin C, Ezan F, Baffet G, Langouet S. The knock-down of ERCC1 but not of XPF causes multinucleation. DNA Repair (Amst). 2011;10:978-90 pubmed 出版商
  • 免疫沉淀; 人类
Kim Y, Lach F, Desetty R, Hanenberg H, Auerbach A, Smogorzewska A. Mutations of the SLX4 gene in Fanconi anemia. Nat Genet. 2011;43:142-6 pubmed 出版商
  • 免疫印迹; 人类
Zhang Y, Regairaz M, Seiler J, Agama K, Doroshow J, Pommier Y. Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells. Nucleic Acids Res. 2011;39:3607-20 pubmed 出版商
  • 免疫印迹; 人类
Arora S, Kothandapani A, Tillison K, Kalman Maltese V, Patrick S. Downregulation of XPF-ERCC1 enhances cisplatin efficacy in cancer cells. DNA Repair (Amst). 2010;9:745-53 pubmed 出版商
  • 免疫沉淀; 人类; 1:1000
  • 免疫细胞化学; 人类; 1:1000
  • 免疫印迹; 人类
Bhagwat N, Roginskaya V, Acquafondata M, Dhir R, Wood R, Niedernhofer L. Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue. Cancer Res. 2009;69:6831-8 pubmed 出版商
  • 免疫沉淀; 人类
Wu Y, Mitchell T, Zhu X. Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms. Mech Ageing Dev. 2008;129:602-10 pubmed 出版商
  • 免疫印迹; 人类; 1:200
Rubio D, Garcia S, Paz M, de la Cueva T, Lopez Fernandez L, Lloyd A, et al. Molecular characterization of spontaneous mesenchymal stem cell transformation. PLoS ONE. 2008;3:e1398 pubmed 出版商
  • 免疫印迹; 人类
Fisher L, Bessho M, Bessho T. Processing of a psoralen DNA interstrand cross-link by XPF-ERCC1 complex in vitro. J Biol Chem. 2008;283:1275-81 pubmed
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Wu Y, Zacal N, Rainbow A, Zhu X. XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening. DNA Repair (Amst). 2007;6:157-66 pubmed
Panier S, Maric M, Hewitt G, Mason Osann E, Gali H, Dai A, et al. SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance. Mol Cell. 2019;76:27-43.e11 pubmed 出版商
Stoepker C, Hain K, Schuster B, Hilhorst Hofstee Y, Rooimans M, Steltenpool J, et al. SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. Nat Genet. 2011;43:138-41 pubmed 出版商
Ahmad A, Enzlin J, Bhagwat N, Wijgers N, Raams A, Appledoorn E, et al. Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients. PLoS Genet. 2010;6:e1000871 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
XPF单克隆抗体(219)
目录# :
MA5-12054
规格 :
500微升
定价 :
美国437
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:50-1:100
物种 :
人类
克隆 :
219
抗体亚型 :
IgG2, kappa
储存 :
4° C
描述 :
The structure specific ERCC 1 / XPF endonuclease complex is implicated in the repair of two distinct types of lesions in DNA: NER for UV induced lesions and bulky chemical adducts; and recombination repair of the very genotoxic interstrand cross links. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells, XPG cleaves 3' of the DNA lesion while the ERCC1 / XPF complex makes the 5' incision. ERCC1 / XPF probably plays a role in processing partially processed recombination intermediates.
免疫原 :
重组人类XPF蛋白
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:50-1:100
别名 :
AI606920; DNA excision repair protein ERCC-4; DNA repair endonuclease subunit; DNA repair endonuclease XPF; DNA repair protein complementing XP-F cells; ERCC excision repair 4, endonuclease catalytic subunit; ERCC11; ERCC4; Ercc4 protein-like; excision repair cross-complementation group 4; excision repair cross-complementing rodent repair deficiency, complementation group 4; excision-repair, complementing defective, in Chinese hamster; FANCQ; RAD1; RGD1560340; Xeroderma pigmentosum group F-complementing protein; xeroderma pigmentosum, complementation group F; XFEPS; XPF
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国