产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
XPF单克隆抗体(51)
目录 :
MA5-12060
规格 :
500微升
价格 :
美国422
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
51
反应物种 :
人类
应用 :
免疫印迹
更多信息或购买 :
文章摘录数: 10
| 参考文献 |
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Chalasani S, Kawale A, Akopiants K, Yu Y, Fanta M, Weinfeld M, et al. Persistent 3'-phosphate termini and increased cytotoxicity of radiomimetic DNA double-strand breaks in cells lacking polynucleotide kinase/phosphatase despite presence of an alternative 3'-phosphatase. DNA Repair (Amst). 2018;68:12-24 pubmed 出版商
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Mocquet V, Laine J, Riedl T, Yajin Z, Lee M, Egly J. Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step. EMBO J. 2008;27:155-67 pubmed
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Mogi S, Oh D. gamma-H2AX formation in response to interstrand crosslinks requires XPF in human cells. DNA Repair (Amst). 2006;5:731-40 pubmed
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Coin F, Auriol J, Tapias A, Clivio P, Vermeulen W, Egly J. Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity. EMBO J. 2004;23:4835-46 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
XPF单克隆抗体(51)
目录# :
MA5-12060
规格 :
500微升
定价 :
美国422
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类
应用 :
ChIP assay: 1.5 µg/10^6 cells, Western Blot: 1-3 µg/mL
物种 :
人类
克隆 :
51
抗体亚型 :
IgG2b, kappa
储存 :
4° C
描述 :
The structure specific ERCC 1 / XPF endonuclease complex is implicated in the repair of two distinct types of lesions in DNA: NER for UV induced lesions and bulky chemical adducts; and recombination repair of the very genotoxic interstrand cross links. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells, XPG cleaves 3' of the DNA lesion while the ERCC1 / XPF complex makes the 5' incision. ERCC1 / XPF probably plays a role in processing partially processed recombination intermediates.
免疫原 :
重组人类XPF蛋白
格式 :
液体
应用w/稀释 :
ChIP assay: 1.5 µg/10^6 cells, Western Blot: 1-3 µg/mL
别名 :
AI606920; DNA excision repair protein ERCC-4; DNA repair endonuclease subunit; DNA repair endonuclease XPF; DNA repair protein complementing XP-F cells; ERCC excision repair 4, endonuclease catalytic subunit; ERCC11; ERCC4; Ercc4 protein-like; excision repair cross-complementation group 4; excision repair cross-complementing rodent repair deficiency, complementation group 4; excision-repair, complementing defective, in Chinese hamster; FANCQ; RAD1; RGD1560340; Xeroderma pigmentosum group F-complementing protein; xeroderma pigmentosum, complementation group F; XFEPS; XPF
更多信息或购买 :
公司信息
赛默飞世尔