c Myc单克隆抗体(9E10.3) | 赛默飞世尔 MA5-12080 产品信息

产品简要

公司名称 :

赛默飞世尔

其他品牌 :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

产品类型 :

抗体

产品名称 :

c Myc单克隆抗体(9E10.3)

MA5-12080

规格 :

500微升

价格 :

美国400

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

未共轭

克隆名称 :

9E10.3

反应物种 :

人类

应用 :

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片

更多信息或购买 :

赛默飞世尔产品网页

文章摘录数: 55

参考文献
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Macia M, Halbritter J, Delous M, Bredrup C, Gutter A, Filhol E, et al. Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronophthisis. Am J Hum Genet. 2017;100:323-333 pubmed 出版商
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Unger C, Popescu R, Giessrigl B, Laimer D, Heider S, Seelinger M, et al. The dichloromethane extract of the ethnomedicinal plant Neurolaena lobata inhibits NPM/ALK expression which is causal for anaplastic large cell lymphomagenesis. Int J Oncol. 2013;42:338-48 pubmed 出版商
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Giaginis C, Politi E, Alexandrou P, Sfiniadakis J, Kouraklis G, Theocharis S. Expression of peroxisome proliferator activated receptor-gamma (PPAR-?) in human non-small cell lung carcinoma: correlation with clinicopathological parameters, proliferation and apoptosis related molecules and patients' survival. Pathol Oncol Res. 2012;18:875-83 pubmed
Huang Y, Chiang N, Hu C, Hsiao C, Cheng K, Tsai W, et al. Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains. Mol Cell Biol. 2012;32:1408-20 pubmed 出版商
Lanham K, Prasch A, Weina K, Peterson R, Heideman W. A dominant negative zebrafish Ahr2 partially protects developing zebrafish from dioxin toxicity. PLoS ONE. 2011;6:e28020 pubmed 出版商
Challagundla K, Sun X, Zhang X, Devine T, Zhang Q, Sears R, et al. Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress. Mol Cell Biol. 2011;31:4007-21 pubmed 出版商
Genovese N, Broker T, Chow L. Nonconserved lysine residues attenuate the biological function of the low-risk human papillomavirus E7 protein. J Virol. 2011;85:5546-54 pubmed 出版商
Li N, Wang J, Shen S, Bu X, Tian X, Huang P. Expression of p53, Ki-67 and c-Myc proteins is predictive of the surgical molecular margin in colorectal carcinoma. Pathol Oncol Res. 2011;17:479-87 pubmed 出版商
Faucherre A, Lopez Schier H. Delaying Gal4-driven gene expression in the zebrafish with morpholinos and Gal80. PLoS ONE. 2011;6:e16587 pubmed 出版商
Huber P, Zhao W. Detection of protein-RNA complexes in Xenopus oocytes. Methods. 2010;51:82-6 pubmed 出版商
Vo N, Madlener S, Bago Horvath Z, Herbacek I, Stark N, Gridling M, et al. Pro- and anticarcinogenic mechanisms of piceatannol are activated dose dependently in MCF-7 breast cancer cells. Carcinogenesis. 2010;31:2074-81 pubmed 出版商
Calcagno D, Guimarães A, Leal M, Seabra A, Khayat A, Pontes T, et al. MYC insertions in diffuse-type gastric adenocarcinoma. Anticancer Res. 2009;29:2479-83 pubmed
Yang L, Shen L, Shao Y, Zhao Q, Zhang W. Cytoplasmic domain of human Fcalpha/mu receptor is required for ligand internalization. Cell Immunol. 2009;258:78-82 pubmed 出版商
Katzenellenbogen R, Vliet Gregg P, Xu M, Galloway D. NFX1-123 increases hTERT expression and telomerase activity posttranscriptionally in human papillomavirus type 16 E6 keratinocytes. J Virol. 2009;83:6446-56 pubmed 出版商
Altintas S, Lambein K, Huizing M, Braems G, Asjoe F, Hellemans H, et al. Prognostic significance of oncogenic markers in ductal carcinoma in situ of the breast: a clinicopathologic study. Breast J. 2009;15:120-32 pubmed 出版商
Pridgeon J, Webber E, Sha D, Li L, Chin L. Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes. FEBS J. 2009;276:118-31 pubmed 出版商
Kong D, Song S, Kim D, Joo K, Yoo J, Koh J, et al. Prognostic significance of c-Met expression in glioblastomas. Cancer. 2009;115:140-8 pubmed 出版商
de Haas T, Hasselt N, Troost D, Caron H, Popovic M, Zadravec Zaletel L, et al. Molecular risk stratification of medulloblastoma patients based on immunohistochemical analysis of MYC, LDHB, and CCNB1 expression. Clin Cancer Res. 2008;14:4154-60 pubmed 出版商
Itahana K, Zhang Y. Mitochondrial p32 is a critical mediator of ARF-induced apoptosis. Cancer Cell. 2008;13:542-53 pubmed 出版商
Fan Y, Wong L, Ding J, Spiridonov N, Johnson R, Johnson G. Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism. J Biol Chem. 2008;283:1588-96 pubmed
Olzmann J, Li L, Chudaev M, Chen J, Perez F, Palmiter R, et al. Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J Cell Biol. 2007;178:1025-38 pubmed
Miettinen P, Ustinov J, Ormio P, Gao R, Palgi J, Hakonen E, et al. Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth. Diabetes. 2006;55:3299-308 pubmed
Fokkema E, Timens W, de Vries E, de Jong S, Fidler V, Meijer C, et al. Expression and prognostic implications of apoptosis-related proteins in locally unresectable non-small cell lung cancers. Lung Cancer. 2006;52:241-7 pubmed
Kilianova Z, Basora N, Kilian P, Payet M, Gallo Payet N. Human melanocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization. Endocrinology. 2006;147:2325-37 pubmed
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Väisänen M, Väisänen T, Tu H, Pirilä P, Sormunen R, Pihlajaniemi T. The shed ectodomain of type XIII collagen associates with the fibrillar fibronectin matrix and may interfere with its assembly in vitro. Biochem J. 2006;393:43-50 pubmed
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Talukder A, Gururaj A, Mishra S, Vadlamudi R, Kumar R. Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator. Mol Cell Biol. 2004;24:6581-91 pubmed
Bennasroune A, Fickova M, Gardin A, Dirrig Grosch S, Aunis D, Cremel G, et al. Transmembrane peptides as inhibitors of ErbB receptor signaling. Mol Biol Cell. 2004;15:3464-74 pubmed
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Bruno M, West R, Schneeman T, Bresnick E, Kaetzel C. Upstream stimulatory factor but not c-Myc enhances transcription of the human polymeric immunoglobulin receptor gene. Mol Immunol. 2004;40:695-708 pubmed
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Kefas B, Cai Y, Ling Z, Heimberg H, Hue L, Pipeleers D, et al. AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase. J Mol Endocrinol. 2003;30:151-61 pubmed
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Castoria G, Migliaccio A, Bilancio A, Di Domenico M, de Falco A, Lombardi M, et al. PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells. EMBO J. 2001;20:6050-9 pubmed
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Chavand O, Spilsbury K, Rakoczy P. Addition of a c-myc epitope tag within the VEGF protein does not affect in vitro biological activity. Biochem Cell Biol. 2001;79:107-12 pubmed
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图像

图像 1 :

图像 2 :

产品信息

产品类型 :

抗体

产品名称 :

c Myc单克隆抗体(9E10.3)

目录# :

MA5-12080

规格 :

500微升

定价 :

美国400

克隆性 :

单克隆

纯度 :

蛋白质G

宿主 :

小鼠

反应物种 :

人类

应用 :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:25-1:50, Immunomicroscopy: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:50-1:200

物种 :

人类

克隆 :

9E10.3

抗体亚型 :

IgG1, kappa

储存 :

4° C

描述 :

The c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in tumor development, which distributes blood throughout the cells. The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation, and the deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins. c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to the immunoglobulin loci on chromosome 14 (heavy chain); 2 (delta light chain); or 22 (light chain) is described in Burkitts lymphoma and other B-cell lymphoproliferative conditions. An aberrant expression of the c-myc gene occurs in tumors of different origins such as colorectal, gastric, gallbladder, hepatic, mammary, ovarian, endometrial, head and neck, pulmonary, prostatic, thyroidal, oral, ocular, nasopharyngeal, endocrine, as well as hematopoietic neoplasms.

免疫原 :

A合成肽, 氨基酸408-439,(AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA)来自C末端人的c Myc

格式 :

液体

应用w/稀释 :

别名 :

AU016757; Avian myelocytomatosis viral (v-myc) oncogene homolog; avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; class E basic helix-loop-helix protein 39; cmyc; c-Myc; c-myc epitope tag; c-myc proto-oncogene; mMyc; MRTL; Myc; Myc protein; Myc proto-oncogene protein; MYC proto-oncogene, bHLH transcription factor; Myc2; MYCC; myc-related translation/localization regulatory factor; myelocytomatosis oncogene; myelocytomatosis viral oncogene homolog; Niard; Nird; Proto-oncogene c-Myc; RNCMYC; Transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene-like protein

更多信息或购买 :

赛默飞世尔产品网页

公司信息

赛默飞世尔

上海浦东新金桥路27号7号楼

analyze.cn@thermofisher.com

http://www.thermo.com.cn

1084193588

公司总部: 美国