产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
细胞角蛋白18单克隆抗体(DC10), 生物素
目录 :
MA5-12101
规格 :
500微升
价格 :
美国425
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
生物素
克隆名称 :
DC10
反应物种 :
African green monkey, 人类, 小鼠, 猕猴
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 25
出版应用/物种/样本/稀释参考文献
  • 免疫沉淀; 人类
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Kuga T, Kume H, Kawasaki N, Sato M, Adachi J, Shiromizu T, et al. A novel mechanism of keratin cytoskeleton organization through casein kinase I? and FAM83H in colorectal cancer. J Cell Sci. 2013;126:4721-31 pubmed 出版商
  • 免疫沉淀; 人类
Snider N, Leonard J, Kwan R, Griggs N, Rui L, Omary M. Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. J Cell Biol. 2013;200:241-7 pubmed 出版商
  • 免疫组化; 人类; 1:200
Marian C, Boilă A, Soanca D, Malau M, Podeanu D, Resetkova E, et al. Malignant transformation of adenomyoepithelioma of the breast by a monophasic population: a report of two cases and review of literature. APMIS. 2013;121:272-9 pubmed 出版商
  • 免疫组化; 人类; 1:500
Szponar A, Kovacs G. Expression of KRT7 and WT1 differentiates precursor lesions of Wilms' tumours from those of papillary renal cell tumours and mucinous tubular and spindle cell carcinomas. Virchows Arch. 2012;460:423-7 pubmed 出版商
  • 免疫印迹; 小鼠
Singla A, Moons D, Snider N, Wagenmaker E, Jayasundera V, Omary M. Oxidative stress, Nrf2 and keratin up-regulation associate with Mallory-Denk body formation in mouse erythropoietic protoporphyria. Hepatology. 2012;56:322-31 pubmed 出版商
  • 免疫沉淀; 小鼠
  • 免疫细胞化学; 小鼠; 1:200
  • 免疫印迹; 小鼠
Snider N, Weerasinghe S, INIGUEZ LLUHI J, Herrmann H, Omary M. Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation. J Biol Chem. 2011;286:2273-84 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Ku N, Toivola D, Strnad P, Omary M. Cytoskeletal keratin glycosylation protects epithelial tissue from injury. Nat Cell Biol. 2010;12:876-85 pubmed 出版商
  • 免疫组化; 人类; 1:500
Robertson F, Ogasawara M, Ye Z, Chu K, Pickei R, Debeb B, et al. Imaging and analysis of 3D tumor spheroids enriched for a cancer stem cell phenotype. J Biomol Screen. 2010;15:820-9 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Yalcin Ozuysal O, Fiche M, Guitierrez M, Wagner K, Raffoul W, Brisken C. Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates. Cell Death Differ. 2010;17:1600-12 pubmed 出版商
  • 免疫组化; African green monkey
Wood C, Kaplan J, Fontenot M, Williams J, Cline J. Endometrial profile of tamoxifen and low-dose estradiol combination therapy. Clin Cancer Res. 2010;16:946-56 pubmed 出版商
  • 流式细胞仪; 人类
Metallo C, Ji L, de Pablo J, Palecek S. Directed differentiation of human embryonic stem cells to epidermal progenitors. Methods Mol Biol. 2010;585:83-92 pubmed 出版商
  • 免疫印迹; 人类; 1:200
Chang C, Chiou P, Chen W, Li Y, Yiu J, Cheng Y, et al. Assessment of the tumorigenesis and drug susceptibility of three new canine mammary tumor cell lines. Res Vet Sci. 2010;88:285-93 pubmed 出版商
  • 免疫组化; 人类
Yu G, Goodloe S, D Angelis C, McGrath B, Chen F. Giant clear cell hidradenoma of the knee. J Cutan Pathol. 2010;37:e37-41 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
Røsland G, Svendsen A, Torsvik A, Sobala E, McCormack E, Immervoll H, et al. Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. Cancer Res. 2009;69:5331-9 pubmed 出版商
  • 酶联免疫吸附测定; 人类; 10 ug/ml
Tao G, Li D, Zhou Q, Toivola D, Strnad P, Sandesara N, et al. Monitoring of epithelial cell caspase activation via detection of durable keratin fragment formation. J Pathol. 2008;215:164-74 pubmed 出版商
  • 免疫组化; 猕猴; 1:100
Wood C, Hester J, Cline J. Mammary gland development in early pubertal female macaques. Toxicol Pathol. 2007;35:795-805 pubmed
  • 免疫印迹; 人类
Tao G, Strnad P, Zhou Q, Kamal A, Zhang L, Madani N, et al. Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease. Clin Gastroenterol Hepatol. 2007;5:857-64 pubmed
  • 免疫组化; 人类
Gurbuz Y, Kose N, Aydin O, Ozturk M. An immunohistochemical profile of giant cell carcinoma of the larynx. Auris Nasus Larynx. 2007;34:413-6 pubmed
  • 免疫印迹; 人类
Tao G, Toivola D, Zhou Q, Strnad P, Xu B, Michie S, et al. Protein phosphatase-2A associates with and dephosphorylates keratin 8 after hyposmotic stress in a site- and cell-specific manner. J Cell Sci. 2006;119:1425-32 pubmed
  • 免疫组化; 人类
Tao G, Nakamichi I, Ku N, Wang J, Frolkis M, Gong X, et al. Bispecific and human disease-related anti-keratin rabbit monoclonal antibodies. Exp Cell Res. 2006;312:411-22 pubmed
Ku N, Toivola D, Zhou Q, Tao G, Zhong B, Omary M. Studying simple epithelial keratins in cells and tissues. Methods Cell Biol. 2004;78:489-517 pubmed
Toivola D, Ku N, Resurreccion E, Nelson D, Wright T, Omary M. Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease. Hepatology. 2004;40:459-66 pubmed
Apaydin R, Gurbuz Y, Bayramgurler D, Muezzinoglu B, Bilen N. Cytokeratin expression in lichen amyloidosus and macular amyloidosis. J Eur Acad Dermatol Venereol. 2004;18:305-9 pubmed
Ku N, Soetikno R, Omary M. Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury. Hepatology. 2003;37:1006-14 pubmed
Ku N, Gish R, Wright T, Omary M. Keratin 8 mutations in patients with cryptogenic liver disease. N Engl J Med. 2001;344:1580-7 pubmed
图像
图像 1 :
赛默飞世尔 MA5-12101 图像 1
Formalin-fixed, paraffin-embedded human breast cancer stained with Keratin 18 antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.
图像 2 :
赛默飞世尔 MA5-12101 图像 2
产品信息
产品类型 :
抗体
产品名称 :
细胞角蛋白18单克隆抗体(DC10), 生物素
目录# :
MA5-12101
规格 :
500微升
定价 :
美国425
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunohistochemistry (Paraffin): 1-2 µg/mL, Western Blot: 1-2 µg/mL
物种 :
人类
克隆 :
DC10
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18. Further, cytokeratin 18 is found primarily in non-squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas. Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for the cytokeratin 18 gene. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
免疫原 :
Human breast cancer PMC 42 cells
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1-2 µg/mL, Western Blot: 1-2 µg/mL
别名 :
cb83; Cell proliferation-inducing gene 46 protein; CK 18; CK18; CK-18; CYK18; cytokeratin 18; cytokeratin endo B; cytokeratin type -1; DAPK-1; Cytokeratin18; cytokeratin-18; dapk1; dorsal aorta proneprin kinesin-1; DreK18; Endo B; I79_023185; K 18; K18; keratin 18; keratin 18, type I; keratin 18a, tandem duplicate 1; keratin complex 1, acidic, gene 18; keratin D; Keratin, type I cytoskeletal 18; Keratin18; keratin-18; Kerd; KRT 18; Krt1-18; KRT18; krt18 {ECO:0000250; krt18a.1; LOC100008885; PIG46; sb:cb83; type I cytoskeletal 18; UniProtKB:P05783}; wu:fa13f02; wu:fb36b04
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国