产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
细胞角蛋白HMW单克隆抗体(34BetaE12)
目录 :
MA5-12135
规格 :
500微升
价格 :
美国431
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
34betaE12
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 16
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类; 1:100; 表 2
Hsieh M, Wang H, Lee Y, Ko J, Chang Y. Reevaluation of MAML2 fusion-negative mucoepidermoid carcinoma: a subgroup being actually hyalinizing clear cell carcinoma of the salivary gland with EWSR1 translocation. Hum Pathol. 2017;61:9-18 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50
Sajin M, Luchian M, Hodorogea Prisăcaru A, Dumitru A, Pătraşcu O, Costache D, et al. Trichilemmal carcinoma - a rare cutaneous malignancy: report of two cases. Rom J Morphol Embryol. 2014;55:687-91 pubmed
  • 免疫组化; 人类
Stefanovic D, Stefanovic M, Nikin Z. Romanowsky-Giemsa as a counterstain for immunohistochemistry: optimizing a traditional reagent. Biotech Histochem. 2013;88:329-35 pubmed 出版商
  • 免疫组化; 人类; 1:50
Marian C, Boilă A, Soanca D, Malau M, Podeanu D, Resetkova E, et al. Malignant transformation of adenomyoepithelioma of the breast by a monophasic population: a report of two cases and review of literature. APMIS. 2013;121:272-9 pubmed 出版商
  • 免疫组化; 人类
Yang S, Sun R, Liang J, Zhou Z, Zhou J, Rui J. Sinonasal teratocarcinosarcoma: a clinical and pathological analysis. Int J Surg Pathol. 2013;21:37-43 pubmed 出版商
  • 免疫组化; 人类; 1:30
Bolzoni Villaret A, Barbieri D, Peretti G, Schreiber A, Fisogni S, Lonardi S, et al. Angiogenesis and lymphangiogenesis in early-stage laryngeal carcinoma: Prognostic implications. Head Neck. 2013;35:1132-7 pubmed 出版商
  • 免疫组化; 人类; 1:100
Lin J, Lu C, Lin W, Wu Y, Huang Y, Shih F, et al. A clinicopathological study of the significance of the proportion of choroid morphology in chordoid meningioma. J Clin Neurosci. 2012;19:836-43 pubmed 出版商
  • 免疫组化; 人类; 1:100
Tao Y, Chai D, Ma L, Zhang T, Feng Z, Cheng Z, et al. Identification of distinct gene expression profiles between esophageal squamous cell carcinoma and adjacent normal epithelial tissues. Tohoku J Exp Med. 2012;226:301-11 pubmed
  • 免疫组化; 人类; 1:100
Lehmusvaara S, Erkkilä T, Urbanucci A, Waltering K, Seppälä J, Larjo A, et al. Chemical castration and anti-androgens induce differential gene expression in prostate cancer. J Pathol. 2012;227:336-45 pubmed 出版商
  • 免疫组化; 人类; 1:100
Lin J, Wu Y, Chang I. The prognostic impact of O6-methylguanine DNA methyltransferase and epidermal growth factor receptor expressions on primary gliosarcoma: a clinicopathologic and immunohistochemical study of seven cases at a single institution. Indian J Pathol Microbiol. 2011;54:683-7 pubmed 出版商
  • 免疫组化; 人类; 1:100
Tolonen T, Kujala P, Laurila M, Tirkkonen M, Ilvesaro J, Tuominen V, et al. Routine dual-color immunostaining with a 3-antibody cocktail improves the detection of small cancers in prostate needle biopsies. Hum Pathol. 2011;42:1635-42 pubmed 出版商
  • 免疫组化; 人类; 1:100
Chen H, Wu Y, Lin Y, Lin J. Clear cell meningioma with frequent chordoid features and aggressive behavior: a clinicopathologic study of ten cases at a single institution. J Neurooncol. 2011;103:551-9 pubmed 出版商
  • 免疫组化; 人类; 1:100
Lin J, Ho J, Lin Y, Wu Y. Chordoid meningioma: a clinicopathologic study of 11 cases at a single institution. J Neurooncol. 2010;100:465-73 pubmed 出版商
  • 免疫组化; 人类; 1:50
Midi A, Tecimer T, Bozkurt S, Ozkan N. Differences in the structural features of atypical adenomatous hyperplasia and low-grade prostatic adenocarcinoma. Indian J Urol. 2008;24:169-77 pubmed
Gornalusse G, Valdez R, Fenkart G, Vojtech L, Fleming L, Pandey U, et al. Mechanisms of Endogenous HIV-1 Reactivation by Endocervical Epithelial Cells. J Virol. 2020;94: pubmed 出版商
Wang W, Bergh A, Damber J. Chronic inflammation in benign prostate hyperplasia is associated with focal upregulation of cyclooxygenase-2, Bcl-2, and cell proliferation in the glandular epithelium. Prostate. 2004;61:60-72 pubmed
图像
图像 1 :
赛默飞世尔 MA5-12135 图像 1
Formalin-fixed, paraffin-embedded human breast cancer stained with Keratin HMW antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.
产品信息
产品类型 :
抗体
产品名称 :
细胞角蛋白HMW单克隆抗体(34BetaE12)
目录# :
MA5-12135
规格 :
500微升
定价 :
美国431
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunocytochemistry: 1:250, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:1,000-1:10,000
物种 :
人类
克隆 :
34BetaE12
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Keratins are heteropolymeric structural proteins that form the intermediate filament. Cytokeratins are intermediate filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue. There are two types of cytokeratins – the low weight, acidic type I and the high weight, basic type II. Cytokeratins are usually found in pairs – one type I and one type II. KRT1 regulates the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase I (RACK1). In complex with C1QBP it is a high affinity receptor for kininogen-1/HMWK. KRT1 is expressed in the spinous and granular layers of the epidermis with family member KRT10. Mutations affecting the gene result in bullous congenital ichthyosiform erythroderma. KRT5 is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations affecting the gene result in epidermolysis bullosa simplex diseases. KRT10 plays a role in the establishment of the epidermal barrier on plantar skin. It also acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB – thus it plays a role in nasal colonization. Mutations affecting the gene result in epidermolytic hyperkeratosis. KRT14’s nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. Mutations affecting the gene result in epidermolysis bullosa simplex.
免疫原 :
Solubilized keratin extracted from human stratum corneum
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:250, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:1,000-1:10,000
别名 :
58 kda cytokeratin; 67 kDa cytokeratin; BCIE; BIE; CK1; CK-1; CK10; CK-10; CK14; CK-14; CK-2P; CK5; CK-5; cytokeratin 1; cytokeratin 10; cytokeratin 14; cytokeratin 2; cytokeratin-1; Cytokeratin-10; Cytokeratin-14; cytokeratin-2P; Cytokeratin-5; DDD; DDD1; EBS2; EBS3; EBS4; EHK; EHK1; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolytic hyperkeratosis 1; EPPK; hair alpha protein; HUMCYT2A; K1; K10; K14; K2P; K5; K76; keratin 1; keratin 1, type II; keratin 10; keratin 10, type I; keratin 14; keratin 14, type I; keratin 2p; keratin 5; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 76; keratin 76, type II; keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 14; keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 2 oral; keratin, type II cytoskeletal 5; Keratin-1; Keratin-10; keratin-14; Keratin-5; Keratin-76; KPP; KRT1; KRT10; KRT14; KRT1A; KRT2B; KRT2P; KRT5; KRT5A; KRT76; KRTA; NEPPK; NFJ; Type-II keratin Kb1; type-II keratin Kb5; Type-II keratin Kb9
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国