产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
TIMP2单克隆抗体(3A4), 生物素
目录 :
MA5-12204
规格 :
500微升
价格 :
美国399.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
生物素
克隆名称 :
3A4
反应物种 :
豚鼠, 人类, 小鼠, 大鼠, 牛, domestic rabbit
应用 :
免疫印迹, 免疫组化, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 37
出版应用/物种/样本/稀释 | 参考文献 |
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| Fernández Guinea O, Alvarez Cofiño A, Eiró N, Gonzalez L, del Casar J, Fernandez Garcia B, et al. Low microvascular density at the tumor center is related to the expression of metalloproteases and their inhibitors and with the occurrence of distant metastasis in breast carcinomas. Int J Clin Oncol. 2013;18:629-40 pubmed 出版商
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| Ucar E, Borazan A, Semerci E, Binici D, Yaldiz M, Aysal A, et al. The effects of interferon alpha2b on chemically-induced peritoneal fibrosis and on peritoneal tissue MMP-2 and TIMP-2 levels in rats. J Int Med Res. 2010;38:187-94 pubmed
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| Gonzalez L, Gonzalez Reyes S, Junquera S, Marin L, Gonzalez L, del Casar J, et al. Expression of metalloproteases and their inhibitors by tumor and stromal cells in ductal carcinoma in situ of the breast and their relationship with microinvasive events. J Cancer Res Clin Oncol. 2010;136:1313-21 pubmed 出版商
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| Yilmaz B, Sucak A, Kilic S, Aksakal O, Aksoy Y, Lortlar N, et al. Metformin regresses endometriotic implants in rats by improving implant levels of superoxide dismutase, vascular endothelial growth factor, tissue inhibitor of metalloproteinase-2, and matrix metalloproteinase-9. Am J Obstet Gynecol. 2010;202:368.e1-8 pubmed 出版商
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| del Casar J, Gonzalez L, Alvarez E, Junquera S, Marin L, Gonzalez L, et al. Comparative analysis and clinical value of the expression of metalloproteases and their inhibitors by intratumor stromal fibroblasts and those at the invasive front of breast carcinomas. Breast Cancer Res Treat. 2009;116:39-52 pubmed 出版商
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| Brun J, Cortez A, Commo F, Uzan S, Rouzier R, Darai E. Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2. Int J Oncol. 2008;33:1239-46 pubmed
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| Yang M, Huang H, Li J, Huang W, Wang H. Connective tissue growth factor increases matrix metalloproteinase-2 and suppresses tissue inhibitor of matrix metalloproteinase-2 production by cultured renal interstitial fibroblasts. Wound Repair Regen. 2007;15:817-24 pubmed
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| Gonzalez L, Pidal I, Junquera S, Corte M, Vazquez J, Rodriguez J, et al. Overexpression of matrix metalloproteinases and their inhibitors in mononuclear inflammatory cells in breast cancer correlates with metastasis-relapse. Br J Cancer. 2007;97:957-63 pubmed
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| Aupperle H, Garbade J, Schubert A, Barten M, Dhein S, Schoon H, et al. Effects of autologous stem cells on immunohistochemical patterns and gene expression of metalloproteinases and their tissue inhibitors in doxorubicin cardiomyopathy in a rabbit model. Vet Pathol. 2007;44:494-503 pubmed
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| Vizoso F, Gonzalez L, Corte M, Rodriguez J, Vazquez J, Lamelas M, et al. Study of matrix metalloproteinases and their inhibitors in breast cancer. Br J Cancer. 2007;96:903-11 pubmed
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| Unsal Kilic D, Uner A, Akyurek N, Erpolat P, Dursun A, Pak Y. Matrix metalloproteinase-9 expression correlated with tumor response in patients with locally advanced rectal cancer undergoing preoperative chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2007;67:196-203 pubmed
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| Rönkkö S, Rekonen P, Kaarniranta K, Puustjarvi T, Teräsvirta M, Uusitalo H. Matrix metalloproteinases and their inhibitors in the chamber angle of normal eyes and patients with primary open-angle glaucoma and exfoliation glaucoma. Graefes Arch Clin Exp Ophthalmol. 2007;245:697-704 pubmed
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| Zhang X, Bo X, Anderson P, Lieberman A, Zhang Y. Distribution and expression of tissue inhibitors of metalloproteinase in dorsal root entry zone and dorsal column after dorsal root injury. J Neurosci Res. 2006;84:278-90 pubmed
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| Masumoto K, de Rooij J, Suita S, Rottier R, Tibboel D, de Krijger R. The distribution of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the lungs of congenital diaphragmatic hernia patients and age-matched controls. Histopathology. 2006;48:588-95 pubmed
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| Sier C, Zuidwijk K, Zijlmans H, Hanemaaijer R, Mulder Stapel A, Prins F, et al. EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma. Int J Cancer. 2006;118:2991-8 pubmed
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| Masumoto K, de Rooij J, Suita S, Rottier R, Tibboel D, de Krijger R. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases during normal human pulmonary development. Histopathology. 2005;47:410-9 pubmed
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Chlenski A, Liu S, Cohn S. The regulation of angiogenesis in neuroblastoma. Cancer Lett. 2003;197:47-52 pubmed
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Gavin P, Crawford S, Shulman S, Garcia F, Rowley A. Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease. Arterioscler Thromb Vasc Biol. 2003;23:576-81 pubmed
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Hashimoto T, Wen G, Lawton M, Boudreau N, Bollen A, Yang G, et al. Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations. Stroke. 2003;34:925-31 pubmed
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图像
图像 1 :
Formalin-fixed, paraffin-embedded human pancreatic tumor stained with TIMP-2 antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.
图像 2 :
产品信息
产品类型 :
抗体
产品名称 :
TIMP2单克隆抗体(3A4), 生物素
目录# :
MA5-12204
规格 :
500微升
价格 :
美国399.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
牛, 豚鼠, 人类, 小鼠, 兔, 大鼠
应用 :
Immunohistochemistry (Paraffin): 1:200, Western Blot: 1-2 µg/mL
物种 :
牛, 豚鼠, 人类, 小鼠, 兔, 大鼠
克隆 :
3A4
抗体亚型 :
IgG2a, kappa
储存 :
4° C
描述 :
TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
免疫原 :
A合成肽来自N末端区域,人的金属蛋白酶组织抑制剂-2蛋白
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1:200, Western Blot: 1-2 µg/mL
别名 :
Collagenase inhibitor; CSC-21K; D11Bwg1104e; DDC8; etID32613.12; fa96h09; Metalloproteinase inhibitor 2; metalloproteinase inhibitor 2a; metalloproteinase inhibitor precursor; metalloproteinase inhibitor TIMP-2; metalloproteinase-2; similar to metalloproteinase inhibitor; testicular secretory protein Li 57; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP metallopeptidase inhibitor 2a; TIMP2; Timp-2; TIMP-2 protein; timp2a; tissue inhibitor of matrix metalloproteinase-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinase 2 precursor; tissue inhibitor of metalloproteinase 2a; tissue inhibitor of metalloproteinase-2; tissue inhibitor of metalloproteinase-2 precursor; tissue inhibitor of metalloproteinases 2; tissue inhibitor of mettaloproteinase 2; wu:fa96h09; zgc:136726
更多信息或购买 :
公司信息
赛默飞世尔