产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
TIMP2单克隆抗体(3A4), 生物素
目录 :
MA5-12204
规格 :
500微升
价格 :
美国399.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
生物素
克隆名称 :
3A4
反应物种 :
豚鼠, 人类, 小鼠, 大鼠, , domestic rabbit
应用 :
免疫印迹, 免疫组化, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 37
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 人类; 1:50
Suárez Roa M, Asbun Bojalil J, Ruiz Godoy L, Meneses García A. Immunoexpression of matrix metalloproteinases and their inhibitors in different areas of oral squamous cell carcinoma. Aust Dent J. 2012;57:300-7 pubmed 出版商
  • 免疫组化; 人类; 1:50
Fernández Guinea O, Alvarez Cofiño A, Eiró N, Gonzalez L, del Casar J, Fernandez Garcia B, et al. Low microvascular density at the tumor center is related to the expression of metalloproteases and their inhibitors and with the occurrence of distant metastasis in breast carcinomas. Int J Clin Oncol. 2013;18:629-40 pubmed 出版商
  • 免疫印迹; 大鼠; 2 ug/ml
Liu C, Wang G, Chen G, Mu Y, Zhang L, Hu X, et al. Huangqi decoction inhibits apoptosis and fibrosis, but promotes Kupffer cell activation in dimethylnitrosamine-induced rat liver fibrosis. BMC Complement Altern Med. 2012;12:51 pubmed 出版商
  • 免疫组化; domestic rabbit
Song M, Shen H, Cui J, Zhou X, Zhong X, Peng C, et al. A novel model of intimal hyperplasia with graded hypoosmotic damage. Cardiovasc Pathol. 2012;21:490-8 pubmed 出版商
  • 免疫组化; 人类
Dimo B, Ioannidis I, Karameris A, Vilaras G, Tzoumakari P, Nonni A, et al. Comparative study of the immunohistochemical expression of tissue inhibitors of metalloproteinases 1 and 2 between clearly invasive carcinomas and "in situ" trophoblast invasion. Med Oncol. 2012;29:2270-5 pubmed 出版商
  • 免疫组化; 人类
Lee S, Park S, Kim S, Choi E. Expression of matrix metalloproteinases and their inhibitors in squamous cell carcinoma of the tonsil and their clinical significance. Clin Exp Otorhinolaryngol. 2011;4:88-94 pubmed 出版商
  • 免疫组化; 牛; 1:100
Moreira L, de Carvalho E, Caldas Bussiere M. Differential immunohistochemical expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in cow uteri with adenomyosis during follicular phase. Vet Res Commun. 2011;35:261-9 pubmed 出版商
  • 免疫组化; 人类; 1:200
Wu Y, Wang P, Tsai A, Yang S, Chen S. Semi-quantitative expression of tissue inhibitor of matrix metalloproteinase-2 in cancer of uterine cervix. J Surg Oncol. 2011;104:210-5 pubmed 出版商
  • 免疫组化; 人类; 1:200
Wang P, Ko J, Yang S, Tsai H, Tee Y, Han C, et al. Significant relation of tissue inhibitor of matrix metalloproteinase-2 and its combination with matrix metalloproteinase-2 to survival of patients with cancer of uterine cervix. Reprod Sci. 2011;18:798-808 pubmed 出版商
  • 免疫印迹; 人类; 1:200
Liu L, Sun L, Zhao P, Yao L, Jin H, Liang S, et al. Hypoxia promotes metastasis in human gastric cancer by up-regulating the 67-kDa laminin receptor. Cancer Sci. 2010;101:1653-60 pubmed 出版商
  • 免疫组化; 人类; 1:50
Gonzalez L, Junquera S, del Casar J, Gonzalez L, Marín L, Gonzalez Reyes S, et al. Immunohistochemical study of matrix metalloproteinases and their inhibitors in pure and mixed invasive and in situ ductal carcinomas of the breast. Hum Pathol. 2010;41:980-9 pubmed 出版商
  • 免疫组化; 大鼠; 1:100
Ucar E, Borazan A, Semerci E, Binici D, Yaldiz M, Aysal A, et al. The effects of interferon alpha2b on chemically-induced peritoneal fibrosis and on peritoneal tissue MMP-2 and TIMP-2 levels in rats. J Int Med Res. 2010;38:187-94 pubmed
  • 免疫组化; 人类; 1:50
Escaff S, Fernandez J, Gonzalez L, Suarez A, Gonzalez Reyes S, Gonzalez J, et al. Study of matrix metalloproteinases and their inhibitors in prostate cancer. Br J Cancer. 2010;102:922-9 pubmed 出版商
  • 免疫组化; 人类; 1:50
Gonzalez L, Gonzalez Reyes S, Junquera S, Marin L, Gonzalez L, del Casar J, et al. Expression of metalloproteases and their inhibitors by tumor and stromal cells in ductal carcinoma in situ of the breast and their relationship with microinvasive events. J Cancer Res Clin Oncol. 2010;136:1313-21 pubmed 出版商
  • 免疫组化; 大鼠; 1:200
Yilmaz B, Ozat M, Kilic S, Gungor T, Aksoy Y, Lordlar N, et al. Atorvastatin causes regression of endometriotic implants in a rat model. Reprod Biomed Online. 2010;20:291-9 pubmed 出版商
  • 免疫组化; 人类; 1:50
del Casar J, Carreño G, Gonzalez L, Junquera S, Gonzalez Reyes S, Gonzalez J, et al. Expression of metalloproteases and their inhibitors in primary tumors and in local recurrences after mastectomy for breast cancer. J Cancer Res Clin Oncol. 2010;136:1049-58 pubmed 出版商
  • 免疫组化; 大鼠; 1:200
Yilmaz B, Sucak A, Kilic S, Aksakal O, Aksoy Y, Lortlar N, et al. Metformin regresses endometriotic implants in rats by improving implant levels of superoxide dismutase, vascular endothelial growth factor, tissue inhibitor of metalloproteinase-2, and matrix metalloproteinase-9. Am J Obstet Gynecol. 2010;202:368.e1-8 pubmed 出版商
  • 免疫组化; 人类; 1:50
Nam E, Lee S, Im S, Kim D, Lee K, Sung S. Expression of cyclooxygenase-2 in human breast cancer: relationship with HER-2/neu and other clinicopathological prognostic factors. Cancer Res Treat. 2005;37:165-70 pubmed 出版商
  • 免疫组化; 人类; 1:50
del Casar J, Gonzalez Reyes S, Gonzalez L, Gonzalez J, Junquera S, Bongera M, et al. Expression of metalloproteases and their inhibitors in different histological types of breast cancer. J Cancer Res Clin Oncol. 2010;136:811-9 pubmed 出版商
  • 免疫组化; 人类; 1:50
del Casar J, Gonzalez L, Alvarez E, Junquera S, Marin L, Gonzalez L, et al. Comparative analysis and clinical value of the expression of metalloproteases and their inhibitors by intratumor stromal fibroblasts and those at the invasive front of breast carcinomas. Breast Cancer Res Treat. 2009;116:39-52 pubmed 出版商
  • 免疫组化; 小鼠; 1:250
Zion O, Genin O, Kawada N, Yoshizato K, Roffe S, Nagler A, et al. Inhibition of transforming growth factor beta signaling by halofuginone as a modality for pancreas fibrosis prevention. Pancreas. 2009;38:427-35 pubmed 出版商
  • 免疫组化; 人类; 4.0 ug/ml
Brun J, Galant C, Delvaux D, Lemoine P, Henriet P, Courtoy P, et al. Menstrual activity of matrix metalloproteinases is decreased in endometrium regenerating after thermal ablation. Hum Reprod. 2009;24:333-40 pubmed 出版商
  • 免疫组化; 人类
Brun J, Cortez A, Commo F, Uzan S, Rouzier R, Darai E. Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2. Int J Oncol. 2008;33:1239-46 pubmed
  • 免疫组化; 人类
Unsal D, Akyurek N, Uner A, Erpolat O, Han U, Akmansu M, et al. Gelatinase B expression as a prognostic factor in patients with stage II/III rectal carcinoma treated by postoperative adjuvant therapy. Am J Clin Oncol. 2008;31:55-63 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Yang M, Huang H, Li J, Huang W, Wang H. Connective tissue growth factor increases matrix metalloproteinase-2 and suppresses tissue inhibitor of matrix metalloproteinase-2 production by cultured renal interstitial fibroblasts. Wound Repair Regen. 2007;15:817-24 pubmed
  • 免疫组化; 人类; 1:50
Gonzalez L, Pidal I, Junquera S, Corte M, Vazquez J, Rodriguez J, et al. Overexpression of matrix metalloproteinases and their inhibitors in mononuclear inflammatory cells in breast cancer correlates with metastasis-relapse. Br J Cancer. 2007;97:957-63 pubmed
  • 免疫组化; domestic rabbit
Aupperle H, Garbade J, Schubert A, Barten M, Dhein S, Schoon H, et al. Effects of autologous stem cells on immunohistochemical patterns and gene expression of metalloproteinases and their tissue inhibitors in doxorubicin cardiomyopathy in a rabbit model. Vet Pathol. 2007;44:494-503 pubmed
  • 免疫组化; 人类; 1:50
Vizoso F, Gonzalez L, Corte M, Rodriguez J, Vazquez J, Lamelas M, et al. Study of matrix metalloproteinases and their inhibitors in breast cancer. Br J Cancer. 2007;96:903-11 pubmed
  • 免疫组化; 人类
Unsal Kilic D, Uner A, Akyurek N, Erpolat P, Dursun A, Pak Y. Matrix metalloproteinase-9 expression correlated with tumor response in patients with locally advanced rectal cancer undergoing preoperative chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2007;67:196-203 pubmed
  • 免疫组化; 人类; 1:100
Rönkkö S, Rekonen P, Kaarniranta K, Puustjarvi T, Teräsvirta M, Uusitalo H. Matrix metalloproteinases and their inhibitors in the chamber angle of normal eyes and patients with primary open-angle glaucoma and exfoliation glaucoma. Graefes Arch Clin Exp Ophthalmol. 2007;245:697-704 pubmed
  • 免疫组化; 人类; 1:200
Zhang X, Bo X, Anderson P, Lieberman A, Zhang Y. Distribution and expression of tissue inhibitors of metalloproteinase in dorsal root entry zone and dorsal column after dorsal root injury. J Neurosci Res. 2006;84:278-90 pubmed
  • 免疫组化; 人类; 1:75
Masumoto K, de Rooij J, Suita S, Rottier R, Tibboel D, de Krijger R. The distribution of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the lungs of congenital diaphragmatic hernia patients and age-matched controls. Histopathology. 2006;48:588-95 pubmed
  • 免疫组化; 人类; 1:400
Sier C, Zuidwijk K, Zijlmans H, Hanemaaijer R, Mulder Stapel A, Prins F, et al. EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma. Int J Cancer. 2006;118:2991-8 pubmed
  • 免疫组化; 人类; 1:75
Masumoto K, de Rooij J, Suita S, Rottier R, Tibboel D, de Krijger R. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases during normal human pulmonary development. Histopathology. 2005;47:410-9 pubmed
Chlenski A, Liu S, Cohn S. The regulation of angiogenesis in neuroblastoma. Cancer Lett. 2003;197:47-52 pubmed
Gavin P, Crawford S, Shulman S, Garcia F, Rowley A. Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease. Arterioscler Thromb Vasc Biol. 2003;23:576-81 pubmed
Hashimoto T, Wen G, Lawton M, Boudreau N, Bollen A, Yang G, et al. Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations. Stroke. 2003;34:925-31 pubmed
图像
图像 1 :
赛默飞世尔 MA5-12204 图像 1
Formalin-fixed, paraffin-embedded human pancreatic tumor stained with TIMP-2 antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.
图像 2 :
赛默飞世尔 MA5-12204 图像 2
产品信息
产品类型 :
抗体
产品名称 :
TIMP2单克隆抗体(3A4), 生物素
目录# :
MA5-12204
规格 :
500微升
价格 :
美国399.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
牛, 豚鼠, 人类, 小鼠, 兔, 大鼠
应用 :
Immunohistochemistry (Paraffin): 1:200, Western Blot: 1-2 µg/mL
物种 :
牛, 豚鼠, 人类, 小鼠, 兔, 大鼠
克隆 :
3A4
抗体亚型 :
IgG2a, kappa
储存 :
4° C
描述 :
TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
免疫原 :
A合成肽来自N末端区域,人的金属蛋白酶组织抑制剂-2蛋白
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1:200, Western Blot: 1-2 µg/mL
别名 :
Collagenase inhibitor; CSC-21K; D11Bwg1104e; DDC8; etID32613.12; fa96h09; Metalloproteinase inhibitor 2; metalloproteinase inhibitor 2a; metalloproteinase inhibitor precursor; metalloproteinase inhibitor TIMP-2; metalloproteinase-2; similar to metalloproteinase inhibitor; testicular secretory protein Li 57; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP metallopeptidase inhibitor 2a; TIMP2; Timp-2; TIMP-2 protein; timp2a; tissue inhibitor of matrix metalloproteinase-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinase 2 precursor; tissue inhibitor of metalloproteinase 2a; tissue inhibitor of metalloproteinase-2; tissue inhibitor of metalloproteinase-2 precursor; tissue inhibitor of metalloproteinases 2; tissue inhibitor of mettaloproteinase 2; wu:fa96h09; zgc:136726
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国