产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Pds1单克隆抗体(DCS-280)
目录 :
MA5-12252
规格 :
500微升
价格 :
美国413.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
DCS-280
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 11
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
| |
| |
| |
| |
| |
| Kim D, Franklyn J, Smith V, Stratford A, Pemberton H, Warfield A, et al. Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity. Carcinogenesis. 2007;28:749-59 pubmed
|
| Huang X, Hatcher R, York J, Zhang P. Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells. Mol Biol Cell. 2005;16:4725-32 pubmed
|
| Huang X, Tran T, Zhang L, Hatcher R, Zhang P. DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint. Proc Natl Acad Sci U S A. 2005;102:1065-70 pubmed
|
Hernando E, Nahle Z, Juan G, Diaz Rodriguez E, Alaminos M, Hemann M, et al. Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature. 2004;430:797-802 pubmed
| |
Michel L, Diaz Rodriguez E, Narayan G, Hernando E, Murty V, Benezra R. Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells. Proc Natl Acad Sci U S A. 2004;101:4459-64 pubmed
|
图像
图像 1 :
Formalin-fixed, paraffin-embedded human tonsil stained with Pds1 antibody using peroxidase-conjugate and AEC chromogen. Note nuclear staining of lympocytes in germinal center.
产品信息
产品类型 :
抗体
产品名称 :
Pds1单克隆抗体(DCS-280)
目录# :
MA5-12252
规格 :
500微升
价格 :
美国413.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类, 小鼠
应用 :
Immunohistochemistry (Paraffin): 1:100-200, Western Blot: 1-3 µg/mL
物种 :
人类, 小鼠
克隆 :
DCS-280
抗体亚型 :
IgG2a, kappa
储存 :
4° C
描述 :
Pds1 is an anaphase inhibitor and plays important role in DNA damage and spindle check point pathways. Pds1 inhibits sister chromatid separation by binding and inhibiting Esp1, cystein protease that causes cleavage of the cohesin Scc1 that binds the sister chromatids together. Pds1 is responsible for targeting of Esp1 to nucleus and its binding to the spindle. Degradation of Pds1 occurs shortly before anaphase, which liberates Esp1 and is a prerequisite for anaphase entry. Pds1 is targeted for degradation by ubiquitination mediated by cyclosome/anaphase-promoting complex (APC) functioning as a ubiquitin ligase. In response to DNA damage Chk1 phosphorylates Pds1 to stabilize it against the APC mediated destruction, hence preventing the entry of such a cell into anaphase.
免疫原 :
人类重组全长Pds1蛋白
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1:100-200, Western Blot: 1-3 µg/mL
别名 :
AL033362; C11orf43; GRDF; Igf2; Igf-2; IGF-II; insulin like growth factor 2; insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; insulin-like growth factor type 2; M6pr; Mpr; multiplication-stimulating polypeptide; Peg2; PP1446; PP9974; preptin; somatomedin A; Somatomedin-A; T3M-11-derived growth factor
更多信息或购买 :
公司信息
赛默飞世尔