产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸酶张力蛋白同源基因单克隆抗体(17.A)
目录 :
MA5-12278
规格 :
500微升
价格 :
美国406.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
17.A
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 24
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 人类; 图 3c
Oktay Y, Ãœlgen E, Can Ã, Akyerli C, Yüksel Å, Erdemgil Y, et al. IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation. Sci Rep. 2016;6:27569 pubmed 出版商
  • 免疫组化; 人类; 1:50; 表 4
Lu B, Chen Q, Zhang X, Cheng L. Serous carcinoma arising from uterine adenomyosis/adenomyotic cyst of the cervical stump: a report of 3 cases. Diagn Pathol. 2016;11:46 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 表 1
Castillo Martin M, Thin T, Collazo Lorduy A, Cordon Cardo C. Immunopathologic Assessment of PTEN Expression. Methods Mol Biol. 2016;1388:23-37 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 表 1
Siddiqui S, Akhter N, Deo S, Shukla N, Husain S. A study on promoter methylation of PTEN in sporadic breast cancer patients from North India. Breast Cancer. 2016;23:922-931 pubmed
  • 免疫组化; 人类; 表 2
Eritja N, Santacana M, Maiques O, González Tallada X, Dolcet X, Matias Guiu X. Modeling glands with PTEN deficient cells and microscopic methods for assessing PTEN loss: endometrial cancer as a model. Methods. 2015;77-78:31-40 pubmed 出版商
  • 免疫组化; 人类; 1:250
Cejas P, Lopez Gomez M, Aguayo C, Madero R, Moreno Rubio J, de Castro Carpeno J, et al. Analysis of the concordance in the EGFR pathway status between primary tumors and related metastases of colorectal cancer patients:implications for cancer therapy. Curr Cancer Drug Targets. 2012;12:124-31 pubmed
  • 免疫组化-石蜡切片; 人类; 1:20
Jung Y, Joo K, Seong D, Choi Y, Kong D, Kim Y, et al. Identification of prognostic biomarkers for glioblastomas using protein expression profiling. Int J Oncol. 2012;40:1122-32 pubmed 出版商
  • 免疫组化; 人类; 1:50
Skirnisdottir I, Seidal T. Prognostic impact of concomitant p53 and PTEN on outcome in early stage (FIGO I-II) epithelial ovarian cancer. Int J Gynecol Cancer. 2011;21:1024-31 pubmed 出版商
  • 免疫组化; 人类; 1:25
Teng H, Wang H, Chen W, Chao T, Hsieh Y, Hsih C, et al. Prevalence and prognostic influence of genomic changes of EGFR pathway markers in synovial sarcoma. J Surg Oncol. 2011;103:773-81 pubmed 出版商
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Wang L, Liu Y, Yan Lu S, Nguyen K, Schroer S, Suzuki A, et al. Deletion of Pten in pancreatic ß-cells protects against deficient ß-cell mass and function in mouse models of type 2 diabetes. Diabetes. 2010;59:3117-26 pubmed 出版商
  • 免疫印迹; 小鼠
Santanam U, Zanesi N, Efanov A, Costinean S, Palamarchuk A, Hagan J, et al. Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression. Proc Natl Acad Sci U S A. 2010;107:12210-5 pubmed 出版商
  • 免疫组化; 人类
Sawaki M, Iwata H, Sato Y, Wada M, Toyama T, Sasaki E, et al. Phase II study of preoperative systemic treatment with the combination of docetaxel and trastuzumab in patients with locally advanced HER-2-overexpressing breast cancer. Breast. 2010;19:370-6 pubmed 出版商
  • 免疫组化; 人类; 1:50
Li H, Zhu R, Wang L, Zhu T, Li Q, Chen Q, et al. PIK3CA mutations mostly begin to develop in ductal carcinoma of the breast. Exp Mol Pathol. 2010;88:150-5 pubmed 出版商
  • 免疫组化; 人类; 1:20
Gazzola A, Bertuzzi C, Agostinelli C, Righi S, Pileri S, Piccaluga P. Physiological PTEN expression in peripheral T-cell lymphoma not otherwise specified. Haematologica. 2009;94:1036-7 pubmed 出版商
  • 免疫组化; 人类
Tokyol C, Aktepe F, Hüsniye Dilek F, Yilmazer M. Comparison of placental PTEN and beta1 integrin expression in early spontaneous abortion, early and late normal pregnancy. Ups J Med Sci. 2008;113:235-42 pubmed
  • 免疫组化; 人类; 1:100
Volante M, Saviozzi S, Rapa I, Ceppi P, Cappia S, Calogero R, et al. Epidermal growth factor ligand/receptor loop and downstream signaling activation pattern in completely resected nonsmall cell lung cancer. Cancer. 2007;110:1321-8 pubmed
  • 免疫组化; 人类; 1:40
Pérez Tenorio G, Alkhori L, Olsson B, Waltersson M, Nordenskjold B, Rutqvist L, et al. PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer. Clin Cancer Res. 2007;13:3577-84 pubmed
  • 免疫组化; 人类; 1:50
Kapucuoglu N, Aktepe F, Kaya H, Bircan S, Karahan N, Ciris M. Immunohistochemical expression of PTEN in normal, hyperplastic and malignant endometrium and its correlation with hormone receptors, bcl-2, bax, and apoptotic index. Pathol Res Pract. 2007;203:153-62 pubmed
  • 免疫组化; 人类; 1:50
Osman I, Dai J, Mikhail M, Navarro D, Taneja S, Lee P, et al. Loss of neutral endopeptidase and activation of protein kinase B (Akt) is associated with prostate cancer progression. Cancer. 2006;107:2628-36 pubmed
  • 免疫组化; 人类; 1:150
Kolasa I, Rembiszewska A, Janiec Jankowska A, Dansonka Mieszkowska A, Lewandowska A, Konopka B, et al. PTEN mutation, expression and LOH at its locus in ovarian carcinomas. Relation to TP53, K-RAS and BRCA1 mutations. Gynecol Oncol. 2006;103:692-7 pubmed
  • 免疫组化; 人类
Deng H, Wu R, Zhou H, Huang X, Chen Y, Liu L. Significance of Survivin and PTEN expression in full lymph node-examined gastric cancer. World J Gastroenterol. 2006;12:1013-7 pubmed
  • 免疫组化; 人类; 1:200
Wang Y, Kristensen G, Helland A, Nesland J, Børresen Dale A, Holm R. Protein expression and prognostic value of genes in the erb-b signaling pathway in advanced ovarian carcinomas. Am J Clin Pathol. 2005;124:392-401 pubmed
Panigrahi A, Pinder S, Chan S, Paish E, Robertson J, Ellis I. The role of PTEN and its signalling pathways, including AKT, in breast cancer; an assessment of relationships with other prognostic factors and with outcome. J Pathol. 2004;204:93-100 pubmed
Maia H, Maltez A, Studart E, Athayde C, Coutinho E. Proliferation kinetics in adenomyosis during the menstrual cycle and during oral contraceptive use. Gynecol Endocrinol. 2004;18:101-6 pubmed
产品信息
产品类型 :
抗体
产品名称 :
磷酸酶张力蛋白同源基因单克隆抗体(17.A)
目录# :
MA5-12278
规格 :
500微升
价格 :
美国406.00
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
人类, 小鼠
应用 :
Immunocytochemistry: 1:1-1:100, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:10-1:100
物种 :
人类, 小鼠
克隆 :
17.A
抗体亚型 :
IgM, kappa
储存 :
4° C
描述 :
PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The PTEN gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. PTEN negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. PTEN plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Also, PTEN may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form of PTEN induces less tumor suppressive ability.
免疫原 :
重组人类磷酸酶张力蛋白同源基因蛋白
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:1-1:100, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:10-1:100
别名 :
10q23del; 2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; BZS; CWS1; DEC; GLM2; homolog of human mutated in multiple advanced cancers; MHAM; mitochondrial phosphatase and tensin protein alpha; mitochondrial PTENalpha; Mmac; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; phosphatase and tensin homolog (mutated in multiple advanced cancers 1); phosphatase and tensin homolog deleted on chromosome ten; phosphatase and tensin-like protein; phosphatidylinositol 3; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase and tensin-like protein; PTEN; pten tumor suppressor; PTEN1; TEP1
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国