产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸酶张力蛋白同源基因单克隆抗体(17.A)
目录 :
MA5-12278
规格 :
500微升
价格 :
美国406.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
17.A
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 24
出版应用/物种/样本/稀释 | 参考文献 |
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| Siddiqui S, Akhter N, Deo S, Shukla N, Husain S. A study on promoter methylation of PTEN in sporadic breast cancer patients from North India. Breast Cancer. 2016;23:922-931 pubmed
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| Cejas P, Lopez Gomez M, Aguayo C, Madero R, Moreno Rubio J, de Castro Carpeno J, et al. Analysis of the concordance in the EGFR pathway status between primary tumors and related metastases of colorectal cancer patients:implications for cancer therapy. Curr Cancer Drug Targets. 2012;12:124-31 pubmed
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| Tokyol C, Aktepe F, Hüsniye Dilek F, Yilmazer M. Comparison of placental PTEN and beta1 integrin expression in early spontaneous abortion, early and late normal pregnancy. Ups J Med Sci. 2008;113:235-42 pubmed
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| Volante M, Saviozzi S, Rapa I, Ceppi P, Cappia S, Calogero R, et al. Epidermal growth factor ligand/receptor loop and downstream signaling activation pattern in completely resected nonsmall cell lung cancer. Cancer. 2007;110:1321-8 pubmed
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| Pérez Tenorio G, Alkhori L, Olsson B, Waltersson M, Nordenskjold B, Rutqvist L, et al. PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer. Clin Cancer Res. 2007;13:3577-84 pubmed
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| Kapucuoglu N, Aktepe F, Kaya H, Bircan S, Karahan N, Ciris M. Immunohistochemical expression of PTEN in normal, hyperplastic and malignant endometrium and its correlation with hormone receptors, bcl-2, bax, and apoptotic index. Pathol Res Pract. 2007;203:153-62 pubmed
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| Osman I, Dai J, Mikhail M, Navarro D, Taneja S, Lee P, et al. Loss of neutral endopeptidase and activation of protein kinase B (Akt) is associated with prostate cancer progression. Cancer. 2006;107:2628-36 pubmed
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| Kolasa I, Rembiszewska A, Janiec Jankowska A, Dansonka Mieszkowska A, Lewandowska A, Konopka B, et al. PTEN mutation, expression and LOH at its locus in ovarian carcinomas. Relation to TP53, K-RAS and BRCA1 mutations. Gynecol Oncol. 2006;103:692-7 pubmed
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| Deng H, Wu R, Zhou H, Huang X, Chen Y, Liu L. Significance of Survivin and PTEN expression in full lymph node-examined gastric cancer. World J Gastroenterol. 2006;12:1013-7 pubmed
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| Wang Y, Kristensen G, Helland A, Nesland J, Børresen Dale A, Holm R. Protein expression and prognostic value of genes in the erb-b signaling pathway in advanced ovarian carcinomas. Am J Clin Pathol. 2005;124:392-401 pubmed
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Panigrahi A, Pinder S, Chan S, Paish E, Robertson J, Ellis I. The role of PTEN and its signalling pathways, including AKT, in breast cancer; an assessment of relationships with other prognostic factors and with outcome. J Pathol. 2004;204:93-100 pubmed
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Maia H, Maltez A, Studart E, Athayde C, Coutinho E. Proliferation kinetics in adenomyosis during the menstrual cycle and during oral contraceptive use. Gynecol Endocrinol. 2004;18:101-6 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
磷酸酶张力蛋白同源基因单克隆抗体(17.A)
目录# :
MA5-12278
规格 :
500微升
价格 :
美国406.00
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
人类, 小鼠
应用 :
Immunocytochemistry: 1:1-1:100, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:10-1:100
物种 :
人类, 小鼠
克隆 :
17.A
抗体亚型 :
IgM, kappa
储存 :
4° C
描述 :
PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The PTEN gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. PTEN negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. PTEN plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Also, PTEN may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form of PTEN induces less tumor suppressive ability.
免疫原 :
重组人类磷酸酶张力蛋白同源基因蛋白
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:1-1:100, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:10-1:100
别名 :
10q23del; 2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; BZS; CWS1; DEC; GLM2; homolog of human mutated in multiple advanced cancers; MHAM; mitochondrial phosphatase and tensin protein alpha; mitochondrial PTENalpha; Mmac; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; phosphatase and tensin homolog (mutated in multiple advanced cancers 1); phosphatase and tensin homolog deleted on chromosome ten; phosphatase and tensin-like protein; phosphatidylinositol 3; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase and tensin-like protein; PTEN; pten tumor suppressor; PTEN1; TEP1
更多信息或购买 :
公司信息
赛默飞世尔