产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD44单克隆抗体(5F12)
目录 :
MA5-12394
规格 :
500微升
价格 :
美国358.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
5F12
反应物种 :
人类, 小鼠
应用 :
免疫细胞化学, 流式细胞仪, 抑制或激活实验
更多信息或购买 :
文章摘录数: 24
出版应用/物种/样本/稀释参考文献
  • 抑制或激活实验; 人类
Horvatinovich J, Grogan E, Norris M, Steinkasserer A, Lemos H, Mellor A, et al. Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14+ Monocytes. J Immunol. 2017;198:2286-2301 pubmed 出版商
  • 抑制或激活实验; 人类; 图 2e
Secundino I, Lizcano A, Roupé K, Wang X, Cole J, Olson J, et al. Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation. J Mol Med (Berl). 2016;94:219-33 pubmed 出版商
  • 抑制或激活实验; 人类
Hayashi T, Unno A, Baba M, Ohno T, Kitoh K, Takashima Y. CD44 mediated hyaluronan adhesion of Toxoplasma gondii-infected leukocytes. Parasitol Int. 2014;63:479-84 pubmed 出版商
  • 抑制或激活实验; 人类; 20 ug/ml
Wu S, Chen C, Chang J, Fu Y, Wang C, Eswaramoorthy R, et al. Hyaluronan initiates chondrogenesis mainly via CD44 in human adipose-derived stem cells. J Appl Physiol (1985). 2013;114:1610-8 pubmed 出版商
  • 流式细胞仪; 人类; 1:50
Zhao J, Gao Z, Mei H, Li Y, Wang Y. Differentiation of human mesenchymal stem cells: the potential mechanism for estrogen-induced preferential osteoblast versus adipocyte differentiation. Am J Med Sci. 2011;341:460-8 pubmed 出版商
  • 抑制或激活实验; 人类; 50 ug/ml
Hashizume M, Mihara M. High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1. Biochem Biophys Res Commun. 2010;403:184-9 pubmed 出版商
  • 流式细胞仪; 人类
Rodgers A, Nair A, Binkley P, TEKMAL R, Schenken R. Inhibition of CD44 N- and O-linked glycosylation decreases endometrial cell lines attachment to peritoneal mesothelial cells. Fertil Steril. 2011;95:823-5 pubmed 出版商
  • 抑制或激活实验; 小鼠; 5 ug/ml
Funayama K, Saito Kurimoto Y, Ebihara Y, Shimane M, Nomura H, Tsuji K, et al. Adhesion-mediated self-renewal abilities of Ph+ blastoma cells. Biochem Biophys Res Commun. 2010;396:193-8 pubmed 出版商
  • 抑制或激活实验; 人类; 5 ug/ml
  • 免疫细胞化学; 人类; 1:100
Funayama K, Shimane M, Nomura H, Asano S. An evidence for adhesion-mediated acquisition of acute myeloid leukemic stem cell-like immaturities. Biochem Biophys Res Commun. 2010;392:271-6 pubmed 出版商
  • 流式细胞仪; 人类
  • 免疫细胞化学; 人类; 1:50
Yamawaki H, Hirohata S, Miyoshi T, Takahashi K, Ogawa H, Shinohata R, et al. Hyaluronan receptors involved in cytokine induction in monocytes. Glycobiology. 2009;19:83-92 pubmed 出版商
  • 流式细胞仪; 人类
Pellizzaro C, Speranza A, Zorzet S, Crucil I, Sava G, Scarlata I, et al. Inhibition of human pancreatic cell line MIA PaCa2 proliferation by HA-But, a hyaluronic butyric ester: a preliminary report. Pancreas. 2008;36:e15-23 pubmed 出版商
  • 抑制或激活实验; 人类; 20 ug/ml
Wang C, Lin Y, Chiang B, Lin Y, Hou S. High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis. Osteoarthritis Cartilage. 2006;14:1237-47 pubmed
  • 流式细胞仪; 人类
He X, Li Y, Wang X, Guo X, Niu Y. [Mesenchymal stem cells transduced by PLEGFP-N1 retroviral vector maintain their biological features and differentiation]. Chin Med J (Engl). 2005;118:1728-34 pubmed
  • 抑制或激活实验; 人类
Tanaka M, Masuko Hongo K, Kato T, Nishioka K, Nakamura H. Suppressive effects of hyaluronan on MMP-1 and RANTES production from chondrocytes. Rheumatol Int. 2006;26:185-90 pubmed
Dorandish S, Devos J, Clegg B, Price D, Muterspaugh R, Guthrie J, et al. Biochemical determinants of the IGFBP-3-hyaluronan interaction. FEBS Open Bio. 2020;10:1668-1684 pubmed 出版商
Price D, Muterspaugh R, Clegg B, Williams A, Stephens A, Guthrie J, et al. IGFBP-3 Blocks Hyaluronan-CD44 Signaling, Leading to Increased Acetylcholinesterase Levels in A549 Cell Media and Apoptosis in a p53-Dependent Manner. Sci Rep. 2020;10:5083 pubmed 出版商
Ferreira S, Motwani M, Faull P, Seymour A, Yu T, Enayati M, et al. Bi-directional cell-pericellular matrix interactions direct stem cell fate. Nat Commun. 2018;9:4049 pubmed 出版商
Ferreira S, Faull P, Seymour A, Yu T, Loaiza S, Auner H, et al. Neighboring cells override 3D hydrogel matrix cues to drive human MSC quiescence. Biomaterials. 2018;176:13-23 pubmed 出版商
Guo J, Hsu H, Tyan S, Li F, Shew J, Lee W, et al. Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner. Oncogene. 2017;36:2457-2471 pubmed 出版商
O Brien S, Chen L, Zhong W, Armellino D, Yu J, Loreth C, et al. Breast cancer cells respond differentially to modulation of TGFβ2 signaling after exposure to chemotherapy or hypoxia. Cancer Res. 2015;75:4605-16 pubmed 出版商
Liang J, Jiang D, Jung Y, Xie T, Ingram J, Church T, et al. Role of hyaluronan and hyaluronan-binding proteins in human asthma. J Allergy Clin Immunol. 2011;128:403-411.e3 pubmed 出版商
Coradini D, Zorzet S, Rossin R, Scarlata I, Pellizzaro C, Turrin C, et al. Inhibition of hepatocellular carcinomas in vitro and hepatic metastases in vivo in mice by the histone deacetylase inhibitor HA-But. Clin Cancer Res. 2004;10:4822-30 pubmed
Coradini D, Pellizzaro C, Abolafio G, Bosco M, Scarlata I, Cantoni S, et al. Hyaluronic-acid butyric esters as promising antineoplastic agents in human lung carcinoma: a preclinical study. Invest New Drugs. 2004;22:207-17 pubmed
Esnault S, Malter J. Hyaluronic acid or TNF-alpha plus fibronectin triggers granulocyte macrophage-colony-stimulating factor mRNA stabilization in eosinophils yet engages differential intracellular pathways and mRNA binding proteins. J Immunol. 2003;171:6780-7 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CD44单克隆抗体(5F12)
目录# :
MA5-12394
规格 :
500微升
价格 :
美国358.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: Assay-dependent, Immunocytochemistry: 10 µg/mL
物种 :
人类
克隆 :
5F12
抗体亚型 :
IgG1
储存 :
4° C
描述 :
CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.
免疫原 :
EBV transformed normal human B-lymphocytes
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-dependent, Immunocytochemistry: 10 µg/mL
别名 :
AU023126; AW121933; AW146109; Bovine CD44; CD44; CD44 antigen; CD44 antigen-like protein; CD44 molecule; CD44 molecule (Indian blood group); CD44 protein; CD44 variant; CD44A; CD44-like protein; CDW44; cell surface glycoprotein CD44; Cell surface glycoprotein CD44 (hyaluronate binding protein); cell-surface glycoprotein; chondroitin sulfate proteoglycan 8; CSPG8; ECMRIII; ECMR-III; Epican; extracellular matrix receptor III; extracellular matrix receptor-III; GP90 lymphocyte homing/adhesion receptor; HCELL; hematopoietic cell E- and L-selectin ligand; heparan sulfate proteoglycan; HERMES; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronan receptor; Hyaluronate receptor; IN; LHR; Ly-24; lymphocyte antigen 24; lymphocyte surface antigen precursor CD44; MC56; MDU2; MDU3; METAA; MIC4; PGP I; Pgp1; PGP-1; PGPI; PGP-I; Phagocytic glycoprotein 1; phagocytic glycoprotein I; putative Bos taurus CD44; RHAMM; sCD 44; sCD44; soluble CD 44; soluble CD44
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国