产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
p53单克隆抗体(多克隆抗体122)
目录 :
MA5-12453
规格 :
500微升
价格 :
美国425.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
多克隆抗体122
反应物种 :
中国人仓鼠, 人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 11
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 大鼠; 1:1000; 图 11
  • 免疫印迹; 大鼠; 图 s6
Lin S, Gou G, Hsia C, Ho C, Huang K, Wu Y, et al. Simulated Microgravity Disrupts Cytoskeleton Organization and Increases Apoptosis of Rat Neural Crest Stem Cells Via Upregulating CXCR4 Expression and RhoA-ROCK1-p38 MAPK-p53 Signaling. Stem Cells Dev. 2016;25:1172-93 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Tanaka T, Okada M, Hozumi Y, Tachibana K, Kitanaka C, Hamamoto Y, et al. Cytoplasmic localization of DGK? exerts a protective effect against p53-mediated cytotoxicity. J Cell Sci. 2013;126:2785-97 pubmed 出版商
  • 免疫印迹; 人类
Cai B, Hsu P, Hsin I, Chao C, Lu M, Lin H, et al. p53 acts as a co-repressor to regulate keratin 14 expression during epidermal cell differentiation. PLoS ONE. 2012;7:e41742 pubmed 出版商
  • 免疫印迹; 小鼠
Kasper J, Arai T, DeCaprio J. A novel p53-binding domain in CUL7. Biochem Biophys Res Commun. 2006;348:132-8 pubmed
  • 免疫沉淀; 人类
Borger D, DeCaprio J. Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53. J Virol. 2006;80:4292-303 pubmed
  • 免疫沉淀; 小鼠
di Masi A, Antoccia A, Dimauro I, Argentino Storino A, Mosiello A, Mango R, et al. Gene expression and apoptosis induction in p53-heterozygous irradiated mice. Mutat Res. 2006;594:49-62 pubmed
Paredes J, Ji P, Lacomb J, Shroyer K, Martello L, Williams J. Establishment of three novel cell lines derived from African American patients with colorectal carcinoma: A unique tool for assessing racial health disparity. Int J Oncol. 2018;53:1516-1528 pubmed 出版商
Liu F, Ma F, Wang Y, Hao L, Zeng H, Jia C, et al. PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis. Nat Cell Biol. 2017;19:1358-1370 pubmed 出版商
Truksa J, Kovar J, Valenta T, Ehrlichova M, Polak J, Naumann P. Iron deprivation induces apoptosis independently of p53 in human and murine tumour cells. Cell Prolif. 2003;36:199-213 pubmed
Ratovitski E, Patturajan M, Hibi K, Trink B, Yamaguchi K, Sidransky D. p53 associates with and targets Delta Np63 into a protein degradation pathway. Proc Natl Acad Sci U S A. 2001;98:1817-22 pubmed
Venkatachalam S, Shi Y, Jones S, Vogel H, Bradley A, Pinkel D, et al. Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. EMBO J. 1998;17:4657-67 pubmed
图像
图像 1 :
赛默飞世尔 MA5-12453 图像 1
产品信息
产品类型 :
抗体
产品名称 :
p53单克隆抗体(多克隆抗体122)
目录# :
MA5-12453
规格 :
500微升
价格 :
美国425.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
Hamster, Human, Mouse, Non-human primate, Rat
应用 :
Immunohistochemistry (Paraffin): 1:20, Immunoprecipitation: 2 µg/mL, Western Blot: 2-4 µg/mL
物种 :
Hamster, Human, Mouse, Non-human primate, Rat
克隆 :
多克隆抗体122
抗体亚型 :
IgG2b, kappa
储存 :
4° C
描述 :
The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization. p53 has been characterized to play a role in blocking the proliferative action of damaged cells and act as an anticancer agent. Phosphorylation of Ser392 in p53 has been shown to associate with the formation of human tumors. In addition, p53 has also been linked to the effects of aging and oxidative stress and an increase in p53 has been linked to deficits in LTP (Long Term Potentiation) in learning and memory. p53 is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families such as Li-Fraumeni syndrome.
免疫原 :
SV40-transformed mouse B4 cells
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1:20, Immunoprecipitation: 2 µg/mL, Western Blot: 2-4 µg/mL
别名 :
Antigen NY-CO-13; bbl; BCC7; bfy; bhy; cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; p53; p53 cellular tumor antigen; p53 protein; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; Trp53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国