产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Perforin Monoclonal Antibody (5B10)
目录 :
MA5-12469
规格 :
500微升
价格 :
美国456.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
5B10
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 8
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类; 表 3
Torrelo A, Noguera Morel L, Hernandez Martin A, Clemente D, Barja J, Buzon L, et al. Recurrent lipoatrophic panniculitis of children. J Eur Acad Dermatol Venereol. 2017;31:536-543 pubmed 出版商
  • 免疫组化; 人类
Fugier E, Marche H, Thelu M, Macek Jilkova Z, Van Campenhout N, Dufeu Duchesne T, et al. Functions of liver natural killer cells are dependent on the severity of liver inflammation and fibrosis in chronic hepatitis C. PLoS ONE. 2014;9:e95614 pubmed 出版商
  • 免疫组化; 人类
Abdou A, Shoeib M, Bakry O, El Bality H. Immunohistochemical expression of granzyme B and perforin in discoid lupus erythematosus. Ultrastruct Pathol. 2013;37:408-16 pubmed 出版商
  • 免疫组化; 人类
Pagni F, Isimbaldi G, Vergani F, Casiraghi P, Marzorati L, Migliorino G, et al. Primary angiitis of the central nervous system: 2 atypical cases. Folia Neuropathol. 2012;50:293-9 pubmed
  • 免疫组化; 人类; 1:10
Milani V, Stangl S, Issels R, Gehrmann M, Wagner B, Hube K, et al. Anti-tumor activity of patient-derived NK cells after cell-based immunotherapy--a case report. J Transl Med. 2009;7:50 pubmed 出版商
  • 免疫组化; 人类
Dunning K, Wudhikarn K, Safo A, Holman C, McKenna R, Pambuccian S. Adrenal extranodal NK/T-cell lymphoma diagnosed by fine-needle aspiration and cerebrospinal fluid cytology and immunophenotyping: a case report. Diagn Cytopathol. 2009;37:686-95 pubmed 出版商
  • 免疫组化; 人类
van Es L, De Heer E, Vleming L, van der Wal A, Mallat M, Bajema I, et al. GMP-17-positive T-lymphocytes in renal tubules predict progression in early stages of IgA nephropathy. Kidney Int. 2008;73:1426-33 pubmed 出版商
Wang L, Wang G, Gao T. Acneiform primary cutaneous CD4-positive small/medium pleomorphic T-cell lymphoma with prominent necrosis. J Cutan Pathol. 2015;42:265-70 pubmed 出版商
图像
图像 1 :
赛默飞世尔 MA5-12469 图像 1
Formalin-fixed, paraffin-embedded human lymphoma stained with Perforin antibody using peroxidase-conjugate and AEC chromogen. Note granular cytoplasmic staining of lymphocytes.
产品信息
产品类型 :
抗体
产品名称 :
Perforin Monoclonal Antibody (5B10)
目录# :
MA5-12469
规格 :
500微升
价格 :
美国456.00
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunohistochemistry (Paraffin): 1:10, Western Blot: 1:500
物种 :
人类
克隆 :
5B10
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Perforin is one of the major cytolytic proteins of cytolytic granules. Perforin is a cytolytic mediator and is stored in and released by cytoplasmic granules. Moreover, perforin is involved in immune defense against tumors and virus infections as mediated by cytotoxic lymphocytes. Perforin is a 555 amino acid protein with a 21 amino acid signal peptide, and has a molecular weight of 70 to 75 kD. Perforin is a pore forming protein with a mechanism of transmembrane channel formation similar to C9, and homology between perforin and C9 have been demonstrated. Studies show that perforin is expressed only in killer cell lines and not in helper T lymphocytes or other tumor cells tested. Perforin is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in the perforin gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants of perforin.
免疫原 :
Recombinant protein corresponding to C-terminal region of human perforin
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1:10, Western Blot: 1:500
别名 :
Cyta; Cytolysin; FLH2; HPLH2; lymphocyte pore forming protein; lymphocyte pore-forming protein; OMAK; OTTHUMP00000019759; P1; perforin 1; perforin 1 (pore forming protein); Perforin1; perforin-1; Pfn; PFN1; Pfp; PGFL; PIGF; PIGF-2; PLGF; pore forming protein; pore-forming protein; PRF1; Prf-1; PRF1 (pore forming protein 1); RATCYTA; RP11-710A11.3
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国