产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
p53单克隆抗体(DO-7), 生物素
目录 :
MA5-12554
规格 :
500µL
价格 :
399.00美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
生物素
克隆名称 :
DO-7
反应物种 :
人类, 小鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 131
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类; 1:500; 表 2
Jang M, Kim S, Hwang D, Kim W, Lim S, Kim W, et al. BRAF-Mutated Colorectal Cancer Exhibits Distinct Clinicopathological Features from Wild-Type BRAF-Expressing Cancer Independent of the Microsatellite Instability Status. J Korean Med Sci. 2017;32:38-46 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Cubillos Rojas M, Amair Pinedo F, Peiró Jordán R, Bartrons R, Ventura F, Rosa J. The E3 ubiquitin protein ligase HERC2 modulates the activity of tumor protein p53 by regulating its oligomerization. J Biol Chem. 2014;289:14782-95 pubmed 出版商
  • 免疫组化; 人类
Akay O, Aras B, Isiksoy S, Toprak C, Mutlu F, Artan S, et al. BCL2, BCL6, IGH, TP53, and MYC protein expression and gene rearrangements as prognostic markers in diffuse large B-cell lymphoma: a study of 44 Turkish patients. Cancer Genet. 2014;207:87-93 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Stelloo E, Nout R, Naves L, Ter Haar N, Creutzberg C, Smit V, et al. High concordance of molecular tumor alterations between pre-operative curettage and hysterectomy specimens in patients with endometrial carcinoma. Gynecol Oncol. 2014;133:197-204 pubmed 出版商
  • 免疫组化; 人类; 1:250
Mingels M, van Ham M, de Kievit I, Snijders M, van Tilborg A, Bulten J, et al. Müllerian precursor lesions in serous ovarian cancer patients: using the SEE-Fim and SEE-End protocol. Mod Pathol. 2014;27:1002-13 pubmed 出版商
  • 免疫组化; 人类; 1:200
  • 免疫印迹; 人类; 1:200
Zhao Z, Lin L, Liang A, Li H, Zhu Y. UNC5H4-induced apoptosis in non-small cell lung cancer is not dependent on p53 status only. Oncol Lett. 2013;6:1363-1369 pubmed
  • 免疫组化; 人类; 1:500
Baumgarten P, Harter P, Tonjes M, Capper D, Blank A, Sahm F, et al. Loss of FUBP1 expression in gliomas predicts FUBP1 mutation and is associated with oligodendroglial differentiation, IDH1 mutation and 1p/19q loss of heterozygosity. Neuropathol Appl Neurobiol. 2014;40:205-16 pubmed 出版商
  • 免疫组化; 人类; 1:50
Bakry O, Hammam M, Abdel Wahed M. Vitiligo: is it grace or curse?. Acta Dermatovenerol Croat. 2013;21:71-9 pubmed
  • 免疫组化; 人类; 1:1000
Sarasqueta A, Forte G, Corver W, de Miranda N, Ruano D, van Eijk R, et al. Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer. BMC Cancer. 2013;13:277 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Lee S, Kim H, Kim W, Han H, Lim S, Kim W, et al. Genetic alteration and immunohistochemical staining patterns of ovarian high-grade serous adenocarcinoma with special emphasis on p53 immnnostaining pattern. Pathol Int. 2013;63:252-9 pubmed 出版商
  • 免疫组化; 人类
Bosse T, Ter Haar N, Seeber L, v Diest P, Hes F, Vasen H, et al. Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations, TP53 and microsatellite instability in endometrial cancer. Mod Pathol. 2013;26:1525-35 pubmed 出版商
  • 免疫组化; 人类
Malhotra P, Anwar M, Nanda N, Kochhar R, Wig J, Vaiphei K, et al. Alterations in K-ras, APC and p53-multiple genetic pathway in colorectal cancer among Indians. Tumour Biol. 2013;34:1901-11 pubmed 出版商
  • 免疫组化; 人类
Gurzu S, Szentirmay Z, Toth E, Bara T, Jung I. Serrated pathway adenocarcinomas: molecular and immunohistochemical insights into their recognition. PLoS ONE. 2013;8:e57699 pubmed 出版商
  • 免疫组化; 人类; 1:100
Rosati A, Poliani P, Todeschini A, Cominelli M, Medicina D, Cenzato M, et al. Glutamine synthetase expression as a valuable marker of epilepsy and longer survival in newly diagnosed glioblastoma multiforme. Neuro Oncol. 2013;15:618-25 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500
  • 免疫组化; 人类; 1:500
Harter P, Dützmann S, Drott U, Zachskorn C, Hattingen E, Capper D, et al. Anti-tissue factor (TF9-10H10) treatment reduces tumor cell invasiveness in a novel migratory glioma model. Neuropathology. 2013;33:515-25 pubmed 出版商
  • 免疫印迹; 人类
Mosoyan G, Nagi C, Marukian S, Teixeira A, Simonian A, Resnick Silverman L, et al. Multiple breast cancer cell-lines derived from a single tumor differ in their molecular characteristics and tumorigenic potential. PLoS ONE. 2013;8:e55145 pubmed 出版商
  • 免疫组化; 人类; 1:100
Ko E, Lee B, Kim Y, Lee E, Cho E, Han J, et al. Association of RASSF1A and p63 with poor recurrence-free survival in node-negative stage I-II non-small cell lung cancer. Clin Cancer Res. 2013;19:1204-12 pubmed 出版商
  • 免疫组化; 人类; 1:30
Lee E, Lee B, Ko E, Kim Y, Han J, Shim Y, et al. Cohypermethylation of p14 in combination with CADM1 or DCC as a recurrence-related prognostic indicator in stage I esophageal squamous cell carcinoma. Cancer. 2013;119:1752-60 pubmed 出版商
  • 免疫组化; 人类; 1:50
Bakry O, Hammam M, Wahed M. Immunohistochemical detection of P53 and Mdm2 in vitiligo. Indian Dermatol Online J. 2012;3:171-6 pubmed 出版商
  • 免疫组化; 人类
Piccinin S, Tonin E, Sessa S, Demontis S, Rossi S, Pecciarini L, et al. A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation. Cancer Cell. 2012;22:404-15 pubmed 出版商
  • 免疫组化; 人类
Vallen M, Massuger L, ten Dam G, Bulten J, van Kuppevelt T. Highly sulfated chondroitin sulfates, a novel class of prognostic biomarkers in ovarian cancer tissue. Gynecol Oncol. 2012;127:202-9 pubmed 出版商
  • 免疫组化; 人类; 1:50
Ni H, Piao Y, Lu D, Fu Y, Ma X, Zhang X. Chordoid glioma of the third ventricle: four cases including one case with papillary features. Neuropathology. 2013;33:134-9 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Hardee M, Marciscano A, Medina Ramirez C, Zagzag D, Narayana A, Lonning S, et al. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-?. Cancer Res. 2012;72:4119-29 pubmed 出版商
  • 免疫印迹; 人类
Roh J, Ko J, Moon S, Ryu C, Choi J, Koch W. The p53-reactivating small-molecule RITA enhances cisplatin-induced cytotoxicity and apoptosis in head and neck cancer. Cancer Lett. 2012;325:35-41 pubmed 出版商
  • 免疫组化; 人类; 1:2000
Smits A, Jin Z, Elsir T, Pedder H, Nister M, Alafuzoff I, et al. GABA-A channel subunit expression in human glioma correlates with tumor histology and clinical outcome. PLoS ONE. 2012;7:e37041 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Nout R, Bosse T, Creutzberg C, Jürgenliemk Schulz I, Jobsen J, Lutgens L, et al. Improved risk assessment of endometrial cancer by combined analysis of MSI, PI3K-AKT, Wnt/?-catenin and P53 pathway activation. Gynecol Oncol. 2012;126:466-73 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Zimmermann M, Arachchige Don A, Donaldson M, Dallapiazza R, Cowan C, Horne M. Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin. J Biol Chem. 2012;287:22838-53 pubmed 出版商
  • 免疫印迹; 人类
Richardson E, Stockwell S, Li H, Aherne W, Cuomo M, Mittnacht S. Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response. PLoS ONE. 2012;7:e31627 pubmed 出版商
  • 免疫组化; 人类; 1:250
Roelofsen T, van Kempen L, van der Laak J, van Ham M, Bulten J, Massuger L. Concurrent endometrial intraepithelial carcinoma (EIC) and serous ovarian cancer: can EIC be seen as the precursor lesion?. Int J Gynecol Cancer. 2012;22:457-64 pubmed 出版商
  • 免疫组化; 人类; 1:1500
Ko Y, Hwang T, Han H, Lim S, Kim W, Oh S. Primary pure squamous cell carcinoma of the thyroid: report and histogenic consideration of a case involving a BRAF mutation. Pathol Int. 2012;62:43-8 pubmed 出版商
  • 免疫组化; 人类
Aydin F, Levent Y, Nilgun S, Pancar Y, Yasar T. Implications of bax, fas, and p53 in the pathogenesis of early-stage mycosis fungoides and alterations in expression following photochemotherapy. Indian J Dermatol. 2011;56:501-4 pubmed 出版商
  • 免疫组化; 人类; 1:300
Van der Vorst S, Dekairelle A, Weynand B, Hamoir M, Gala J. Assessment of p53 functional activity in tumor cells and histologically normal mucosa from patients with head and neck squamous cell carcinoma. Head Neck. 2012;34:1542-50 pubmed 出版商
  • 免疫组化; 人类
Rosztoczy A, Izbeki F, Nemeth I, Dulic S, Vadászi K, Roka R, et al. Detailed esophageal function and morphological analysis shows high prevalence of gastroesophageal reflux disease and Barrett's esophagus in patients with cervical inlet patch. Dis Esophagus. 2012;25:498-504 pubmed 出版商
  • 免疫组化; 人类
Manganoni A, Rossi M, Sala R, Venturini M, Sereni E, Ungari M, et al. Dermoscopic, histological and immunohistochemical evaluation of cancerous features in acquired melanocytic nevi that have been repeatedly exposed to UVA or UVB. Exp Dermatol. 2012;21:86-90 pubmed 出版商
  • 免疫组化; 人类
Nemeth I, Rosztoczy A, Izbeki F, Roka R, Gecse K, Sukosd F, et al. A renewed insight into Barrett's esophagus: comparative histopathological analysis of esophageal columnar metaplasia. Dis Esophagus. 2012;25:395-402 pubmed 出版商
  • 免疫组化; 人类; 1:2000
Heusinkveld M, Goedemans R, Briet R, Gelderblom H, Nortier J, Gorter A, et al. Systemic and local human papillomavirus 16-specific T-cell immunity in patients with head and neck cancer. Int J Cancer. 2012;131:E74-85 pubmed 出版商
  • 免疫组化; 人类; 1:200
Wolfárd A, Paszt A, Szentpali K, Hideghéthy K, Uhercsak G, Nemeth I, et al. Efficacy and drawbacks of neoadjuvant chemoradiotherapy in squamous cell carcinoma of the thoracic esophagus. Hepatogastroenterology. 2011;58:1214-9 pubmed 出版商
  • 免疫组化; 人类
Arik D, Kulacoglu S. P53, bcl-2, and nm23 expressions in serous ovarian tumors: correlation with the clinical and histopathological parameters. Turk Patoloji Derg. 2011;27:38-45 pubmed
  • 免疫组化; 人类; 1:300
Ege C, Akbulut M, Zekioglu O, Ozdemir N. Investigation of galectin-3 and heparanase in endometrioid and serous carcinomas of the endometrium and correlation with known predictors of survival. Arch Gynecol Obstet. 2011;284:1231-9 pubmed 出版商
  • 免疫印迹; 人类
Halperin R, Stafford P, Johnston S. Exploring antibody recognition of sequence space through random-sequence peptide microarrays. Mol Cell Proteomics. 2011;10:M110.000786 pubmed 出版商
  • 免疫组化; 人类; 1:50
Pfaff E, Remke M, Sturm D, Benner A, Witt H, Milde T, et al. TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma. J Clin Oncol. 2010;28:5188-96 pubmed 出版商
  • 免疫组化; 人类; 1:500
Radotra B, Apostolopoulos V, Sandison A, Hatfield E, Mendoza N, Moss J, et al. Primary sellar neuroblastoma presenting with syndrome of inappropriate secretion of anti-diuretic hormone. Endocr Pathol. 2010;21:266-73 pubmed 出版商
  • 免疫印迹; 人类
Tarjan G, Haines G, Vesper B, Xue J, Altman M, Yarmolyuk Y, et al. Part II. Initial molecular and cellular characterization of high nitric oxide-adapted human tongue squamous cell carcinoma cell lines. Tumour Biol. 2011;32:87-98 pubmed 出版商
  • 免疫组化; 人类; 1:100
Kosemehmetoglu K, Akpinar E, Sokmensuer C, Hamaloglu E. Papillary carcinoma with diffuse papillomatosis of gallbladder and cystic duct. Ann Diagn Pathol. 2011;15:140-4 pubmed 出版商
  • 免疫组化; 人类; 1:150
Angiero F, Gatta L, Seramondi R, Berenzi A, Benetti A, Magistro S, et al. Frequency and role of HPV in the progression of epithelial dysplasia to oral cancer. Anticancer Res. 2010;30:3435-40 pubmed
  • 免疫组化; 人类; 1:25
Giordano G, D Adda T, Brigati F, Lombardi M, Raboni S. A Unique case of primary squamous carcinoma of the salpinx associated with serous carcinoma of the omentum: a pathological and molecular study. Int J Gynecol Pathol. 2010;29:533-8 pubmed 出版商
  • 免疫组化; 人类; 1:1000
van der Avoort I, van de Nieuwenhof H, Otte Holler I, Nirmala E, Bulten J, Massuger L, et al. High levels of p53 expression correlate with DNA aneuploidy in (pre)malignancies of the vulva. Hum Pathol. 2010;41:1475-85 pubmed 出版商
  • 免疫组化; 人类; 1:150
Safadi R, Al Jaber S, Hammad H, Hamasha A. Oral lichen planus shows higher expressions of tumor suppressor gene products of p53 and p21 compared to oral mucositis. An immunohistochemical study. Arch Oral Biol. 2010;55:454-61 pubmed 出版商
  • 免疫组化; 人类; 1:100
Bircan A, Bircan S, Kapucuoglu N, Songur N, Ozturk O, Akkaya A. Maspin, VEGF and p53 expression in small biopsies of primary advanced lung cancer and relationship with clinicopathologic parameters. Pathol Oncol Res. 2010;16:553-61 pubmed 出版商
  • 免疫印迹; 人类; 1:400
Yu F, Hao X, Zhao H, Ge C, Yao M, Yang S, et al. Delta-like 1 contributes to cell growth by increasing the interferon-inducible protein 16 expression in hepatocellular carcinoma. Liver Int. 2010;30:703-14 pubmed 出版商
  • 免疫印迹; 人类; 1:200
Yang L, Xu H, Han Y, Li Q, Liu Y, Zhao Y, et al. Axin downregulates TCF-4 transcription via beta-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells. Mol Cancer. 2010;9:25 pubmed 出版商
  • 免疫组化; 人类; 1:50
Sarafoleanu D, Postelnicu V, Iosif C, Manea C, Sarafoleanu C. The role of p53, PCNA and Ki-67 as outcome predictors in the treatment of laryngeal cancer. J Med Life. 2009;2:219-26 pubmed
  • 免疫组化; 人类; 1:100
Kim H, Park Y, Lee J, Ahn J, Kim J, Shim Y, et al. Clinical impact of phosphorylated signal transducer and activator of transcription 3, epidermal growth factor receptor, p53, and vascular endothelial growth factor receptor 1 expression in resected adenocarcinoma of lung by using tissue microarray. Cancer. 2010;116:676-85 pubmed 出版商
  • 免疫组化; 人类; 1:100
Angiero F, Farronato G, Dessy E, Magistro S, Seramondi R, Farronato D, et al. Evaluation of the cytotoxic and genotoxic effects of orthodontic bonding adhesives upon human gingival papillae through immunohistochemical expression of p53, p63 and p16. Anticancer Res. 2009;29:3983-7 pubmed
  • 免疫印迹; 人类
de Frias M, Iglesias Serret D, Cosialls A, Coll Mulet L, Santidrian A, González Gironès D, et al. Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells. Haematologica. 2009;94:1698-707 pubmed 出版商
  • 免疫组化; 人类; 1:200
Han Y, Wang Y, Xu H, Yang L, Wei Q, Liu Y, et al. X-radiation induces non-small-cell lung cancer apoptosis by upregulation of Axin expression. Int J Radiat Oncol Biol Phys. 2009;75:518-26 pubmed 出版商
  • 免疫组化; 人类; 1:50
Liu Z, Christensson M, Forslöw A, De Meester I, Sundqvist K. A CD26-controlled cell surface cascade for regulation of T cell motility and chemokine signals. J Immunol. 2009;183:3616-24 pubmed 出版商
  • 免疫组化; 人类; 1:200
Sakiz D, Turkmenoglu T, Kabukcuoglu F. The expression of p63 and p53 in keratoacanthoma and intraepidermal and invasive neoplasms of the skin. Pathol Res Pract. 2009;205:589-94 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Nielsen M, de Miranda N, van Puijenbroek M, Jordanova E, Middeldorp A, van Wezel T, et al. Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas. BMC Cancer. 2009;9:184 pubmed 出版商
  • 免疫印迹; 人类
Molenaar J, Ebus M, Geerts D, Koster J, Lamers F, Valentijn L, et al. Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells. Proc Natl Acad Sci U S A. 2009;106:12968-73 pubmed 出版商
  • 免疫组化; 人类; 1:50
Jung I, Gurzu S, Raica M, Cimpean A, Szentirmay Z. The differences between the endothelial area marked with CD31 and CD105 in colorectal carcinomas by computer-assisted morphometrical analysis. Rom J Morphol Embryol. 2009;50:239-43 pubmed
  • 免疫组化; 人类
Ozger H, Eralp L, Atalar A, Toker B, Esberk Ateş L, Sungur M, et al. [The effect of resistance-related proteins on the prognosis and survival of patients with osteosarcoma: an immunohistochemical analysis]. Acta Orthop Traumatol Turc. 2009;43:28-34 pubmed 出版商
  • 免疫印迹; 小鼠
Kawauchi K, Araki K, Tobiume K, Tanaka N. Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification. Proc Natl Acad Sci U S A. 2009;106:3431-6 pubmed 出版商
  • 免疫组化; 人类
Thant A, Wu Y, Lee J, Mishra D, Garcia H, Koeffler H, et al. Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells. Anticancer Res. 2008;28:3579-92 pubmed
  • 免疫组化; 人类; 1:150
Angiero F, Berenzi A, Benetti A, Rossi E, Del Sordo R, Sidoni A, et al. Expression of p16, p53 and Ki-67 proteins in the progression of epithelial dysplasia of the oral cavity. Anticancer Res. 2008;28:2535-9 pubmed
  • 免疫组化; 人类; 1:100
Alkim C, Savas B, Ensari A, Alkim H, Dagli U, Parlak E, et al. Expression of p53, VEGF, microvessel density, and cyclin-D1 in noncancerous tissue of inflammatory bowel disease. Dig Dis Sci. 2009;54:1979-84 pubmed 出版商
  • 免疫组化; 人类
Kresty L, Mallery S, Knobloch T, Li J, Lloyd M, Casto B, et al. Frequent alterations of p16INK4a and p14ARF in oral proliferative verrucous leukoplakia. Cancer Epidemiol Biomarkers Prev. 2008;17:3179-87 pubmed 出版商
  • 免疫组化; 人类
Gurzu S, Jung I, Prantner I, Ember I, Pávai Z, Mezei T. The expression of cytoskeleton regulatory protein Mena in colorectal lesions. Rom J Morphol Embryol. 2008;49:345-9 pubmed
  • 免疫组化; 人类; 1:50
Ceausu M, Curca C, Ardeleanu C, Dermengiu D. Immunophenotypical pleomorphism expression in sudden cardiac death. Rom J Morphol Embryol. 2008;49:315-20 pubmed
  • 免疫组化; 人类; 1:50
Villanacci V, Cestari R, Giulini S, Cengia P, Missale G, Berenzi A, et al. Immunocytochemical assessment of p53 protein to detect malignancy in increased cell-yield brush cytology from the biliopancreatic tree. Dig Dis Sci. 2009;54:789-92 pubmed 出版商
  • 免疫印迹; 人类
Hamamoto T, Suzuki K, Yamauchi M, Kodama S, Sasaki H, Watanabe M. p53 status-dependent sensitization of human tumour cells to hyperthermia by plant flavonol. Int J Hyperthermia. 2008;24:415-24 pubmed 出版商
  • 免疫印迹; 人类
Turner N, Lord C, Iorns E, Brough R, Swift S, Elliott R, et al. A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor. EMBO J. 2008;27:1368-77 pubmed 出版商
  • 免疫组化; 人类
Kaya H, Bozkurt S, Erbarut I, Djamgoz M. Apocrine carcinomas of the breast in Turkish women: hormone receptors, c-erbB-2 and p53 immunoexpression. Pathol Res Pract. 2008;204:367-71 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Lips E, van Eijk R, de Graaf E, Doornebosch P, de Miranda N, Oosting J, et al. Progression and tumor heterogeneity analysis in early rectal cancer. Clin Cancer Res. 2008;14:772-81 pubmed 出版商
  • 免疫组化; 人类
Barbareschi M, Buttitta F, Felicioni L, Cotrupi S, Barassi F, Del Grammastro M, et al. Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas. Clin Cancer Res. 2007;13:6064-9 pubmed
  • 免疫组化; 人类; 1:200
Melck A, Masoudi H, Griffith O, Rajput A, Wilkins G, Bugis S, et al. Cell cycle regulators show diagnostic and prognostic utility for differentiated thyroid cancer. Ann Surg Oncol. 2007;14:3403-11 pubmed
  • 免疫组化; 人类; 1:100
Erdamar S, Ucaryilmaz E, Demir G, Karahasanoglu T, Dogusoy G, Dirican A, et al. Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal cancer. World J Gastroenterol. 2007;13:4437-44 pubmed
  • 免疫组化; 人类; 1:50
Kim D. Prognostic implications of cyclin B1, p34cdc2, p27(Kip1) and p53 expression in gastric cancer. Yonsei Med J. 2007;48:694-700 pubmed
  • 免疫组化; 人类
Gurzu S, Jung J, Mezei T, Pávai Z. The correlation between the immunostains for p53 and Ki67 with bcl-2 expression and classical prognostic factors in colorectal carcinomas. Rom J Morphol Embryol. 2007;48:95-9 pubmed
  • 免疫印迹; 小鼠
Arany P, Flanders K, DeGraff W, Cook J, Mitchell J, Roberts A. Absence of Smad3 confers radioprotection through modulation of ERK-MAPK in primary dermal fibroblasts. J Dermatol Sci. 2007;48:35-42 pubmed
  • 免疫组化; 人类; 1:25
Giordano G, D Adda T, Gnetti L, Merisio C, Raboni S. Transitional cell carcinoma of the endometrium associated with benign ovarian brenner tumor: a case report with immunohistochemistry molecular analysis and a review of the literature. Int J Gynecol Pathol. 2007;26:298-304 pubmed
  • 免疫组化; 人类
Senzer N, Nemunaitis J, Nemunaitis M, Lamont J, Gore M, Gabra H, et al. p53 therapy in a patient with Li-Fraumeni syndrome. Mol Cancer Ther. 2007;6:1478-82 pubmed
  • 免疫印迹; 小鼠; 1:1000
Ray S, Chatterjee A. Influence of glutathione on the induction of chromosome aberrations, delay in cell cycle kinetics and cell cycle regulator proteins in irradiated mouse bone marrow cells. Int J Radiat Biol. 2007;83:347-54 pubmed
  • 免疫组化; 人类; 1:50
Giordano G, D Adda T, Gnetti L, Merisio C, Gabrielli M, Melpignano M. Villoglandular adenocarcinoma of the cervix: two new cases with morphological and molecular study. Int J Gynecol Pathol. 2007;26:199-204 pubmed
  • 免疫沉淀; 人类; 2 ug/ml
Kerley Hamilton J, Pike A, Hutchinson J, Freemantle S, Spinella M. The direct p53 target gene, FLJ11259/DRAM, is a member of a novel family of transmembrane proteins. Biochim Biophys Acta. 2007;1769:209-19 pubmed
  • 免疫组化; 人类
Nadasi E, Anga B, Sandor J, Megyesi J, Kelemen D, Mottolese M, et al. Prognostic factors in Hungarian breast cancer patients. Anticancer Res. 2007;27:279-82 pubmed
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图像
图像 1 :
赛默飞世尔 MA5-12554 图像 1
图像 2 :
赛默飞世尔 MA5-12554 图像 2
图像 3 :
赛默飞世尔 MA5-12554 图像 3
Formalin-fixed, paraffin-embedded human colon carcinoma stained with p53 antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of tumor cells.
产品信息
产品类型 :
抗体
产品名称 :
p53单克隆抗体(DO-7), 生物素
目录# :
MA5-12554
规格 :
500µL
价格(美元) :
399.00美元
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
Bovine, Human, Non-human primate
应用 :
Flow Cytometry: 0.5 µg/test, Immunocytochemistry: 1:20-1:200, Immunofluorescence: 1:20-1:200, Immunohistochemistry (Paraffin): 1:100-1:200, Immunoprecipitation: 1:50-1:100, Western Blot: 1:50-1:200
物种 :
Bovine, Human, Non-human primate
克隆 :
DO-7
抗体亚型 :
IgG2b, kappa
储存 :
4° C
描述 :
The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization. p53 has been characterized to play a role in blocking the proliferative action of damaged cells and act as an anticancer agent. Phosphorylation of Ser392 in p53 has been shown to associate with the formation of human tumors. In addition, p53 has also been linked to the effects of aging and oxidative stress and an increase in p53 has been linked to deficits in LTP (Long Term Potentiation) in learning and memory. p53 is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families such as Li-Fraumeni syndrome.
免疫原 :
Recombinant human wild-type p53 protein expressed in E. coli
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.5 µg/test, Immunocytochemistry: 1:20-1:200, Immunofluorescence: 1:20-1:200, Immunohistochemistry (Paraffin): 1:100-1:200, Immunoprecipitation: 1:50-1:100, Western Blot: 1:50-1:200
别名 :
antigen NY-CO-13; bbl; BCC7; bfy; bhy; Cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; P53; p53 cellular tumor antigen; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; TRP53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; Tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国