产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
p53单克隆抗体(DO-7)
目录 :
MA5-12557
规格 :
500微升
价格 :
美国391.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
DO-7
反应物种 :
人类, 小鼠, 大鼠, 牛
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 166
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| Basak K, Doguc D, Aylak F, Karadayi N, Gultekin F. Effects of maternally exposed food coloring additives on laryngeal histology in rats. J Environ Pathol Toxicol Oncol. 2014;33:123-30 pubmed
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| Zhao Z, Lin L, Liang A, Li H, Zhu Y. UNC5H4-induced apoptosis in non-small cell lung cancer is not dependent on p53 status only. Oncol Lett. 2013;6:1363-1369 pubmed
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| Bakry O, Hammam M, Abdel Wahed M. Vitiligo: is it grace or curse?. Acta Dermatovenerol Croat. 2013;21:71-9 pubmed
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| Arik D, Kulacoglu S. P53, bcl-2, and nm23 expressions in serous ovarian tumors: correlation with the clinical and histopathological parameters. Turk Patoloji Derg. 2011;27:38-45 pubmed
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| Angiero F, Gatta L, Seramondi R, Berenzi A, Benetti A, Magistro S, et al. Frequency and role of HPV in the progression of epithelial dysplasia to oral cancer. Anticancer Res. 2010;30:3435-40 pubmed
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| Sarafoleanu D, Postelnicu V, Iosif C, Manea C, Sarafoleanu C. The role of p53, PCNA and Ki-67 as outcome predictors in the treatment of laryngeal cancer. J Med Life. 2009;2:219-26 pubmed
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| Kim H, Park Y, Lee J, Ahn J, Kim J, Shim Y, et al. Clinical impact of phosphorylated signal transducer and activator of transcription 3, epidermal growth factor receptor, p53, and vascular endothelial growth factor receptor 1 expression in resected adenocarcinoma of lung by using tissue microarray. Cancer. 2010;116:676-85 pubmed 出版商
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| Angiero F, Farronato G, Dessy E, Magistro S, Seramondi R, Farronato D, et al. Evaluation of the cytotoxic and genotoxic effects of orthodontic bonding adhesives upon human gingival papillae through immunohistochemical expression of p53, p63 and p16. Anticancer Res. 2009;29:3983-7 pubmed
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| Jung I, Gurzu S, Raica M, Cimpean A, Szentirmay Z. The differences between the endothelial area marked with CD31 and CD105 in colorectal carcinomas by computer-assisted morphometrical analysis. Rom J Morphol Embryol. 2009;50:239-43 pubmed
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| Thant A, Wu Y, Lee J, Mishra D, Garcia H, Koeffler H, et al. Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells. Anticancer Res. 2008;28:3579-92 pubmed
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| Angiero F, Berenzi A, Benetti A, Rossi E, Del Sordo R, Sidoni A, et al. Expression of p16, p53 and Ki-67 proteins in the progression of epithelial dysplasia of the oral cavity. Anticancer Res. 2008;28:2535-9 pubmed
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| Gurzu S, Jung I, Prantner I, Ember I, Pávai Z, Mezei T. The expression of cytoskeleton regulatory protein Mena in colorectal lesions. Rom J Morphol Embryol. 2008;49:345-9 pubmed
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| Ceausu M, Curca C, Ardeleanu C, Dermengiu D. Immunophenotypical pleomorphism expression in sudden cardiac death. Rom J Morphol Embryol. 2008;49:315-20 pubmed
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| Barbareschi M, Buttitta F, Felicioni L, Cotrupi S, Barassi F, Del Grammastro M, et al. Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas. Clin Cancer Res. 2007;13:6064-9 pubmed
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| Melck A, Masoudi H, Griffith O, Rajput A, Wilkins G, Bugis S, et al. Cell cycle regulators show diagnostic and prognostic utility for differentiated thyroid cancer. Ann Surg Oncol. 2007;14:3403-11 pubmed
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| Erdamar S, Ucaryilmaz E, Demir G, Karahasanoglu T, Dogusoy G, Dirican A, et al. Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal cancer. World J Gastroenterol. 2007;13:4437-44 pubmed
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| Kim D. Prognostic implications of cyclin B1, p34cdc2, p27(Kip1) and p53 expression in gastric cancer. Yonsei Med J. 2007;48:694-700 pubmed
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| Gurzu S, Jung J, Mezei T, Pávai Z. The correlation between the immunostains for p53 and Ki67 with bcl-2 expression and classical prognostic factors in colorectal carcinomas. Rom J Morphol Embryol. 2007;48:95-9 pubmed
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| Arany P, Flanders K, DeGraff W, Cook J, Mitchell J, Roberts A. Absence of Smad3 confers radioprotection through modulation of ERK-MAPK in primary dermal fibroblasts. J Dermatol Sci. 2007;48:35-42 pubmed
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| Giordano G, D Adda T, Gnetti L, Merisio C, Raboni S. Transitional cell carcinoma of the endometrium associated with benign ovarian brenner tumor: a case report with immunohistochemistry molecular analysis and a review of the literature. Int J Gynecol Pathol. 2007;26:298-304 pubmed
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| Senzer N, Nemunaitis J, Nemunaitis M, Lamont J, Gore M, Gabra H, et al. p53 therapy in a patient with Li-Fraumeni syndrome. Mol Cancer Ther. 2007;6:1478-82 pubmed
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| Ray S, Chatterjee A. Influence of glutathione on the induction of chromosome aberrations, delay in cell cycle kinetics and cell cycle regulator proteins in irradiated mouse bone marrow cells. Int J Radiat Biol. 2007;83:347-54 pubmed
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| Giordano G, D Adda T, Gnetti L, Merisio C, Gabrielli M, Melpignano M. Villoglandular adenocarcinoma of the cervix: two new cases with morphological and molecular study. Int J Gynecol Pathol. 2007;26:199-204 pubmed
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| Kerley Hamilton J, Pike A, Hutchinson J, Freemantle S, Spinella M. The direct p53 target gene, FLJ11259/DRAM, is a member of a novel family of transmembrane proteins. Biochim Biophys Acta. 2007;1769:209-19 pubmed
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| Nadasi E, Anga B, Sandor J, Megyesi J, Kelemen D, Mottolese M, et al. Prognostic factors in Hungarian breast cancer patients. Anticancer Res. 2007;27:279-82 pubmed
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| Vardar E, Gunlusoy B, Arslan M, Kececi S. Myointimoma of the glans penis. Pathol Int. 2007;57:158-61 pubmed
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| Schumacher G, Scheunert S, Rueggeberg A, Bachem M, Nussler A, Spinelli A, et al. A very low toxic agent induces apoptosis and reduces growth of human hepatocellular carcinoma cells. J Gastroenterol Hepatol. 2006;21:1207-12 pubmed
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| Akyurek N, Memis L, Ekinci O, Kokturk N, Ozturk C. Survivin expression in pre-invasive lesions and non-small cell lung carcinoma. Virchows Arch. 2006;449:164-70 pubmed
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| Aldovini D, Demichelis F, Doglioni C, Di Vizio D, Galligioni E, Brugnara S, et al. M-CAM expression as marker of poor prognosis in epithelial ovarian cancer. Int J Cancer. 2006;119:1920-6 pubmed
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| Bulut S, Uslu H, Ozdemir B, Bulut O. Expression of caspase-3, p53 and Bcl-2 in generalized aggressive periodontitis. Head Face Med. 2006;2:17 pubmed
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| Ardeleanu C, Ceausu M, Butur G, Grămadă Z, Danaila L, Hălălău F, et al. p53 protein and bcl-2 expression in glioblastomas. Pathological correlations in a comprehensive series. Rom J Morphol Embryol. 2005;46:275-8 pubmed
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| Sun B, Sun Y, Wang J, Zhao X, Wang X, Hao X. Extent, relationship and prognostic significance of apoptosis and cell proliferation in synovial sarcoma. Eur J Cancer Prev. 2006;15:258-65 pubmed
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| Lee M, Suh C, Li Z. Clinicopathological significance of maspin expression in breast cancer. J Korean Med Sci. 2006;21:309-14 pubmed
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| Cao Y, Zhang M, Wang J, Zhang W, Li G, Zhao J. Recurrent intracranial hemangiopericytoma with multiple metastases. Chin Med J (Engl). 2006;119:169-73 pubmed
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| Coll Mulet L, Iglesias Serret D, Santidrian A, Cosialls A, de Frias M, Castaño E, et al. MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells. Blood. 2006;107:4109-14 pubmed
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| Schrier B, Vriesema J, Witjes J, Kiemeney L, Schalken J. The predictive value of p53, p27(kip1), and alpha-catenin for progression in superficial bladder carcinoma. Eur Urol. 2006;50:76-82 pubmed
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| Gao R, Bao H, Yang Q, Cong Q, Song J, Wang L. The presence of serum anti-p53 antibodies from patients with invasive ductal carcinoma of breast: correlation to other clinical and biological parameters. Breast Cancer Res Treat. 2005;93:111-5 pubmed
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| Yilmazbayhan D, Ates L, Dilege S, Gulluoglu M, Tanju S, Kalayci G. Pulmonary large cell carcinoma with rhabdoid phenotype. Ann Diagn Pathol. 2005;9:223-6 pubmed
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| Berghmans T, Mascaux C, Martin B, Ninane V, Sculier J. Prognostic role of p53 in stage III non-small cell lung cancer. Anticancer Res. 2005;25:2385-9 pubmed
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| Akhan S, Yavuz E, Tecer A, Iyibozkurt C, Topuz S, Tuzlali S, et al. The expression of Ki-67, p53, estrogen and progesterone receptors affecting survival in uterine leiomyosarcomas. A clinicopathologic study. Gynecol Oncol. 2005;99:36-42 pubmed
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| Osada M, Nagakawa Y, Park H, Yamashita K, Wu G, Kim M, et al. p63-specific activation of the BPAG-1e promoter. J Invest Dermatol. 2005;125:52-60 pubmed
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| Nemes J, Nemes Z, Marton I. p21WAF1/CIP1 expression is a marker of poor prognosis in oral squamous cell carcinoma. J Oral Pathol Med. 2005;34:274-9 pubmed
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| Uluoglu O, Akyurek N, Uner A, Coskun U, Ozdemir A, Gokcora N. Interdigitating dendritic cell tumor with breast and cervical lymph-node involvement: a case report and review of the literature. Virchows Arch. 2005;446:546-54 pubmed
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| Aker F, Ozkara S, Eren P, Peker O, Armağan S, Hakan T. Cerebellar liponeurocytoma/lipidized medulloblastoma. J Neurooncol. 2005;71:53-9 pubmed
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| Torkin R, Lavoie J, Kaplan D, Yeger H. Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma. Mol Cancer Ther. 2005;4:1-11 pubmed
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| Kale A, Soylemez F, Ensari A. Expressions of proliferation markers (Ki-67, proliferating cell nuclear antigen, and silver-staining nucleolar organizer regions) and of p53 tumor protein in gestational trophoblastic disease. Am J Obstet Gynecol. 2001;184:567-74 pubmed
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Lewinska A, Adamczyk Grochala J, Kwasniewicz E, Deregowska A, Semik E, Zabek T, et al. Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression. Redox Biol. 2018;14:20-34 pubmed 出版商
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Li Z, Day C, Yang J, Tsai W, Lozano G, Shih H, et al. Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53. Cancer Res. 2004;64:9080-5 pubmed
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Sirianni N, Ha P, Oelke M, Califano J, Gooding W, Westra W, et al. Effect of human papillomavirus-16 infection on CD8+ T-cell recognition of a wild-type sequence p53264-272 peptide in patients with squamous cell carcinoma of the head and neck. Clin Cancer Res. 2004;10:6929-37 pubmed
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Milne A, Carvalho R, van Rees B, van Lanschot J, Offerhaus G, Weterman M. Do collision tumors of the gastroesophageal junction exist? A molecular analysis. Am J Surg Pathol. 2004;28:1492-8 pubmed
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Marchioni D, Monzani D, Rossi G, Rivasi F, Presutti L. Breast carcinoma metastases in paranasal sinuses, a rare occurrence mimicking a primary nasal malignancy. case report. Acta Otorhinolaryngol Ital. 2004;24:87-91 pubmed
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Fomenkov A, Zangen R, Huang Y, Osada M, Guo Z, Fomenkov T, et al. RACK1 and stratifin target DeltaNp63alpha for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage. Cell Cycle. 2004;3:1285-95 pubmed
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Tokumaru Y, Yamashita K, Osada M, Nomoto S, Sun D, Xiao Y, et al. Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing. Cancer Res. 2004;64:5982-7 pubmed
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Tulunay O, Gogus C, Baltaci S, Bulut S. Clear cell adenocarcinoma of the tunica vaginalis of the testis with an adjacent uterus-like tissue. Pathol Int. 2004;54:641-7 pubmed
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller A, Caruso A, et al. Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain. J Neurosci. 2004;24:6021-7 pubmed
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Tabs S, Avci O. Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity. Eur J Dermatol. 2004;14:96-102 pubmed
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Ozkara S, Corakci A. Significantly decreased P27 expression in endometrial carcinoma compared to complex hyperplasia with atypia (correlation with p53 expression). Pathol Oncol Res. 2004;10:89-97 pubmed
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Meert A, Martin B, Verdebout J, Paesmans M, Berghmans T, Ninane V, et al. Correlation of different markers (p53, EGF-R, c-erbB-2, Ki-67) expression in the diagnostic biopsies and the corresponding resected tumors in non-small cell lung cancer. Lung Cancer. 2004;44:295-301 pubmed
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Jayasurya R, Francis G, Kannan S, Lekshminarayanan K, Nalinakumari K, Abraham T, et al. p53, p16 and cyclin D1: molecular determinants of radiotherapy treatment response in oral carcinoma. Int J Cancer. 2004;109:710-6 pubmed
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Roberts K, Bhatia K, Stanton P, Lord R. Proteomic analysis of selected prognostic factors of breast cancer. Proteomics. 2004;4:784-92 pubmed
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Deveci M, Deveci G. Altered distribution of metaplastic Paneth, gastrin and pancreatic acinar cells in atrophic gastritic mucosa with endocrine cell lesions. Tohoku J Exp Med. 2004;202:13-22 pubmed
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Doglioni C, Piccinin S, Demontis S, Cangi M, Pecciarini L, Chiarelli C, et al. Alterations of beta-catenin pathway in non-melanoma skin tumors: loss of alpha-ABC nuclear reactivity correlates with the presence of beta-catenin gene mutation. Am J Pathol. 2003;163:2277-87 pubmed
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Alami J, Williams B, Yeger H. Derivation and characterization of a Wilms' tumour cell line, WiT 49. Int J Cancer. 2003;107:365-74 pubmed
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Schwartz J, Muscat J, Baker V, Larios E, Stephenson G, Guo W, et al. Oral cytology assessment by flow cytometry of DNA adducts, aneuploidy, proliferation and apoptosis shows differences between smokers and non-smokers. Oral Oncol. 2003;39:842-54 pubmed
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Ko J, Lee Y, Hwang S, Lee Y, Shin S, Hwang J, et al. Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization. Oncogene. 2003;22:4679-89 pubmed
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Kumpawat K, Deb S, Ray S, Chatterjee A. Genotoxic effect of raw betel-nut extract in relation to endogenous glutathione levels and its mechanism of action in mammalian cells. Mutat Res. 2003;538:1-12 pubmed
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Mascaux C, Martin B, Verdebout J, Meert A, Ninane V, Sculier J. Fragile histidine triad protein expression in nonsmall cell lung cancer and correlation with Ki-67 and with p53. Eur Respir J. 2003;21:753-8 pubmed
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Campas C, Dalmau M, Montaner B, Barragan M, Bellosillo B, Colomer D, et al. Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia. Leukemia. 2003;17:746-50 pubmed
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Campas C, Lopez J, Santidrian A, Barragan M, Bellosillo B, Colomer D, et al. Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes. Blood. 2003;101:3674-80 pubmed
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Kilicli Camur N, Kilicaslan I, Gulluoglu M, Esen T, Uysal V. Impact of p53 and Ki-67 in predicting recurrence and progression of superficial (pTa and pT1) urothelial cell carcinomas of urinary bladder. Pathol Int. 2002;52:463-9 pubmed
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DiRenzo J, Signoretti S, Nakamura N, Rivera Gonzalez R, Sellers W, Loda M, et al. Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line. Cancer Res. 2002;62:89-98 pubmed
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Lee H, Kim J, Ha S, Roh K, Seo E, Park W, et al. p53 gene mutations in Bowen's disease in Koreans: clustering in exon 5 and multiple mutations. Cancer Lett. 2000;158:27-33 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
p53单克隆抗体(DO-7)
目录# :
MA5-12557
规格 :
500微升
价格 :
美国391.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
牛, 人类
应用 :
ChIP assay: Assay-dependent, Flow Cytometry: 1:50, Immunocytochemistry: 1:20-1:200, Immunohistochemistry (Paraffin): 1:100-1:200, Immunoprecipitation: 1:50-1:100, Western Blot: 1:500-1:1,000
物种 :
牛, 人类
克隆 :
DO-7
抗体亚型 :
IgG2b, kappa
储存 :
-20°C
描述 :
The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization. p53 has been characterized to play a role in blocking the proliferative action of damaged cells and act as an anticancer agent. Phosphorylation of Ser392 in p53 has been shown to associate with the formation of human tumors. In addition, p53 has also been linked to the effects of aging and oxidative stress and an increase in p53 has been linked to deficits in LTP (Long Term Potentiation) in learning and memory. p53 is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families such as Li-Fraumeni syndrome.
免疫原 :
Recombinant human wild-type p53 protein expressed in E. coli
格式 :
液体
应用w/稀释 :
ChIP assay: Assay-dependent, Flow Cytometry: 1:50, Immunocytochemistry: 1:20-1:200, Immunohistochemistry (Paraffin): 1:100-1:200, Immunoprecipitation: 1:50-1:100, Western Blot: 1:500-1:1,000
别名 :
Antigen NY-CO-13; bbl; BCC7; bfy; bhy; cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; p53; p53 cellular tumor antigen; p53 protein; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; Trp53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3
更多信息或购买 :
公司信息
赛默飞世尔