产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
孕酮受体单克隆抗体(PgR636)
目录 :
MA5-12581
规格 :
500微升
价格 :
美国1048.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
PgR636
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 8
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类; 1:50
Carvajal Hausdorf D, Mani N, Velcheti V, Schalper K, Rimm D. Objective measurement and clinical significance of IDO1 protein in hormone receptor-positive breast cancer. J Immunother Cancer. 2017;5:81 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Coelho R, Calaça I, Celestrini D, Correia Carneiro A, Costa M, Zancan P, et al. Hexokinase and phosphofructokinase activity and intracellular distribution correlate with aggressiveness and invasiveness of human breast carcinoma. Oncotarget. 2015;6:29375-87 pubmed 出版商
  • 免疫组化; 人类; 1:1000
de Deus Moura R, Carvalho F, Bacchi C. Breast cancer in very young women: Clinicopathological study of 149 patients ≤25 years old. Breast. 2015;24:461-7 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:300
Tamega A, Miot H, Moço N, Silva M, Marques M, Miot L. Gene and protein expression of oestrogen-β and progesterone receptors in facial melasma and adjacent healthy skin in women. Int J Cosmet Sci. 2015;37:222-8 pubmed 出版商
  • 免疫组化; 小鼠
Naidu R, Har Y, Taib N. Analysis of peptidyl-propyl-cis/trans isomerase 1 (PIN1) gene -842(G > C) and -667(T > C) polymorphic variants in relation to breast cancer risk and clinico-pathological parameters. Scand J Clin Lab Invest. 2011;71:500-6 pubmed 出版商
  • 免疫组化; 人类
Christgen M, Christgen H, Heil C, Krech T, Langer F, Kreipe H, et al. Expression of KAI1/CD82 in distant metastases from estrogen receptor-negative breast cancer. Cancer Sci. 2009;100:1767-71 pubmed 出版商
Kim M, Chung Y, Kim H, Woo J, Ahn S, Park S. Immune microenvironment in ductal carcinoma in situ: a comparison with invasive carcinoma of the breast. Breast Cancer Res. 2020;22:32 pubmed 出版商
Jung Y, Kim H, Koo J. Expression of Lipid Metabolism-Related Proteins in Metastatic Breast Cancer. PLoS ONE. 2015;10:e0137204 pubmed 出版商
图像
图像 1 :
赛默飞世尔 MA5-12581 图像 1
Formalin-fixed, paraffin-embedded human breast cancer stained with PR antibody using peroxidase-conjugate and AEC chromogen. Note nuclear staining of tumor cells.
产品信息
产品类型 :
抗体
产品名称 :
孕酮受体单克隆抗体(PgR636)
目录# :
MA5-12581
规格 :
500微升
价格 :
美国1048.00
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:10-1:20, Western Blot: 1:500-1:1,000
物种 :
人类
克隆 :
PgR636
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.
免疫原 :
Formalin fixed recombinant full length A-form of human progesterone receptor
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:10-1:20, Western Blot: 1:500-1:1,000
别名 :
9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国