产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
细胞角蛋白5单克隆抗体(XM26)
目录 :
MA5-12596
规格 :
500微升
价格 :
美国395.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
XM26
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 39
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类; 图 1a
Gomi K, Tang Y, Arbelaez V, Crystal R, Walters M. Endothelial Cell Mediated Promotion of Ciliated Cell Differentiation of Human Airway Basal Cells via Insulin and Insulin-Like Growth Factor 1 Receptor Mediated Signaling. Stem Cell Rev. 2017;13:309-317 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 3a
Fang W, Yao M, Brummer G, Acevedo D, Alhakamy N, Berkland C, et al. Targeted gene silencing of CCL2 inhibits triple negative breast cancer progression by blocking cancer stem cell renewal and M2 macrophage recruitment. Oncotarget. 2016;7:49349-49367 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2a
  • 免疫印迹; 人类; 图 3h
Kuga T, Sasaki M, Mikami T, Miake Y, Adachi J, Shimizu M, et al. FAM83H and casein kinase I regulate the organization of the keratin cytoskeleton and formation of desmosomes. Sci Rep. 2016;6:26557 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:20; 图 1
Wang S, Liu J, Kim D, Datti A, Zacksenhaus E. Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer. Breast Cancer Res. 2016;18:9 pubmed 出版商
  • 免疫细胞化学; 人类; 图 5
Goodman C, Sato T, Peck A, Girondo M, Yang N, Liu C, et al. Steroid induction of therapy-resistant cytokeratin-5-positive cells in estrogen receptor-positive breast cancer through a BCL6-dependent mechanism. Oncogene. 2016;35:1373-85 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 s9
Liu H, Du L, Wang R, Wei C, Liu B, Zhu L, et al. High frequency of loss of PTEN expression in human solid salivary adenoid cystic carcinoma and its implication for targeted therapy. Oncotarget. 2015;6:11477-91 pubmed
  • 免疫组化-石蜡切片; 人类; 1:100; 表 2
Syed B, Green A, Nolan C, Morgan D, Ellis I, Cheung K. Biological characteristics and clinical outcome of triple negative primary breast cancer in older women - comparison with their younger counterparts. PLoS ONE. 2014;9:e100573 pubmed 出版商
  • 免疫组化; 人类; 200 mg/ml
Mitchell D, Israr M, Alam S, Dinello D, Kishel J, Jia R, et al. HIV nucleoside reverse transcriptase inhibitors efavirenz and tenofovir change the growth and differentiation of primary gingival epithelium. HIV Med. 2014;15:196-202 pubmed 出版商
  • 免疫组化; 人类; 1:200
Gremel G, Bergman J, Djureinovic D, Edqvist P, Maindad V, Bharambe B, et al. A systematic analysis of commonly used antibodies in cancer diagnostics. Histopathology. 2014;64:293-305 pubmed 出版商
  • 免疫沉淀; 人类; 1:50
Perez A, Rocha R, Balabram D, Souza Á, Gobbi H. Immunohistochemical profile of high-grade ductal carcinoma in situ of the breast. Clinics (Sao Paulo). 2013;68:674-8 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫组化; 人类; 1:200
  • 免疫印迹; 人类
Sato T, Tran T, Peck A, Girondo M, Liu C, Goodman C, et al. Prolactin suppresses a progestin-induced CK5-positive cell population in luminal breast cancer through inhibition of progestin-driven BCL6 expression. Oncogene. 2014;33:2215-24 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:300; 图 3
Corrêa N, Kuasne H, Faria J, Seixas C, Santos I, Abreu F, et al. Genomic and phenotypic profiles of two Brazilian breast cancer cell lines derived from primary human tumors. Oncol Rep. 2013;29:1299-307 pubmed 出版商
  • 免疫组化; 人类; 1:40
Niemiec J, Adamczyk A, Małecki K, Ambicka A, Rys J. Tumor grade and matrix metalloproteinase 2 expression in stromal fibroblasts help to stratify the high-risk group of patients with early breast cancer identified on the basis of st Gallen recommendations. Clin Breast Cancer. 2013;13:119-28 pubmed 出版商
  • 免疫组化; 人类; 200 mg/mL
Mitchell D, Israr M, Alam S, Kishel J, Dinello D, Meyers C. Effect of the HIV nucleoside reverse transcriptase inhibitor zidovudine on the growth and differentiation of primary gingival epithelium. HIV Med. 2012;13:276-90 pubmed 出版商
  • 免疫组化; 人类; 1:250
Mackiewicz M, Huppi K, Pitt J, Dorsey T, Ambs S, Caplen N. Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA. Breast Cancer Res Treat. 2011;130:663-79 pubmed 出版商
  • 免疫组化; 人类
Garcia M, Santiago J, Terron A, Hernandez Martin A, Vicente A, Fortuny C, et al. Two novel recessive mutations in KRT14 identified in a cohort of 21 Spanish families with epidermolysis bullosa simplex. Br J Dermatol. 2011;165:683-92 pubmed 出版商
  • 免疫组化; 人类; 1:50
Martins D, Sousa B, Lopes N, Gomes M, Veronese L, Albergaria A, et al. Molecular phenotypes of matched in situ and invasive components of breast carcinomas. Hum Pathol. 2011;42:1438-46 pubmed 出版商
  • 免疫组化; 人类
Eloy C, Vinagre J, Cameselle Teijeiro J, Paiva M, Soares P, Sobrinho Simoes M. Tumor-in-tumor of the thyroid with basaloid differentiation: a lesion with a solid cell nest neoplastic component?. Int J Surg Pathol. 2011;19:276-80 pubmed 出版商
  • 免疫组化; 人类
Rezze G, Fregnani J, Duprat J, Landman G. Cell adhesion and communication proteins are differentially expressed in melanoma progression model. Hum Pathol. 2011;42:409-18 pubmed 出版商
  • 免疫组化; 人类; 1:250
Glynn S, Boersma B, Dorsey T, Yi M, Yfantis H, Ridnour L, et al. Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients. J Clin Invest. 2010;120:3843-54 pubmed 出版商
  • 免疫组化; 人类
Israr M, Mitchell D, Alam S, Dinello D, Kishel J, Meyers C. The HIV protease inhibitor lopinavir/ritonavir (Kaletra) alters the growth, differentiation and proliferation of primary gingival epithelium. HIV Med. 2011;12:145-56 pubmed 出版商
  • 免疫组化; 人类
Carvalho L, Pereira E, Frappart L, Boniol M, Bernardo W, Tarricone V, et al. Molecular characterization of breast cancer in young Brazilian women. Rev Assoc Med Bras (1992). 2010;56:278-87 pubmed
  • 免疫组化; 人类; 1:50
Lopes N, Sousa B, Vieira D, Milanezi F, Schmitt F. Vessel density assessed by endoglin expression in breast carcinomas with different expression profiles. Histopathology. 2009;55:594-9 pubmed 出版商
  • 免疫组化; 人类
Gonzalez L, Corte M, Junquera S, González Fernández R, del Casar J, Garcia C, et al. Expression and prognostic significance of metalloproteases and their inhibitors in luminal A and basal-like phenotypes of breast carcinoma. Hum Pathol. 2009;40:1224-33 pubmed 出版商
  • 免疫组化; 人类; 1:50
Dufloth R, Alves J, Martins D, Vieira D, Chikota H, Zeferino L, et al. Cytological criteria to predict basal phenotype of breast carcinomas. Diagn Cytopathol. 2009;37:809-14 pubmed 出版商
  • 免疫组化; 人类; 1:250
Martin D, Boersma B, Yi M, Reimers M, Howe T, Yfantis H, et al. Differences in the tumor microenvironment between African-American and European-American breast cancer patients. PLoS ONE. 2009;4:e4531 pubmed 出版商
  • 免疫组化; 人类; 1:25
Bori R, Cserni G. Basal phenotype in breast carcinoma occurring in women aged 35 or younger. Pathol Oncol Res. 2009;15:41-5 pubmed 出版商
  • 免疫组化; 人类; 1:25
Gama A, Alves A, Schmitt F. Identification of molecular phenotypes in canine mammary carcinomas with clinical implications: application of the human classification. Virchows Arch. 2008;453:123-32 pubmed 出版商
  • 免疫组化; 人类
Trompetter M, Smedts F, van der Wijk J, Schoots C, de Jong H, Hopman A, et al. Keratin profiling in the developing human prostate. A different approach to understanding epithelial lineage. Anticancer Res. 2008;28:237-43 pubmed
  • 免疫组化; 人类; 1:80
Dufloth R, Matos I, Schmitt F, Zeferino L. Tissue microarrays for testing basal biomarkers in familial breast cancer cases. Sao Paulo Med J. 2007;125:226-30 pubmed
  • 免疫组化; 人类; 1:25
Li H, Cherukuri P, Li N, Cowling V, Spinella M, Cole M, et al. Nestin is expressed in the basal/myoepithelial layer of the mammary gland and is a selective marker of basal epithelial breast tumors. Cancer Res. 2007;67:501-10 pubmed
  • 免疫组化; 人类; 1:50
Paredes J, Lopes N, Milanezi F, Schmitt F. P-cadherin and cytokeratin 5: useful adjunct markers to distinguish basal-like ductal carcinomas in situ. Virchows Arch. 2007;450:73-80 pubmed
  • 免疫组化; 人类; 1:80
Matos I, Dufloth R, Alvarenga M, Zeferino L, Schmitt F. p63, cytokeratin 5, and P-cadherin: three molecular markers to distinguish basal phenotype in breast carcinomas. Virchows Arch. 2005;447:688-94 pubmed
Hao S, Ning K, Kuz C, Vorhies K, Yan Z, Qiu J. Long-Term Modeling of SARS-CoV-2 Infection of In Vitro Cultured Polarized Human Airway Epithelium. MBio. 2020;11: pubmed 出版商
Hao S, Ning K, Kuz C, Vorhies K, Yan Z, Qiu J. Long Period Modeling SARS-CoV-2 Infection of in Vitro Cultured Polarized Human Airway Epithelium. bioRxiv. 2020;: pubmed 出版商
Brummer G, Acevedo D, Hu Q, Portsche M, Fang W, Yao M, et al. Chemokine Signaling Facilitates Early-Stage Breast Cancer Survival and Invasion through Fibroblast-Dependent Mechanisms. Mol Cancer Res. 2018;16:296-308 pubmed 出版商
Yao M, Smart C, Hu Q, Cheng N. Continuous Delivery of Neutralizing Antibodies Elevate CCL2 Levels in Mice Bearing MCF10CA1d Breast Tumor Xenografts. Transl Oncol. 2017;10:734-743 pubmed 出版商
Behbod F, Kittrell F, LaMarca H, Edwards D, Kerbawy S, Heestand J, et al. An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ. Breast Cancer Res. 2009;11:R66 pubmed 出版商
Fukui D, Bando G, Ishikawa Y, Kadota K. Adenosquamous carcinoma with cilium formation, mucin production and keratinization in the nasal cavity of a red fox (Vulpes vulpes schrencki). J Comp Pathol. 2007;137:142-5 pubmed
图像
图像 1 :
赛默飞世尔 MA5-12596 图像 1
Formalin-fixed, paraffin-embedded human mesothelioma stained with Keratin 5 antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.
产品信息
产品类型 :
抗体
产品名称 :
细胞角蛋白5单克隆抗体(XM26)
目录# :
MA5-12596
规格 :
500微升
价格 :
美国395.00
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunocytochemistry: 1:200-1:250, Immunohistochemistry (Paraffin): 1:20, Immunohistochemistry: 1:50, Western Blot: 1:1,000
物种 :
人类
克隆 :
XM26
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
免疫原 :
Recombinant protein corresponding to C-terminal 103 aa of cytokeratin 5
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:200-1:250, Immunohistochemistry (Paraffin): 1:20, Immunohistochemistry: 1:50, Western Blot: 1:1,000
别名 :
3300001P10Rik; 58 kDa cytokeratin; alpha keratin; AW146334; C DDD; C KRT5A; CK5; CK-5; ckii; ckii protein; cytokeratin 5; cytokeratin-5; DDD; DDD1; EBS2; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K5; keratin 5; keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin complex 2, basic, gene 5; keratin type II, tail domain; keratin, type II cytoskeletal 5; keratin, type II cytoskeletal 5; keratin 5; keratin-5; Krt2-5; KRT5; KRT5A; Sak57; Tfip8; tuftelin interacting protein 8; type II alpha-keratin IIA; type II cytokeratin; type-II keratin Kb5; wu:fb02h09; wu:fj02d02; wu:fk78b12; zfCKII
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国