产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
孕酮受体单克隆抗体(hPRa 2)
目录 :
MA5-12642
规格 :
500微升
价格 :
美国453.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
hPRa 2
反应物种 :
人类, 猫
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 58
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 猫; 图 1b
Granados Soler J, Bornemann Kolatzki K, Beck J, Brenig B, Schütz E, Betz D, et al. Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival. Sci Rep. 2020;10:1003 pubmed 出版商
Grzegorzewska A, Grot E, Sechman A. Sodium Fluoride In Vitro Treatment Affects the Expression of Gonadotropin and Steroid Hormone Receptors in Chicken Embryonic Gonads. Animals (Basel). 2021;11: pubmed 出版商
Menendez J, Peirce S, Papadimitropoulou A, Cuyàs E, Steen T, Verdura S, et al. Progesterone receptor isoform-dependent cross-talk between prolactin and fatty acid synthase in breast cancer. Aging (Albany NY). 2020;12:24671-24692 pubmed 出版商
Pezzolato M, Botta M, Baioni E, Richelmi G, Pitardi D, Varello K, et al. Confirmation of the progesterone receptor as an efficient marker of treatment with 17β-estradiol in veal calves. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016;33:60-5 pubmed 出版商
Nelis H, Wojciechowicz B, Franczak A, Leemans B, D Herde K, Goossens K, et al. Steroids affect gene expression, ciliary activity, glucose uptake, progesterone receptor expression and immunoreactive steroidogenic protein expression in equine oviduct explants in vitro. Reprod Fertil Dev. 2016;28:1926-1944 pubmed 出版商
Nelis H, Vanden Bussche J, Wojciechowicz B, Franczak A, Vanhaecke L, Leemans B, et al. Steroids in the equine oviduct: synthesis, local concentrations and receptor expression. Reprod Fertil Dev. 2015;: pubmed 出版商
de Sant Ana F, Carvalho F, de O Gamba C, Cassali G, Riet Correa F, Schild A. Mammary diffuse fibroadenomatoid hyperplasia in water buffalo (Bubalus bubalis): three cases. J Vet Diagn Invest. 2014;26:453-456 pubmed
Dressing G, Knutson T, Schiewer M, Daniel A, Hagan C, Diep C, et al. Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells. Mol Endocrinol. 2014;28:442-57 pubmed 出版商
Hussein O, Mosbah M, Farouk O, Farag K, El Saed A, Arafa M, et al. Hormone receptors and age distribution in breast cancer patients at a university hospital in northern egypt. Breast Cancer (Auckl). 2013;7:51-7 pubmed 出版商
Pezzolato M, Richelmi G, Maurella C, Pitardi D, Varello K, Caramelli M, et al. Histopathology as a simple and reliable method to detect 17?-oestradiol illegal treatment in male calves. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30:1096-9 pubmed 出版商
Palm F, Walter I, Nowotny N, Budik S, Helmreich M, Aurich C. Progestin treatment does not affect expression of cytokines, steroid receptors, oxytocin receptor, and cyclooxygenase 2 in fetal membranes and endometrium from pony mares at parturition. Theriogenology. 2013;79:59-68 pubmed 出版商
D Amato N, OSTRANDER J, Bowie M, Sistrunk C, Borowsky A, Cardiff R, et al. Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system. PLoS ONE. 2012;7:e45684 pubmed 出版商
Machado S, Bahr J, Hales D, Braundmeier A, Quade B, Nowak R. Validation of the aging hen (Gallus gallus domesticus) as an animal model for uterine leiomyomas. Biol Reprod. 2012;87:86 pubmed 出版商
Wang N, Geng L, Zhang S, He B, Wang J. Expression of PRB, FKBP52 and HB-EGF relating with ultrasonic evaluation of endometrial receptivity. PLoS ONE. 2012;7:e34010 pubmed 出版商
Almeida Francia C, Keator C, Mah K, Holden L, Hergert C, Slayden O. Localization and hormonal regulation of endometrial matrix metalloproteinase-26 in the rhesus macaque. Hum Reprod. 2012;27:1723-34 pubmed 出版商
van der Horst P, Wang Y, Vandenput I, Kühne L, Ewing P, van Ijcken W, et al. Progesterone inhibits epithelial-to-mesenchymal transition in endometrial cancer. PLoS ONE. 2012;7:e30840 pubmed 出版商
Charles N, Thomas P, Lange C. Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events. Horm Cancer. 2010;1:167-76 pubmed 出版商
Martignani E, Eirew P, Accornero P, Eaves C, Baratta M. Human milk protein production in xenografts of genetically engineered bovine mammary epithelial stem cells. PLoS ONE. 2010;5:e13372 pubmed 出版商
Kim H, Kim M, Ahn S, Son B, Kim S, Ahn J, et al. Different prognostic significance of CD24 and CD44 expression in breast cancer according to hormone receptor status. Breast. 2011;20:78-85 pubmed 出版商
Saruhan B, Sagsoz H, Akbalik M, Ketani M. Distribution of estrogen receptor ? and progesterone receptor B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study. Biotech Histochem. 2011;86:315-25 pubmed 出版商
Sagsoz H, Akbalik M, Saruhan B, Ketani M. Localization of estrogen receptor ? and progesterone receptor B in bovine cervix and vagina during the follicular and luteal phases of the sexual cycle. Biotech Histochem. 2011;86:262-71 pubmed 出版商
Sharrow A, Ronnett B, Thoburn C, Barber J, Giuntoli R, Armstrong D, et al. Identification and characterization of a spontaneous ovarian carcinoma in Lewis rats. J Ovarian Res. 2010;3:9 pubmed 出版商
Ferreira E, Gobbi H, Saraiva B, Cassali G. Columnar cell lesions of the canine mammary gland: pathological features and immunophenotypic analysis. BMC Cancer. 2010;10:61 pubmed 出版商
Afhüppe W, Beekman J, Otto C, Korr D, Hoffmann J, Fuhrmann U, et al. In vitro characterization of ZK 230211--A type III progesterone receptor antagonist with enhanced antiproliferative properties. J Steroid Biochem Mol Biol. 2010;119:45-55 pubmed 出版商
Chang C, Chiou P, Chen W, Li Y, Yiu J, Cheng Y, et al. Assessment of the tumorigenesis and drug susceptibility of three new canine mammary tumor cell lines. Res Vet Sci. 2010;88:285-93 pubmed 出版商
Wang Y, Hanifi Moghaddam P, Hanekamp E, Kloosterboer H, Franken P, Veldscholte J, et al. Progesterone inhibition of Wnt/beta-catenin signaling in normal endometrium and endometrial cancer. Clin Cancer Res. 2009;15:5784-93 pubmed 出版商
Misirlioglu D, Nak D, Ozyigit M, Nak Y, Akkoc A. HER-2/neu (c-erbB-2) oncoprotein in hyperplastic endometrial polyps detected in two cats. J Feline Med Surg. 2009;11:885-8 pubmed 出版商
Gul A, Ugur M, Iskender C, Zulfikaroglu E, Ozaksit G. Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps and its relationship to clinical parameters. Arch Gynecol Obstet. 2010;281:479-83 pubmed 出版商
Chakravarty D, Gupta N, Goda J, Srinivasan R, Patel F, Dhaliwal L. Steroid receptors, HER2/neu and Ki-67, in endometrioid type of endometrial carcinoma: Correlation with conventional histomorphological features of prognosis. Acta Histochem. 2010;112:355-63 pubmed 出版商
Yanagawa Y, Matsuura Y, Suzuki M, Katagiri S, Tsubota T. Immunohistochemical localization of the estrogen receptor alpha (ERalpha) and progesterone receptor (PR) in the uterus of sika deer (Cervus nippon) during pregnancy. Jpn J Vet Res. 2008;56:139-49 pubmed
Chakravarty D, Srinivasan R, Ghosh S, Rajwanshi A, Gopalan S. Estrogen receptor beta (ERbeta) in endometrial simple hyperplasia and endometrioid carcinoma. Appl Immunohistochem Mol Morphol. 2008;16:535-42 pubmed 出版商
Honorat M, Mesnier A, Di Pietro A, Lin V, Cohen P, Dumontet C, et al. Dexamethasone down-regulates ABCG2 expression levels in breast cancer cells. Biochem Biophys Res Commun. 2008;375:308-14 pubmed 出版商
Martin I, Torres Neto R, Oba E, Buratini J, Binelli M, Laufer Amorim R, et al. Immunohistochemical detection of receptors for oestrogen and progesterone in endometrial glands and stroma during the oestrous cycle in Nelore (Bos taurus indicus) cows. Reprod Domest Anim. 2008;43:415-21 pubmed 出版商
Yaren A, Kelten C, Akbulut M, Teke Z, Duzcan E, Erdem E. Primary neuroendocrine carcinoma of the breast: a case report. Tumori. 2007;93:496-8 pubmed
Slayden O, Keator C. Role of progesterone in nonhuman primate implantation. Semin Reprod Med. 2007;25:418-30 pubmed
Brayman M, Dharmaraj N, Lagow E, Carson D. MUC1 expression is repressed by protein inhibitor of activated signal transducer and activator of transcription-y. Mol Endocrinol. 2007;21:2725-37 pubmed
Hanifi Moghaddam P, Sijmons B, Ott M, van Ijcken W, Nowzari D, Kuhne E, et al. The hormone replacement therapy drug tibolone acts very similar to medroxyprogesterone acetate in an estrogen-and progesterone-responsive endometrial cancer cell line. J Mol Endocrinol. 2006;37:405-13 pubmed
Ishizuka M, Hatori M, Dohi O, Suzuki T, Miki Y, Tazawa C, et al. Expression profiles of sex steroid receptors in desmoid tumors. Tohoku J Exp Med. 2006;210:189-98 pubmed
Faivre E, Lange C. Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cells. Mol Cell Biol. 2007;27:466-80 pubmed
Valle G, Cassali G, Nogueira J, Castro A, Reis A, Cardoso F, et al. Nuclear estrogen and progesterone receptors in the oviduct of heifers under natural and superovulated estrous cycles. Anim Reprod Sci. 2007;101:28-37 pubmed
Saito S, Ito K, Nagase S, Suzuki T, Akahira J, Okamura K, et al. Progesterone receptor isoforms as a prognostic marker in human endometrial carcinoma. Cancer Sci. 2006;97:1308-14 pubmed
Cabioglu N, Sahin A, Doucet M, Yavuz E, Igci A, O Yildirim E, et al. Chemokine receptor CXCR4 expression in breast cancer as a potential predictive marker of isolated tumor cells in bone marrow. Clin Exp Metastasis. 2005;22:39-46 pubmed
Akhan S, Yavuz E, Tecer A, Iyibozkurt C, Topuz S, Tuzlali S, et al. The expression of Ki-67, p53, estrogen and progesterone receptors affecting survival in uterine leiomyosarcomas. A clinicopathologic study. Gynecol Oncol. 2005;99:36-42 pubmed
Mrusek S, Classen Linke I, Vloet A, Beier H, Krusche C. Estradiol and medroxyprogesterone acetate regulated genes in T47D breast cancer cells. Mol Cell Endocrinol. 2005;235:39-50 pubmed
Hasegawa J, Yanaihara A, Iwasaki S, Otsuka Y, Negishi M, Akahane T, et al. Reduction of progesterone receptor expression in human cumulus cells at the time of oocyte collection during IVF is associated with good embryo quality. Hum Reprod. 2005;20:2194-200 pubmed
Fritah A, Saucier C, Mester J, Redeuilh G, Sabbah M. p21WAF1/CIP1 selectively controls the transcriptional activity of estrogen receptor alpha. Mol Cell Biol. 2005;25:2419-30 pubmed
Zheng Z, Bay B, Aw S, Lin V. A novel antiestrogenic mechanism in progesterone receptor-transfected breast cancer cells. J Biol Chem. 2005;280:17480-7 pubmed
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Skildum A, Faivre E, Lange C. Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases. Mol Endocrinol. 2005;19:327-39 pubmed
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Abd Elaziz M, Akahira J, Moriya T, Suzuki T, Yaegashi N, Sasano H. Nuclear receptor DAX-1 in human common epithelial ovarian carcinoma: an independent prognostic factor of clinical outcome. Cancer Sci. 2003;94:980-5 pubmed
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González Morán G, Camacho Arroyo I. Changes in the presence of progesterone receptor isoforms in the oviduct magnum of newly-hatched chicks after gonadotropins treatment. Life Sci. 2003;73:871-82 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
孕酮受体单克隆抗体(hPRa 2)
目录# :
MA5-12642
规格 :
500微升
价格 :
美国453.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:100, Immunoprecipitation: 2 µg/mL, Western Blot: 1:50-1:100
物种 :
人类
克隆 :
hPRa 2
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.
免疫原 :
PgR from a human endometrial carcinoma (EnCa 101) grown in athymic mice
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:100, Immunoprecipitation: 2 µg/mL, Western Blot: 1:50-1:100
别名 :
9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国