产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
孕酮受体单克隆抗体(hPRa 7)
目录 :
MA5-12658
规格 :
500微升
价格 :
美国446.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
hPRa 7
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 39
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 小鼠; 图 4
Joshi P, Waterhouse P, Kannan N, Narala S, Fang H, Di Grappa M, et al. RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1. Stem Cell Reports. 2015;5:31-44 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:50
Chen F, Li A, Gao S, Hollern D, Williams M, Liu F, et al. Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression. Cell Death Dis. 2014;5:e1242 pubmed 出版商
  • 免疫细胞化学; 小鼠
Melchor L, Molyneux G, Mackay A, Magnay F, Atienza M, Kendrick H, et al. Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models. J Pathol. 2014;233:124-37 pubmed 出版商
  • 免疫印迹; 小鼠
Spallanzani R, Dalotto Moreno T, Raffo Iraolagoitia X, Ziblat A, Domaica C, Avila D, et al. Expansion of CD11b(+)Ly6G (+)Ly6C (int) cells driven by medroxyprogesterone acetate in mice bearing breast tumors restrains NK cell effector functions. Cancer Immunol Immunother. 2013;62:1781-95 pubmed 出版商
  • 免疫组化; 小鼠; 1:50
Aupperlee M, Leipprandt J, Bennett J, Schwartz R, Haslam S. Amphiregulin mediates progesterone-induced mammary ductal development during puberty. Breast Cancer Res. 2013;15:R44 pubmed 出版商
  • 免疫印迹; 人类
Rivas M, Venturutti L, Huang Y, Schillaci R, Huang T, Elizalde P. Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development. Breast Cancer Res. 2012;14:R77 pubmed
  • 免疫印迹; 人类; 4 ug/ml; 图 5
Tieszen C, Goyeneche A, Brandhagen B, Ortbahn C, Telleria C. Antiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expression. BMC Cancer. 2011;11:207 pubmed 出版商
  • 免疫组化; 小鼠
Welsh J, Zinser L, Mianecki Morton L, Martin J, Waltz S, James H, et al. Age-related changes in the epithelial and stromal compartments of the mammary gland in normocalcemic mice lacking the vitamin D3 receptor. PLoS ONE. 2011;6:e16479 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫组化; 人类; 1:100
Kariagina A, Xie J, Leipprandt J, Haslam S. Amphiregulin mediates estrogen, progesterone, and EGFR signaling in the normal rat mammary gland and in hormone-dependent rat mammary cancers. Horm Cancer. 2010;1:229-44 pubmed 出版商
  • 免疫印迹; 人类
Proietti C, Beguelin W, Flaqué M, Cayrol F, Rivas M, Tkach M, et al. Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer. Steroids. 2011;76:381-92 pubmed 出版商
  • 免疫组化; 小鼠; 1:50
Zhang C, Mori M, Gao S, Li A, Hoshino I, Aupperlee M, et al. Tip30 deletion in MMTV-Neu mice leads to enhanced EGFR signaling and development of estrogen receptor-positive and progesterone receptor-negative mammary tumors. Cancer Res. 2010;70:10224-33 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Beguelin W, Díaz Flaqué M, Proietti C, Cayrol F, Rivas M, Tkach M, et al. Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Mol Cell Biol. 2010;30:5456-72 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100
  • 免疫印迹; 小鼠; 1:100
Bottino M, Cerliani J, Rojas P, Giulianelli S, Soldati R, Mondillo C, et al. Classical membrane progesterone receptors in murine mammary carcinomas: agonistic effects of progestins and RU-486 mediating rapid non-genomic effects. Breast Cancer Res Treat. 2011;126:621-36 pubmed 出版商
  • 免疫组化; 小鼠; 1:200
  • 免疫印迹; 小鼠; 2 ug/ml
Wargon V, Fernandez S, Goin M, Giulianelli S, Russo J, Lanari C. Hypermethylation of the progesterone receptor A in constitutive antiprogestin-resistant mouse mammary carcinomas. Breast Cancer Res Treat. 2011;126:319-32 pubmed 出版商
  • 免疫组化; 小鼠
Soldati R, Wargon V, Cerliani J, Giulianelli S, Vanzulli S, Gorostiaga M, et al. Inhibition of mammary tumor growth by estrogens: is there a specific role for estrogen receptors alpha and beta?. Breast Cancer Res Treat. 2010;123:709-24 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
Salama S, Kamel M, Botting S, Salih S, Borahay M, Hamed A, et al. Catechol-o-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells. PLoS ONE. 2009;4:e7356 pubmed 出版商
  • 免疫印迹; 人类
Proietti C, Rosemblit C, Beguelin W, Rivas M, Díaz Flaqué M, Charreau E, et al. Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth. Mol Cell Biol. 2009;29:1249-65 pubmed 出版商
  • 免疫组化; 小鼠; 1:50
Giulianelli S, Cerliani J, Lamb C, Fabris V, Bottino M, Gorostiaga M, et al. Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis. Int J Cancer. 2008;123:2518-31 pubmed 出版商
  • 流式细胞仪; 人类
  • 免疫细胞化学; 人类; 1:50
  • 免疫印迹; 人类; 2 ug/ml
Arruvito L, Giulianelli S, Flores A, Paladino N, Barboza M, Lanari C, et al. NK cells expressing a progesterone receptor are susceptible to progesterone-induced apoptosis. J Immunol. 2008;180:5746-53 pubmed
  • 免疫组化; 人类; 1:50
Hoogendoorn W, Hollema H, van Boven H, Bergman E, de Leeuw Mantel G, Platteel I, et al. Prognosis of uterine corpus cancer after tamoxifen treatment for breast cancer. Breast Cancer Res Treat. 2008;112:99-108 pubmed
  • 免疫细胞化学; 人类
Chi J, Rodriguez E, Wang Z, Nuyten D, Mukherjee S, van de Rijn M, et al. Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers. PLoS Genet. 2007;3:1770-84 pubmed
  • 免疫组化; 大鼠; 1:50, 1:100
Kariagina A, Aupperlee M, Haslam S. Progesterone receptor isoforms and proliferation in the rat mammary gland during development. Endocrinology. 2007;148:2723-36 pubmed
  • 免疫组化; 人类; 1:200
Ishizuka M, Hatori M, Dohi O, Suzuki T, Miki Y, Tazawa C, et al. Expression profiles of sex steroid receptors in desmoid tumors. Tohoku J Exp Med. 2006;210:189-98 pubmed
  • 免疫沉淀; 小鼠
  • 免疫细胞化学; 小鼠; 1:100
  • 免疫印迹; 小鼠
Salatino M, Beguelin W, Peters M, Carnevale R, Proietti C, Galigniana M, et al. Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation. Oncogene. 2006;25:7723-39 pubmed
  • 免疫组化; 人类; 1:100
Akahane T, Sekizawa A, Okuda T, Kushima M, Saito H, Okai T. Disappearance of steroid hormone dependency during malignant transformation of ovarian clear cell cancer. Int J Gynecol Pathol. 2005;24:369-76 pubmed
  • 免疫组化; 人类; 1:100
Yamashita H, Nishio M, Kobayashi S, Ando Y, Sugiura H, Zhang Z, et al. Phosphorylation of estrogen receptor alpha serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer. Breast Cancer Res. 2005;7:R753-64 pubmed
  • 免疫组化; 人类; 1:100
Oh S, Kim C, Park I, Romero R, Sohn Y, Moon K, et al. Progesterone receptor isoform (A/B) ratio of human fetal membranes increases during term parturition. Am J Obstet Gynecol. 2005;193:1156-60 pubmed
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Proietti C, Salatino M, Rosemblit C, Carnevale R, Pecci A, Kornblihtt A, et al. Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells. Mol Cell Biol. 2005;25:4826-40 pubmed
  • 免疫组化; 人类
Hasegawa J, Yanaihara A, Iwasaki S, Otsuka Y, Negishi M, Akahane T, et al. Reduction of progesterone receptor expression in human cumulus cells at the time of oocyte collection during IVF is associated with good embryo quality. Hum Reprod. 2005;20:2194-200 pubmed
  • 免疫组化; 人类; 1:100
Nishimura Y, Watanabe J, Jobo T, Hattori M, Arai T, Kuramoto H. Cytologic scoring of endometrioid adenocarcinoma of the endometrium. Cancer. 2005;105:8-12 pubmed
Ponikwicka Tyszko D, Chruściel M, Pulawska K, Bernaczyk P, Sztachelska M, Guo P, et al. Mifepristone Treatment Promotes Testicular Leydig Cell Tumor Progression in Transgenic Mice. Cancers (Basel). 2020;12: pubmed 出版商
Ponikwicka Tyszko D, Chruściel M, Stelmaszewska J, Bernaczyk P, Chrusciel P, Sztachelska M, et al. Molecular mechanisms underlying mifepristone's agonistic action on ovarian cancer progression. EBioMedicine. 2019;47:170-183 pubmed 出版商
Dinh D, Breen J, Akison L, DeMayo F, Brown H, Robker R, et al. Tissue-specific progesterone receptor-chromatin binding and the regulation of progesterone-dependent gene expression. Sci Rep. 2019;9:11966 pubmed 出版商
Grindstad T, Richardsen E, Andersen S, Skjefstad K, Rakaee Khanehkenari M, Donnem T, et al. Progesterone Receptors in Prostate Cancer: Progesterone receptor B is the isoform associated with disease progression. Sci Rep. 2018;8:11358 pubmed 出版商
Salatino M, Schillaci R, Proietti C, Carnevale R, Frahm I, Molinolo A, et al. Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor. Oncogene. 2004;23:5161-74 pubmed
Abd Elaziz M, Akahira J, Moriya T, Suzuki T, Yaegashi N, Sasano H. Nuclear receptor DAX-1 in human common epithelial ovarian carcinoma: an independent prognostic factor of clinical outcome. Cancer Sci. 2003;94:980-5 pubmed
Vermeulen M, Pazos P, Lanari C, Molinolo A, Gamberale R, Geffner J, et al. Medroxyprogesterone acetate enhances in vivo and in vitro antibody production. Immunology. 2001;104:80-6 pubmed
Kirma N, Gill K, Mandava U, Tekmal R. Overexpression of aromatase leads to hyperplasia and changes in the expression of genes involved in apoptosis, cell cycle, growth, and tumor suppressor functions in the mammary glands of transgenic mice. Cancer Res. 2001;61:1910-8 pubmed
O Brien S, Welter B, Mantzke K, Price T. Identification of progesterone receptor in human subcutaneous adipose tissue. J Clin Endocrinol Metab. 1998;83:509-13 pubmed
图像
图像 1 :
赛默飞世尔 MA5-12658 图像 1
产品信息
产品类型 :
抗体
产品名称 :
孕酮受体单克隆抗体(hPRa 7)
目录# :
MA5-12658
规格 :
500微升
价格 :
美国446.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
Human, Mouse, Non-human primate, Rat
应用 :
Immunocytochemistry: 1:50, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
物种 :
Human, Mouse, Non-human primate, Rat
克隆 :
hPRa 7
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.
免疫原 :
PgR from a human endometrial carcinoma (EnCa 101) grown in athymic mice
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:50, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
别名 :
9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国