产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Cyclin D2 Antibody Cocktail
目录 :
MA5-12731
规格 :
500µL
价格 :
美国345
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
DCS-3.1 + DCS-5.2
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 16
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类
Turner J, Kashyap T, Dawson J, Gomez J, Bauer A, Grant S, et al. XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IκBα and overcomes acquired proteasome inhibitor resistance in human multiple myeloma. Oncotarget. 2016;7:78896-78909 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:100
Mirzaa G, Parry D, Fry A, Giamanco K, Schwartzentruber J, Vanstone M, et al. De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. Nat Genet. 2014;46:510-515 pubmed 出版商
  • 免疫组化; 小鼠
Komada M, Iguchi T, Takeda T, Ishibashi M, Sato M. Smoothened controls cyclin D2 expression and regulates the generation of intermediate progenitors in the developing cortex. Neurosci Lett. 2013;547:87-91 pubmed 出版商
  • 免疫印迹; 小鼠; 1:400
Yang Y, Chang B, Chan L. Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults. EMBO Mol Med. 2013;5:92-104 pubmed 出版商
  • 免疫沉淀; 小鼠
  • 免疫印迹; 小鼠
Zhang Q, Sakamoto K, Liu C, Triplett A, Lin W, Rui H, et al. Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression. Cancer Res. 2011;71:7513-24 pubmed 出版商
  • 免疫印迹; 人类
Stein J, Milewski W, Hara M, Steiner D, Dey A. GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1). Islets. 2011;3:21-34 pubmed
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
He L, Sartori D, Teta M, Opare Addo L, Rankin M, Long S, et al. Cyclin D2 protein stability is regulated in pancreatic beta-cells. Mol Endocrinol. 2009;23:1865-75 pubmed 出版商
  • 免疫印迹; 小鼠
Rankin M, Kushner J. Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes. 2009;58:1365-72 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000
Glickstein S, Moore H, Slowinska B, Racchumi J, Suh M, Chuhma N, et al. Selective cortical interneuron and GABA deficits in cyclin D2-null mice. Development. 2007;134:4083-93 pubmed
  • 免疫组化; 小鼠; 1:500
Pogoriler J, Millen K, Utset M, Du W. Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation. Development. 2006;133:3929-37 pubmed
  • 免疫印迹; 大鼠; 1:200; 图 1b
Friedrichsen B, Richter H, Hansen J, Rhodes C, Nielsen J, Billestrup N, et al. Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells. Mol Endocrinol. 2003;17:945-58 pubmed
Jirawatnotai S, Aziyu A, Osmundson E, Moons D, Zou X, Kineman R, et al. Cdk4 is indispensable for postnatal proliferation of the anterior pituitary. J Biol Chem. 2004;279:51100-6 pubmed
Chen B, Pollard J. Cyclin D2 compensates for the loss of cyclin D1 in estrogen-induced mouse uterine epithelial cell proliferation. Mol Endocrinol. 2003;17:1368-81 pubmed
Clark W, Black E, MacLaren A, Kruse U, LaThangue N, Vogt P, et al. v-Jun overrides the mitogen dependence of S-phase entry by deregulating retinoblastoma protein phosphorylation and E2F-pocket protein interactions as a consequence of enhanced cyclin E-cdk2 catalytic activity. Mol Cell Biol. 2000;20:2529-42 pubmed
Tsutsui T, Hesabi B, Moons D, Pandolfi P, Hansel K, Koff A, et al. Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity. Mol Cell Biol. 1999;19:7011-9 pubmed
Ladha M, Lee K, Upton T, Reed M, Ewen M. Regulation of exit from quiescence by p27 and cyclin D1-CDK4. Mol Cell Biol. 1998;18:6605-15 pubmed
产品信息
产品类型 :
抗体
产品名称 :
Cyclin D2 Antibody Cocktail
目录# :
MA5-12731
规格 :
500µL
价格 :
美国345
克隆性 :
Cocktail
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 1-2 µg/mL, Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (Paraffin): 1:20, Western Blot: Assay Dependent
物种 :
人类, 小鼠, 大鼠
克隆 :
DCS-3.1 + DCS-5.2
抗体亚型 :
IgG2a/IgG2b
储存 :
4° C
描述 :
Cyclin D2 is a G1 cyclin required for G1 phase progression and is a strong candidate for a proto-oncogene. Cyclin D2 can phosphorylate pRB when associated with cdk 4 and / or cdk 6.
免疫原 :
纯化组氨酸标签人类重组全长细胞周期蛋白D2蛋白
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1-2 µg/mL, Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (Paraffin): 1:20, Western Blot: Assay Dependent
别名 :
2600016F06Rik; AI256817; BF642806; C86853; CCND2; cD2; cyclin D2; Cyl-2; G1/S-specific cyclin-D2; KIAK0002; MGC102758; MPPH3; Vin1; Vin-1; Vin-1 proto-oncogene
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国