产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
TGM2单克隆抗体(CUB 7402)
目录 :
MA5-12739
规格 :
500微升
价格 :
美国404.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
CUB 7402
反应物种 :
豚鼠, African green monkey, 仓鼠, 人类, 小鼠, 大鼠, , pigs , domestic rabbit
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, reverse phase protein lysate microarray, 抑制或激活实验
更多信息或购买 :
文章摘录数: 129
出版应用/物种/样本/稀释参考文献
  • reverse phase protein lysate microarray; 人类; 图 7a
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed 出版商
  • reverse phase protein lysate microarray; 人类; 图 3a
. Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378-384 pubmed 出版商
  • 免疫印迹; 人类
Hill S, Nesser N, Johnson Camacho K, Jeffress M, Johnson A, Boniface C, et al. Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling. Cell Syst. 2017;4:73-83.e10 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类; 1:5000
Csomós K, Kristóf E, Jakob B, Csomós I, Kovács G, Rotem O, et al. Protein cross-linking by chlorinated polyamines and transglutamylation stabilizes neutrophil extracellular traps. Cell Death Dis. 2016;7:e2332 pubmed 出版商
  • 免疫沉淀; 人类; 图 3
  • 免疫印迹; 人类; 图 2
Altuntas S, Rossin F, Marsella C, D Eletto M, Diaz Hidalgo L, Farrace M, et al. The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation. Oncotarget. 2015;6:44941-54 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
Myneni V, Melino G, Kaartinen M. Transglutaminase 2--a novel inhibitor of adipogenesis. Cell Death Dis. 2015;6:e1868 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 1:1000; 图 1f
Di Niro R, Snir O, Kaukinen K, Yaari G, Lundin K, Gupta N, et al. Responsive population dynamics and wide seeding into the duodenal lamina propria of transglutaminase-2-specific plasma cells in celiac disease. Mucosal Immunol. 2016;9:254-64 pubmed 出版商
  • 免疫细胞化学; 人类
Piacentini M, D Eletto M, Farrace M, Rodolfo C, Del Nonno F, Ippolito G, et al. Characterization of distinct sub-cellular location of transglutaminase type II: changes in intracellular distribution in physiological and pathological states. Cell Tissue Res. 2014;358:793-805 pubmed 出版商
  • 免疫组化; 人类; 1:50-100
  • 免疫印迹; 人类; 1:5000
Leicht D, Kausar T, Wang Z, Ferrer Torres D, Wang T, Thomas D, et al. TGM2: a cell surface marker in esophageal adenocarcinomas. J Thorac Oncol. 2014;9:872-81 pubmed 出版商
  • 免疫组化; 人类
Quaglia S, De Leo L, Ziberna F, Vatta S, Villanacci V, Granzotto M, et al. Intestinal-mucosa anti-transglutaminase antibody assays to test for genetic gluten intolerance. Cell Mol Immunol. 2014;11:617-20 pubmed 出版商
  • 免疫组化; 大鼠; 5 ug/ml
Steppan J, Sikka G, Jandu S, Barodka V, Halushka M, Flavahan N, et al. Exercise, vascular stiffness, and tissue transglutaminase. J Am Heart Assoc. 2014;3:e000599 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Boisvert H, Lorand L, Duncan M. Transglutaminase 2 is essential for adherence of Porphyromonas gingivalis to host cells. Proc Natl Acad Sci U S A. 2014;111:5355-60 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Ku B, Lee C, Lee S, Kim S. Increased expression of transglutaminase 2 drives glycolytic metabolism in renal carcinoma cells. Amino Acids. 2014;46:1527-36 pubmed 出版商
  • 免疫细胞化学; 小鼠
  • 免疫印迹; 小鼠; 1:500
Kim J, Hong J, Jeong E, Lee W, Kim H, Kang J, et al. Lack of transglutaminase 2 diminished T-cell responses in mice. Immunology. 2014;142:506-16 pubmed 出版商
  • 免疫印迹; 人类
Lee D, Chang G. Methylglyoxal in cells elicits a negative feedback loop entailing transglutaminase 2 and glyoxalase 1. Redox Biol. 2014;2:196-205 pubmed 出版商
  • 免疫组化; 人类; 1:200
Caruso R, Marafini I, Del Vecchio Blanco G, Fina D, Paoluzi O, Colantoni A, et al. Sampling of proximal and distal duodenal biopsies in the diagnosis and monitoring of celiac disease. Dig Liver Dis. 2014;46:323-9 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Ciacci C, Russo I, Bucci C, Iovino P, Pellegrini L, Giangrieco I, et al. The kiwi fruit peptide kissper displays anti-inflammatory and anti-oxidant effects in in-vitro and ex-vivo human intestinal models. Clin Exp Immunol. 2014;175:476-84 pubmed 出版商
  • 酶联免疫吸附测定; 人类; 1:200
Antonella Nadalutti C, Korponay Szabo I, Kaukinen K, Wang Z, Griffin M, Maki M, et al. Thioredoxin is involved in endothelial cell extracellular transglutaminase 2 activation mediated by celiac disease patient IgA. PLoS ONE. 2013;8:e77277 pubmed 出版商
  • 抑制或激活实验; 人类; 0.5 ug/ml
  • 免疫印迹; 人类
Wang Z, Perez M, Caja S, Melino G, Johnson T, Lindfors K, et al. A novel extracellular role for tissue transglutaminase in matrix-bound VEGF-mediated angiogenesis. Cell Death Dis. 2013;4:e808 pubmed 出版商
  • 酶联免疫吸附测定; 人类; 1:200
  • 免疫印迹; 人类
Nadalutti C, Korponay Szabo I, Kaukinen K, Griffin M, Maki M, Lindfors K. Celiac disease patient IgA antibodies induce endothelial adhesion and cell polarization defects via extracellular transglutaminase 2. Cell Mol Life Sci. 2014;71:1315-26 pubmed 出版商
  • 酶联免疫吸附测定; 人类
  • 免疫印迹; 人类; 1:2000
Kanchan K, Ergülen E, Kiraly R, Simon Vecsei Z, Fuxreiter M, Fesus L. Identification of a specific one amino acid change in recombinant human transglutaminase 2 that regulates its activity and calcium sensitivity. Biochem J. 2013;455:261-72 pubmed 出版商
  • 免疫沉淀; 人类; 1:1000
  • 免疫印迹; 人类; 1:1000
Currò M, Ferlazzo N, Risitano R, Condello S, Vecchio M, Caccamo D, et al. Transglutaminase 2 and phospholipase A? interactions in the inflammatory response in human Thp-1 monocytes. Amino Acids. 2014;46:759-66 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Ku B, Kim D, Kim K, Yoo B, Kim S, Gong Y, et al. Transglutaminase 2 inhibition found to induce p53 mediated apoptosis in renal cell carcinoma. FASEB J. 2013;27:3487-95 pubmed 出版商
  • 流式细胞仪; 人类
  • 酶联免疫吸附测定; 人类
Iversen R, Di Niro R, Stamnaes J, Lundin K, Wilson P, Sollid L. Transglutaminase 2-specific autoantibodies in celiac disease target clustered, N-terminal epitopes not displayed on the surface of cells. J Immunol. 2013;190:5981-91 pubmed 出版商
  • 免疫组化; 人类
Bucci C, Zingone F, Russo I, Morra I, Tortora R, Pogna N, et al. Gliadin does not induce mucosal inflammation or basophil activation in patients with nonceliac gluten sensitivity. Clin Gastroenterol Hepatol. 2013;11:1294-1299.e1 pubmed 出版商
  • 免疫印迹; 大鼠; 图 5
Wang Z, Griffin M. The role of TG2 in regulating S100A4-mediated mammary tumour cell migration. PLoS ONE. 2013;8:e57017 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Byrne G, Freeley M, Feighery C, Whelan A, Long A. Protein kinase C delta is a substrate of tissue transglutaminase and a novel autoantigen in coeliac disease. Clin Immunol. 2013;147:1-8 pubmed 出版商
  • 免疫印迹; 人类
Park M, You H, Lee H, Kang J, Oh S, Kim S, et al. Transglutaminase-2 induces N-cadherin expression in TGF-?1-induced epithelial mesenchymal transition via c-Jun-N-terminal kinase activation by protein phosphatase 2A down-regulation. Eur J Cancer. 2013;49:1692-705 pubmed 出版商
  • 免疫印迹; 小鼠
Yoo H, Ahn E, Kim S, Lee S, Oh S, Kim S. Divergent results induced by different types of septic shock in transglutaminase 2 knockout mice. Amino Acids. 2013;44:189-97 pubmed 出版商
  • 免疫组化; 人类
Elli L, Roncoroni L, Hils M, Pasternack R, Barisani D, Terrani C, et al. Immunological effects of transglutaminase-treated gluten in coeliac disease. Hum Immunol. 2012;73:992-7 pubmed 出版商
  • 免疫印迹; 大鼠
D Argenio G, Mazzone G, Ribecco M, Lembo V, Vitaglione P, Guarino M, et al. Garlic extract attenuating rat liver fibrosis by inhibiting TGF-?1. Clin Nutr. 2013;32:252-8 pubmed 出版商
  • 免疫细胞化学; 大鼠
Lauzier A, Charbonneau M, Paquette M, Harper K, Dubois C. Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis. Arthritis Res Ther. 2012;14:R159 pubmed 出版商
  • 免疫印迹; 人类
Ai L, Skehan R, Saydi J, Lin T, Brown K. Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor ? light chain enhancer of activated B cells (NF?B) signaling controls basal and DNA damage-induced transglutaminase 2 expression. J Biol Chem. 2012;287:18330-41 pubmed 出版商
  • 免疫细胞化学; 人类
Russo L, Marsella C, Nardo G, Massignan T, Alessio M, Piermarini E, et al. Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E. Acta Diabetol. 2013;50:61-72 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2000
D Argenio G, Mazzone G, Tuccillo C, Ribecco M, Graziani G, Gravina A, et al. Apple polyphenols extract (APE) improves colon damage in a rat model of colitis. Dig Liver Dis. 2012;44:555-62 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫细胞化学; 人类; 1:25
  • 免疫印迹; 小鼠
D Eletto M, Farrace M, Rossin F, Strappazzon F, Giacomo G, Cecconi F, et al. Type 2 transglutaminase is involved in the autophagy-dependent clearance of ubiquitinated proteins. Cell Death Differ. 2012;19:1228-38 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类; 1:1000
Kojima S, Kuo T, Tatsukawa H. Regulation of transglutaminase-mediated hepatic cell death in alcoholic steatohepatitis and non-alcoholic steatohepatitis. J Gastroenterol Hepatol. 2012;27 Suppl 2:52-7 pubmed 出版商
  • 免疫组化; 人类
Oikarinen M, Tauriainen S, Oikarinen S, Honkanen T, Collin P, Rantala I, et al. Type 1 diabetes is associated with enterovirus infection in gut mucosa. Diabetes. 2012;61:687-91 pubmed 出版商
  • 抑制或激活实验; 人类; 1 mg/ml
Silano M, Vincentini O, Luciani A, Felli C, Caserta S, Esposito S, et al. Early tissue transglutaminase-mediated response underlies K562(S)-cell gliadin-dependent agglutination. Pediatr Res. 2012;71:532-8 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫组化; 人类
  • 免疫印迹; 人类
Jung H, Chen Z, Wang M, Fayad L, Romaguera J, Kwak L, et al. Calcium blockers decrease the bortezomib resistance in mantle cell lymphoma via manipulation of tissue transglutaminase activities. Blood. 2012;119:2568-78 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Kumar A, Xu J, Sung B, Kumar S, Yu D, Aggarwal B, et al. Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells. Breast Cancer Res. 2012;14:R4 pubmed
  • 免疫细胞化学; 大鼠; 1:500
  • 免疫印迹; 大鼠; 1:1000
Campisi A, Spatuzza M, Russo A, Raciti G, Vanella A, Stanzani S, et al. Expression of tissue transglutaminase on primary olfactory ensheathing cells cultures exposed to stress conditions. Neurosci Res. 2012;72:289-95 pubmed 出版商
  • 免疫印迹; 人类
van Geel R, Debets M, Löwik D, Pruijn G, Boelens W. Detection of transglutaminase activity using click chemistry. Amino Acids. 2012;43:1251-63 pubmed 出版商
  • 抑制或激活实验; 人类; 2 ug/ml
Caputo I, Lepretti M, Secondo A, Martucciello S, Paolella G, Sblattero D, et al. Anti-tissue transglutaminase antibodies activate intracellular tissue transglutaminase by modulating cytosolic Ca2+ homeostasis. Amino Acids. 2013;44:251-60 pubmed 出版商
  • 免疫细胞化学; 豚鼠; 1:1000
  • 免疫组化; 豚鼠; 1:1000
Wilhelmus M, de Jager M, Rozemuller A, Brevé J, Bol J, Eckert R, et al. Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies. J Pathol. 2012;226:132-42 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:500
  • 免疫印迹; 小鼠; 1:1000
van Strien M, Baron W, Bakker E, Bauer J, Bol J, Brevé J, et al. Tissue transglutaminase activity is involved in the differentiation of oligodendrocyte precursor cells into myelin-forming oligodendrocytes during CNS remyelination. Glia. 2011;59:1622-34 pubmed 出版商
  • 免疫细胞化学; 人类
Zemskov E, Mikhailenko I, Smith E, Belkin A. Tissue transglutaminase promotes PDGF/PDGFR-mediated signaling and responses in vascular smooth muscle cells. J Cell Physiol. 2012;227:2089-96 pubmed 出版商
  • 免疫组化; 人类
Stenberg R, Kaukinen K, Bengtsson M, Lindberg E, Dahle C. Early developing celiac disease in children with cerebral palsy. J Pediatr Gastroenterol Nutr. 2011;53:674-8 pubmed 出版商
  • 免疫组化; 人类
Ruuskanen A, Luostarinen L, Collin P, Krekelä I, Patrikainen H, Tillonen J, et al. Persistently positive gliadin antibodies without transglutaminase antibodies in the elderly: gluten intolerance beyond coeliac disease. Dig Liver Dis. 2011;43:772-8 pubmed 出版商
  • 流式细胞仪; 小鼠
  • 免疫细胞化学; 小鼠
Zemskov E, Mikhailenko I, Hsia R, Zaritskaya L, Belkin A. Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes. PLoS ONE. 2011;6:e19414 pubmed 出版商
  • 流式细胞仪; 人类; 图 4
  • 免疫印迹; 人类; 1:200; 图 4
Chiang N, Hsiao C, Huang Y, Chen H, Hsieh I, Chang G, et al. Disease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms. J Biol Chem. 2011;286:14215-25 pubmed 出版商
  • 免疫印迹; 人类
Tatsukawa H, Sano T, Fukaya Y, Ishibashi N, Watanabe M, Okuno M, et al. Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells. Mol Cancer. 2011;10:4 pubmed 出版商
  • 免疫组化; 人类; 1:500
Wilhelmus M, Verhaar R, Andringa G, Bol J, Cras P, Shan L, et al. Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain. Brain Pathol. 2011;21:130-9 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Kim D, Han B, Park K, Lee B, Kim S, Bae C. I-kappaBalpha depletion by transglutaminase 2 and mu-calpain occurs in parallel with the ubiquitin-proteasome pathway. Biochem Biophys Res Commun. 2010;399:300-6 pubmed 出版商
  • 免疫组化; African green monkey; 1:2000
Steele K, Anderson A, Mohamadzadeh M. Fibroblastic reticular cell infection by hemorrhagic fever viruses. Immunotherapy. 2009;1:187-97 pubmed 出版商
  • 免疫印迹; 人类
Frese Schaper M, Schardt J, Sakai T, Carboni G, Schmid R, Frese S. Inhibition of tissue transglutaminase sensitizes TRAIL-resistant lung cancer cells through upregulation of death receptor 5. FEBS Lett. 2010;584:2867-71 pubmed 出版商
  • 免疫组化; 人类
Koskinen O, Lindfors K, Collin P, Peräaho M, Laurila K, Woolley N, et al. Intestinal transglutaminase 2 specific antibody deposits in non-responsive coeliac disease. Dig Liver Dis. 2010;42:692-7 pubmed 出版商
  • 免疫组化; 大鼠; 1:1000
  • 免疫印迹; 人类; 1:1000
Boscolo S, Lorenzon A, Sblattero D, Florian F, Stebel M, Marzari R, et al. Anti transglutaminase antibodies cause ataxia in mice. PLoS ONE. 2010;5:e9698 pubmed 出版商
  • 免疫细胞化学; 犬
Prunotto M, Compagnone A, Bruschi M, Candiano G, Colombatto S, Bandino A, et al. Endocellular polyamine availability modulates epithelial-to-mesenchymal transition and unfolded protein response in MDCK cells. Lab Invest. 2010;90:929-39 pubmed 出版商
  • 酶联免疫吸附测定; 豚鼠; 1:1000
  • 免疫细胞化学; 人类
  • 酶联免疫吸附测定; 人类; 1:1000
Faye C, Inforzato A, Bignon M, Hartmann D, Muller L, Ballut L, et al. Transglutaminase-2: a new endostatin partner in the extracellular matrix of endothelial cells. Biochem J. 2010;427:467-75 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类; 1:100
Luciani A, Villella V, Vasaturo A, Giardino I, Pettoello Mantovani M, Guido S, et al. Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARgamma downregulation in intestinal epithelial cells and coeliac mucosa. Gut. 2010;59:311-9 pubmed 出版商
  • 免疫印迹; 人类
Suenaga Y, Kaneko Y, Matsumoto D, Hossain M, Ozaki T, Nakagawara A. Positive auto-regulation of MYCN in human neuroblastoma. Biochem Biophys Res Commun. 2009;390:21-6 pubmed 出版商
  • 免疫组化; 人类; 1:100
Gorgun J, Portyanko A, Marakhouski Y, Cherstvoy E. Tissue transglutaminase expression in celiac mucosa: an immunohistochemical study. Virchows Arch. 2009;455:363-73 pubmed 出版商
  • 流式细胞仪; 人类
  • 免疫沉淀; 人类
Telci D, Collighan R, Basaga H, Griffin M. Increased TG2 expression can result in induction of transforming growth factor beta1, causing increased synthesis and deposition of matrix proteins, which can be regulated by nitric oxide. J Biol Chem. 2009;284:29547-58 pubmed 出版商
  • 免疫细胞化学; 人类; 1:30
Malorni W, Farrace M, Matarrese P, Tinari A, Ciarlo L, Mousavi Shafaei P, et al. The adenine nucleotide translocator 1 acts as a type 2 transglutaminase substrate: implications for mitochondrial-dependent apoptosis. Cell Death Differ. 2009;16:1480-92 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类; 1:500
Luciani A, Villella V, Vasaturo A, Giardino I, Raia V, Pettoello Mantovani M, et al. SUMOylation of tissue transglutaminase as link between oxidative stress and inflammation. J Immunol. 2009;183:2775-84 pubmed 出版商
  • 免疫组化; pigs
Huebner J, Johnson K, Kraus V, Terkeltaub R. Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA. Osteoarthritis Cartilage. 2009;17:1056-64 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
  • 免疫印迹; 人类; 1:500
Kwon M, Jung J, Jung S, Park J, Kim Y, Ha K. Quantitative and rapid analysis of transglutaminase activity using protein arrays in mammalian cells. Mol Cells. 2009;27:337-43 pubmed 出版商
  • 抑制或激活实验; 人类; 1:400
  • 免疫组化; 人类; 1:100
Anjum N, Baker P, Robinson N, Aplin J. Maternal celiac disease autoantibodies bind directly to syncytiotrophoblast and inhibit placental tissue transglutaminase activity. Reprod Biol Endocrinol. 2009;7:16 pubmed 出版商
  • 免疫组化; 人类; 1:200
  • 免疫印迹; 人类
Cho B, Kim M, Suh D, Hahn J, Lee B, Choi Y, et al. Increased tissue transglutaminase expression in human atherosclerotic coronary arteries. Coron Artery Dis. 2008;19:459-68 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Bramanti V, Campisi A, Tomassoni D, Li Volti G, Caccamo D, Cannavo G, et al. Effect of acetylcholine precursors on proliferation and differentiation of astroglial cells in primary cultures. Neurochem Res. 2008;33:2601-8 pubmed 出版商
  • 免疫组化; 人类; 6.5 ug/ml
Hadjivassiliou M, Aeschlimann P, Strigun A, Sanders D, Woodroofe N, Aeschlimann D. Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase. Ann Neurol. 2008;64:332-43 pubmed 出版商
  • 免疫印迹; 人类
Kim D, Park K, Jeong K, Lee B, Lee C, Kim S. Glucosamine is an effective chemo-sensitizer via transglutaminase 2 inhibition. Cancer Lett. 2009;273:243-9 pubmed 出版商
  • 免疫印迹; 人类
Lai T, Liu Y, Tucker T, Daniel K, Sane D, Toone E, et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol. 2008;15:969-78 pubmed 出版商
  • 酶联免疫吸附测定; 人类
  • 免疫印迹; 人类
Stamnaes J, Fleckenstein B, Lund Johansen F, Sollid L. The monoclonal antibody 6B9 recognizes CD44 and not cell surface transglutaminase 2. Scand J Immunol. 2008;68:534-42 pubmed 出版商
  • 免疫组化; 人类; 1:500
Wilhelmus M, Grunberg S, Bol J, van Dam A, Hoozemans J, Rozemuller A, et al. Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain. Brain Pathol. 2009;19:612-22 pubmed 出版商
  • 免疫印迹; 小鼠
Telci D, Wang Z, Li X, Verderio E, Humphries M, Baccarini M, et al. Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling. J Biol Chem. 2008;283:20937-47 pubmed 出版商
  • 免疫印迹; 人类
Li H, Shen J, Chang S, Hsu W, Sung Y. Calcitonin promotes outgrowth of trophoblast cells on endometrial epithelial cells: involvement of calcium mobilization and protein kinase C activation. Placenta. 2008;29:20-9 pubmed
  • 免疫印迹; 仓鼠
Zemskov E, Mikhailenko I, Strickland D, Belkin A. Cell-surface transglutaminase undergoes internalization and lysosomal degradation: an essential role for LRP1. J Cell Sci. 2007;120:3188-99 pubmed
  • 抑制或激活实验; 人类; 2.5 ug/ml
Barone M, Caputo I, Ribecco M, Maglio M, Marzari R, Sblattero D, et al. Humoral immune response to tissue transglutaminase is related to epithelial cell proliferation in celiac disease. Gastroenterology. 2007;132:1245-53 pubmed
  • 免疫印迹; 人类
Kim D, Park S, Nam B, Kim I, Kim S. Reversal of drug resistance in breast cancer cells by transglutaminase 2 inhibition and nuclear factor-kappaB inactivation. Cancer Res. 2006;66:10936-43 pubmed
  • 免疫印迹; 人类
Zanoni G, Navone R, Lunardi C, Tridente G, Bason C, Sivori S, et al. In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes. PLoS Med. 2006;3:e358 pubmed
  • 酶联免疫吸附测定; 人类; 1:1000
  • 免疫印迹; 人类; 1:1000
Byrne G, Ryan F, Jackson J, Feighery C, Kelly J. Mutagenesis of the catalytic triad of tissue transglutaminase abrogates coeliac disease serum IgA autoantibody binding. Gut. 2007;56:336-41 pubmed
  • 免疫组化; 人类; 1:500
  • 免疫印迹; 人类; 1:500
Singer C, Hudelist G, Walter I, Rueckliniger E, Czerwenka K, Kubista E, et al. Tissue array-based expression of transglutaminase-2 in human breast and ovarian cancer. Clin Exp Metastasis. 2006;23:33-9 pubmed
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类; 1:2000 or 1:8000
Balajthy Z, Csomós K, Vámosi G, Szanto A, Lanotte M, Fesus L. Tissue-transglutaminase contributes to neutrophil granulocyte differentiation and functions. Blood. 2006;108:2045-54 pubmed
  • 免疫印迹; 小鼠
Strnad P, Siegel M, Toivola D, Choi K, Kosek J, Khosla C, et al. Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation. FEBS Lett. 2006;580:2351--2357 pubmed
  • 免疫细胞化学; 小鼠
  • 免疫印迹; 小鼠
Al Jallad H, Nakano Y, Chen J, McMillan E, Lefebvre C, Kaartinen M. Transglutaminase activity regulates osteoblast differentiation and matrix mineralization in MC3T3-E1 osteoblast cultures. Matrix Biol. 2006;25:135-48 pubmed
  • 免疫印迹; 大鼠
Caccamo D, Campisi A, Currò M, Aguennouz M, Li Volti G, Avola R, et al. Nuclear factor-kappab activation is associated with glutamate-evoked tissue transglutaminase up-regulation in primary astrocyte cultures. J Neurosci Res. 2005;82:858-65 pubmed
  • 免疫组化; 人类; 1:100
  • 免疫印迹; 人类; 1:2000
  • 免疫组化; 小鼠; 1:100
Chlenski A, Liu S, Guerrero L, Yang Q, Tian Y, Salwen H, et al. SPARC expression is associated with impaired tumor growth, inhibited angiogenesis and changes in the extracellular matrix. Int J Cancer. 2006;118:310-6 pubmed
  • 免疫沉淀; 小鼠
Chae K, Kim J, Park W, Kim Y, Yun H, Kwon N, et al. Distinct pH modulation for dual function of Galphah (transglutaminase II). J Biochem. 2005;137:407-13 pubmed
  • 免疫细胞化学; 豚鼠
  • 免疫组化; 豚鼠
  • 免疫印迹; 豚鼠
  • 免疫细胞化学; 人类
  • 免疫组化; 人类
  • 免疫印迹; 人类
Mehta K. Mammalian transglutaminases: a family portrait. Prog Exp Tumor Res. 2005;38:1-18 pubmed
  • 酶联免疫吸附测定; 人类; 1:5000
  • 酶联免疫吸附测定; 小鼠; 1:5000
Di Niro R, Ferrara F, Not T, Bradbury A, Chirdo F, Marzari R, et al. Characterizing monoclonal antibody epitopes by filtered gene fragment phage display. Biochem J. 2005;388:889-94 pubmed
  • 免疫沉淀; 人类; 图 4
  • 免疫印迹; 人类; 图 4
Rodolfo C, Mormone E, Matarrese P, Ciccosanti F, Farrace M, Garofano E, et al. Tissue transglutaminase is a multifunctional BH3-only protein. J Biol Chem. 2004;279:54783-92 pubmed
  • 免疫印迹; 大鼠; 1:1000
Wu Y, Lai W, Tsai Y. Characterization of purified rat testicular transglutaminase and age-dependent changes of the enzyme activities. Int J Biochem Cell Biol. 2005;37:386-96 pubmed
Ulukan B, Bihorac A, Sipahioglu T, Kiraly R, Fesus L, Telci D. Role of Tissue Transglutaminase Catalytic and Guanosine Triphosphate-Binding Domains in Renal Cell Carcinoma Progression. ACS Omega. 2020;5:28273-28284 pubmed 出版商
Lee S, Kang J, Ha J, Lee J, Oh S, Choi H, et al. Transglutaminase 2-Mediated p53 Depletion Promotes Angiogenesis by Increasing HIF-1α-p300 Binding in Renal Cell Carcinoma. Int J Mol Sci. 2020;21: pubmed 出版商
Cho S, Oh Y, Jeong E, Park S, Lee D, Wang X, et al. Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers. Exp Mol Med. 2020;52:854-864 pubmed 出版商
Trus I, Bérubé N, Jiang P, Rak J, Gerdts V, Karniychuk U. Zika Virus with Increased CpG Dinucleotide Frequencies Shows Oncolytic Activity in Glioblastoma Stem Cells. Viruses. 2020;12: pubmed 出版商
Villella V, Venerando A, Cozza G, Esposito S, Ferrari E, Monzani R, et al. A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease. EMBO J. 2019;38: pubmed 出版商
Hietikko M, Koskinen O, Kurppa K, Laurila K, Saavalainen P, Salmi T, et al. Small-intestinal TG2-specific plasma cells at different stages of coeliac disease. BMC Immunol. 2018;19:36 pubmed 出版商
Lee S, Lee W, Kim N, Kang J, Kim K, Kim S, et al. Renal Cell Carcinoma Is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition. Cancers (Basel). 2018;10: pubmed 出版商
Costa S, Currò G, Pellegrino S, Lucanto M, Tuccari G, Ieni A, et al. Case report on pathogenetic link between gluten and IgA nephropathy. BMC Gastroenterol. 2018;18:64 pubmed 出版商
Condello S, Sima L, Ivan C, Cárdenas H, Schiltz G, Mishra R, et al. Tissue Tranglutaminase Regulates Interactions between Ovarian Cancer Stem Cells and the Tumor Niche. Cancer Res. 2018;78:2990-3001 pubmed 出版商
Piacentini M, Baiocchini A, Del Nonno F, Melino G, Barlev N, Rossin F, et al. Non-alcoholic fatty liver disease severity is modulated by transglutaminase type 2. Cell Death Dis. 2018;9:257 pubmed 出版商
Borrelli M, Maglio M, Korponay Szabo I, Vass V, Mearin M, Meijer C, et al. Intestinal anti-transglutaminase2 IgA deposits in children at risk for coeliac disease: data from the Prevent CD study. Clin Exp Immunol. 2017;: pubmed 出版商
Del Duca S, Serafini Fracassini D, Bonner P, Cresti M, Cai G. Effects of post-translational modifications catalysed by pollen transglutaminase on the functional properties of microtubules and actin filaments. Biochem J. 2009;418:651-64 pubmed 出版商
Lee J, Kim Y, Choi D, Bang M, Han T, Joh T, et al. Transglutaminase 2 induces nuclear factor-kappaB activation via a novel pathway in BV-2 microglia. J Biol Chem. 2004;279:53725-35 pubmed
Kweon S, Lee Z, Yi S, Kim Y, Han J, Paik S, et al. Protective role of tissue transglutaminase in the cell death induced by TNF-alpha in SH-SY5Y neuroblastoma cells. J Biochem Mol Biol. 2004;37:185-91 pubmed
Suh M, Park C, Kim S, Kil M, Lee G, Johnson G, et al. Tissue transglutaminase is not involved in the aggregate formation of stably expressed alpha-synuclein in SH-SY5Y human neuroblastoma cells. Arch Pharm Res. 2004;27:850-6 pubmed
Ientile R, Caccamo D, Marciano M, Currò M, Mannucci C, Campisi A, et al. Transglutaminase activity and transglutaminase mRNA transcripts in gerbil brain ischemia. Neurosci Lett. 2004;363:173-7 pubmed
D Argenio G, Farrace M, Cosenza V, De Ritis F, Della Valle N, Manguso F, et al. Expression of apoptosis-related proteins in rat with induced colitis. Int J Colorectal Dis. 2004;19:451-60 pubmed
Caccamo D, Currò M, Cusumano G, Crisafulli G, Ientile R. Excitotoxin-induced changes in transglutaminase during differentiation of cerebellar granule cells. Amino Acids. 2004;26:197-201 pubmed
Ciccocioppo R, Di Sabatino A, Ara C, Biagi F, Perilli M, Amicosante G, et al. Gliadin and tissue transglutaminase complexes in normal and coeliac duodenal mucosa. Clin Exp Immunol. 2003;134:516-24 pubmed
Ladd P, Du L, Capdevila J, Mernaugh R, Keeney D. Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes. J Biol Chem. 2003;278:35184-92 pubmed
Campisi A, Caccamo D, Raciti G, Cannavo G, Macaione V, Currò M, et al. Glutamate-induced increases in transglutaminase activity in primary cultures of astroglial cells. Brain Res. 2003;978:24-30 pubmed
Biagi F, Bassi E, Ardigo M, Vignini M, Caravaggi M, Borroni G, et al. In patients with dermatitis herpetiformis distribution of transglutaminase in cutaneous tissue does not differ from controls. Dig Liver Dis. 2003;35:41-5 pubmed
Sugai E, Cherñavsky A, Pedreira S, Smecuol E, Vazquez H, Niveloni S, et al. Bone-specific antibodies in sera from patients with celiac disease: characterization and implications in osteoporosis. J Clin Immunol. 2002;22:353-62 pubmed
Ientile R, Caccamo D, Macaione V, Torre V, Macaione S. NMDA-evoked excitotoxicity increases tissue transglutaminase in cerebellar granule cells. Neuroscience. 2002;115:723-9 pubmed
Piacentini M, Farrace M, Piredda L, Matarrese P, Ciccosanti F, Falasca L, et al. Transglutaminase overexpression sensitizes neuronal cell lines to apoptosis by increasing mitochondrial membrane potential and cellular oxidative stress. J Neurochem. 2002;81:1061-72 pubmed
Kang S, Kim D, Damron D, Baek K, Im M. Modulation of intracellular Ca(2+) via alpha(1B)-adrenoreceptor signaling molecules, G alpha(h) (transglutaminase II) and phospholipase C-delta 1. Biochem Biophys Res Commun. 2002;293:383-90 pubmed
Sárdy M, Karpati S, Merkl B, Paulsson M, Smyth N. Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis. J Exp Med. 2002;195:747-57 pubmed
Balklava Z, Verderio E, Collighan R, Gross S, Adams J, Griffin M. Analysis of tissue transglutaminase function in the migration of Swiss 3T3 fibroblasts: the active-state conformation of the enzyme does not affect cell motility but is important for its secretion. J Biol Chem. 2002;277:16567-75 pubmed
Tolentino P, DeFord S, Notterpek L, Glenn C, Pike B, Wang K, et al. Up-regulation of tissue-type transglutaminase after traumatic brain injury. J Neurochem. 2002;80:579-88 pubmed
Chun W, Lesort M, Tucholski J, Ross C, Johnson G. Tissue transglutaminase does not contribute to the formation of mutant huntingtin aggregates. J Cell Biol. 2001;153:25-34 pubmed
Sakai K, Busby W, Clarke J, Clemmons D. Tissue transglutaminase facilitates the polymerization of insulin-like growth factor-binding protein-1 (IGFBP-1) and leads to loss of IGFBP-1's ability to inhibit insulin-like growth factor-I-stimulated protein synthesis. J Biol Chem. 2001;276:8740-5 pubmed
De Laurenzi V, Melino G. Gene disruption of tissue transglutaminase. Mol Cell Biol. 2001;21:148-55 pubmed
Esposito C, Lombardi M, Ruocco V, Cozzolino A, Mariniello L, Porta R. Implication of tissue transglutaminase and desmoplakin in cell adhesion mechanism in human epidermis. Mol Cell Biochem. 2000;206:57-65 pubmed
Akimov S, Krylov D, Fleischman L, Belkin A. Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin. J Cell Biol. 2000;148:825-38 pubmed
Feng J, Gray C, Im M. Alpha 1B-adrenoceptor interacts with multiple sites of transglutaminase II: characteristics of the interaction in binding and activation. Biochemistry. 1999;38:2224-32 pubmed
产品信息
产品类型 :
抗体
产品名称 :
TGM2单克隆抗体(CUB 7402)
目录# :
MA5-12739
规格 :
500微升
价格 :
美国404.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
狗, 豚鼠, 人类, 兔
应用 :
Immunohistochemistry (Paraffin): 1-2 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
物种 :
狗, 豚鼠, 人类, 兔
克隆 :
CUB 7402
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
免疫原 :
纯化豚鼠肝TGase II
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1-2 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
别名 :
C polypeptide; C polypeptide, protein-glutamine-gamma-glutamyltransferase; G alpha h; G[a]h; G-ALPHA-h; GNAH; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine-gamma-glutamyltransferase; RP5-1054A22.2; TG C; TG(C); TG2; TGase C; TGase H; TGase2; TGase-2; TGase-H; TgaseII; TGC; TGM2; Tissue transglutaminase; Tissue type transglutaminase; tissue-type transglutaminase; transglutaminase; transglutaminase 2; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); Transglutaminase 2 C polypeptide; transglutaminase 2, C polypeptide; transglutaminase C; Transglutaminase H; transglutaminase-2; tTG; tTGas
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国