产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
v-erb-b2成红细胞白血病病毒致瘤基因2(HER-2)单克隆抗体(9G6.10)
目录 :
MA5-12759
规格 :
500微升
价格 :
美国446.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
9G6.10
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 59
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 人类; 图 3a
Kang S, Wang Y, Reder N, Liu J. Multiplexed Molecular Imaging of Biomarker-Targeted SERS Nanoparticles on Fresh Tissue Specimens with Channel-Compressed Spectrometry. PLoS ONE. 2016;11:e0163473 pubmed 出版商
  • 流式细胞仪; 人类; 图 5
Wang Y, Kang S, Khan A, Ruttner G, Leigh S, Murray M, et al. Quantitative molecular phenotyping with topically applied SERS nanoparticles for intraoperative guidance of breast cancer lumpectomy. Sci Rep. 2016;6:21242 pubmed 出版商
  • 免疫印迹; 人类
Mahajan K, Lawrence H, Lawrence N, Mahajan N. ACK1 tyrosine kinase interacts with histone demethylase KDM3A to regulate the mammary tumor oncogene HOXA1. J Biol Chem. 2014;289:28179-91 pubmed 出版商
  • 流式细胞仪; 人类
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Galletti G, Sung M, Vahdat L, Shah M, Santana S, Altavilla G, et al. Isolation of breast cancer and gastric cancer circulating tumor cells by use of an anti HER2-based microfluidic device. Lab Chip. 2014;14:147-56 pubmed 出版商
  • 酶联免疫吸附测定; 人类
Jin H, Daly D, Marks J, Zangar R. Oxidatively modified proteins as plasma biomarkers in breast cancer. Cancer Biomark. 2013;13:193-200 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200
Hernandez L, Flenker K, Hernandez F, Klingelhutz A, McNamara J, Giangrande P. Methods for Evaluating Cell-Specific, Cell-Internalizing RNA Aptamers. Pharmaceuticals (Basel). 2013;6:295-319 pubmed
  • 免疫细胞化学; 人类; 20 ug/ml
  • 免疫印迹; 人类; 2 ug/ml
Gunaherath G, Marron M, Wijeratne E, Whitesell L, Gunatilaka A. Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors. Bioorg Med Chem. 2013;21:5118-29 pubmed 出版商
  • 流式细胞仪; 人类
Mosoyan G, Nagi C, Marukian S, Teixeira A, Simonian A, Resnick Silverman L, et al. Multiple breast cancer cell-lines derived from a single tumor differ in their molecular characteristics and tumorigenic potential. PLoS ONE. 2013;8:e55145 pubmed 出版商
  • 免疫细胞化学; 人类
Miller K, Koide A, Leung B, Fitzsimmons J, Yoder B, Yuan H, et al. T cell receptor-like recognition of tumor in vivo by synthetic antibody fragment. PLoS ONE. 2012;7:e43746 pubmed 出版商
  • 免疫组化; 人类
Hwang S, Bae J, Lee H, Kim H. Circulating Tumor Cells Detected by RT-PCR for CK-20 before Surgery Indicate Worse Prognostic Impact in Triple-Negative and HER2 Subtype Breast Cancer. J Breast Cancer. 2012;15:34-42 pubmed 出版商
  • 酶联免疫吸附测定; 人类
Huang C, Chaudhery V, Pokhriyal A, George S, Polans J, Lu M, et al. Multiplexed cancer biomarker detection using quartz-based photonic crystal surfaces. Anal Chem. 2012;84:1126-33 pubmed 出版商
  • 免疫组化; 人类
Menju T, Hashimoto S, Hashimoto A, Otsuka Y, Handa H, Ogawa E, et al. Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma. PLoS ONE. 2011;6:e25301 pubmed 出版商
  • 免疫组化; 人类
Lee Y, Huh S, Lee D, Yoon H, Seol Y, Choi Y, et al. Phase II Study of Vinorelbine Plus Trastuzumab in HER2 Overexpressing Metastatic Breast Cancer Pretreated with Anthracyclines and Taxanes. J Breast Cancer. 2011;14:140-6 pubmed 出版商
  • 免疫细胞化学; 人类; 2.5 ug/ml
Eifler R, Lind J, Falkenhagen D, Weber V, Fischer M, Zeillinger R. Enrichment of circulating tumor cells from a large blood volume using leukapheresis and elutriation: proof of concept. Cytometry B Clin Cytom. 2011;80:100-11 pubmed 出版商
  • 流式细胞仪; 人类
Milano F, Guarriera M, Rygiel A, Krishnadath K. Trastuzumab mediated T-cell response against HER-2/neu overexpressing esophageal adenocarcinoma depends on intact antigen processing machinery. PLoS ONE. 2010;5:e12424 pubmed 出版商
  • 免疫沉淀; 人类
Mahajan K, Challa S, Coppola D, Lawrence H, Luo Y, Gevariya H, et al. Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. Prostate. 2010;70:1274-85 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Pfister A, Wood R, Salas P, Zea D, Ramsauer V. Early response to ErbB2 over-expression in polarized Caco-2 cells involves partial segregation from ErbB3 by relocalization to the apical surface and initiation of survival signaling. J Cell Biochem. 2010;111:643-52 pubmed 出版商
  • 免疫组化; 人类
Kwon H, Oh S, Kim S, Lee S, Kwon K, Choi Y, et al. Clinical outcomes and breast cancer subtypes in patients with brain metastases. Onkologie. 2010;33:146-52 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Mahajan K, Coppola D, Challa S, Fang B, Chen Y, Zhu W, et al. Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation. PLoS ONE. 2010;5:e9646 pubmed 出版商
  • 免疫沉淀; 人类
Kimple R, Vaseva A, Cox A, Baerman K, Calvo B, Tepper J, et al. Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status. Clin Cancer Res. 2010;16:912-23 pubmed 出版商
  • 免疫组化; 人类; 1:100
van der Groep P, van Diest P, Menko F, Bart J, de Vries E, van der Wall E. Molecular profile of ductal carcinoma in situ of the breast in BRCA1 and BRCA2 germline mutation carriers. J Clin Pathol. 2009;62:926-30 pubmed 出版商
  • 免疫组化; 人类; 1:250
Milano F, Jorritsma T, Rygiel A, Bergman J, Sondermeijer C, ten Brinke A, et al. Expression pattern of immune suppressive cytokines and growth factors in oesophageal adenocarcinoma reveal a tumour immune escape-promoting microenvironment. Scand J Immunol. 2008;68:616-23 pubmed 出版商
  • 流式细胞仪; 人类
  • 免疫细胞化学; 人类
Vernet E, Konrad A, Lundberg E, Nygren P, Gräslund T. Affinity-based entrapment of the HER2 receptor in the endoplasmic reticulum using an affibody molecule. J Immunol Methods. 2008;338:1-6 pubmed 出版商
  • 免疫细胞化学; 人类
Strohecker A, Yehiely F, Chen F, Cryns V. Caspase cleavage of HER-2 releases a Bad-like cell death effector. J Biol Chem. 2008;283:18269-82 pubmed 出版商
  • 免疫细胞化学; 人类; 1:10
Katsumi Y, Kuwahara Y, Tamura S, Kikuchi K, Otabe O, Tsuchiya K, et al. Trastuzumab activates allogeneic or autologous antibody-dependent cellular cytotoxicity against malignant rhabdoid tumor cells and interleukin-2 augments the cytotoxicity. Clin Cancer Res. 2008;14:1192-9 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
Schulz T, Swistowska A, Liu Y, Swistowski A, Palmarini G, Brimble S, et al. A large-scale proteomic analysis of human embryonic stem cells. BMC Genomics. 2007;8:478 pubmed
  • 流式细胞仪; 人类
  • 免疫印迹; 人类
Fan Y, Wong L, Ding J, Spiridonov N, Johnson R, Johnson G. Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism. J Biol Chem. 2008;283:1588-96 pubmed
  • 免疫组化; 人类; 1:100
Elliott D, Sherman S, Busaidy N, Williams M, Santarpia L, Clayman G, et al. Growth factor receptors expression in anaplastic thyroid carcinoma: potential markers for therapeutic stratification. Hum Pathol. 2008;39:15-20 pubmed
  • 流式细胞仪; 小鼠
Xu Y, Darcy P, Kershaw M. Tumor-specific dendritic cells generated by genetic redirection of Toll-like receptor signaling against the tumor-associated antigen, erbB2. Cancer Gene Ther. 2007;14:773-80 pubmed
  • 流式细胞仪; 人类; 1-100 ug/time
Garrett J, Rawale S, Allen S, Phillips G, Forni G, Morris J, et al. Novel engineered trastuzumab conformational epitopes demonstrate in vitro and in vivo antitumor properties against HER-2/neu. J Immunol. 2007;178:7120-31 pubmed
  • 流式细胞仪; 人类
Zhang J, Eguchi J, Kruse C, Gomez G, Fakhrai H, Schroter S, et al. Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics. Clin Cancer Res. 2007;13:566-575 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Muraoka Cook R, Caskey L, Sandahl M, Hunter D, Husted C, Strunk K, et al. Heregulin-dependent delay in mitotic progression requires HER4 and BRCA1. Mol Cell Biol. 2006;26:6412-24 pubmed
  • 流式细胞仪; 人类; 5 ug/ml
Chan C, Metz M, Kane S. Differential sensitivities of trastuzumab (Herceptin)-resistant human breast cancer cells to phosphoinositide-3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors. Breast Cancer Res Treat. 2005;91:187-201 pubmed
  • 免疫沉淀; 人类
Liu Y, Majumder S, McCall W, Sartor C, Mohler J, Gregory C, et al. Inhibition of HER-2/neu kinase impairs androgen receptor recruitment to the androgen responsive enhancer. Cancer Res. 2005;65:3404-9 pubmed
  • 免疫沉淀; 人类
Gregory C, Whang Y, McCall W, Fei X, Liu Y, Ponguta L, et al. Heregulin-induced activation of HER2 and HER3 increases androgen receptor transactivation and CWR-R1 human recurrent prostate cancer cell growth. Clin Cancer Res. 2005;11:1704-12 pubmed
  • 流式细胞仪; 人类
Dakappagari N, Lute K, Rawale S, Steele J, Allen S, Phillips G, et al. Conformational HER-2/neu B-cell epitope peptide vaccine designed to incorporate two native disulfide bonds enhances tumor cell binding and antitumor activities. J Biol Chem. 2005;280:54-63 pubmed
  • 酶联免疫吸附测定; 人类; 表 2
Traxler P, Allegrini P, Brandt R, Brueggen J, Cozens R, Fabbro D, et al. AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 2004;64:4931-41 pubmed
Wu X, Subramaniam M, Negron V, Cicek M, Reynolds C, Lingle W, et al. Development, characterization, and applications of a novel estrogen receptor beta monoclonal antibody. J Cell Biochem. 2012;113:711-23 pubmed 出版商
Dragowska W, Warburton C, Yapp D, Minchinton A, Hu Y, Waterhouse D, et al. HER-2/neu overexpression increases the viable hypoxic cell population within solid tumors without causing changes in tumor vascularization. Mol Cancer Res. 2004;2:606-19 pubmed
Abuharbeid S, Apel J, Sander M, Fiedler B, Langer M, Zuzarte M, et al. Cytotoxicity of the novel anti-cancer drug rViscumin depends on HER-2 levels in SKOV-3 cells. Biochem Biophys Res Commun. 2004;321:403-12 pubmed
Kershaw M, Jackson J, Haynes N, Teng M, Moeller M, Hayakawa Y, et al. Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer. J Immunol. 2004;173:2143-50 pubmed
Kansra S, Stoll S, Johnson J, Elder J. Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK. Mol Biol Cell. 2004;15:4299-309 pubmed
Tanimura K, Nakago S, Murakoshi H, Takekida S, Moriyama T, Matsuo H, et al. Changes in the expression and cytological localization of betacellulin and its receptors (ErbB-1 and ErbB-4) in the trophoblasts in human placenta over the course of pregnancy. Eur J Endocrinol. 2004;151:93-101 pubmed
Bennasroune A, Fickova M, Gardin A, Dirrig Grosch S, Aunis D, Cremel G, et al. Transmembrane peptides as inhibitors of ErbB receptor signaling. Mol Biol Cell. 2004;15:3464-74 pubmed
Tedesco K, Thor A, Johnson D, Shyr Y, Blum K, Goldstein L, et al. Docetaxel combined with trastuzumab is an active regimen in HER-2 3+ overexpressing and fluorescent in situ hybridization-positive metastatic breast cancer: a multi-institutional phase II trial. J Clin Oncol. 2004;22:1071-7 pubmed
Punj V, Graves J, Mehta R. Effect of vitamin D analog (1alpha hydroxy D5) immunoconjugated to Her-2 antibody on breast cancer. Int J Cancer. 2004;108:922-9 pubmed
Mortensen K, Larsson L. Effects of cytochalasin D on the actin cytoskeleton: association of neoformed actin aggregates with proteins involved in signaling and endocytosis. Cell Mol Life Sci. 2003;60:1007-12 pubmed
Ramsauer V, Carraway C, Salas P, Carraway K. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, translocates ErbB2 to the apical surface in polarized epithelial cells. J Biol Chem. 2003;278:30142-7 pubmed
Dakappagari N, Pyles J, Parihar R, Carson W, Young D, Kaumaya P. A chimeric multi-human epidermal growth factor receptor-2 B cell epitope peptide vaccine mediates superior antitumor responses. J Immunol. 2003;170:4242-53 pubmed
Haynes N, Trapani J, Teng M, Jackson J, Cerruti L, Jane S, et al. Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors. Blood. 2002;100:3155-63 pubmed
Dillon C, Creer A, Kerr K, Kümin A, Dickson C. Basolateral targeting of ERBB2 is dependent on a novel bipartite juxtamembrane sorting signal but independent of the C-terminal ERBIN-binding domain. Mol Cell Biol. 2002;22:6553-63 pubmed
Mackeigan J, Taxman D, Hunter D, Earp H, Graves L, Ting J. Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition. Clin Cancer Res. 2002;8:2091-9 pubmed
Kashentseva E, Seki T, Curiel D, Dmitriev I. Adenovirus targeting to c-erbB-2 oncoprotein by single-chain antibody fused to trimeric form of adenovirus receptor ectodomain. Cancer Res. 2002;62:609-16 pubmed
Piechocki M, Pilon S, Wei W. Quantitative measurement of anti-ErbB-2 antibody by flow cytometry and ELISA. J Immunol Methods. 2002;259:33-42 pubmed
Hsieh S, Malerczyk C, Aigner A, Czubayko F. ERbB-2 expression is rate-limiting for epidermal growth factor-mediated stimulation of ovarian cancer cell proliferation. Int J Cancer. 2000;86:644-51 pubmed
Aigner A, Hsieh S, Malerczyk C, Czubayko F. Reversal of HER-2 over-expression renders human ovarian cancer cells highly resistant to taxol. Toxicology. 2000;144:221-8 pubmed
Kunisue H, Kurebayashi J, Otsuki T, Tang C, Kurosumi M, Yamamoto S, et al. Anti-HER2 antibody enhances the growth inhibitory effect of anti-oestrogen on breast cancer cells expressing both oestrogen receptors and HER2. Br J Cancer. 2000;82:46-51 pubmed
Tang C, Concepcion X, Milan M, Gong X, Montgomery E, Lippman M. Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both in vitro and in vivo. Cancer Res. 1999;59:5315-22 pubmed
Tang C, Goldstein D, Payne J, Czubayko F, Alimandi M, Wang L, et al. ErbB-4 ribozymes abolish neuregulin-induced mitogenesis. Cancer Res. 1998;58:3415-22 pubmed
图像
图像 1 :
赛默飞世尔 MA5-12759 图像 1
Paraformaldehyde-fixed, human colon cancer cells stained with c-erbB2 antibody using peroxidase-conjugate and AEC chromogen. Note cell membrane staining of cultured cells.
产品信息
产品类型 :
抗体
产品名称 :
v-erb-b2成红细胞白血病病毒致瘤基因2(HER-2)单克隆抗体(9G6.10)
目录# :
MA5-12759
规格 :
500微升
价格 :
美国446.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: Assay-dependent, Immunocytochemistry: 1-2 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: 2 µg/mL
物种 :
人类
克隆 :
9G6.10
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
免疫原 :
RAC311 cells transfected with SV40-neu construct, expressing human neu protein
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-dependent, Immunocytochemistry: 1-2 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: 2 µg/mL
别名 :
avian erythroblastosis oncogene B 2; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); CD antigen CD340; CD340; c-erb B2/neu protein; c-erbB2; C-erbB-2; c-neu; epidermal growth factor receptor-related protein; erbb 2; ERBB2; erb-b2; Erbb-2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; erb-b2 receptor tyrosine kinase 2; her 2; HER2; HER-2; HER-2/neu; herstatin; human epidermal growth factor receptor 2; Kiaa3023; metas; Metastatic lymph node gene 19 protein; mKIAA3023; MLN 19; MLN19; NEU; Neu oncogene; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; p185neu; phospho ErbB2; proto-oncogene c-ErbB-2; Proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国