产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Tau Monoclonal Antibody (TAU-5), Biotin
目录 :
MA5-12805
规格 :
500µL
价格 :
美国399.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
生物素
克隆名称 :
Tau-5
反应物种 :
人类, 小鼠, 大鼠, ,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
文章摘录数: 49
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 4b
Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, et al. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun. 2017;8:14740 pubmed 出版商
  • 免疫印迹; 大鼠
Du L, Xie J, Cheng X, Li X, Kong F, Jiang X, et al. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordr). 2014;36:613-23 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类; 1:5000
Cameron A, Giacomozzi B, Joyce J, Gray A, Graham D, Ousson S, et al. Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400. FEBS Lett. 2013;587:3722-8 pubmed 出版商
  • 免疫印迹; 小鼠
Li X, Du L, Cheng X, Jiang X, Zhang Y, Lv B, et al. Glycation exacerbates the neuronal toxicity of ?-amyloid. Cell Death Dis. 2013;4:e673 pubmed 出版商
  • 免疫印迹; 人类; 1:200
Park Y, Ko J, Jang Y, Kwon Y. Activation of AMP-activated protein kinase alleviates homocysteine-mediated neurotoxicity in SH-SY5Y cells. Neurochem Res. 2013;38:1561-71 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Tackenberg C, Grinschgl S, Trutzel A, Santuccione A, Frey M, Konietzko U, et al. NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss. Cell Death Dis. 2013;4:e608 pubmed 出版商
  • 免疫印迹; 小鼠
Cheng X, Zhao K, Jiang X, Du L, Li X, Ma Z, et al. Nmnat2 attenuates Tau phosphorylation through activation of PP2A. J Alzheimers Dis. 2013;36:185-95 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Yu G, Yan T, Feng Y, Liu X, Xia Y, Luo H, et al. Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease. Neurobiol Aging. 2013;34:1748-58 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Hebron M, Algarzae N, Lonskaya I, Moussa C. Fractalkine signaling and Tau hyper-phosphorylation are associated with autophagic alterations in lentiviral Tau and A?1-42 gene transfer models. Exp Neurol. 2014;251:127-38 pubmed 出版商
  • 免疫印迹; 小鼠
Bhoiwala D, Koleilat I, Qian J, Beyer B, Hushmendy S, Mathew A, et al. Overexpression of RCAN1 isoform 4 in mouse neurons leads to a moderate behavioral impairment. Neurol Res. 2013;35:79-89 pubmed 出版商
  • 免疫印迹; 大鼠; 1:5000
Zussy C, Brureau A, Keller E, Marchal S, Blayo C, Delair B, et al. Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-? peptide injection in rats. PLoS ONE. 2013;8:e53117 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
  • 免疫印迹; 人类; 1:1000
Liu X, Song J, Jiang Q, Wang Q, Tian Q, Wang J. Expression of the hyperphosphorylated tau attenuates ER stress-induced apoptosis with upregulation of unfolded protein response. Apoptosis. 2012;17:1039-49 pubmed 出版商
  • 免疫印迹; 小鼠
Li X, Xie J, Jiang X, Lv B, Cheng X, Du L, et al. Methylglyoxal induces tau hyperphosphorylation via promoting AGEs formation. Neuromolecular Med. 2012;14:338-48 pubmed 出版商
  • 免疫印迹; 小鼠
Tweedie D, Ferguson R, Fishman K, Frankola K, van Praag H, Holloway H, et al. Tumor necrosis factor-? synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease. J Neuroinflammation. 2012;9:106 pubmed 出版商
  • 免疫印迹; 大鼠
Yao Z, Zhang J, Xie X. Enriched environment prevents cognitive impairment and tau hyperphosphorylation after chronic cerebral hypoperfusion. Curr Neurovasc Res. 2012;9:176-84 pubmed
  • 免疫印迹; 人类; 1:1000
Liu Z, Fu Z, Song J, Zhang J, Wei Y, Chu J, et al. Bip enhanced the association of GSK-3? with tau during ER stress both in vivo and in vitro. J Alzheimers Dis. 2012;29:727-40 pubmed 出版商
  • 免疫印迹; 大鼠
Li G, Cai F, Yan W, Li C, Wang J. A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease. Toxicol Sci. 2012;127:485-95 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
  • 免疫印迹; 人类; 1:1000
Jones N, Nguyen T, Corcoran N, Velakoulis D, Chen T, Grundy R, et al. Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models. Neurobiol Dis. 2012;45:897-901 pubmed 出版商
  • 免疫印迹; 人类
Kim J, Park Y, Jang Y, Kwon Y. AMPK activation inhibits apoptosis and tau hyperphosphorylation mediated by palmitate in SH-SY5Y cells. Brain Res. 2011;1418:42-51 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Wei W, Liu Y, Zhang C, Wang Q, Wei Z, Mousseau D, et al. Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats. J Alzheimers Dis. 2011;27:639-50 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Fu Z, Yang Y, Song J, Jiang Q, Lin Z, Wang Q, et al. LiCl attenuates thapsigargin-induced tau hyperphosphorylation by inhibiting GSK-3? in vivo and in vitro. J Alzheimers Dis. 2010;21:1107-17 pubmed
  • 免疫组化; 人类
  • 免疫印迹; 人类
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Chen L, Xiong Y, Kong F, Qu M, Wang Q, Chen X, et al. Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. J Neurochem. 2012;120:157-64 pubmed 出版商
  • 免疫印迹; 人类
Li X, Lv B, Xie J, Liu J, Zhou X, Wang J. AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation. Neurobiol Aging. 2012;33:1400-10 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Yu G, Li Y, Tian Q, Liu R, Wang Q, Wang J, et al. Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation in HEK293 cells. J Alzheimers Dis. 2011;24:525-35 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Zhang Z, Zhao R, Qi J, Wen S, Tang Y, Wang D. Inhibition of glycogen synthase kinase-3? by Angelica sinensis extract decreases ?-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons. J Neurosci Res. 2011;89:437-47 pubmed 出版商
  • 免疫细胞化学; 小鼠
Dachsel J, Behrouz B, Yue M, Beevers J, Melrose H, Farrer M. A comparative study of Lrrk2 function in primary neuronal cultures. Parkinsonism Relat Disord. 2010;16:650-5 pubmed 出版商
  • 免疫印迹; 大鼠
Yuzwa S, Yadav A, Skorobogatko Y, Clark T, Vosseller K, Vocadlo D. Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody. Amino Acids. 2011;40:857-68 pubmed 出版商
  • 免疫印迹; 人类
Park Y, Jang Y, Kwon Y. Protective effect of isoflavones against homocysteine-mediated neuronal degeneration in SH-SY5Y cells. Amino Acids. 2010;39:785-94 pubmed 出版商
  • 免疫印迹; 人类
Liu X, Liao K, Liu R, Wang H, Zhang Y, Zhang Q, et al. Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2. J Alzheimers Dis. 2010;19:953-62 pubmed 出版商
  • 免疫印迹; 小鼠; 1:200
Kulic L, Wollmer M, Rhein V, Pagani L, Kuehnle K, Cattepoel S, et al. Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration. Neurobiol Aging. 2011;32:1827-38 pubmed 出版商
  • 免疫印迹; 人类
Hundelt M, Fath T, Selle K, Oesterwind K, Jordan J, Schultz C, et al. Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation. Neurobiol Aging. 2011;32:991-1006 pubmed 出版商
  • 免疫印迹; 人类
Park Y, Jang Y, Kwon Y. Isoflavones prevent endoplasmic reticulum stress-mediated neuronal degeneration by inhibiting tau hyperphosphorylation in SH-SY5Y cells. J Med Food. 2009;12:528-35 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Zhang J, Peng C, Shi H, Wang S, Wang Q, Wang J. Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain. J Alzheimers Dis. 2009;16:39-47 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Liu X, Zhu L, Zhang Q, Shi H, Wang S, Wang Q, et al. Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A. Neurochem Res. 2008;33:1811-20 pubmed 出版商
  • 免疫印迹; 小鼠
Shi H, Zhu L, Wang S, Liu X, Tian Q, Zhang Q, et al. 17beta-estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner. J Neural Transm (Vienna). 2008;115:879-88 pubmed 出版商
  • 免疫组化; 小鼠; 1:5
  • 免疫印迹; 小鼠; 1:200
Bai F, Xi J, Andley U. Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice. Mol Vis. 2007;13:1589-600 pubmed
  • 免疫印迹; 人类; 1:200
Liu G, Zhang Y, Yao X, Zhang C, Fang J, Wang Q, et al. Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms. Neurobiol Aging. 2008;29:1348-58 pubmed
  • 免疫印迹; 人类; 1:2000
Ren Q, Liao X, Chen X, Liu G, Wang J. Effects of tau phosphorylation on proteasome activity. FEBS Lett. 2007;581:1521-8 pubmed
  • 免疫印迹; 人类; 1:200
Ren Q, Liao X, Wang Z, Qu Z, Wang J. The involvement of glycogen synthase kinase-3 and protein phosphatase-2A in lactacystin-induced tau accumulation. FEBS Lett. 2006;580:2503-11 pubmed
  • 免疫印迹; 大鼠; 1:250
Esposito G, De Filippis D, Carnuccio R, Izzo A, Iuvone T. The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells. J Mol Med (Berl). 2006;84:253-8 pubmed
  • 免疫沉淀; 人类
Dalfo E, Albasanz J, Rodriguez A, Martín M, Ferrer I. Abnormal group I metabotropic glutamate receptor expression and signaling in the frontal cortex in Pick disease. J Neuropathol Exp Neurol. 2005;64:638-47 pubmed
  • 免疫印迹; 人类
Hu Lieskovan S, Zhang J, Wu L, Shimada H, Schofield D, Triche T. EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. Cancer Res. 2005;65:4633-44 pubmed
  • 免疫印迹; 人类; 1:2000
Zhang Y, Xu Y, Chen X, Wang X, Wang J. Nitration and oligomerization of tau induced by peroxynitrite inhibit its microtubule-binding activity. FEBS Lett. 2005;579:2421-7 pubmed
Lin D, Cao L, Wang Z, Li J, Washington J, Zuo Z. Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats. Behav Brain Res. 2012;228:319-27 pubmed 出版商
Patzke H, Maddineni U, Ayala R, Morabito M, Volker J, Dikkes P, et al. Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene. J Neurosci. 2003;23:2769-78 pubmed
Stanford P, Shepherd C, Halliday G, Brooks W, Schofield P, Brodaty H, et al. Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia. Brain. 2003;126:814-26 pubmed
Xu G, Gonzales V, Borchelt D. Rapid detection of protein aggregates in the brains of Alzheimer patients and transgenic mouse models of amyloidosis. Alzheimer Dis Assoc Disord. 2002;16:191-5 pubmed
LoPresti P, Konat G. Hydrogen peroxide induces transient dephosphorylation of tau protein in cultured rat oligodendrocytes. Neurosci Lett. 2001;311:142-4 pubmed
Kins S, Crameri A, Evans D, Hemmings B, Nitsch R, Gotz J. Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. J Biol Chem. 2001;276:38193-200 pubmed
图像
图像 1 :
赛默飞世尔 MA5-12805 图像 1
图像 2 :
赛默飞世尔 MA5-12805 图像 2
产品信息
产品类型 :
抗体
产品名称 :
Tau Monoclonal Antibody (TAU-5), Biotin
目录# :
MA5-12805
规格 :
500µL
价格 :
美国399.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
Bovine, Human, Mouse, Ovine, Rat
应用 :
Immunofluorescence: Assay Dependent, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
物种 :
Bovine, Human, Mouse, Ovine, Rat
克隆 :
TAU-5
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
免疫原 :
纯化牛微管相关蛋白
格式 :
Liquid
应用w/稀释 :
Immunofluorescence: Assay Dependent, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
别名 :
G protein beta1/gamma2 subunit-interacting factor 1, PHF-tau, microtubule-associated protein tau, isoform 4, neurofibrillary tangle protein, paired helical filament-tau, Tau5
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
www.thermo.com.cn
1084193588
公司总部: 美国