产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Tau Monoclonal Antibody (TAU-5)
目录 :
MA5-12808
规格 :
500µL
价格 :
美国375.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
Tau-5
反应物种 :
人类, 小鼠, 大鼠, , ,
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 94
出版应用/物种/样品/稀释参考文献
  • 免疫细胞化学; 大鼠; 1:1000; 图 s1a
Soo Hoo L, Banna C, Radeke C, Sharma N, Albertolle M, Low S, et al. The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons. PLoS ONE. 2016;11:e0163671 pubmed 出版商
  • 免疫印迹; 人类; 1:10,000; 图 3f
Choi W, de Poot S, Lee J, Kim J, Han D, Kim Y, et al. Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation. Nat Commun. 2016;7:10963 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 表 1
  • 免疫印迹; 人类; 1:1000; 表 1
Piedrahita D, Castro Álvarez J, Boudreau R, Villegas Lanau A, Kosik K, Gallego Gómez J, et al. β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. Front Cell Neurosci. 2015;9:498 pubmed 出版商
  • 免疫印迹; 猫; 1:1000; 图 4
Chambers J, Tokuda T, Uchida K, Ishii R, Tatebe H, Takahashi E, et al. The domestic cat as a natural animal model of Alzheimer's disease. Acta Neuropathol Commun. 2015;3:78 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 2
  • 免疫印迹; 人类; 1:1000; 图 4
Ohia Nwoko O, Montazari S, Lau Y, Eriksen J. Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice. Mol Neurodegener. 2014;9:54 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Castro Alvarez J, Uribe Arias S, Kosik K, Cardona Gómez G. Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice. Front Aging Neurosci. 2014;6:243 pubmed 出版商
  • 免疫组化; 小鼠; 1:3000
Gheyara A, Ponnusamy R, Djukic B, Craft R, Ho K, Guo W, et al. Tau reduction prevents disease in a mouse model of Dravet syndrome. Ann Neurol. 2014;76:443-56 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Liu X, Zhou J, Abid M, Yan H, Huang H, Wan L, et al. Berberine attenuates axonal transport impairment and axonopathy induced by Calyculin A in N2a cells. PLoS ONE. 2014;9:e93974 pubmed 出版商
  • 免疫印迹; 小鼠; 1:4000
Notter T, Panzanelli P, PFISTER S, Mircsof D, Fritschy J. A protocol for concurrent high-quality immunohistochemical and biochemical analyses in adult mouse central nervous system. Eur J Neurosci. 2014;39:165-75 pubmed 出版商
  • 免疫印迹; 大鼠
Du L, Xie J, Cheng X, Li X, Kong F, Jiang X, et al. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordr). 2014;36:613-23 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类; 1:5000
Cameron A, Giacomozzi B, Joyce J, Gray A, Graham D, Ousson S, et al. Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400. FEBS Lett. 2013;587:3722-8 pubmed 出版商
  • 免疫印迹; 小鼠
Li X, Du L, Cheng X, Jiang X, Zhang Y, Lv B, et al. Glycation exacerbates the neuronal toxicity of ?-amyloid. Cell Death Dis. 2013;4:e673 pubmed 出版商
  • 免疫印迹; 人类; 1:200; 图 2
Park Y, Ko J, Jang Y, Kwon Y. Activation of AMP-activated protein kinase alleviates homocysteine-mediated neurotoxicity in SH-SY5Y cells. Neurochem Res. 2013;38:1561-71 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Tackenberg C, Grinschgl S, Trutzel A, Santuccione A, Frey M, Konietzko U, et al. NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss. Cell Death Dis. 2013;4:e608 pubmed 出版商
  • 免疫印迹; 小鼠
Cheng X, Zhao K, Jiang X, Du L, Li X, Ma Z, et al. Nmnat2 attenuates Tau phosphorylation through activation of PP2A. J Alzheimers Dis. 2013;36:185-95 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Yu G, Yan T, Feng Y, Liu X, Xia Y, Luo H, et al. Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease. Neurobiol Aging. 2013;34:1748-58 pubmed 出版商
  • 免疫组化; 人类; 1:1000
  • 免疫印迹; 人类; 1:1000; 图 3
  • 免疫印迹; 大鼠; 1:1000
Hebron M, Algarzae N, Lonskaya I, Moussa C. Fractalkine signaling and Tau hyper-phosphorylation are associated with autophagic alterations in lentiviral Tau and A?1-42 gene transfer models. Exp Neurol. 2014;251:127-38 pubmed 出版商
  • 免疫印迹; 小鼠
Bhoiwala D, Koleilat I, Qian J, Beyer B, Hushmendy S, Mathew A, et al. Overexpression of RCAN1 isoform 4 in mouse neurons leads to a moderate behavioral impairment. Neurol Res. 2013;35:79-89 pubmed 出版商
  • 免疫印迹; 大鼠; 1:5000
Zussy C, Brureau A, Keller E, Marchal S, Blayo C, Delair B, et al. Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-? peptide injection in rats. PLoS ONE. 2013;8:e53117 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Tian M, Zhu D, Xie W, Shi J. Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains. FEBS Lett. 2012;586:3737-45 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
  • 免疫印迹; 人类; 1:1000
Liu X, Song J, Jiang Q, Wang Q, Tian Q, Wang J. Expression of the hyperphosphorylated tau attenuates ER stress-induced apoptosis with upregulation of unfolded protein response. Apoptosis. 2012;17:1039-49 pubmed 出版商
  • 免疫印迹; 小鼠
Li X, Xie J, Jiang X, Lv B, Cheng X, Du L, et al. Methylglyoxal induces tau hyperphosphorylation via promoting AGEs formation. Neuromolecular Med. 2012;14:338-48 pubmed 出版商
  • 免疫印迹; 小鼠
Tweedie D, Ferguson R, Fishman K, Frankola K, van Praag H, Holloway H, et al. Tumor necrosis factor-? synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease. J Neuroinflammation. 2012;9:106 pubmed 出版商
  • 免疫印迹; 大鼠
Yao Z, Zhang J, Xie X. Enriched environment prevents cognitive impairment and tau hyperphosphorylation after chronic cerebral hypoperfusion. Curr Neurovasc Res. 2012;9:176-84 pubmed
  • 免疫印迹; 人类; 1:1000
Liu Z, Fu Z, Song J, Zhang J, Wei Y, Chu J, et al. Bip enhanced the association of GSK-3? with tau during ER stress both in vivo and in vitro. J Alzheimers Dis. 2012;29:727-40 pubmed 出版商
  • 免疫印迹; 大鼠
Li G, Cai F, Yan W, Li C, Wang J. A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease. Toxicol Sci. 2012;127:485-95 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Sontag J, Nunbhakdi Craig V, White C, Halpain S, Sontag E. The protein phosphatase PP2A/B? binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies. J Biol Chem. 2012;287:14984-93 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
  • 免疫印迹; 人类; 1:1000
Jones N, Nguyen T, Corcoran N, Velakoulis D, Chen T, Grundy R, et al. Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models. Neurobiol Dis. 2012;45:897-901 pubmed 出版商
  • 免疫印迹; 人类
Kim J, Park Y, Jang Y, Kwon Y. AMPK activation inhibits apoptosis and tau hyperphosphorylation mediated by palmitate in SH-SY5Y cells. Brain Res. 2011;1418:42-51 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Wei W, Liu Y, Zhang C, Wang Q, Wei Z, Mousseau D, et al. Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats. J Alzheimers Dis. 2011;27:639-50 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Fu Z, Yang Y, Song J, Jiang Q, Lin Z, Wang Q, et al. LiCl attenuates thapsigargin-induced tau hyperphosphorylation by inhibiting GSK-3? in vivo and in vitro. J Alzheimers Dis. 2010;21:1107-17 pubmed
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
  • 免疫组化; 人类
  • 免疫印迹; 人类
Chen L, Xiong Y, Kong F, Qu M, Wang Q, Chen X, et al. Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. J Neurochem. 2012;120:157-64 pubmed 出版商
  • 免疫印迹; 人类
Li X, Lv B, Xie J, Liu J, Zhou X, Wang J. AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation. Neurobiol Aging. 2012;33:1400-10 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Yu G, Li Y, Tian Q, Liu R, Wang Q, Wang J, et al. Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation in HEK293 cells. J Alzheimers Dis. 2011;24:525-35 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Zhang Z, Zhao R, Qi J, Wen S, Tang Y, Wang D. Inhibition of glycogen synthase kinase-3? by Angelica sinensis extract decreases ?-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons. J Neurosci Res. 2011;89:437-47 pubmed 出版商
  • 免疫细胞化学; 小鼠
Dachsel J, Behrouz B, Yue M, Beevers J, Melrose H, Farrer M. A comparative study of Lrrk2 function in primary neuronal cultures. Parkinsonism Relat Disord. 2010;16:650-5 pubmed 出版商
  • 免疫印迹; 大鼠
Yuzwa S, Yadav A, Skorobogatko Y, Clark T, Vosseller K, Vocadlo D. Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody. Amino Acids. 2011;40:857-68 pubmed 出版商
  • 免疫印迹; 人类
Park Y, Jang Y, Kwon Y. Protective effect of isoflavones against homocysteine-mediated neuronal degeneration in SH-SY5Y cells. Amino Acids. 2010;39:785-94 pubmed 出版商
  • 免疫印迹; 人类
Liu X, Liao K, Liu R, Wang H, Zhang Y, Zhang Q, et al. Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2. J Alzheimers Dis. 2010;19:953-62 pubmed 出版商
  • 免疫印迹; 小鼠; 1:200
Kulic L, Wollmer M, Rhein V, Pagani L, Kuehnle K, Cattepoel S, et al. Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration. Neurobiol Aging. 2011;32:1827-38 pubmed 出版商
  • 酶联免疫吸附测定; 人类; 图 1a
Hall E, Lee S, Mairuae N, Simmons Z, Connor J. Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues. Neurobiol Aging. 2011;32:1409-19 pubmed 出版商
  • 免疫印迹; 人类
Hundelt M, Fath T, Selle K, Oesterwind K, Jordan J, Schultz C, et al. Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation. Neurobiol Aging. 2011;32:991-1006 pubmed 出版商
  • 免疫印迹; 人类
Park Y, Jang Y, Kwon Y. Isoflavones prevent endoplasmic reticulum stress-mediated neuronal degeneration by inhibiting tau hyperphosphorylation in SH-SY5Y cells. J Med Food. 2009;12:528-35 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 3
Kim H, Sul D, Lim J, Lee D, Joo S, Hwang K, et al. Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation. Biosci Biotechnol Biochem. 2009;73:1685-9 pubmed
  • 免疫印迹; 大鼠; 1:1000
Zhang J, Peng C, Shi H, Wang S, Wang Q, Wang J. Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain. J Alzheimers Dis. 2009;16:39-47 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Sul D, Kim H, Lee D, Joo S, Hwang K, Park S. Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation. Life Sci. 2009;84:257-62 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Sul D, Kim H, Cho E, Lee M, Kim H, Jung W, et al. 2,3,7,8-TCDD neurotoxicity in neuroblastoma cells is caused by increased oxidative stress, intracellular calcium levels, and tau phosphorylation. Toxicology. 2009;255:65-71 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:200
Irons H, Cullen D, Shapiro N, Lambert N, Lee R, LaPlaca M. Three-dimensional neural constructs: a novel platform for neurophysiological investigation. J Neural Eng. 2008;5:333-41 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 6
Park S, Kim H, Cho E, Kwon B, Phark S, Hwang K, et al. Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation. Food Chem Toxicol. 2008;46:2881-7 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Liu X, Zhu L, Zhang Q, Shi H, Wang S, Wang Q, et al. Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A. Neurochem Res. 2008;33:1811-20 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Fukuzaki E, Takuma K, Himeno Y, Yoshida S, Funatsu Y, Kitahara Y, et al. Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits. Neurosci Lett. 2008;433:141-5 pubmed 出版商
  • 免疫印迹; 小鼠
Shi H, Zhu L, Wang S, Liu X, Tian Q, Zhang Q, et al. 17beta-estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner. J Neural Transm (Vienna). 2008;115:879-88 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5
Liu R, Zhou X, Tanila H, Bjorkdahl C, Wang J, Guan Z, et al. Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology. J Cell Mol Med. 2008;12:241-57 pubmed 出版商
  • 免疫印迹; 大鼠; 1:5000
Selenica M, Jensen H, Larsen A, Pedersen M, Helboe L, Leist M, et al. Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation. Br J Pharmacol. 2007;152:959-79 pubmed
  • 免疫组化; 小鼠; 1:5
  • 免疫印迹; 小鼠; 1:200
Bai F, Xi J, Andley U. Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice. Mol Vis. 2007;13:1589-600 pubmed
  • 免疫印迹; 人类; 1:200
Liu G, Zhang Y, Yao X, Zhang C, Fang J, Wang Q, et al. Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms. Neurobiol Aging. 2008;29:1348-58 pubmed
  • 免疫印迹; 人类; 1:2000
Ren Q, Liao X, Chen X, Liu G, Wang J. Effects of tau phosphorylation on proteasome activity. FEBS Lett. 2007;581:1521-8 pubmed
  • 免疫印迹; 大鼠; 1:1000; 图 3
Park S, Tournell C, Sinjoanu R, Ferreira A. Caspase-3- and calpain-mediated tau cleavage are differentially prevented by estrogen and testosterone in beta-amyloid-treated hippocampal neurons. Neuroscience. 2007;144:119-27 pubmed
  • 免疫组化-石蜡切片; 人类; 1:10,000; 表 1
  • 免疫印迹; 人类; 1:10,000; 表 1
Schindowski K, Bretteville A, Leroy K, Bégard S, Brion J, Hamdane M, et al. Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. Am J Pathol. 2006;169:599-616 pubmed
  • 免疫印迹; 小鼠
Yoshida S, Maeda M, Kaku S, Ikeya H, Yamada K, Nakaike S. Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus. J Neural Transm (Vienna). 2006;113:1803-14 pubmed
  • 免疫印迹; 人类; 1:200
Ren Q, Liao X, Wang Z, Qu Z, Wang J. The involvement of glycogen synthase kinase-3 and protein phosphatase-2A in lactacystin-induced tau accumulation. FEBS Lett. 2006;580:2503-11 pubmed
  • 免疫印迹; 大鼠; 1:250
Esposito G, De Filippis D, Carnuccio R, Izzo A, Iuvone T. The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells. J Mol Med (Berl). 2006;84:253-8 pubmed
  • 免疫沉淀; 人类
Dalfo E, Albasanz J, Rodriguez A, Martín M, Ferrer I. Abnormal group I metabotropic glutamate receptor expression and signaling in the frontal cortex in Pick disease. J Neuropathol Exp Neurol. 2005;64:638-47 pubmed
  • 免疫印迹; 小鼠; 1:1000
Lobsiger C, Garcia M, Ward C, Cleveland D. Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS. Proc Natl Acad Sci U S A. 2005;102:10351-6 pubmed
  • 免疫印迹; 人类
Hu Lieskovan S, Zhang J, Wu L, Shimada H, Schofield D, Triche T. EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. Cancer Res. 2005;65:4633-44 pubmed
  • 免疫印迹; 人类; 1:2000
Zhang Y, Xu Y, Chen X, Wang X, Wang J. Nitration and oligomerization of tau induced by peroxynitrite inhibit its microtubule-binding activity. FEBS Lett. 2005;579:2421-7 pubmed
  • 免疫印迹; 大鼠
Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttila T. Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation. Biochem Biophys Res Commun. 2002;298:693-8 pubmed
Ibáñez Salazar A, Bañuelos Hernández B, Rodriguez Leyva I, Chi Ahumada E, Monreal Escalante E, Jiménez Capdeville M, et al. Oxidative Stress Modifies the Levels and Phosphorylation State of Tau Protein in Human Fibroblasts. Front Neurosci. 2017;11:495 pubmed 出版商
Maphis N, Jiang S, Binder J, Wright C, Gopalan B, Lamb B, et al. Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology. Front Mol Neurosci. 2017;10:69 pubmed 出版商
Bodea L, Evans H, Van der Jeugd A, Ittner L, Delerue F, Kril J, et al. Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging Cell. 2017;16:377-386 pubmed 出版商
Park T, Ryu Y, Park H, Kim J, Go J, Noh J, et al. Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model. Int J Mol Med. 2017;39:21-30 pubmed 出版商
Guo J, Narasimhan S, Changolkar L, He Z, Stieber A, Zhang B, et al. Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice. J Exp Med. 2016;213:2635-2654 pubmed
Yoshitake J, Soeda Y, Ida T, Sumioka A, Yoshikawa M, Matsushita K, et al. Modification of Tau by 8-Nitroguanosine 3',5'-Cyclic Monophosphate (8-Nitro-cGMP): EFFECTS OF NITRIC OXIDE-LINKED CHEMICAL MODIFICATION ON TAU AGGREGATION. J Biol Chem. 2016;291:22714-22720 pubmed
Chen X, Wagener J, Ghribi O, Geiger J. Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease. Front Aging Neurosci. 2016;8:129 pubmed 出版商
Tiernan C, Combs B, Cox K, Morfini G, Brady S, Counts S, et al. Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. Exp Neurol. 2016;283:318-29 pubmed 出版商
Sohn P, Tracy T, Son H, Zhou Y, Leite R, Miller B, et al. Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment. Mol Neurodegener. 2016;11:47 pubmed 出版商
Wang Y, Ren Q, Gong W, Wu D, Tang X, Li X, et al. Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt/GSK-3β pathway. Oncotarget. 2016;7:13328-39 pubmed 出版商
Maeda S, Djukic B, Taneja P, Yu G, Lo I, Davis A, et al. Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice. EMBO Rep. 2016;17:530-51 pubmed 出版商
Kailainathan S, Piers T, Yi J, Choi S, Fahey M, Borger E, et al. Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF). Pharmacol Res. 2016;104:97-107 pubmed 出版商
de Paula C, Santiago F, de Oliveira A, Oliveira F, Almeida M, Carrettiero D. The Co-chaperone BAG2 Mediates Cold-Induced Accumulation of Phosphorylated Tau in SH-SY5Y Cells. Cell Mol Neurobiol. 2016;36:593-602 pubmed 出版商
Gyoneva S, Kim D, Katsumoto A, Kokiko Cochran O, Lamb B, Ransohoff R. Ccr2 deletion dissociates cavity size and tau pathology after mild traumatic brain injury. J Neuroinflammation. 2015;12:228 pubmed 出版商
De Zio D, Molinari F, Rizza S, Gatta L, Ciotti M, Salvatore A, et al. Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth. Cell Mol Life Sci. 2015;72:4173-91 pubmed 出版商
Maphis N, Xu G, Kokiko Cochran O, Jiang S, Cardona A, Ransohoff R, et al. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain. 2015;138:1738-55 pubmed 出版商
Ittner A, Bertz J, Suh L, Stevens C, Götz J, Ittner L. Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. J Neurochem. 2015;132:135-45 pubmed 出版商
Liu C, Götz J. Profiling murine tau with 0N, 1N and 2N isoform-specific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1N isoform being enriched in the nucleus. PLoS ONE. 2013;8:e84849 pubmed 出版商
Oz S, Ivashko Pachima Y, Gozes I. The ADNP derived peptide, NAP modulates the tubulin pool: implication for neurotrophic and neuroprotective activities. PLoS ONE. 2012;7:e51458 pubmed 出版商
Herzig M, Bidinosti M, Schweizer T, Hafner T, Stemmelen C, Weiss A, et al. High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain. PLoS ONE. 2012;7:e36581 pubmed 出版商
Zhang Q, Gao T, Luo Y, Chen X, Gao G, Gao X, et al. Transient focal cerebral ischemia/reperfusion induces early and chronic axonal changes in rats: its importance for the risk of Alzheimer's disease. PLoS ONE. 2012;7:e33722 pubmed 出版商
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图像
图像 1 :
赛默飞世尔 MA5-12808 图像 1
图像 2 :
赛默飞世尔 MA5-12808 图像 2
产品信息
产品类型 :
抗体
产品名称 :
Tau Monoclonal Antibody (TAU-5)
目录# :
MA5-12808
规格 :
500µL
价格 :
美国375.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
Bovine, Human, Mouse, Ovine, Rat
应用 :
Immunocytochemistry: 2-3 µg/mL, Immunofluorescence: 2-3 µg/mL, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 2 µg/mg protein lysate, Western Blot: 1-2 µg/mL
物种 :
Bovine, Human, Mouse, Ovine, Rat
克隆 :
TAU-5
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
免疫原 :
纯化牛微管相关蛋白
格式 :
Liquid
应用w/稀释 :
Immunocytochemistry: 2-3 µg/mL, Immunofluorescence: 2-3 µg/mL, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 2 µg/mg protein lysate, Western Blot: 1-2 µg/mL
别名 :
G protein beta1/gamma2 subunit-interacting factor 1, PHF-tau, microtubule-associated protein tau, isoform 4, neurofibrillary tangle protein, paired helical filament-tau, Tau5
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
www.thermo.com.cn
1084193588
公司总部: 美国