产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Prohibitin Monoclonal Antibody (II-14-10)
目录 :
MA5-12858
规格 :
500微升
价格 :
美国446.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
II-14-10
反应物种 :
人类, 小鼠, 大鼠, , pigs , 肝炎病毒C
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 68
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类; 图 2b
Yurugi H, Marini F, Weber C, David K, Zhao Q, Binder H, et al. Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours. Oncogene. 2017;36:4778-4789 pubmed 出版商
  • 免疫印迹; 人类; 图 2c
Zaganelli S, Rebelo Guiomar P, Maundrell K, Rozanska A, Pierredon S, Powell C, et al. The Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitochondrial RNA Granules. J Biol Chem. 2017;292:4519-4532 pubmed 出版商
  • 免疫印迹; 人类; 图 2b
Diaz Hidalgo L, Altuntas S, Rossin F, D Eletto M, Marsella C, Farrace M, et al. Transglutaminase type 2-dependent selective recruitment of proteins into exosomes under stressful cellular conditions. Biochim Biophys Acta. 2016;1863:2084-92 pubmed 出版商
  • 免疫印迹; 大鼠; 1:250; 图 5a
Poitelon Y, Bogni S, Matafora V, Della Flora Nunes G, Hurley E, Ghidinelli M, et al. Spatial mapping of juxtacrine axo-glial interactions identifies novel molecules in peripheral myelination. Nat Commun. 2015;6:8303 pubmed 出版商
  • 免疫印迹; pigs ; 1:100
Rogée S, Le Gall M, Chafey P, Bouquet J, Cordonnier N, Frederici C, et al. Quantitative proteomics identifies host factors modulated during acute hepatitis E virus infection in the swine model. J Virol. 2015;89:129-43 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
Leal M, Cirilo P, Mazzotti T, Calcagno D, Wisnieski F, Demachki S, et al. Prohibitin expression deregulation in gastric cancer is associated with the 3' untranslated region 1630 C>T polymorphism and copy number variation. PLoS ONE. 2014;9:e98583 pubmed 出版商
  • 流式细胞仪; 人类
Wang Y, Guo X, Li S, Zhao Y, Liu Z, Lee W, et al. Prohibitin is involved in the activated internalization and degradation of protease-activated receptor 1. Biochim Biophys Acta. 2014;1843:1393-401 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类; 1:400
Begum A, Lin Q, Yu C, Kim Y, Yun Z. Interaction of delta-like 1 homolog (Drosophila) with prohibitins and its impact on tumor cell clonogenicity. Mol Cancer Res. 2014;12:155-64 pubmed 出版商
  • 免疫印迹; 人类
Panico K, Forti F. Proteomic, cellular, and network analyses reveal new DUSP3 interactions with nucleolar proteins in HeLa cells. J Proteome Res. 2013;12:5851-66 pubmed 出版商
  • 流式细胞仪; 人类; 1:100
  • 免疫组化; 人类; 1:100
  • 免疫印迹; 人类; 1:500
Jiang P, Xiang Y, Wang Y, Li S, Wang Y, Hua H, et al. Differential expression and subcellular localization of Prohibitin 1 are related to tumorigenesis and progression of non-small cell lung cancer. Int J Clin Exp Pathol. 2013;6:2092-101 pubmed
  • 免疫印迹; 人类
Yurugi H, Tanida S, Akita K, Ishida A, Toda M, Nakada H. Prohibitins function as endogenous ligands for Siglec-9 and negatively regulate TCR signaling upon ligation. Biochem Biophys Res Commun. 2013;434:376-81 pubmed 出版商
  • 免疫印迹; 人类
Jourdain A, Koppen M, Wydro M, Rodley C, Lightowlers R, Chrzanowska Lightowlers Z, et al. GRSF1 regulates RNA processing in mitochondrial RNA granules. Cell Metab. 2013;17:399-410 pubmed 出版商
  • 免疫细胞化学; 人类; 1:50
Picard C, Pellicelli M, Taheri M, Lavoie J, Doucet R, Wang D, et al. Nuclear accumulation of prohibitin 1 in osteoarthritic chondrocytes down-regulates PITX1 expression. Arthritis Rheum. 2013;65:993-1003 pubmed 出版商
  • 免疫印迹; 小鼠
Leanza L, Zoratti M, Gulbins E, Szabo I. Induction of apoptosis in macrophages via Kv1.3 and Kv1.5 potassium channels. Curr Med Chem. 2012;19:5394-404 pubmed
  • 免疫印迹; 人类; 1:1000
Quast S, Berger A, Buttstädt N, Friebel K, Schönherr R, Eberle J. General Sensitization of melanoma cells for TRAIL-induced apoptosis by the potassium channel inhibitor TRAM-34 depends on release of SMAC. PLoS ONE. 2012;7:e39290 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Fletcher C, Dart D, Sita Lumsden A, Cheng H, Rennie P, Bevan C. Androgen-regulated processing of the oncomir miR-27a, which targets Prohibitin in prostate cancer. Hum Mol Genet. 2012;21:3112-27 pubmed 出版商
  • 免疫印迹; 人类
Leanza L, Henry B, Sassi N, Zoratti M, Chandy K, Gulbins E, et al. Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells. EMBO Mol Med. 2012;4:577-93 pubmed 出版商
  • 免疫组化; 大鼠; 1:300
Zhou T, Qin Y, Li Z, Xu H, Zhao Y, Lei F. All-trans retinoic acid treatment is associated with prohibitin expression in renal interstitial fibrosis rats. Int J Mol Sci. 2012;13:2769-82 pubmed 出版商
  • 免疫印迹; 人类
Kamiński M, Roth D, Sass S, Sauer S, Krammer P, Gülow K. Manganese superoxide dismutase: a regulator of T cell activation-induced oxidative signaling and cell death. Biochim Biophys Acta. 2012;1823:1041-52 pubmed 出版商
  • 免疫印迹; 小鼠
Yurugi H, Tanida S, Ishida A, Akita K, Toda M, Inoue M, et al. Expression of prohibitins on the surface of activated T cells. Biochem Biophys Res Commun. 2012;420:275-80 pubmed 出版商
  • 免疫印迹; 人类
Orr S, Boutz D, Wang R, Chronis C, Lea N, Thayaparan T, et al. Proteomic and protein interaction network analysis of human T lymphocytes during cell-cycle entry. Mol Syst Biol. 2012;8:573 pubmed 出版商
  • 免疫印迹; 人类
Masgras I, Rasola A, Bernardi P. Induction of the permeability transition pore in cells depleted of mitochondrial DNA. Biochim Biophys Acta. 2012;1817:1860-6 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Sofiadis A, Becker S, Hellman U, Hultin Rosenberg L, Dinets A, Hulchiy M, et al. Proteomic profiling of follicular and papillary thyroid tumors. Eur J Endocrinol. 2012;166:657-67 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类; 1:1000
Dart D, Brooke G, Sita Lumsden A, Waxman J, Bevan C. Reducing prohibitin increases histone acetylation, and promotes androgen independence in prostate tumours by increasing androgen receptor activation by adrenal androgens. Oncogene. 2012;31:4588-98 pubmed 出版商
  • 免疫印迹; 人类
Minet A, Gaster M. The dynamic equilibrium between ATP synthesis and ATP consumption is lower in isolated mitochondria from myotubes established from type 2 diabetic subjects compared to lean control. Biochem Biophys Res Commun. 2011;409:591-5 pubmed 出版商
  • 免疫印迹; 大鼠
Zhang J, Ye J, Altafaj A, Cardona M, Bahi N, Llovera M, et al. EndoG links Bnip3-induced mitochondrial damage and caspase-independent DNA fragmentation in ischemic cardiomyocytes. PLoS ONE. 2011;6:e17998 pubmed 出版商
  • 免疫印迹; 人类; 1:150
Yan Y, Xu H, Peng S, Zhao W, Wang B. Proteome analysis of ultraviolet-B-induced protein expression in vitro human dermal fibroblasts. Photodermatol Photoimmunol Photomed. 2010;26:318-26 pubmed 出版商
  • 免疫印迹; 人类
Theiss A, Laroui H, Obertone T, Chowdhury I, Thompson W, Merlin D, et al. Nanoparticle-based therapeutic delivery of prohibitin to the colonic epithelial cells ameliorates acute murine colitis. Inflamm Bowel Dis. 2011;17:1163-76 pubmed 出版商
  • 免疫印迹; 人类
Lee H, Arnouk H, Sripathi S, Chen P, Zhang R, Bartoli M, et al. Prohibitin as an oxidative stress biomarker in the eye. Int J Biol Macromol. 2010;47:685-90 pubmed 出版商
  • 免疫细胞化学; 人类; 1:50
  • 免疫印迹; 人类; 1:200
Sperandio S, Poksay K, Schilling B, Crippen D, Gibson B, Bredesen D. Identification of new modulators and protein alterations in non-apoptotic programmed cell death. J Cell Biochem. 2010;111:1401-12 pubmed 出版商
  • 免疫组化; 大鼠; 1:100
  • 免疫印迹; 大鼠; 1:500
Shen Q, Xu H, Wei L, Chen J, Liu H. Intrauterine growth restriction and postnatal high-protein diet affect the kidneys in adult rats. Nutrition. 2011;27:364-71 pubmed 出版商
  • 免疫印迹; 人类
Sofiadis A, Dinets A, Orre L, Branca R, Juhlin C, Foukakis T, et al. Proteomic study of thyroid tumors reveals frequent up-regulation of the Ca2+ -binding protein S100A6 in papillary thyroid carcinoma. Thyroid. 2010;20:1067-76 pubmed 出版商
  • 免疫印迹; 人类
Liu H, Hsu P, Lai M, Chang H, Ho C, Cheng H, et al. An unusual function of RON receptor tyrosine kinase as a transcriptional regulator in cooperation with EGFR in human cancer cells. Carcinogenesis. 2010;31:1456-64 pubmed 出版商
  • 免疫印迹; 人类
Sassi N, De Marchi U, Fioretti B, Biasutto L, Gulbins E, Franciolini F, et al. An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1. Biochim Biophys Acta. 2010;1797:1260-7 pubmed 出版商
  • 免疫沉淀; 小鼠
  • 免疫细胞化学; 小鼠; 1:50
  • 免疫印迹; 小鼠
Jain R, Ghoshal A, Mandal C, Shaha C. Leishmania cell surface prohibitin: role in host-parasite interaction. Cell Microbiol. 2010;12:432-52 pubmed 出版商
  • 免疫组化; 人类; 1:100
  • 免疫印迹; 人类; 1:200
He Q, Zhang S, Chu Y, Jia X, Zhao L, Wang X. Separation and identification of differentially expressed nuclear matrix proteins in breast carcinoma forming. Acta Oncol. 2010;49:76-84 pubmed 出版商
  • 免疫细胞化学; 人类; 1:300
  • 免疫印迹; 人类; 1:1000
Shi S, Li Q, Liu Q, Xu D, Tang J, Liang Y, et al. Nuclear matrix protein, prohibitin, was down-regulated and translocated from nucleus to cytoplasm during the differentiation of osteosarcoma MG-63 cells induced by ginsenoside Rg1, cinnamic acid, and tanshinone IIA (RCT). J Cell Biochem. 2009;108:926-34 pubmed 出版商
  • 免疫印迹; 人类
  • 免疫印迹; 小鼠
Theiss A, Jenkins A, Okoro N, Klapproth J, Merlin D, Sitaraman S. Prohibitin inhibits tumor necrosis factor alpha-induced nuclear factor-kappa B nuclear translocation via the novel mechanism of decreasing importin alpha3 expression. Mol Biol Cell. 2009;20:4412-23 pubmed 出版商
  • 免疫印迹; 人类
Rothfuss O, Fischer H, Hasegawa T, Maisel M, Leitner P, Miesel F, et al. Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair. Hum Mol Genet. 2009;18:3832-50 pubmed 出版商
  • 免疫印迹; 人类
Proulx D, Aubin E, Lemieux R, Bazin R. Spontaneous internalization of IVIg in activated B cells. Immunol Lett. 2009;124:18-26 pubmed 出版商
  • 免疫印迹; 人类
De Marchi U, Sassi N, Fioretti B, Catacuzzeno L, Cereghetti G, Szabo I, et al. Intermediate conductance Ca2+-activated potassium channel (KCa3.1) in the inner mitochondrial membrane of human colon cancer cells. Cell Calcium. 2009;45:509-16 pubmed 出版商
  • 免疫印迹; 人类; 1:400
Zhang Z, Jia L, Feng Y, Zheng W. Overexpression of follicle-stimulating hormone receptor facilitates the development of ovarian epithelial cancer. Cancer Lett. 2009;278:56-64 pubmed 出版商
  • 免疫印迹; 大鼠
Chuang Y, Chen S, Liou C, Lin T, Chang W, Chan S, et al. Contribution of nitric oxide, superoxide anion, and peroxynitrite to activation of mitochondrial apoptotic signaling in hippocampal CA3 subfield following experimental temporal lobe status epilepticus. Epilepsia. 2009;50:731-46 pubmed 出版商
  • 免疫印迹; 肝炎病毒C; 1:1000
Nitahara Kasahara Y, Fukasawa M, Shinkai Ouchi F, Sato S, Suzuki T, Murakami K, et al. Cellular vimentin content regulates the protein level of hepatitis C virus core protein and the hepatitis C virus production in cultured cells. Virology. 2009;383:319-27 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Da Cruz S, Martinou J. Purification and proteomic analysis of the mouse liver mitochondrial inner membrane. Methods Mol Biol. 2008;432:101-16 pubmed 出版商
  • 免疫组化; 人类
Vesela K, Hulkova H, Hansikova H, Zeman J, Elleder M. Structural analysis of tissues affected by cytochrome C oxidase deficiency due to mutations in the SCO2 gene. APMIS. 2008;116:41-9 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Schmidt V, Chiariello C, Capilla E, Miller F, Bahou W. Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent. Mol Cell Biol. 2008;28:1489-502 pubmed 出版商
  • 免疫组化; 人类; 1:500
Sikora J, Dvorakova L, Vlaskova H, Stolnaja L, Betlach J, Spacek J, et al. A case of excessive autophagocytosis with multiorgan involvement and low clinical penetrance. Cesk Patol. 2007;43:93-103 pubmed
  • 免疫印迹; 人类
Wu T, Wu H, Wang Y, Chang T, Chan S, Lin Y, et al. Prohibitin in the pathogenesis of transitional cell bladder cancer. Anticancer Res. 2007;27:895-900 pubmed
  • 免疫印迹; 大鼠
Chuang Y, Chen S, Lin T, Liou C, Chang W, Chan S, et al. Upregulation of nitric oxide synthase II contributes to apoptotic cell death in the hippocampal CA3 subfield via a cytochrome c/caspase-3 signaling cascade following induction of experimental temporal lobe status epilepticus in the rat. Neuropharmacology. 2007;52:1263-73 pubmed
  • 免疫印迹; 大鼠
Chan J, Cheng H, Chou J, Li F, Dai K, Chan S, et al. Heat shock protein 60 or 70 activates nitric-oxide synthase (NOS) I- and inhibits NOS II-associated signaling and depresses the mitochondrial apoptotic cascade during brain stem death. J Biol Chem. 2007;282:4585-600 pubmed
  • 免疫印迹; 鸡; 1:400
Pucci B, Adams C, Fertala J, Snyder B, Mansfield K, Tafani M, et al. Development of the terminally differentiated state sensitizes epiphyseal chondrocytes to apoptosis through caspase-3 activation. J Cell Physiol. 2007;210:609-15 pubmed
  • 免疫细胞化学; 大鼠; 1:100
  • 免疫印迹; 大鼠; 1:1000
  • 免疫组化; 人类; 1:100
Guo W, Xu H, Chen J, Yang Y, Jin J, Fu R, et al. Prohibitin suppresses renal interstitial fibroblasts proliferation and phenotypic change induced by transforming growth factor-beta1. Mol Cell Biochem. 2007;295:167-77 pubmed
  • 免疫组化; 人类; 1:500
Sikora J, Harzer K, Elleder M. Neurolysosomal pathology in human prosaposin deficiency suggests essential neurotrophic function of prosaposin. Acta Neuropathol. 2007;113:163-75 pubmed
  • 染色质免疫沉淀 ; 人类
Joshi B, Rastogi S, Morris M, Carastro L, DeCook C, Seto E, et al. Differential regulation of human YY1 and caspase 7 promoters by prohibitin through E2F1 and p53 binding sites. Biochem J. 2007;401:155-66 pubmed
  • 免疫印迹; 人类
Tsintzas K, Jewell K, Kamran M, Laithwaite D, Boonsong T, Littlewood J, et al. Differential regulation of metabolic genes in skeletal muscle during starvation and refeeding in humans. J Physiol. 2006;575:291-303 pubmed
  • 免疫印迹; 大鼠
Chang A, Chan J, Chou J, Li F, Dai K, Chan S. Heat shock protein 60 in rostral ventrolateral medulla reduces cardiovascular fatality during endotoxaemia in the rat. J Physiol. 2006;574:547-64 pubmed
  • 免疫印迹; 人类
Chan H, Gharbi S, Gaffney P, Cramer R, Waterfield M, Timms J. Proteomic analysis of redox- and ErbB2-dependent changes in mammary luminal epithelial cells using cysteine- and lysine-labelling two-dimensional difference gel electrophoresis. Proteomics. 2005;5:2908-26 pubmed
  • 免疫印迹; 人类
Suzuki R, Sakamoto S, Tsutsumi T, Rikimaru A, Tanaka K, Shimoike T, et al. Molecular determinants for subcellular localization of hepatitis C virus core protein. J Virol. 2005;79:1271-81 pubmed
  • 免疫印迹; 人类; 图 5
Li Q, Ching A, Chan B, Chow S, Lim P, Ho T, et al. A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway. J Biol Chem. 2004;279:52106-16 pubmed
Manjunath L, Singh A, Sahoo S, Mishra A, Padmarajan J, Basavaraju C, et al. Stop codon read-through of mammalian MTCH2 leading to an unstable isoform regulates mitochondrial membrane potential. J Biol Chem. 2020;295:17009-17026 pubmed 出版商
Li X, Chai R, Chen G, Zhang L, Tan Tai W, Shi H, et al. Prohibitin (PHB) interacts with AKT in mitochondria to coordinately modulate sperm motility. Asian J Androl. 2020;22:583-589 pubmed 出版商
Ludwig A, de Miroschedji K, Doeppner T, Börger V, Ruesing J, Rebmann V, et al. Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scales. J Extracell Vesicles. 2018;7:1528109 pubmed 出版商
Anderson C, Kahl A, Qian L, Stepanova A, Starkov A, Manfredi G, et al. Prohibitin is a positive modulator of mitochondrial function in PC12 cells under oxidative stress. J Neurochem. 2018;146:235-250 pubmed 出版商
Yarmishyn A, Kremenskoy M, Batagov A, Preuss A, Wong J, Kurochkin I. Genome-wide analysis of mRNAs associated with mouse peroxisomes. BMC Genomics. 2016;17:1028 pubmed 出版商
Wakatsuki S, Tokunaga S, Shibata M, Araki T. GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration. J Cell Biol. 2017;216:477-493 pubmed 出版商
Ullmann R, Morbini P, Halbwedl I, Bongiovanni M, Gogg Kammerer M, Papotti M, et al. Protein expression profiles in adenocarcinomas and squamous cell carcinomas of the lung generated using tissue microarrays. J Pathol. 2004;203:798-807 pubmed
Thompson W, Ramalho Santos J, Sutovsky P. Ubiquitination of prohibitin in mammalian sperm mitochondria: possible roles in the regulation of mitochondrial inheritance and sperm quality control. Biol Reprod. 2003;69:254-60 pubmed
产品信息
产品类型 :
抗体
产品名称 :
Prohibitin Monoclonal Antibody (II-14-10)
目录# :
MA5-12858
规格 :
500微升
价格 :
美国446.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
Chicken, Human, Mouse, Non-human primate, Porcine, Rat
应用 :
Immunohistochemistry (Paraffin): 2-4 µg/mL, Western Blot: 0.5-1.0 µg/mL
物种 :
Chicken, Human, Mouse, Non-human primate, Porcine, Rat
克隆 :
II-14-10
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
免疫原 :
Purified recombinant rat prohibitin protein
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 2-4 µg/mL, Western Blot: 0.5-1.0 µg/mL
别名 :
BAP 32; Bap32; B-cell receptor-associated protein 32; epididymis luminal protein 215; epididymis secretory sperm binding protein Li 54e; fa18f07; fb09f05; HEL-215; HEL-S-54e; OTTHUMP00000165765; OTTHUMP00000165766; OTTHUMP00000220103; OTTHUMP00000220170; OTTHUMP00000220171; PHB; phb protein; PHB1; Prohibitin; sr:nyz128; wu:fa18f07; wu:fb09f05
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国